Fighting diseases of aging by wasting energy
...activity of so-called uncoupling protein 1 (UCP1). ucp1
disrupts the transfer of electrons from food to ox...engineered to express modestly increased levels of ucp1
in skeletal muscle had a mildly increased metaboli...disease.
They found that animals with increased ucp1
only in skeletal muscle lived longer. Altered fema...
Making metabolism more inefficient can reduce obesity
...t this may not be the case. They knocked-out two thermogenic genes in mice, ucp1
(mitochondrial uncoupling protein) and Gdm (glycerol 3-phosphate dehydrogen...ulted from the mice turning on backup heat generators, so to speak. Lacking ucp1
and Gdm, genes that have been designed for the efficient production of heat...
Medical College researchers find dinosaur clues in fat
...ructured and behave like brown fat. These chicken cells can even activate a ucp1
gene if presented with one from a mouse.
The ability to produce brown fa...ammalian lineage (the researchers found the lizard genome similarly lacks a ucp1
gene). This strongly implies that dinosaurs, which diverged from birds even...
How appetite-stimulating brain cells work overtime during fasting
... mitochondrial uncoupling protein 1 (UCP1) by T3, the researchers said. The ucp1
activation, which is controlled by the sympathetic nervous system, also lea...in the brain likely also causes changes in temperature in the same way that ucp1
does in brown fat, Diano said.
"It's possible that heat may act like ...