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Tykerb in Medical News

GlaxoSmithKline’s Tykerb is to Be Started Earlier in Breast Cancer, Study Find

London: Statistics from a Phase III study has shown that GlaxoSmithKline's Tykerb along with Roche's Xeloda is far better than Xeloda alone in women with HER2// positive advanced breast cancer, where the disease had progressed despite previous therapy involving Herceptin. Basis the findings, ...

GSK Seeks Permission to Market Breast Cancer Pill Tykerb

GlaxoSmithKline PLC has filed for permission with European medicine regulators to begin selling its new breast cancer pill Tykerb//. This follows a similar move in the US last month, and comes slightly earlier than some commentators were expecting. The drug is foreseen to be one of GSK'...

Research Findings on Nine GlaxoSmithKline Cancer Compounds to be Presented at ASCO 2009

...the following compounds will also be presented at ASCO 2009: AVODART(R) (dutasteride), elesclomol, eltrombopag, topotecan and GSK923925. About tykerb (R) /TYVERB (R) (lapatinib) Lapatinib is an oral small-molecule inhibitor of the HER2/ErbB2 tyrosine kinase receptor. Stimulation of HER2/Erb...

GSK Submits TYVERB(R)/TYKERB(R) (lapatinib) for First-Line Treatment of Metastatic Breast Cancer in Europe, US

...NG and Additional Important Safety Information for tykerb Hepatotoxicity - tykerb has been associated with hepatotoxicity. Hepatoto...changes in liver function are severe, therapy with tykerb should be discontinued and patients should not be ...

Prescription Drug Benefits for Medicare Patients with Cancer to Cost More in 2009

...r consumers. In 2009, the large majority of PDPs placed name-brand oral oncology products -- including Gleevec, Sutent, Tarceva, Thalomid, and tykerb -- on specialty tiers that require cost sharing of 26 percent to 35 percent for each prescription. For example, 84 percent of PDP enrollees are in pl...

Combination of TYKERB(R) (lapatinib) Plus Letrozole Demonstrated Significant Improvement in Delaying Disease Progression for HER2+/ErbB2+ Post-Menopausal Metastatic Breast Cancer

...Safety Information Hepatotoxicity - tykerb has been associated with hepatotoxicity. Hepatoto...changes in liver function are severe, therapy with tykerb should be discontinued and patients should not be ... Decreased Left Ventricular Ejection Fraction - tykerb has been reported to decrease LVEF. Caution shoul...

India's Breast Cancer Drug Market Will Almost Double by 2012

...of targeted therapies in other major markets and have started to increasingly incorporate targeted therapies --- Herceptin, Avastin, GlaxoSmithKline's tykerb --- into breast cancer treatment to achieve better efficacy and toxicity profiles than conventional therapies. However, premium prices are the major c...

Karmanos Cancer Institute Seeks Breast Cancer Patients to Participate in a New Drug Trial

...stated that eligible patients must have HER2 positive metastatic breast cancer, tumors measurable by radiographic evaluation, progressed on Herceptin, tykerb and Xeloda, and show no current evidence of brain cancer. Patients should call the Karmanos Clinical Trials office at 313-576-8749. Dr. LoRusso ha...

GlaxoSmithKline Presents Innovative Neuroscience Pipeline

... Volibris (EU) Ofatumumab (RA) (EU) tykerb (US) Requip XL (PD) (US) Promacta (he... c) Wellbutrin XR (EU) Rotarix (US) tykerb (H&N cancer) tykerb + Pazopanib ...

Advanced Scientific Brings Help for Breast Cancer Survivors

...ine, had produced encouraging results in a group of 241 patients whose breast cancer had spread to the brain. After a treatment of six months with the tykerb pill, seven percent of patients had their tumors reduced by at least 50 percent while 20 percent saw their tumors reduced by less than 50 percent. ...
Tykerb in Medical Technology

Surveyed Oncologists Say That the Most Promising Targeted Therapy in Adjuvant Clinical Trials is Avastin for the Treatment of Early-Stage Colorectal Cancer

..., according to National Cancer Institute guidelines, patients who fail Sutent could benefit from Nexavar. However, four of the MCOs that fail to cover tykerb and six of the MCOs that fail to cover Nexavar cite the ability to negotiate a more favorable contract for a comparable drug. This suggests that some ...

New Data Offers Insights Into the Potential Role for TYKERB(R) (Lapatinib) in Non-Cytotoxic Chemotherapy-Based Treatment Regimens

... tykerb Demonstrates Activity in Combination with Other Ta... breast cancer(1) - Phase II results combining tykerb and AVASTIN(R) (bevacizumab), a monoclonal antibo...her targeted therapies or as a monotherapy. Use of tykerb in these settings is investigational. Results from...

GSK Announces Results of First Phase III Trial Evaluating Tykerb(R) (Lapatinib) Plus Herceptin(R) (Trastuzumab)

...ighlights Include: -- Results demonstrating that tykerb and trastuzumab together resulted in a clinically ... of progression-free survival (PFS) -- Combining tykerb and trastuzumab to attack both the inside and outs... HER2 blockade -- Data demonstrating activity of tykerb alone despite patients' previous treatment with mu...

TYKERB(R) (Lapatinib) to be Investigated in Landmark Early Breast Cancer Trial

... treatment is referred to as neo-adjuvant therapy. tykerb is an investigational drug and has not yet been ap...uvant trastuzumab and a combination of neoadjuvant tykerb and trastuzumab in women with HER2-positive primar...rkers that help to better identify the benefits of tykerb or trastuzumab. "GSK is proud to collaborate w...

GlaxoSmithKline Reports Further Progress of Oncology Portfolio

...e) Important Safety Information for TYKERB tykerb has been associated with hepatotoxicity. The hepat...ould be considered. Discontinue and do not restart tykerb if patients experience severe changes in liver fun... As with other therapies for HER2 overexpression, tykerb has been associated with reports of decreases in l...

BiPar Begins Phase 2 Study of Lead PARP Inhibitor in Triple-Negative Breast Cancer Based on Overexpression Biomarker Data

... breast cancer, who make up 10 to 15 percent of all patients, have few effective therapeutic options. Neither targeted therapies such as Herceptin and tykerb nor anti-estrogens such as tamoxifen provide a benefit, and triple-negative tumors are associated with a high rate of relapse. Such cancers are partic...
Tykerb in Biological News

Genes and biomarkers that allow doctors to choose the right therapy for the right patient

...harmacogenomic to discover genetic determinants of tykerb response: Abstract 5684 A new high-throughp...e predicted to be synergistic with Tykerb." tykerb is an enzyme inhibitor that effectively blocks two...ving molecular signals. By blocking these signals, tykerb could effectively shut down the growth of solid tu...
Tykerb in Biological Technology

The Breast Cancer Therapeutics Market in Australia

...availability on the Pharmaceutical Benefits Scheme (PBS)," says Gaffud. Currently, only Herceptin (for early stage breast cancer patients) and tykerb (for advanced/metastatic breast cancer patients) are subsidized through the PBS. Nonetheless, innovative targeted therapies are showing great promise ...

GlaxoSmithKline Announces Data on TYKERB(R) (Lapatinib) Plus Capecitabine for the Treatment of HER2 Positive Breast Cancer Brain Metastases

... Study Shows tykerb Combination Reduced the Size of Brain Tumors Assoc... Specifically, 20 percent of patients who received tykerb plus capecitabine experienced at least a 50 percen...ir disease(2). Results of this and other important tykerb studies are being presented at the 2007 San Antoni...
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