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Tubulin in Medical News

Erroneous Laboratory Operation May Lead To a Cancer Drug

...cording to Schaefer, mode of action of PPAR-gamma is different from the current drugs. It attacks a section of cell cytoskeleton called tubulin. While tubulin is involved in building the cell arrangement, PPAR-gamma breaks it down. This indirectly indicates that the gamma compound could actually counter the ...

Hope For Patients With Prostate Cancer

... say Taxotere in combination with prednisone offers hope to certain patients who have not responded to other treatments. Taxotere works by stopping tubulin -- a protein that helps cancer cells divide and grow. The drug Taxotere in combination with prednisone was found to extend the lifespan of patients by...
Tubulin in Medical Technology

CuraGen Completes Enrollment in Phase II Trial of CR011-vcMMAE in Metastatic Melanoma

...st cancer and brain tumors. CR011-vcMMAE is an antibody-drug conjugate comprised of a fully-human monoclonal antibody against GPNMB linked to a potent tubulin destabilizing agent, monomethyl auristatin E (MMAE). The enzyme-sensitive linker, which was licensed from Seattle Genetics, is designed to be stable i...

EntreMed Presents MKC-1 and ENMD-1198 Preclinical Data at AACR Annual Meeting

...ls of the oncogenic transcription factor proteins HIF-1alpha, pSTAT3, and pNFkappaB. Treatment with ENMD-1198 also downregulates expression of several tubulin isotypes in 1A9 cells, but not in ENMD-1198-resistant (1A9-1198R) cells. This, combined with the relative lack of inhibition of oncogenic proteins obs...

EntreMed Presents Mechanism Data for Its Three Lead Oncology Compounds

...iogenesis. The mechanisms of action of these three tubulin agents was compared and contrasted during the pres...e highly dynamic filaments are composed of dimeric tubulin proteins. Microtubule targeting drugs are one of t...h antiproliferative and antiangiogenic properties. tubulin binding and subsequent microtubule disruption are ...

Nereus Pharmaceuticals to Present Data at the American Association for Cancer Research 2007 Annual Meeting

...ion as well as single-agent efficacy in a number of orthotopic models. NPI-2358 interacts with soluble beta-tubulin and prevents the polymerization of tubulin without altering dynamic microtubule function of formed microtubules. As demonstrated in pre-clinical testing, this target profile results in a highly...

ZIOPHARM Presents Unique Mechanism Data for Indibulin at AACR

...to peripheral neuropathy. While indibulin binds to tubulin in general, it does not bind to neuronal specific tubulin and does not disrupt normal axonal microtubules in...ir building blocks, tubulin. However, the specific tubulin binding site for indibulin is different from that ...

Threshold Pharmaceuticals Announces Multiple Presentations on Oncology Pipeline at the 2007 American Association for Cancer Research (AACR) Annual Meeting

...H-302, in Pancreatic and Prostate Orthotopic Models of Cancer Poster Session: Angiogenesis Inhibitors Poster 3984: A Novel Class of tubulin Inhibitors that Exhibit Potent Antiproliferation and Vascular Targeting Activities Poster Session: Angiogenesis Inhibitors Poster 3...

EntreMed Presents Multi-Mechanism Antitumor Data for ENMD-1420 in Preclinical Models

...s. Previous studies showed that ENMD-1420 inhibits tubulin polymerization and TNF-alpha production, contribut... stated, "We continue to make good progress on our tubulin inhibitor program. The results of these studies wi...tp://www.entremed.com/">www.entremed.com . About tubulin Inhibitors Tubulins are the proteins that form m...

EntreMed Presents Multi-Mechanism Results for ENMD-1198 at AACR Annual Meeting

...well as in preclinical development for rheumatoid arthritis. MKC-1, an oral cell cycle regulator, is in Phase 2 studies for cancer. ENMD-1198, a novel tubulin binding agent, is also in Phase 1 studies in advanced cancers. EntreMed's goal is to develop and commercialize new compounds based on the Company's ex...

EntreMed Presents Preclinical Data for MKC-1 in Hematological Cancers

...s resulting from MKC-1 binding to multiple intracellular targets, including tubulin and the importin-beta proteins. The importin-beta family of proteins plays ... cell cycle regulator, is in Phase 2 studies for cancer. ENMD-1198, a novel tubulin binding agent, is also in Phase 1 studies in advanced cancers. EntreMed's g...

Study Shows Advantages of Complete Phase Ib Trial Over Separate Phase I Trials

... is the basis for which drugs are utilized in studies. The design of the protocol is (assuming the new agent is synergistic with an anthracycline, a tubulin interactive agent, an antimetabolite, or an angiogenesis inhibitor of an antibody to epidermal growth factor receptor, EGFR) patients with advanced ca...
Tubulin in Biological News

Advance in understanding cellulose synthesis

...hanism. Previously Ehrhardt and team found that plant microtubules move by shortening at one end while lengthening at the other end. They do this one tubulin molecule at a time, in a process the researchers call treadmilling. They now think that the tethering discovered in this research allows the cellulose...

Changing climate likely to make 'super weed' even more powerful

...ith a double-whammy. The mesoxalic acid triggers a similar "cellular death cascade" in victim plants as gallic acid does, Bais said, destroying the tubulin and actin, the structural protein in the roots, within minutes of exposure. The scientific team detected the biological concentrations of mesoxalic...

MBL director and CEO and cell biology pioneer Gary Borisy elected to National Academy of Sciences

...s one of the great pioneers of cell biology," said Tim Hunt, 2001 Nobel Laureate and principal scientist at Cancer Research UK. "The identification of tubulin was a landmark, a turning point in the field." In 2006 Dr. Borisy became the MBL's 13th Director and 3rd CEO. Previously he was Associate Vice Pres...

Biophysical Society announces winners of 2008 Minority Travel Awards

...on Conditions of A Proteins: Alzheimers Disease Passive Immunotherapy. Eric Johnson, University of Texas San Antonio, Effects of Porphyrins on tubulin Polymerization. Ann Kimble-Hill, Indiana University-Purdue University Indianapolis, Biophysical Mechanisms of Protein Recruitment To Raft Doma...

UD plant biologists uncover top wetland plant's hidden weapon

... that helps plant roots to maintain their cellular integrity and grow straight in the soil. Within 10 minutes of exposure to the toxin in the lab, the tubulin of a marsh plant under siege starts to disintegrate. Within 20 minutes, the structural material is completely gone. When the roots collapse from th...

Gut research yields new anti-cancer approach

...Rgamma inhibitors reduced levels of alpha and beta tubulin by 60 to 70 percent. Also described in the publica...e underway. While PPARgamma inhibitors reduce tubulin levels, older anti-microtubule drug classes; Vinca...ust remain flexible. Taxol, for example, "freezes" tubulin subunits, making the cell skeleton rigid and unabl...

Researchers now able to look deep into heart to view triggers of a heart's beat

... eggs of two parasitic wasps (Nasonia vitripennis and Muscidifurax uniraptor). Using fluorescently labeled antibodies that recognize and bind to gamma tubulin and other centrosomal proteins, they demonstrated the presence of these proteins in accessory nuclei and showed that the accessory nuclei appear to gi...

Insects that produce males from unfertilized eggs reveal a surprising cellular feat

... eggs of two parasitic wasps (Nasonia vitripennis and Muscidifurax uniraptor). Using fluorescently labeled antibodies that recognize and bind to gamma tubulin and other centrosomal proteins, they demonstrated the presence of these proteins in accessory nuclei and showed that the accessory nuclei appear to gi...

Sea coral's trick helps scientists tag proteins

...ow well the new tag labeled and tracked target proteins, the team fused Dendra to proteins that form the cytoskeleton of the cell, including actin and tubulin filaments and found the expected patterns of intracellular protein distribution. Dendra belongs to a small family of green-to-red PAFPs. The first...

Snapin: A protein with therapy potential for autism

...al building block of the dendrite skeleton. Now Firestein's research group has turned its attention to the protein snapin. When snapin binds to cypin, tubulin is crowded out, so fewer dendrites assemble and more branching occurs. When researchers overexpressed snapin in hippocampal neurons in the lab, the...
Tubulin in Biological Technology

AEterna Zentaris Presents Phase 1 Results for AEZS-112 in Patients with Advanced Cancer and Lymphoma at AACR Annual Meeting in Denver

...a global biopharmaceutical company focused on endocrine therapy and oncology, today presented a poster outlining Phase 1 results for its orally-active tubulin and topoisomerase II inhibitor compound, AEZS-112, in patients with advanced solid tumors or lymphoma, which may potentially provide a new therapeutic...

AEterna Zentaris To Present Data on Anticancer Compounds AEZS-112 and AEZS-126 at AACR Annual Meeting

...PI3K inhibitor compound, AEZS-126, as well as a poster on its orally-active tubulin and topoisomerase II inhibitor compound, AEZS-112, at the American Associat...Mendelson, the poster outlines Phase 1 results for this orally-active tubulin and topoisomerase II inhibitor compound, in patients with advanced so...

Nereus Pharmaceuticals Initiates ADVANCE, a Randomized Phase 2 Clinical Trial of NPI-2358 in Non-Small Cell Lung Cancer

...bination with docetaxel and other oncology therapies, as well as single-agent efficacy in a number of models. NPI-2358 prevents the polymerization of tubulin monomers without altering the dynamic function of formed microtubules. As demonstrated in preclinical testing, this results in a highly specific nano...

MacroChem Acquires Virium Pharmaceuticals

... a family of novel, small-molecule compounds that are in the class known as tubulin binding agents. One compound, VP601, has initially exhibited strong broad-spectrum in vitro tubulin polymerization inhibitory activity and cytotoxicity against numerous cancer...

Nereus Pharmaceuticals Initiates Clinical Trial of NPI-2358 in Non-Small Cell Lung Cancer Following Encouraging Phase 1 Data

...es, as well as single-agent efficacy in a number of orthotopic models. NPI-2358 interacts with soluble beta-tubulin and prevents the polymerization of tubulin without altering dynamic microtubule function of formed microtubules. As demonstrated in preclinical testing, this target profile results in a highly ...

AEterna Zentaris to Further Develop Three Follow-up Multi-targeted Cytotoxic Candidates to AEZS-112 as Potential Novel Cancer Treatment

...ent Cytotoxic Compounds with Inhibitory Effects on tubulin Polymerization and Topoisomerase II", reviewed res...ariations in either mode of action - inhibition of tubulin polymerization, topoisomerase activity as well as ...xic activity in tumor cell lines and inhibiting tubulin polymerization than AEZS-112, whereas induction of...

Assessing Gene Function with siRNA Libraries

... to determine their root causes. This was done by immunofluorescence staining of multiple markers, including tubulin to reveal microtubule distribution. This approach revealed one kinase siRNA that triggered a prometaphase-li...

cMaster RTplusPCR System for increased sensitivity and product length in RT-PCR

... Target for RT-PCR amplification: human Alpha tubulin mRNA, a 500 fragment. Template RNA: total...ep RT-PCR amplification: Alpha tubulin mRNA (mouse and human), 500 bp fragment T... Two step cycling program used for tubulin and TNFR1 ...
Tubulin in Biological Definition

Tubulin

Tubulin is the protein which makes up microtubules . Microtubules are assembled from dimers of α- and β-tubulin. Each of these subunits has three domains . γ-tubulin is important in the nucleation and polar orientation of microtubule. Tubulin binds GTP and assemb...

Colchicine

...ame is N -[(7 S )-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[ a ]heptalen-7-yl)acetamide] . It inhibits the cytoskeleton by binding to tubulin , one of the main constituents of microtubules . Apart from inhibiting mitosis , a process heavily dependent on cytoskeletal changes, it also inhibi...

Cytoskeleton

...Main article: microtubules They are hollow cylinders of about 25 nm., formed by 13 protofilaments which, in turn, are polymers of alpha and beta tubulin . They have a very dynamic behaviour, binding GTP for polymerization, they are organized by the centrosome . They play key roles in: Intracel...
Tubulin in Biological Dictionary

Tubulin

Tubulin is one of several members of a small family of globular proteins. The most common members of the tubulin family are α- tubulin and β- tubulin , the proteins that make up microtubules. Each has a molecular weight of... tubulin n. A globular protein that is the basic structura...

Microtubules

... 25 micrometers. Microtubules serve as structural components within cells and are involved in... These straight, hollow cylinders, composed of tubulin proteins, are found throughout the cytoplasm of all eukaryotic cells and perform a number of functions. Microtubules are filamentous intrace...

Hela cell

...amera magnifies HeLa cells and displays them on a ... Hela Cell tubulin may be used in all situations where previously bovine brain ... HeLa cell tubulin is also available as a biotinylated conjugate for ... GeneXplore the Hu...

Centrosome

...to organize the centrosome in which they are embedded. ... The two centrosomes of the cell, each with its pair of centrioles, move to ... from tubulin monomers in the cytoplasm and grow out from each centrosome . ... ... high degrees of aneuploidy (and centrosome amplification) are also ha...
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