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Tuberous in Medical News

Are imaging features of hepatic angiomyolipoma related to its clinical setting?

..., and prominent central vessels in six sporadic cases, and multiple, small hepatic angiomyolipomas, with or without a fat component in four cases with tuberous sclerosis complex (TSC). Lymphangioleiomyomatosis (LAM) and multiple hepatic angiomyolipomas were found in one patient with TSC. The results suggest...

Explorer's Bounty Unveils New Line of Tribal Stone Crackers

...uthentic, these artisan-baked crackers have no added sweeteners, are gluten free, allergen and fat free as well as vegan friendly. A starchy tuberous root, Yuca (also known as cassava) has earned the distinction of being the third largest source of carbohydrates for human food in the world. The root...

Teaming Up to Tackle a Deadly Cancer

...usetts General Hospital who had published two case reports of patients with tuberous sclerosis who developed chordomas along the spine. Sommer asked the scienti...r she thought the genetic mutations on two tumor-suppressor genes linked to tuberous sclerosis could be involved with the development of chordomas. Ramesh sa...

Springer adds Journal of Neurodevelopmental Disorders to biomedical journal portfolio

...he Journal of Neurodevelopmental Disorders will support and promote interdisciplinary research into such disorders as autism, Fragile X Syndrome and tuberous sclerosis, helping to bridge the gap between basic research and treatment in these critical areas." Dr. Joseph Piven, Editor-in-Chief, said, "Progr...

The first autism disease genes

... affected four times more often than females. In approximately 10% of cases, autism is associated with a recognized cause, such as Fragile X Syndrome, tuberous Sclerosis or diverse chromosomal abnormalities (mean observed rates between 5-10%), but in a vast majority of cases, no known causes are associated wi...

New research demonstrates potential diagnosis, treatment benefits

...testing the drug sirolimus in patients with LAM or tuberous sclerosis complex (TSC) with angiomyolipomas, beni.... Support was provided by The LAM Foundation, the tuberous Sclerosis Alliance (with funding from the Ketterin... (pneumothorax) and/or lung cysts. Women who have tuberous sclerosis complex (TSC) may also be tested, as 40-...

Transplant Drug Shrinks Tumors in Women With Rare Lung Disease

...tion, as many as 250,000 women worldwide might have the disease. The new treatment was also effective in reducing tumors in patients suffering from tuberous sclerosis complex (TSC), a rare genetic multi-system disease. The two diseases share a genetic mutation that affects the activation of the enzyme m...

Pathway links inflammation, angiogenesis and breast cancer

...s by attaching phosphate groups to other proteins. IKK phosphorylates tuberous sclerosis 1 (TSC1) blocking it from working with its ally, tuberous sclerosis 2, to repress the mammalian target of rapamycin (mTOR) pathway. ...

Rare Womens Lung Disease May Yield Insights Into Common Diseases

...ding to two diseases not well-known to the public: tuberous sclerosis complex (TSC) and lymphangioleiomyomatos... her work, Henske discovered that mutations in the tuberous sclerosis gene, which triggers TSC, a genetic diso...ecause the cellular pathways that are activated in tuberous sclerosis and LAM are also activated in many forms...

Young Women Beware Of LAM

...s hope… Krymskaya’s discovery in 2002 revealed that abnormal smooth muscle-like LAM cells invading the lungs are due to the loss of growth control by tuberous sclerosis (a genetic disorder which causes tumors to form in organs) complex proteins - and furthermore, Krymskaya then discovered that growth can pot...
Tuberous in Medical Technology

Afinitor(R) Phase II Data Show Positive Results for Patients With Multiple Types of Lymphoma, Leading to Phase III Trial

...anced kidney cancer. Afinitor is being studied in multiple cancer types, including NET, breast, gastric and hepatocellular carcinoma (HCC), as well as tuberous sclerosis complex (TSC) and NHL. The active ingredient in Afinitor is everolimus, which is available in different dosage strengths under the tra...

Video: Afinitor(R) Approved in US as First Treatment for Patients With Advanced Kidney Cancer After Failure of Either Sunitinib or Sorafenib

...ism. Afinitor is also being studied in multiple cancer types, including neuroendocrine, breast, gastric and hepatocellular carcinoma (HCC), as well as tuberous sclerosis complex (TSC) and non-Hodgkin's lymphoma(11). The active ingredient in Afinitor is everolimus, which is available in different dosage ...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

... in combination with existing therapies for renal cell carcinoma, neuroendocrine tumors, lymphoma, breast, gastric, lung and other cancers, as well as tuberous sclerosis. About LBH589 (panobinostat) Panobinostat (LBH589), is an investigational pan-deacetylase (DAC) inhibitor which interferes wi...

RAD001 Combined with Sandostatin LAR(R) Depot and as Monotherapy Controls Growth of Rare Pancreatic Neuroendocrine Tumors

...ted as a single agent or in combination with existing therapies in renal cell carcinoma, lymphoma, breast, gastric, lung and other cancers, as well as tuberous sclerosis. About Sandostatin LAR Depot Sandostatin LAR(R) Depot (octreotide acetate for injectable suspension) is a long-acting, injectable depot ...

Early Data Presented at ASCO Show Potential of RAD001 to Enhance Efficacy of, and Overcome Resistance to, Breast Cancer Treatments

...sently being evaluated in renal cell carcinoma; neuroendocrine tumors; lymphoma, lung, stomach and liver cancers, in addition to other cancers; and in tuberous sclerosis complex as a single agent or in combination with existing cancer therapies. As an investigational compound, the safety and efficacy profil...

RAD001 More Than Doubles Time Without Tumor Growth After Failure of Standard Treatment in Patients With Advanced Kidney Cancer

...ovides continuous inhibition of mTOR. In addition to RCC, RAD001 is presently being evaluated in neuroendocrine tumors, lymphoma, other cancers, and tuberous sclerosis as a single agent or in combination with existing cancer therapies. As an investigational compound, the safety and efficacy profile of RAD...

Everolimus (RAD001) Significantly Extends Progression-Free Survival in Advanced Kidney Cancer Patients After Failure of Other Targeted Therapy

...e prognosis of patients with RCC. In addition to RCC, everolimus is presently being evaluated in neuroendocrine tumors, lymphoma, other cancers, and tuberous sclerosis as a single agent or in combination with existing cancer therapies. Safety findings in the study were manageable and consistent with prior...
Tuberous in Medical Definition

Fat transfer

...nlarge female breasts is done, not only for cosmetic reasons, but to reconstruct deformities like a mastectomy , a breast implant collapse and or a tuberous breast, a condition in which the adult breasts fail to develop in puberty and result in extremely small, narrow and sagging breasts. Plastic surgeon...
Tuberous in Medical Dictionary

Ungual

...ee encyclopedia ... ungual adj. Of, resembling, or bearing a hoof, nail, or claw. ... Ungual . Odonto-Tricho- Ungual -Digital -Palmar syndrome. tuberous sclerosis. Saltriosaurus ... Definition of ungual from Webster's New World College Dictionary. Meaning of ungual . ... Retrieved July 31st, 200...

Tuberous sclerosis

... tuberous sclerosis or tuberous sclerosis complex (TSC) is a rare, multi-system...stitute of Neurological Disorders and Stroke. tuberous sclerosis complex is a genetic disorder chara...

Potato

... The potato is a starchy, tuberous crop from the perennial Solanum tuberosum of the Solanaceae family . The word potato may refer to the plant itself as well. In the region of the And...

Ovary

...tic ovary syndrome (PCOS) cannot be prevented. ... Angiomyolipoma is a benign tumor seen in the kidney and in many cases associated with tuberous sclerosis.Extra-renal angiomyolipomas have rarely been reported in ... Polycystic ovary syndrome is not usually a cause of symptoms before mid...
Tuberous in Biological News

Rutgers research tackles childhood epilepsy

...mycin. It had already shown promise in a different mouse model for treating tuberous sclerosis complex (TSC), a subtype of cortical dysplasia. "We demonstrat... future," said D'Arcangelo. "This drug is being tested on human patients of tuberous sclerosis in a multicenter study involving six TSC clinics throughout the U...

Origin of root offshoots revealed

... firmly anchored in the soil and can be used to counteract erosion. On the other hand, slowing down secondary root formation can be advantageous in tuberous plants, like potatoes or sugar beets. This enables these food crops to invest all their energy in the production of nutrients. Fewer root offshoots al...

Rare genetic disorder gives clues to autism, epilepsy, mental retardation

... A rare genetic disorder called tuberous sclerosis complex (TSC) is yielding insight into a..., who also directs the clinical Multi-Disciplinary tuberous Sclerosis program at Children's. Since autism ... from Autism Speaks, the Manton Foundation and the tuberous Sclerosis Alliance to pursue this idea further. ...

Drug reverses mental retardation caused by genetic disorder

... dysfunction inflicted by a genetic disease called tuberous sclerosis complex (TSC). Because half of TSC pati...n development is to blame for mental impairment in tuberous sclerosis," added first author Dan Ehninger, postg... "Our research offers hope to patients affected by tuberous sclerosis and to their families. The new findings...

Genetic breakthrough offers promise in tackling kidney tumors

... on Easter Island could treat the genetic disorder tuberous sclerosis. tuberous sclerosis is an inherited disease affecting childr.... If the genes fail, mTOR is too active leading to tuberous sclerosis. The UK study tested the effects of S...

Protein key to organ growth

... homologue enriched in brain), a protein controlling growth and differentiation, and may give clues to treatment of a particular benign disease called tuberous sclerosis that is associated with the control exerted through the same pathway, said Dr. Kwang-Wook Choi, associate professor of molecular and cellula...

Super-sized cassava plants may help fight hunger in Africa

...ble. Cassava is the primary food source for more than 250 million Africans ?about 40 percent of the continent's population. And the plant's starchy tuberous root is a substantial portion of the diet of nearly 600 million people worldwide. Sayre said he hopes to offer these plants to countries where cass...

Tiny RNA molecules fine-tune the brain's synapses

... to a chromosomal deletion is associated with Williams syndrome, and that the BDNF pathway that activates Limk1 includes proteins that are disabled in tuberous sclerosis and Fragile X syndrome. All three genetic disorders can cause cognitive impairment and autistic-like behaviors. ...
Tuberous in Biological Technology

cMaster RTplusPCR System for increased sensitivity and product length in RT-PCR

... Target for RT-PCR amplification: human tuberous Sclerosis Factor (hTSF) mRNA, a 5.3 kb fr... (mouse and human), 1.3 kb fragment Human tuberous Sclerosis Factor (hTSF) mRNA, 5.3 kb fragment ...: Long range One Step RT-PCR of the human tuberous Sclerosis Factor mRNA. M: DNA Ruler Ladde...
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