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Trough in Medical News

Beeston To Pursue Gold And Silver Royalty Interests

...400 million in silver and gold. About Beeston Beeston is a mineral exploration Company with extensive mineral tenures located in the Quesnel trough area in Southern British Columbia. The Company is planning on conducting an exploration program on its Ruth Lake properties later this summer. The Com...

Frutarom Continues to Implement its Rapid Growth Strategy

...ic human need), its solid capital structure and its ability to generate cash from current activities, will enable it to successfully glide trough the global economic crisis and exploit the opportunities which have emerged and continue to emerge as a result of this crisis." Frutar...

Tibotec presents interim findings for TMC435, an investigational genotype 1 hepatitis C treatment

...435 were nausea, diarrhea, and headache. There were no clinically relevant changes in laboratory parameters, ECGs, or vital signs. Steady-state plasma trough levels of TMC435 25 mg and 75 mg represented ~10 and >30-fold excess above the HCV replicon EC50 value, respectively. Mean reductions of HCV RNA fr...

Drug may prolong organ life in noncompliant kidney transplant patients

... more protection from rejection. On average, the participants, 160 kidney transplant patients, were 6.4 years out from their transplant. At these trough levels of drug in the blood stream, the assay demonstrated that sirolimus caused a significantly lower level of mitogenic response, and results appear...

Multiple Independent Studies Report on Use of Cylex's Immune Cell Function Assay in Postoperative Monitoring of Kidney, Liver, and Heart Transplant Recipients

...d lymphocyte count in monitoring 26 heart transplant patients of whom 15 had various infections. -- "Sirolimus (SRL) blunts mitogen response at trough (C0) levels more than cyclosporine (CSA) or tacrolimus (TAC) -- a safeguard for our many long-term noncompliant kidney transplant patients (KT...

Road Rescue Introduces Patient-Centric Concept Ambulance at FDIC

...its patient - as the central point. "This allowed us to develop a central trough across the center of the ambulance where we could position all the key feat...- All medical equipment is mounted in a specially designed longitudinal trough directly overhead from the patient, putting vital tools conveniently at...

Triumph-1 Trial of Viveta in Pulmonary Arterial Hypertension Meets Primary Endpoint

... in accordance with the trial's pre-specified statistical analysis plan), in patients receiving Viveta as compared to patients receiving placebo. The trough exposure, defined by the trial protocol as a minimum of four hours after inhalation of Viveta, for treatment change in 6MW distance at week 12 relativ...

FDA Approves First Artificial Cervical Disc

...would instead replace the impaired natural disc. It consists of two main pieces of stainless steel that articulate against one another with a ball and trough (groove). After a doctor removes the impaired natural disc, the artificial disc is attached to the adjacent vertebrae with bone screws. FDA based...

FDA Approves INTUNIV (guanfacine) for the Treatment of ADHD

... provides a controlled, steady delivery of drug throughout the day and evening with a delivery system that minimizes the fluctuations between peak and trough concentrations as seen with immediate-release guanfacine. It has been shown that guanfacine, the active ingredient in INTUNIV, binds selectively to al...

Every Child Needs to Be Vaccinated to Lead India into a Polio Free Future - Ramadoss

... Appreciating the efforts made by the State Governments, the Minister said the number of polio cases have been lower both during the peak and the trough of the last outbreak as compared to 2002-2003. The core districts of western UP, responsible for the outbreak, have not had a single case of type 1 p...
Trough in Medical Technology

FDA Approves Tekturna HCT(R) as Initial Treatment in Patients Unlikely to Achieve Their Blood Pressure Goals With a Single Agent

...ponse. The combination of Tekturna and hydrochlorothiazide resulted in additive placebo-adjusted decreases in systolic and diastolic blood pressure at trough of 10-14/5-7 mmHg at doses of 150-300 mg/12.5-25 mg, compared to 5-8/2-3 mmHg for Tekturna 150 mg to 300 mg and 6-7/2-3 mmHg for hydrochlorothiazide 1...

Analysis of Edoxaban Phase II Data Provides Insight Into Reduced Bleeding Events Seen in Once-Daily Dosing

...sis finds that bleeding associated with edoxaban is most closely correlated with minimum concentration levels of the drug in the blood, and that these trough levels may best predict bleeding events, rather than total exposure or maximum concentration levels. These findings were presented today at ...

Boehringer Ingelheim Unveils Diabetes Pipeline

... More than 85% of the patients receiving the 5mg and 10mg doses of linagliptin demonstrated greater that or equal to 80% DPP-4 inhibition at trough at week 12(1) HbA1c reductions of at least 0.5 percent were achieved in 44 percent to 53 percent of patients on linagliptin, but only in 13 p...

Phase III Clinical Studies of Aclidinium Bromide Show Statistical Significance vs. Placebo in Patients With Chronic Obstructive Pulmonary Disease (COPD)

...emonstrated a significant difference vs placebo in trough FEV1 at 12 weeks (p-value <0.001) and 28 weeks (p-... one year (p-value <0.001). The improvement in the trough FEV1, at weeks 12 and 28, of aclidinium arms compa...ion at the end of the dosing interval, assessed as trough FEV1 (measured at 23-24h post-dose). For both tria...

New Drug Application for Inhaled Treprostinil Submitted to the U.S. Food and Drug Administration

...in patients receiving ITRE as compared to patients receiving only background therapy. In addition, the 6MW distance at week 12 relative to baseline at trough exposure was also significantly improved, with an estimated treatment effect of approximately 14 meters (p<0.007). Secondary endpoints related to qual...

Positive Phase I/II Data of IDX899 Confirm Potent Antiviral Activity and Favorable Safety Profile in Treatment-Naive HIV-Infected Patients

...eased by about 80 cells/mm3 for patients receiving placebo. No clear pharmacokinetic/pharmacodynamic relationship was demonstrated, likely due to drug trough levels well above the EC(90) of IDX899 against wild-type HIV-1. "We believe any new HIV treatment must demonstrate potent antiviral activity at low ...

Final Results of the CellCept(R) Spare the Nephron (STN) Study Show Maintenance Therapy is Associated with Improved Renal Function

...nts (maintained on MMF and a CNI) for 30-180 days post-transplant to receive either MMF (1-1.5 g BID) plus SRL (2-10 mg followed by at least 2 mg/day; trough 5-10 ng/mL) and discontinue the CNI (MMF/SRL) or to continue their current regimen (MMF/CNI). Antibody induction and/or corticosteroids were administe...

Treprostinil Data Presented at American Thoracic Society Conference Demonstrates Significant Clinical Progress in All Four Routes of Administration

...n patients receiving inhaled treprostinil as compared to patients receiving placebo, with a durable and significant effect on 6MW distance observed at trough exposure. Dr. McLaughlin also presented data showing that inhaled treprostinil improved both quality of life and levels of NT-pro-BNP, a plasma biom...

Forest and Almirall Announce Positive Results of Clinical Studies for Aclidinium Bromide, a Novel, Long-Acting Anticholinergic for the Treatment for COPD

... an active control. The study demonstrated aclidinium (200 mcg and 400 mcg), administered via a multi-dose dry powder inhaler, significantly increased trough (24-hour) forced expiratory volume in one second (FEV1) -- an important measure of lung function -- on Day 29 compared with placebo (p<0.05 vs placebo...

Micromet Shows Feasibility of Subcutaneous Delivery of BiTE Antibody in Preclinical Primate Study

...ts with diabetes for the delivery of insulin. Both subcutaneous regimens resulted in bioavailability of MT110 of 30 to 40 percent, with constant serum trough levels over the six-day treatment period. "Our pre-clinical results are paving the way for the development of alternative routes of administration f...
Trough in Medical Products

Vancomycin, Trough Level

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Vancor, Trough Level

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Vancocin, Trough Level

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Tobramycin, Trough Level

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Nebcin, Trough Level

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Gentamicin, Trough Level

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Garamycin, Trough Level

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Amikin, Trough Level

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Amikacin, Trough Level

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Zaldivar forceps for Acrylic lens

Description:... Thin and smooth jaws, designed to enter trough 3 mm incision, cross action....
Company:Rumex International Co.

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Trough in Biological News

August 2009 Geology and GSA Today media highlights

...cs of high-grade zones related to alteration halos. Elevated fluid pressure and extreme mechanical weakness of a plate boundary thrust, Nankai trough subduction zone Harold J. Tobin and Demian M. Saffer, Dept. of Geology and Geophysics, University of Wisconsin-Madison, Madison, Wisconsin 53706, US...

DOE-funded research projects win 46 R&D 100 Awards for 2009

...ne UX Microbattery has a long life cycle even if it is frequently and fully discharged. (Jointly with Planar Energy Devices) SkyTrough Parabolic trough Solar Concentrating Collector uses a lightweight and weatherproof reflector to create a low cost system for utility-sized power generation. This inn...

First riser-drilling research operations undertaken

...has resumed IODP drilling operations in the Nankai trough Seismogenic Zone off the Kii Peninsula of Japan. T...that have never been reached before. The Nankai trough subduction zone, located southwest of Japan, is on...he Kumano Basin, is a fore-arc basin of the Nankai trough under the influence of the strong Kuroshio ocean c...

IODP to operate 3 drilling platforms in 2009

...will be conducted using platforms customized for specific environments. Scheduled operations will explore climate change, sea level change, the Nankai trough Seismogenic Zone, and oceanic plateau formation. "Scientific ocean drilling is the only technique that can ground-truth surface geophysical and geo...

Northwest climate change is target of $3.2M in grants to University of Oregon

...e project will involve a series of 23-foot climate-controlled circles of prairie vegetation on properties owned by The Nature Conservancy in the Puget trough near Olympia, Wash., the Rogue River Valley outside Medford, Ore., and the Willamette Valley west of Eugene. The three sites form a natural climate gr...

Scientists obtain core samples from subsea fault system off Japan

... The third expedition of the Integrated Ocean Drilling Programs Nankai trough Seismogenic Zone Experiment (NanTroSEIZE) completed its mission off the Kii...mation, structural partitioning, and physical characteristics of the Nankai trough fault zone. The expedition was led by co-chief scientists Elizabeth Screato...

100 percent of people carry at least 1 type of pesticide

...organic compound (POCs), substances internationally classified as potentially harmful to ones health, in their bodies. These substances enter the body trough food, water or even air. All of them tend to accumulate in human adipose tissue and easily enter into the organism through the aforementioned mediums....

Scientists launch deep-sea scientific drilling program to study volatile earthquake zone

...gu Port, Japan- Sept. 21, 2007 - Today, the Nankai trough Seismogenic Zone Experiment (NanTroSEIZE) gets und...amples and provide scientific data from the Nankai trough fault zone for the first time. Situated off Japan's southwest coast, the Nankai trough has reliably generated large-scale earthquakes and...

AGU journal highlights -- Sept. 6, 2007

...g of the monsoon since this time. The authors hypothesize that the difference reflects a southward shift in the average summer position of the monsoon trough since the 15th century. They note that the change in monsoon circulation seen here is synchronous with a reduction in solar irradiance and the onset o...

Discovering an ecosystem beneath a collapsed Antarctic ice shelf

...the origins of life in extreme environments. Researchers discovered the sunless habitat after a recent underwater video study examining a deep glacial trough in the northwestern Weddell Sea following the sudden Larsen B shelf collapse in 2002. "This is definitely the biggest thing I've ever been involved ...
Trough in Biological Technology

Idenix Pharmaceuticals Reports Data From Three Hepatitis C Development Programs at the 44th Annual Meeting of the European Association for the Study of the Liver

...metabolite concentrations in serum and viral load reductions in this study. trough serum nucleoside metabolite levels were low, ranging from 2-8 ng/mL, and th...al load reductions observed as the NM levels increased. Specifically, serum trough NM levels of greater than 2 ng/mL were associated with HCV RNA reductions o...

AEterna Zentaris Presents Phase 1 Results for AEZS-112 in Patients with Advanced Cancer and Lymphoma at AACR Annual Meeting in Denver

...le in human plasma. As predicted by pharmacokinetic modelling based on data from part I of the study, the split-dose scheme leads to a higher Cmax and trough values after administration of comparable doses. Conclusions - AEZS-112 was well tolerated over repeated treatment courses; - So fa...

Idenix Announces Data Presentations from Three HCV Discovery and Development Programs at the 44th Annual Meeting of the European Association for the Study of the Liver (EASL)

...ted abstracts are as follows: ANTIVIRAL ACTIVITY OF THE LIVER-TARGETED NUCLEOTIDE HCV POLYMERASE INHIBITOR IDX184 CORRELATES WITH trough SERUM LEVELS OF THE NUCLEOSIDE METABOLITE IN HCV-INFECTED CHIMPANZEES - Abstract #583; Oral presentation; Parallel session entitled: Hepatitis C Vir...

Romark Announces Presentation of New Data for Controlled Release Nitazoxanide in Chronic Hepatitis C

... and 1,350 mg twice daily doses of controlled release nitazoxanide produced trough plasma concentrations of tizoxanide, the active metabolite of nitazoxanide, that were approximately 3x and 12x the trough concentrations observed in historical studies using a standard nitazoxanide...

InterMune to Present Four Abstracts on HCV Protease Inhibitor ITMN-191 at the AASLD Meeting

...g). The pharmacokinetics of ITMN-191 were linear over the dose range of 100mg to 800mg. Co-administration of ITMN-191 with food increased the expected trough and AUC by 40-50% compared with administration of ITMN-191 without food. This "food effect" enabled InterMune and Roche to explore a lower range of do...

Presentation of Phase IIa Results for Cytos Biotechnology's Hypertension Vaccine at the American Heart Association Scientific Sessions 2007

...static but undergoes natural variations which follow a circadian pattern. Highest levels are reached during the morning, which then decline to reach a trough value at about midnight. In the early morning, a steep increase in blood pressure occurs naturally. It has been suggested that this morning rise in bl...

Motorcycling entrepreneur to speak in Madison on success, failure, capital

...ring that time period, the Internet bubble had a corresponding trough, Hanlon recalled. If you look at that bubble of funds, there was a corresponding trough of funds that were not going to traditional types of businesses. Road rash As a result, the man who was credited with the company's rebirth, w...

FERMENTATION BASICS

...lic activity is related to the utilization of the carbon and the energy source. When the carbon source is being actively incorporated into biomass trough anabolism during growth, about 40-50 % of the available enthalpy in the substrate is conserved in the biomass, the rest being given off as heat. Whe...

HEK293 Calcium Flux Assay

... d) Combine b) with c) e) Add 10 μL of 0.5 M Probencecid * Make fresh daily ROW MARKER (IN trough BUFFER) * 0.25 μM Fluorescein 100% CONTROL ON PLATE ( AGONIST) * 200 μM Carbachol Load cells w...
Trough in Biological Products

micro 10 from Hudson Control Group, Inc.

Description:...dispensers Tip Touch capability to touch-off droplets AutoPrimes at programmed intervals to prevent drying or clogging Self-draining prime trough for repeated priming without overflows Stores up to 20 Dispense programs and 10 Priming programs Full RS-232 external control capability for e...
Company:Hudson Control Group, Inc.

micro 1 from Hudson Control Group, Inc.

Description:...8-tip dispensers Tip Touch capability to touch-off droplets AutoPrimes at programmed intervals to prevent drying or clogging Self-draining prime trough for repeated priming without overflows Stores up to 20 Dispense programs and 10 Priming programs Full RS-232 external control capability for easy ...
Company:Hudson Control Group, Inc.
Trough in Biological Definition

Antibody

...unoglobulin and is approximately equally distributed in blood and in tissue liquids. It is important that this is the only isotype that can traverse trough the placenta , because this gives protection to the fetus in its first weeks of life, when its own immune system has not yet developed. It can bind...
Trough in Biological Dictionary

Negative interference

...ere destructive interference occurs. ... meets a trough of a second wave, a point of large negative disp...urs when two waves meet while ... Moments later, a trough meets a trough to produce a large negative displacement. ... ...
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