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Tropism in Medical News

Monogram Biosciences Announces Immediate Availability of Enhanced Sensitivity Trofile(TM) HIV Tropism Assay

Now 100% Sensitive at Detecting CXCR4 HIV-1 Levels as Low as 0.3% SOUTH SAN FRANCISCO, Calif., June 5 /PRNewswire-FirstCall/ -- Monogram Biosciences, Inc. (Nasdaq: MGRM ) today announced immediate availability of enhanced sensitivity in its Trofile assay. Trofile was introduced commerciall...

Quest Diagnostics Licenses Technology Underlying SensiTrop(TM) HIV Co-Receptor Tropism Test from Pathway Diagnostics

-First national diagnostic testing company to license proprietary technology- MADISON, N.J., Oct. 26 /PRNewswire-FirstCall/ -- Quest Diagnostics Incorporated (NYSE: DGX ), the nation's leading provider of diagnostic testing, information and services, announced ...

Pathway Diagnostics Announces Commercial Availability of SensiTrop(TM) HIV Co-receptor Tropism Assay

Rapid, highly sensitive diagnostic provides patient HIV tropism status needed to initiate therapy with Pfizer's recently approved Selzentry(TM) (Maraviroc), CCR5 antagonist. MALIBU, Calif., Sept. 17 /PRNewswire/ -- Pathway Diagnostics announces nationwide availability of...

Sales of Antiretroviral Agents Will Drive Substantial Six Percent Annual Growth in the HIV Drug Market Through 2013

...cant obstacles that include its limited patient eligibility and the lengthy tropism test required for its prescription. The landscape for CCR5 antagonists is expected to improve, however, once better tropism tests and improved protocols are established. About Decision Resource...

Monogram Announces 2008 Second Quarter Financial Results

...n cash, cash equivalents and short-term investments at June 30, 2008. Cash used in operations for the first six months of 2008 was $8.4 million. HIV tropism and Resistance Testing Recent significant developments in Monogram's HIV business include: -- Introduction in June of sensitivity enhancements to ...

Monogram Biosciences Collaborates with Gilead Sciences for Elvitegravir Phase III Studies

...atient selection. Monogram is a leader in providing drug susceptibility and tropism assays for pharmaceutical development. PhenoSense GT(TM) is the only assay ...-looking statements include references to the demand for our resistance and tropism assays, the size and timing of clinical trials utilizing our products and t...

Is it pancreatitis in acute abdominal pain in acute viral hepatitis?

... Hepatitis viruses have a strong tropism for hepatocytes; viral antigen also has been detected in pancreas and gallbladder. Acute pancreatitis is common in Fulminant hepatic failure but rarel...

Monogram Announces First Medicare Payment for Trofile(TM)

...e for healthcare providers references the need for tropism testing as indicated in the FDA labeling for marav...ges that Monogram's Trofile Assay was the test for tropism on which the FDA clinical trials of Selzentry (mar... the only clinically validated assay for assessing tropism of patients, is the only assay that has been used ...

Mixed HIV Coreceptor Use Associated With Lower CD4 Count

...l of 37 days). The authors say they believe that this evidence of change in tropism is more likely to reflect the variability of the Trofile coreceptor assay used in the study rather than the speed at which tropism can switch in a treatment-experienced population. Dual-tropic viral ...
Tropism in Medical Technology

Monogram Provides Update on Trofile(TM) Co-Receptor Tropism Assay

Pfizer reports long-term safety and efficacy data for HIV drug Selzentry(TM) (Maraviroc) SOUTH SAN FRANCISCO, Calif., Sept. 18 /PRNewswire-FirstCall/ -- Monogram Biosciences, Inc. (Nasdaq: MGRM ) announced today that its collaborator Pfizer, Inc. (NYSE: PFE ) has s...

Data Reported at ICAAC Indicates Selzentry(TM) Phase III Treatment-Naive Trial Shows Increased Efficacy When Used With Enhanced Trofile(TM) Assay

... assumes no obligation to provide updated information except as required by law. About Trofile Trofile is a clinically validated patient selection tropism assay that determines whether a patient is infected with a strain of HIV that uses either the CCR5 coreceptor, the CXCR4 coreceptor, or a combination ...

Monogram Biosciences Provides Progenics Pharmaceuticals with HIV Assays for Use in Clinical Trials

...als, Inc. (Nasdaq: PGNX) to provide resistance and tropism testing for Progenics' clinical development progra...studies, Progenics is using Monogram's Trofile(TM) tropism test to screen and monitor HIV infected individual...ent." Trofile is a patient selection co-receptor tropism assay that determines whether a patient is infecte...

DHHS Guidelines Support Use of Trofile(TM) Assay Prior to CCR5 Inhibitor Use

...Human Services (DHHS) recommend that a co-receptor tropism test, such as Monogram's Trofile(TM) assay, should... instructions on Selzentry's label, which call for tropism testing prior to prescribing the drug. Pfizer's Se...ore the importance of using a clinically validated tropism test to determine whether a patient should be trea...

Medicare Contractor Establishes Reimbursement Coding Guidance for Monogram's Trofile Assay

...g of claims to Medicare for Trofile(TM) as tropism test for Pfizer's Selzentry(TM) SOUTH SAN FRANCI...into browser). The article references the need for tropism testing as indicated in the FDA labeling for marav...ges that Monogram's Trofile Assay was the test for tropism on which the FDA clinical trials of Selzentry (mar...
Tropism in Medical Dictionary

Macrophage

...rentiate into macrophages or other related cell types. Eukaryotic cells also produce M-CSF in order to... This suggests either that macrophage tropism is defined by structural ... Shioda T, Levy JA, Cheng-Mayer C. Macrophage and T cell-line tropisms of HIV-1 ... Macrophage -tropic human immuno...

Herpesvirus

... Control and Prevention (CDC) Yellow blocks represent ß- herpesvirus subfamily-specific genes (from U2 to U14) ... Predominant CD4 T-lymphocyte tropism of human herpesvirus 6-related virus. ... Online Medical Dictionary and glossary with ... Human herpesvirus 3 (HHV-3) -- The ... Human herpes...
Tropism in Biological Technology

Pathway Diagnostics Announces Commercial Availability of Second Generation SensiTrop(TM) II Molecular HIV Co-receptor Tropism Assay

SensiTrop II accurately classifies Dual/Mixed tropic HIV patients with samples provided by Pfizer. MALIBU, Calif., May 7 /PRNewswire/ -- Pathway Diagnostics announces nationwide availability of its patented second generation molecular SensiTrop(TM) II assay, combining the...

Data Presented on Monogram HIV Tropism Tests at Retrovirus Conference sets New Standards of Assay Sensitivity

Company Continues to Lead Tropism Testing Field SOUTH SAN FRANCISCO, Calif., Feb. 7 /PRNewswire-FirstCall/ -- Monogram Biosciences, Inc (Nasdaq: MGRM ) today announced that data related to the company's advanced HIV tropism assay have been presented as multiple posters during the ...

Pathway Diagnostics Announces Patent Issuance for the Diagnostic Measurement of HIV Tropism for the Initiation or Modification of HIV Therapy

HIV tropism status needed to initiate therapy with Pfizer's recently approved Selzentry(TM) (Maraviroc), CCR5 antagonist MALIBU, Calif., Nov. 15 /PRNewswire/ -- Pathway Diagnostics announces that the U.S. Patent & Trademark Office (USPTO) has issued U.S. Patent number 7,294,458 (the...

New Test from Quest Diagnostics Helps Physicians Choose HIV Antiretroviral Therapy in Patients with History of Drug Resistance

...HIV antiretroviral therapies. The HIV-1 Coreceptor tropism Test, which reports results in approximately half ... medical officer, Quest Diagnostics. "Our new HIV tropism test will advance personalized medicine for HIV by...r spent on a different drug." HIV coreceptor tropism refers to the preference of strains of HIV to bind...

Monogram Announces 2008 Third Quarter Financial Results

...y $21.8 million in cash and cash equivalents at September 30, 2008. Cash used in operations for the first nine months of 2008 was $13.0 million. HIV tropism Testing "Monogram's enhanced Trofile Assay, introduced earlier this year with a thirty-fold improvement in sensitivity, has allowed a very important...

Half of Surveyed Physicians Expect to Replace Between 6 Percent and 15 Percent of Their Sustiva Prescriptions with Isentress

...antagonist drug treatment. Physicians consider the prerequisite co-receptor tropism test for HIV patients to be a critical deterrent to prescribing CCR5 antago...all subsequent members of the CCR5 antagonist drug class will necessitate a tropism test prior to prescribing," said Sylvia Eash, Ph.D., analyst at Decision Re...

Medical Policy Guideline for Trofile(TM) Established By Wellpoint, Inc.

...unced that Wellpoint, Inc. has established a national Medical Policy Guideline for Monogram's Trofile Assay. Wellpoint's guidelines provide that HIV tropism testing with Trofile is considered medically necessary for selecting individuals for treatment with CCR5 antagonists (i.e. Selzentry(TM)) for patients...

Monogram Biosciences Launches First Resistance Assay for HIV Integrase Inhibitors

...University Medical Center. "Tools like HIV resistance phenotype tests (including Monogram's PhenoSense Integrase and PhenoSense GT assays) and the HIV tropism assay (Trofile(TM)) are important tools to help clinicians make good choices. They can also help with modifying regimens that are not suppressive by d...

Sensitivity Enhancements to Monogram's Trofile(TM) Assay Demonstrate Improved Power to Select Patients for CCR5 Antagonist Therapy

...d to the enhanced performance of the company's HIV tropism assay were presented in an oral presentation at th...rofile is a clinically validated patient selection tropism assay that determines whether a patient is infecte...4 cells or both cell types defines the co-receptor tropism of the patient virus. Trofile is the only clinical...

Monogram Biosciences and Avexa Announce Exclusive Collaboration to Support New HIV Drug Discovery and Development Efforts

...daq: MGRM ) announced today that the Company has signed an agreement with AVEXA Limited (ASX: AVX) to be the exclusive provider of HIV resistance and tropism testing technology in support of Avexa's drug discovery and development programs. Avexa plans to use Monogram's assays across its virology portfolio...
Tropism in Biological Dictionary

Tropism

A tropism is a biological phenomenon, indicating growth or turning movement of a biological organism, usually a plant, in response to an environmental stimulus. In tropisms, this response is dependent on the direction of the stimulus . Viruses and other pathogens also... ... negative gravitro...
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