Viral DNA sequence a possible trigger for breast cancer
A small sequence of DNA in the envelope (Env) protein of a mouse breast tumor virus (called MMTV) can transform breast cells into cancer cells, according to a study by Katz et al. in the February 7 issue of The Journal of Experimental Medicine. The ability of this motif to transform cells single-handedly suggests that viral infection may be an important and previously unrecognized trigger for bre...Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats
Dana-Farber Cancer Institute researchers have identified a molecular mechanism in the liver that explains, for the first time, how consuming foods rich in saturated fats and trans-fatty acids causes elevated blood levels of cholesterol and triglycerides and increases one's risk of heart disease and certain cancers. In the Jan. 28 issue of Cell, scientists led by Bruce Spiegelman, PhD, rep...FDA Approves Human Hookworm Vaccine for Phase I Safety Trials
As any dedicated video game player knows, the first requireme...Source of molecular triggers in cutaneous T cell lymphoma identified
In a study published in the journal Blood, Yale scientists identify the molecular triggers that stimulate Cutaneous T Cell Lymphoma (CTCL) cells to clonally expand into large populations of malignant lymphocytes. CTCL is the most common adult malignancy of T lymphocytes, the white blood cells of the immune system. Finding CTCL triggering factors has been a major goal of Richard L. Edelson...Poor prenatal nutrition permanently damages function of insulin-producing cells in the pancreas
Scientists at Joslin Diabetes Center have discovered one reason why infants with low birth weight have a high potential of developing type 2 diabetes later in life. In studies of mice, the researchers found that poor prenatal nutrition impairs the pancreas's ability to later secrete enough insulin in response to blood glucose. "The bottom line is that if you don't have delivery of enough...Glutathione-S-Transferase (GST) Colorimetric Assay Kit from Sigma-Aldrich
Description:Biochem/physiol Actions: Glutathione-S-transferases (GSTs) are a group of enzymes important in the detoxification of many xenobiotics in mammals. The enzymes protect cells against toxicants by conjugating the thiol group of the glutathione to electrophilic xenobiotics, and thereby defend cells against the mutagenic, carcinogenic, and toxic effects of the compounds. GST activity is presen...DNAscope AT from Biomedical Photometrics Inc.
Description:'A New Concept in Microarrays: Biomedical Photometrics Inc. (Waterloo, Ontario, Canada) and CLONDIAG chip technologies GmbH (Jena, Germany) have collaborated to develop a fluorescence reader for the new CLONDIAG ArrayTube System. The DNAscope AT is based on BPIs patented MACROscope technology. The new DNAscope AT automatically reads up to six ArrayTubes in sequence using a confocal laser scannin...ELx50 Microplate Strip Washer from BioTek Instruments
Description:The ELx50 is a fast and versatile automated strip washer which can come equipped with our patented Dual-ActionTM 16-channel manifold. This breakthrough design allows for independent control of the dispense and aspiration manifolds for overfill washing and overflow protection in both 96- and 384-well formats. The problem of fitting dispense and aspirate tubes into a much smaller 384-well is solved...adenosine 5'-O-(3-thiotriphosphate), BODIPY FL conjugated/tagged from Molecular Probes (Invitrogen)
Description:BODIPY FL ATP-Gamma-S binds to ATP-binding proteins. To create this fluorescent nucleotide the BODIPY FL fluorophore was linked through the Gamma-thiol of ATP-Gamma-S. In addition to its potential use for binding studies the BODIPY FL ATP-Gamma-S thioether is an important new substrate for Fhit a member of the histidine triad superfamily of nucleotide-binding proteins....Nutrient Mixture F-12 Ham, Coon's Modification (Ham's F-12 Coon's) from Sigma-Aldrich
Description:Coon's Modification of Ham's F-12 was developed for culturing hybrid cells that were produced by viral fusion. The modification consists of doubling the amino acids and pyruvate, and including ascorbic acid. The salt concentrations have been altered as well. This formula contains 0.863 mg zinc sulfate per liter, which may render it unsuitable for culturing mouse L-cells....Detecting Gastrin-Releasing Peptide Receptor by in situ PCR on Archived Tissue
In situ Adapter for the RoboCycler 40 Temperature Cycler allows rapidamplification of rare mRNA Department of Medicine, University of Illinois at Chicago Figure 1: RoboCycler 40 Temperature Cycler In Situ Adapter Syst...Efficiently Insert Unique Restriction Sites into Plasmid Vectors
Stratagene A 28-base insertion was introduced into a plasmid vector using theQuikChange site-directed mutagenesis kit.* Theinsertion created three unique restriction enzyme digestion sites. Plasmid DNAisolated from 9 o...Restriction Endonucleases Undergo Rigorous QC Testing to Ensure Optimal Performance
Stratagene Restriction endonucleases are used in many molecular biology protocols,making the functional purity of critical importance. Each restriction enzymepreparation must be free of contaminants that can potentiall...Restriction Digests of DNA Isolated with the Perfectprep Gel Cleanup Kit
Gel Cleanup Kit George Halley, Eppendorf 5 Prime, Inc. Agarose gel electrophoresis is used extensively to separate and analyze DNA that is subsequently used for downstream applic...Restriction fragment length polymorphism
sequences) by which they may be dis...Human Genome Project Achieves Technological Triumph
The completion of rough draft sequence of the human genes is a major scientific milestone and was achieved on 26.06.2000. The project began more than 10 years ago to map out almost 35 billion chemical letters that make up the recipe of human life. This breakthrough is expected to revolutionize the practice of medicine by paving the way for new drugs and medical therapies.Specific sequ...Heart disease in the newborn is related to maternal malnutrition
In its December issue Heart has carried a study on maternal malnutrition in the first trimester of pregnancy and how it causes coronary heart diseases in the newborn. Dr. Tessa .J. Rosé boom of the university of Amsterdam and her team have studied the occurrence of coronary heart diseases in children and correlated the findings to maternal malnutrition in the three trimesters of pregnancy...Dietary phytonutrients – Secret for the good food to taste ba
Phytonutrients have been associated with cancer prevention and other health benefits. They are trace chemicals and taste bitter, acid or astringent. If phytonutrients have to be consumed then demands of good taste and good health may be wholly incompatible. The bitter phytonutrients protect the plant against being eaten by harmful herbivores. The plants which contains phyto nutrients are...Man against HIV – new vaccine ready for human trials
A new vaccine called the TAT vaccine has been developed in Italy as the latest and most exciting HIV vaccine to date. And more importantly it has had a 71% success rate when tested on monkeys. This vaccine is now ready for human testing and this may be the brightest hope for mankind against the destructive HIV. Dr.Barbara Ensoli, Head of the Department of Virology at Italy’s National Hea...Pharmaceutical giant offers AIDS related antifungal drug free to 50 countries
Diflucan Partnership seems to be the latest mantra of Pfizer. The pharmaceutical giant has announced that it will supply free antifungal drug to 50 countries hardest hit by the AIDS virus. The decision by the Pfizer comes close on the heels of the South African Government winning a landmark case against pharmaceutical companies. In an announcement on Wednesday Pfizer said AIDS related a...McNeil-Goldman Scleral and Blepharostat Ring - Pediatric
Description:Pediatric size. Loops retract lids. Polished finish....Kratz-Barraquer Eye Speculum - Pediatric
Description:Open 10 mm blades. Dull finish....Barraquer Pediatric Speculum - Solid Blade
Description:Solid 6 mm solid blade speculum for newborn or pediatric use....Barraquer Pediatric Speculum - Wire Blade
Description:Closed wire 5 mm blade with a wing tip twist giving the surgeon better on-axis accessibility....New Advances in Gastric Diagnostics: Smaller is Better
In recent years, miniaturization has opened up exciting possibilities in the area of gastric diagnostics. New technology may make routine GI diagnostic procedures as simple as swallowing a vitamin pill-sized encapsulated unit in the not-too-far future, and the present reality is that these units are becoming valuable adjuncts to traditional diagnostics. Capsule endoscopy (enteroscopy...Bench-Top Centrifuges--Basic Tools for the Small Lab
No matter how elementary or advanced, every clinical laboratory possesses one essential devicea centrifuge. It may be a bench-top or floor model, refrigerated or non-cooled, but this apparatus, because of its unique ability to fractionate liquid specimens by creating spin-induced high g-forces, has long been a standard tool for both diagnosis and research applications. For all this utility, t...Antisoma Announces Further Data From ASA404 Ovarian Cancer Trial
LONDON, 12 July 2007 - Cancer drug developer Antisoma plc(LSE: ASM, US OTC: ATSMY) today announces new data from its phaseII trial of ASA404 in recurrent, platinum-sensitive ovarian cancer.This trial compares patients receiving ASA404 plus chemotherapy(n=37) with patients receiving chemotherapy alone (n=38). The mainfindings are as follows: * There was no advantage in median time t...European Prospective Investigation into Cancer and Nutrition
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