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Transposon in Medical News

Genome Annotation by Mutation

... cancers, Capecchi says. Jumping Genes Help Make More Mutant DNA Wu and Capecchi improved their new method by using it in combination with a transposon or so-called jumping gene named piggyBac, which comes from a moth. They used piggyBac to insert pieces of loxP DNA randomly into numerous spots on the...
Transposon in Biological News

Methods for gene transfer in stem cells featured in Cold Spring Harbor Protocols

... safety concerns associated with viral vectors. Use of the "Sleeping Beauty transposon System for Stable Gene Expression in Mouse Embryonic Stem Cells" from Cathe...ed transfection is a two-component system consisting of a transposase and a transposon containing inverted repeat/direct repeat sequences that result in precise i...

Parasites ready to jump

...olecular mechanisms have evolved which can repress transposon activity. Professor Klaus Frstemann of the Gene Ce...ction, the system of so-called piRNAs ensures that transposon activity is inhibited but only if these RNAs are ...e them into the host cells they infect. Therefore, transposon activity must also be repressed in somatic cells. ...

Singapore scientists elected into National Academy of Sciences

...Beauty," a mutagenic transposon, a sequence of DNA that can move around to different positions within the genome of a single cell. In moving around, a transposon can cause mutations and change the amount of DNA in the genome. In addition, Drs. Copeland and Jenkins' group plans to use another whimsically nam...

Moving gene therapy forward with mobile DNA

... without success. We are glad that we could now overcome this hurdle' claims Thierry VandenDriessche. Zsuzsanna Izsvak and Zoltan Ivics concur: 'This transposon technology may greatly simplify the way gene therapy is conducted, improve its overall safety and reduce the costs'. The VIB researchers are furth...

CSHL scientists discover how 'companion' cells to sperm protect them from genetic damage

...e sperm cells. There, they inactivate or "silence" transposon DNA via a phenomenon known as RNA interference. ...entially just enforce epigenetic reprogramming and transposon silencing in the next generation." Other organi...enome of companion cells results in the control of transposon activity in the sperm. ...

CSHL researchers map changing epigenetic modifications that enable transposons to run amok

...n immortalized cells -- cells that are coaxed to grow endlessly in culture dishes -- the epigenetic changes resulting in a loss of heterochromatin and transposon "re-activation" are not due to a loss of the proteins that regulate heterochromatin. Instead, they find that the epigenetic modifications are due to a...

Plants display 'molecular amnesia'

...ggered, the maize plant "remembers," and keeps the transposon "silenced" generation after generation, even after...ositions, although the trigger works fine, and the transposon is silenced, once the trigger is lost, the transposon reawakens," said Jaswinder Singh, a professor in t...

CSHL scientists discover a new way in which epigenetic information is inherited

... is absent in lab strains. In hybrid dysgenesis, the transmission of the transposon by a parent induces sterility in the offspring unless the offspring also inherits a factor that suppresses the transposon and maintains fertility. Since the phenomenon had only been seen when the t...

Consortium develops new method to manipulate genetic material

...uences for inactivation or repair. The potential for discovery is great, said Dan Voytas, Ph.D., director of the Arnold and Mabel Beckman Center for transposon Research, and co-investigator on the research. In human therapeutics, researchers may aim to correct genetic disorders or diseases, and in plants, sci...

KGI professor contributes new insights on 'jumping genes'

...and Lynn Sniderhan from the University of Rochester and co-author Ueli Grossniklaus, professor at the University of Zurich, were reported in the paper transposon Excision from an Atypical Site: A Mechanism of Evolution of Novel Transposable Elements. The work extends theories of the renowned cytogeneticist Barb...
Transposon in Biological Technology

RNA Interference and Gene Silencing: History and Overview

... and animals and has roles in viral defense and transposon silencing mechanisms. Perhaps most exciti...they also demonstrate increased levels of transposon activity. Thus, silencing of transposons appears t... RH. (1999). Mut-7 of C. elegans , required for transposon silencing and RNA interference, is a ho...

WHOLE GENOME SEQUENCING

...rates well below 1 in 10,000 nucleotides in the assembled contigs. Our finishing strategies can include custom primer walking or transposon insertion methodologies. We use both commercial and proprietary bioinformatics software packages for finishing and assembly incl...

FULL LENGTH INSERT SEQUENCING

...error rates well below 1 in 10,000 nucleotides in the assembled contigs. Our finishing strategies can include custom primer walking, transposon insertion and/or direct PCR sequencing. We use both commercial and proprietary software for semi-automated finishing and assembly in...
Transposon in Biological Products

HyperMu Transposon from EPICENTRE Biotechnologies

Description: Component of HyperMu™ Insertion Kit...
Company:EPICENTRE Biotechnologies

GPS -M Mutagenesis System from New England Biolabs

Description:...tion transposition reaction. Notes: The Kanr marker on the Transprimer is not designed to express in Gram positive organisms or eukaryotic cells. transposon ends have stop codons in all frames, so translational fusions are not practical....
Company:New England Biolabs

EZ-Tn5 Transposase from EPICENTRE Biotechnologies

Description:... EZ-Tn5™ Transposase is designed for use with our pMOD™ series of vectors as well as any EZ-Tn5™ transposon system....
Company:EPICENTRE Biotechnologies
Transposon in Biological Definition

Microsatellite

...s . Hence a tumour cell line might show a different genetic fingerprint from that of the host tissue. See also: minisatellite , mobile element , transposon , short interspersed repetitive element , long interspersed repetitive element , junk DNA , selfish DNA ...
Transposon in Biological Dictionary

Transposon

A DNA composite transposon . Transposons are sequences of DNA that can move around to ... The most common form of transposon in humans is the Alu sequence. ... After the transposon is ligated to the host DNA, the gaps are filled in by ... This creates identical direct repeats at e...

Composite transposon

A composite transposon is similar in function to simple transposons and Insertion Sequence (IS) elements in that it has protein coding DNA segments flanked by inverted, repeated sequences that can be recognized by transposase enzymes. A composite transposon , however, is flanked by two s...

Transposon mapping

... global mapping approach for identifying transposon locations in any genome, ... We also apply this method to mapping bacterial transposon ... ... describe a global mapping approach for identifying transposon locations in any ... apply this method to mappin...

Transposase

...osase is an enzyme that binds to the ends of a transposon and catalyzes the movement of the transposon to another part of the genome by a cut and past...e key enzyme in forming transposomes for random transposon insertions. ... of cut out fragments with transp...

RNA interference

...published Reviews, Perspectives and Highlights on this topic. until the discovery of RNA interference provided a most unexpected ... RNA ... transposon silencing and RNA interference , is a homolog of ... RNA INTERFERENCE ... The discovery of RNA interference ... Potent and specific gen...

Retrotransposons

...-1. LINES (Long interspersed elements) SINES (Short interspersed elements) ... Retrotransposons and the C-value paradox ... retrotransposon n. A transposon copied from RNA with the use of reverse ... Retrotransposons (also called transposons via RNA intermediates) are genetic ... Retrotransposons ...

P elements

... A P element is a transposon that is present in the fruit fly Drosophila melanogaster and is used widely for mutagenesis and the creation of genetically modified flies used for...

Multi-locus probe

... from multi - locus probes, these probes ... March 2001: "Climate Variability and Valley Fever. ... Fungus, Coccidioides immitis, using the Tcim1 transposon as a Multi - Locus Probe . ... including single- locus probe and multi - locus probe RFLP methods and more ... Analysis of multi - locus...

Inverse PCR

...mplify genomic DNA sequences that lie adjacent to transposon insertions by ... of techniques called " inverse ...and Biomedical Sciences. 6 Inverse PCR for transposon location identification. 7 Inverse PCR for sequencing transposon location. 8 Sequence analysis. 9 References ... ...

Insertion Sequence

...) for each insertion sequence ... Any sequence in the genome can become an IS element and, therefore, these ... As a result, a copy of the transposon appears at the site of insertion . ... ...
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