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Transporter in Medical News

SNPs of ABC transporter genes linked to lung cancer risk

Individuals with particular variants of certain genes involved in metabolizing the most potent carcinogen found in cigarette smoke have an increased risk of developing lung cancer. That is the conclusion of a new study published in the February 1, 2009 issue of CANCER , a peer-reviewed journal of...

New insight for dopamine transporter

Researchers of Yale University had discovered a changed version of dopamine// transporter in healthy persons with genetical variations that may be associated with substance abuse or attention deficit hyperactivity disorder (ADHD). Dopamine is a protein produced in the hypothalamus and some a...

Inflammation may trigger Alzheimer's disease, Saint Louis University findings suggest

.... The blood-brain barrier is a system of cells that regulates the exchange of substances between the brain and the blood. The blood-brain barrier transporter known as LRP is the pump that removes amyloid beta protein from the brain and into the bloodstream. "LRP malfunctions like a stop light stuck on re...

Hormones May Affect Neurological Disease Risk

...aid researchers at the University of Texas Medical Branch. They found that a number of estrogens acting through their receptors affect the dopamine transporter (DAT). Dopamine is a neurotransmitter in the brain that plays an important role in normal functioning of the central nervous system. "The significa...

Breakthrough in combating the side effects of quinine

...cess revealed that strains of yeast unable to make tryptophan were extremely susceptible to quinine poisoning, which led them to identify a tryptophan transporter as a key quinine target (yeast that cannot make their own tryptophan have to rely exclusively on external sources, and thus die if tryptophan transpor...

Animal model for schizophrenia identifies a novel approach for treating cognitive impairments

... line of research are just beginning to be tested in patients. For example, several pharmaceutical companies are studying drugs that block the glycine transporter (GlyT1) and thereby raise synaptic glycine levels. A new study in Biological Psychiatry , published by Elsevier, by Dr. Kenji Hashimoto and colleagu...

Raptor Pharmaceuticals to Collaborate with Roche on Therapeutic Delivery Across Blood-Brain Barrier

...rting with Raptor's proprietary NeuroTrans(TM) BBB transporter platform. Under terms of the agreement, Roche will...brain has resulted in an intensive search for "BBB transporter molecules" that could be attached to these potenti...her the development of Raptor's NeuroTrans(TM) BBB transporter molecules, in conjunction with Roche's proprietary...

Capsules encapsulated

...his requires transport systems that can encapsulate medications and other substances and release them in a controlled fashion at the right moment. The transporter must be able to interact with the surroundings in order to receive the signal to unload its cargo. A team led by Frank Caruso at the University of Mel...

Protein Might Mute Effects of Methamphetamine

...rain cells tied to Parkinson's disease might also help fight drug addiction, according to a newly published study. The protein -- organic cation transporter 3, or oct3 -- normally guides molecules in and out of cells, but it seems to lead the toxic brain chemical MPP+ straight to brain cells, where it kill...

Wayne State University and Children's Hospital of Michigan Research Team Discover Chemical That Plays a Major Role in Pediatric Obsessive-Compulsive Disorder

... laboratory at the University of Toronto and Hospital for Sick Kids. The studies found significant associations between glutamate receptor and transporter genes and abnormal brain volumes in brain regions implicated in OCD such as the thalamus ('grand central station' in the brain), caudate nucleus (brai...
Transporter in Medical Technology

Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions

...ria in Multiple Species and is Safe and Well-Tolerated," Dr. Sanjay Bhanot highlighted data that demonstrated that antisense reduction of SGLT2, a key transporter involved in glucose re-absorption in the kidney, produced the following results in preclinical models: Dose-dependent reduction in kid...

Celladon Provides MYDICAR(R) Program Update of First-In-Human Trial for Advanced Heart Failure at American Society of Gene Therapy Annual Meeting

... M.D., Director of the Cardiovascular Research Center at Mount Sinai School of Medicine, New York, developed MYDICAR for restoring the SERCA2a calcium transporter in heart failure and validated the overall beneficial effects on cardiac function. MYDICAR is a recombinant adeno-associated viral (rAAV) vector that ...

Alseres Pharmaceuticals Completes Enrollment in First Stage of the Altropane(R) POET-2 Phase III Program

...30-40 medical facilities throughout the U.S. About Altropane Altropane is a molecular imaging agent that specifically binds to the dopamine transporter (DAT) protein found on the surface of dopamine-producing neurons, making it visible during Single Photon Emission Computed Tomography or "SPECT" imagi...

Intra-Cellular Therapies Announces Successful Outcome of a Phase II Clinical Trial with ITI-007 in Patients with Sleep Maintenance Insomnia

...highest dose tested (10 mg) we expect to have full occupancy of 5HT2A receptors while adding incremental amounts of D2 receptor and serotonin reuptake transporter (SERT) occupancy. This has been confirmed in an ongoing human Positron Emission Tomography (PET) study where we have demonstrated that this dose is as...

Ardea Biosciences Presents Preclinical Anti-Inflammatory Data on its Lead MEK Inhibitor, RDEA119, at the ACG 2008 Annual Meeting

..., our lead product candidate for the treatment of gout, is being evaluated in a Phase 1 clinical trial and is believed to be an inhibitor of the URAT1 transporter in the kidney, which is responsible for regulation of uric acid levels. We are evaluating our lead MEK inhibitor, RDEA119, in a Phase 1 study in advan...

The First Direct Structural Evidence of SV2A has Been Revealed Thanks to Protein Tomography(TM), and Published in BBRC

... a trademark of UCB). The result shows the first direct structural proof of the "alternating access model" that has been proposed for the MFS class of transporter proteins. The "alternating access model" postulates that the trans-membrane MFS class proteins can exist in two different conformations; as a valve th...

Ardea Biosciences to Present Data on Lead MEK Inhibitor, RDEA119, at American College of Gastroenterology Annual Scientific Meeting

..., our lead product candidate for the treatment of gout, is being evaluated in a Phase 1 clinical trial and is believed to be an inhibitor of the URAT1 transporter in the kidney, which is responsible for regulation of uric acid levels. We are evaluating our lead MEK inhibitor, RDEA119, in a Phase 1 study in advan...

European CHMP Issues Positive Opinion on Cymbalta for the Treatment of Generalised Anxiety Disorder

...ww.nimh.nih.gov/health/publications/anxiety-disorders/generalized - anxiety-disorder-gad.shtml. Accessed on 2.5.08 (13) Bymaster, FP et al. The Dual transporter Inhibitor Duloxetine: A Review of its Preclinical Pharmacology, Pharmacokinetic Profile, and Clinical Results in Depression. Current Pharmaceutical De...

Ardea Biosciences Reports Additional Positive Phase 2a Results for Lead HIV Candidate, RDEA806, Demonstrating Up to 1.9 Log Reduction in Plasma Viral Load with Once-Daily Dosing

...date. RDEA594, our lead development candidate for the treatment of gout, is in preclinical development and is believed to be an inhibitor of the URAT1 transporter in the kidney, which is responsible for regulation of uric acid levels. We are evaluating our lead MEK inhibitor, RDEA119, in a Phase 1 study in advan...

Isis Highlights Robust Drug Portfolio for Diabetes and Obesity at ADA Conference

...ing that antisense drugs potently reduce levels of sodium dependent glucose transporter type 2 (SGLT2), a key component in controlling glucose re-absorption in the...nic diseases." About SGLT2 and ISIS 388626 The sodium dependent glucose transporter type 2 (SGLT2) is the primary mechanism responsible for glucose re-absorpti...
Transporter in Medical Dictionary

VLDL

...t of triglycerides. VLDL is considered a type of bad cholesterol, because it helps cholesterol build ... In growing birds, VLDL is the major transporter of triglycerides, and attempts ... pathways of chicken HDL are believed to be similar to those of VLDL . ... The ability of the β- VLDL to stimu...

HDL

...phytosterols ... high-density lipoprotein n. ( Abbr. HDL ) A complex of lipids and proteins in approximately equal amounts that functions as a transporter of ... HDL ) ... LDL- and HDL -Cholesterol: The Bad and The Good. Things That Affect Blood Cholestero l ... HDL -cholesterol helps remove chol...
Transporter in Biological News

Contribution of cholesterol transporter to vascular disease

Low-density lipoprotein (LDL), a transporter of cholesterol, may also contribute to vascular diseases by a previously unidentified mechanism, according to a report published online this week in EMBO reports. The study reveals a link between native LDL (nLDL) and the vascular endothelial growth fac...

High dopamine transporter levels not correlated with ADHD

Results from a brain-imaging study conducted at the U.S. Department of Energy's Brookhaven National Laboratory in collaboration with Mount Sinai School of Medicine in New York indicate that levels of a brain protein proposed as a diagnostic marker for attention-deficit hyperactivity disorder (ADHD)...

New study reveals structure of E. coli multidrug transporter protein

This new study could potentially help researchers find new ways to avoid the problem of multidrug resistance and enhance the potency of existing drug compounds. The study is being published in ScienceXpress, an advance online edition of the journal Science, on May 5. "The development of antib...

Carnegie donates landmark clones to biology

...hed in the July 6, Journal of Biological Chemistry . In the previous work, the scientists looked at the end of the protein Arabidopsis ammonium transporter (AMT1;1). This protein portion is called the C-terminus and it regulates the interactions of the pore-like structures at the membrane surface in plant...

Got zinc? New zinc research suggests novel therapeutic targets

...lls taken from the zinc-supplemented group had higher activation than those from the placebo group. Specifically, cell activation stimulated the zinc transporter in T cells called "ZIP8," which transports stored zinc into the cell cytoplasm where it then alters the expression of a T cell protein in a way needed...

Early initiation of Arctic sea-ice formation

...r their survival," said Catherine Stickley. Moreover, their analysis of quartz grain textural characteristics further supports sea ice as the dominant transporter of ice-rafted debris at this time. "It is likely that sea ice formed in autumn and winter and melted in spring and summer, as seasonal sea ice doe...

Tryptophan deficiency may underlie quinine side effects

... Their screen revealed that strains unable to make tryptophan were extremely susceptible to quinine poisoning, which led them to identify a tryptophan transporter as a key quinine target (yeast that cannot make their own tryptophan have to rely exclusively on external sources, and thus die if tryptophan transpor...

Brain protein central to both Parkinson's, drug addiction identified

...ther addictive drugs. The action of the protein, known as organic cation transporter 3 or oct3, fills a longstanding gap in scientists' understanding of the bra...nding dopamine neurons. That's where another molecule known as the dopamine transporter picks it up and brings it into the neuron itself. When the team blocked ...

New study reveals the protein that makes phosphate chains in yeast

... now show that in yeast a protein called Vtc4p is responsible for the production of polyphosphates. Vtc4p is part of a protein complex called vacuolar transporter chaperone complex (VTC) that is usually found in the membranes of vacuoles pouches in which cells store molecules for later use, transport or destruc...

Jefferson researcher awarded Landenberger Foundation grant for ALS research

...e disease, rendering pharmacological treatments for ALS mostly ineffective. This grant will support research towards finding ways to inactivate these transporter proteins to counteract their negative effect on ALS therapy. We are extremely grateful to the Margaret Q. Landenberger Research Foundation for seeing...
Transporter in Biological Technology

Alseres Pharmaceuticals Presents Inosine and Dopamine Transporter (DAT) Blocker Preclinical Data at the American Society for Experimental NeuroTherapeutics (ASENT) Conference

Preclinical Studies Demonstrate a Viable Intravenous Inosine Formulation and Support Oral Dosing for Three Alseres' DAT Blocker Compounds HOPKINTON, Mass., March 10 /PRNewswire-FirstCall/ -- Alseres Pharmaceuticals, Inc. (Nasdaq: ALSE ) announced that data from preclinical studies of the C...

Neurocrine Biosciences Reports Second Quarter 2009 Results

... to standard-of-care treatment; enrollment of 50 subjects is planned. VMAT2 Update The highly selective blockade of the Vesicular Monoamine transporter 2 (VMAT2) with NBI-98854 should be of clinical benefit in patients with a variety of CNS diseases, especially those with involuntary hyperkinetic move...

Genomas and Institute of Living Among Organizers of Pharmacogenetics Symposium at 2009 Annual Meeting of the American Psychiatric Association

...ford Hospital, Hartford, CT Cytochrome P-450 2D6, 2C19, and Serotonin transporter Genotyping for Depressed Inpatients at the Mayo Clinic Mood Disorders Unit ... M.F.A. Medical College of Wisconsin , Milwaukee, WI The Serotonin transporter Gene ( SLC 6A4): Understanding Variability and Enhancing the Clinical Ut...

Neurocrine Biosciences Reports First Quarter 2009 Results

...rability and efficacy of UCN2 in this group. Initiation of this trial is expected in mid-2009 pending regulatory approval. Vesicular Monoamine transporter 2 Inhibitor (VMAT2 ) VMAT2 is a protein concentrated in the human brain that is essential for the transmission of nerve impulses between neu...

Intra-Cellular Therapies Reports Positive Final Results of a Phase II Clinical Trial with ITI-007 in Patients with Sleep Maintenance Insomnia

...he highest dose tested (10 mg) is thought to fully occupy 5HT2A receptors while adding incremental amounts of dopamine receptor and serotonin reuptake transporter (SERT) occupancy. Together, these data suggest that ITI-007 induces a novel pattern of sleep improvement. Doses of ITI-007 were safe and well-...

Isis Initiates Phase 1 Clinical Trial of SGLT2 Antisense Drug

...1 study of ISIS-SGLT2Rx, an antisense drug that inhibits the production of sodium dependent glucose co-transporter type 2 (SGLT2). SGLT2 is the major transporter responsible for glucose re-absorption in the kidney. Decreasing SGLT2 levels promotes glucose excretion in the urine and reduces blood sugar levels, ...

Study Shows Machine Perfusion Significantly Improves Transplant Results

... in kidney survival and function when compared to those stored in a traditional "ice box", or cold storage. Unlike the icebox, the LifePort(R) Kidney transporter monitors the temperature and vascular performance of the organ in real time, while preserving it by pumping the kidney continuously with a cold soluti...

Ardea Biosciences to Present at the UBS Global Life Sciences Conference and the Third Annual JMP Securities Healthcare Focus Conference

..., our lead product candidate for the treatment of gout, is being evaluated in a Phase 1 clinical trial and is believed to be an inhibitor of the URAT1 transporter in the kidney, which is responsible for regulation of uric acid levels. We are evaluating our lead MEK inhibitor, RDEA119, in a Phase 1 study in advan...

Ardea Biosciences to Present Data on Gout and Inflammation Programs at the 2008 ACR/ARHP Annual Scientific Meeting

..., our lead product candidate for the treatment of gout, is being evaluated in a Phase 1 clinical trial and is believed to be an inhibitor of the URAT1 transporter in the kidney, which is responsible for regulation of uric acid levels. We are evaluating our lead MEK inhibitor, RDEA119, in a Phase 1 study in advan...

Ardea Biosciences to Present Data on Lead MEK inhibitor, RDEA119, at EORTC-NCI-AACR Symposium

..., our lead product candidate for the treatment of gout, is being evaluated in a Phase 1 clinical trial and is believed to be an inhibitor of the URAT1 transporter in the kidney, which is responsible for regulation of uric acid levels. We are evaluating our lead MEK inhibitor, RDEA119, in a Phase 1 study in advan...
Transporter in Biological Products

Mouse Anti-Vesicular Glutamate Transporter 2 (VGLUT2) Antibody, Unconjugated from CHEMICON

Description: Vesicular Glutamate Transporter 2 [VGLUT2]...
Company:CHEMICON

Anti-Monocarboxylate Transporter 2 (MCT2) Polyclonal Antibody, Unconjugated from CHEMICON

Description: Monocarboxylate (lactate) transporter 2...
Company:CHEMICON

Anti-Glycine Transporter 2, Neuronal (GLYT2) Polyclonal Antibody, Unconjugated from CHEMICON

Description: Glycine Transporter 2, Neuronal (GLYT2). The antiserum has been tested on tissue sections from the central nervous system. The staining pattern obtained with AB1773 corresponds to the pattern described using in situ hybridization with probes to GLYT2 mRNA and to what has been described for glyciner...
Company:CHEMICON

Anti-Vesicular Monoamine Transporter 2 (VMAT2) Polyclonal Antibody, Unconjugated from CHEMICON

Description: Vesicular Monoamine Transporter 2 (VMAT2). An antibody made to the C-terminal VMAT2 peptide detected a major band at ~55 kDa in postnuclear supernatants of CHO transfected with VMAT2 and not in wild type cells (2). Some additional bands, both higher and lower molecular weight, were also detected an...
Company:CHEMICON

Rabbit Anti-Human TAP2 Polyclonal Antibody, Unconjugated from Atlas Antibodies

Description:... Antigen peptide transporter 2 (APT2) (Peptide transporter TAP2) (Peptide transporter PSF2) (Peptide supply factor 2) (PSF-2) (Peptide...
Company:Atlas Antibodies
Transporter in Biological Definition

Blood

...port of oxygen The amount of oxygen dissolved in blood is directly proportional to the PO2 of the blood. The hemoglobin molecule is the primary transporter of oxygen. 98.5% of the oxygen is chemically combined with the Hb . Only 1.5% is physically dissolved. Transport of carbon dioxide When system...

Endoplasmic reticulum

...role in carbohydrate metabolism , detoxification of the cell (enzymes in the smooth ER detoxify chemicals), and calcium storage. It also is a large transporter of nutrient found in each cell. Functions The endoplasmic reticulum serves many general functions, including the facilitation of protein foldin...

Insulin

...variations in blood glucose levels through the following mechanism (see figure to the right): Glucose enters the beta cells through the glucose transporter GLUT2 Glucose goes into the glycolysis and the respiratory cycle where the high-energy ATP molecule is produced by oxidation Dependent o...

Endoplasmic reticulum

...role in carbohydrate metabolism , detoxification of the cell (enzymes in the smooth ER detoxify chemicals), and calcium storage. It also is a large transporter of nutrient found in each cell. Functions The endoplasmic reticulum serves many general functions, including the facilitation of protein foldin...

Endoplasmic reticulum

...role in carbohydrate metabolism , detoxification of the cell (enzymes in the smooth ER detoxify chemicals), and calcium storage. It also is a large transporter of nutrient found in each cell. Functions The endoplasmic reticulum serves many general functions, including the facilitation of protein foldin...

Endoplasmic reticulum

...role in carbohydrate metabolism , detoxification of the cell (enzymes in the smooth ER detoxify chemicals), and calcium storage. It also is a large transporter of nutrient found in each cell. Functions The endoplasmic reticulum serves many general functions, including the facilitation of protein foldin...

Virus

...y involved in attachment and entry into the host-cell. The complete virus particle is referred to as a virion . A virion is little more than a gene transporter and components of the envelope and capsid provide the mechanism for injecting the viral genome into a host cell. Viral replication Because ...
Transporter in Biological Dictionary

Membrane transporter

A membrane transport protein is a protein involved in the movement of ions, small molecules, or macromolecules, such as another protein across a biological membrane . Transport proteins are integral membrane proteins; that is... The dopamine transporter is a membrane -spanning p...

Intermembrane space

...The European Bioinformatics Institute ... GO:0005758 mitochondrial intermembrane space ... 0042719 mitochondrial intermembrane space protein transporter ... ,biological,biology definition,biology terminology,biology terms,biology ... The intermembrane space is the region between the inner membra...

Amp resistance

...due to two well-known mechanisms. ... resistance due to the latter mechanism are termed β-lactamase-negative AMP ... In addition, the regulated transporter system may be involved in AMP resistance . ... bacterial metabolism that goes beyond the control of AMP resistance mechanisms. ... We are ...
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