SNPs of ABC transporter genes linked to lung cancer risk
Individuals with particular variants of certain genes involved in metabolizing the most potent carcinogen found in cigarette smoke have an increased risk of developing lung cancer. That is the conclusion of a new study published in the February 1, 2009 issue of CANCER , a peer-reviewed journal of...New insight for dopamine transporter
Researchers of Yale University had discovered a changed version of dopamine// transporter in healthy persons with genetical variations that may be associated with substance abuse or attention deficit hyperactivity disorder (ADHD). Dopamine is a protein produced in the hypothalamus and some a...Inflammation may trigger Alzheimer's disease, Saint Louis University findings suggest
.... The blood-brain barrier is a system of cells that regulates the exchange of substances between the brain and the blood. The blood-brain barrier transporter known as LRP is the pump that removes amyloid beta protein from the brain and into the bloodstream. "LRP malfunctions like a stop light stuck on re...Hormones May Affect Neurological Disease Risk
...aid researchers at the University of Texas Medical Branch. They found that a number of estrogens acting through their receptors affect the dopamine transporter (DAT). Dopamine is a neurotransmitter in the brain that plays an important role in normal functioning of the central nervous system. "The significa...Breakthrough in combating the side effects of quinine
...cess revealed that strains of yeast unable to make tryptophan were extremely susceptible to quinine poisoning, which led them to identify a tryptophan transporter as a key quinine target (yeast that cannot make their own tryptophan have to rely exclusively on external sources, and thus die if tryptophan transpor...Animal model for schizophrenia identifies a novel approach for treating cognitive impairments
... line of research are just beginning to be tested in patients. For example, several pharmaceutical companies are studying drugs that block the glycine transporter (GlyT1) and thereby raise synaptic glycine levels. A new study in Biological Psychiatry , published by Elsevier, by Dr. Kenji Hashimoto and colleagu...Raptor Pharmaceuticals to Collaborate with Roche on Therapeutic Delivery Across Blood-Brain Barrier
...rting with Raptor's proprietary NeuroTrans(TM) BBB transporter platform. Under terms of the agreement, Roche will...brain has resulted in an intensive search for "BBB transporter molecules" that could be attached to these potenti...her the development of Raptor's NeuroTrans(TM) BBB transporter molecules, in conjunction with Roche's proprietary...Protein Might Mute Effects of Methamphetamine
...rain cells tied to Parkinson's disease might also help fight drug addiction, according to a newly published study. The protein -- organic cation transporter 3, or oct3 -- normally guides molecules in and out of cells, but it seems to lead the toxic brain chemical MPP+ straight to brain cells, where it kill...European CHMP Issues Positive Opinion on Cymbalta for the Treatment of Generalised Anxiety Disorder
...ww.nimh.nih.gov/health/publications/anxiety-disorders/generalized - anxiety-disorder-gad.shtml. Accessed on 2.5.08 (13) Bymaster, FP et al. The Dual transporter Inhibitor Duloxetine: A Review of its Preclinical Pharmacology, Pharmacokinetic Profile, and Clinical Results in Depression. Current Pharmaceutical De...Isis Highlights Robust Drug Portfolio for Diabetes and Obesity at ADA Conference
...ing that antisense drugs potently reduce levels of sodium dependent glucose transporter type 2 (SGLT2), a key component in controlling glucose re-absorption in the...nic diseases." About SGLT2 and ISIS 388626 The sodium dependent glucose transporter type 2 (SGLT2) is the primary mechanism responsible for glucose re-absorpti...Contribution of cholesterol transporter to vascular disease
Low-density lipoprotein (LDL), a transporter of cholesterol, may also contribute to vascular diseases by a previously unidentified mechanism, according to a report published online this week in EMBO reports. The study reveals a link between native LDL (nLDL) and the vascular endothelial growth fac...High dopamine transporter levels not correlated with ADHD
Results from a brain-imaging study conducted at the U.S. Department of Energy's Brookhaven National Laboratory in collaboration with Mount Sinai School of Medicine in New York indicate that levels of a brain protein proposed as a diagnostic marker for attention-deficit hyperactivity disorder (ADHD)...New study reveals structure of E. coli multidrug transporter protein
This new study could potentially help researchers find new ways to avoid the problem of multidrug resistance and enhance the potency of existing drug compounds. The study is being published in ScienceXpress, an advance online edition of the journal Science, on May 5. "The development of antib...Carnegie donates landmark clones to biology
...hed in the July 6, Journal of Biological Chemistry . In the previous work, the scientists looked at the end of the protein Arabidopsis ammonium transporter (AMT1;1). This protein portion is called the C-terminus and it regulates the interactions of the pore-like structures at the membrane surface in plant...Got zinc? New zinc research suggests novel therapeutic targets
...lls taken from the zinc-supplemented group had higher activation than those from the placebo group. Specifically, cell activation stimulated the zinc transporter in T cells called "ZIP8," which transports stored zinc into the cell cytoplasm where it then alters the expression of a T cell protein in a way needed...Early initiation of Arctic sea-ice formation
...r their survival," said Catherine Stickley. Moreover, their analysis of quartz grain textural characteristics further supports sea ice as the dominant transporter of ice-rafted debris at this time. "It is likely that sea ice formed in autumn and winter and melted in spring and summer, as seasonal sea ice doe...Tryptophan deficiency may underlie quinine side effects
... Their screen revealed that strains unable to make tryptophan were extremely susceptible to quinine poisoning, which led them to identify a tryptophan transporter as a key quinine target (yeast that cannot make their own tryptophan have to rely exclusively on external sources, and thus die if tryptophan transpor...Brain protein central to both Parkinson's, drug addiction identified
...ther addictive drugs. The action of the protein, known as organic cation transporter 3 or oct3, fills a longstanding gap in scientists' understanding of the bra...nding dopamine neurons. That's where another molecule known as the dopamine transporter picks it up and brings it into the neuron itself. When the team blocked ...New study reveals the protein that makes phosphate chains in yeast
... now show that in yeast a protein called Vtc4p is responsible for the production of polyphosphates. Vtc4p is part of a protein complex called vacuolar transporter chaperone complex (VTC) that is usually found in the membranes of vacuoles pouches in which cells store molecules for later use, transport or destruc...Jefferson researcher awarded Landenberger Foundation grant for ALS research
...e disease, rendering pharmacological treatments for ALS mostly ineffective. This grant will support research towards finding ways to inactivate these transporter proteins to counteract their negative effect on ALS therapy. We are extremely grateful to the Margaret Q. Landenberger Research Foundation for seeing...Neurocrine Biosciences Reports Second Quarter 2009 Results
... to standard-of-care treatment; enrollment of 50 subjects is planned. VMAT2 Update The highly selective blockade of the Vesicular Monoamine transporter 2 (VMAT2) with NBI-98854 should be of clinical benefit in patients with a variety of CNS diseases, especially those with involuntary hyperkinetic move...Neurocrine Biosciences Reports First Quarter 2009 Results
...rability and efficacy of UCN2 in this group. Initiation of this trial is expected in mid-2009 pending regulatory approval. Vesicular Monoamine transporter 2 Inhibitor (VMAT2 ) VMAT2 is a protein concentrated in the human brain that is essential for the transmission of nerve impulses between neu...Isis Initiates Phase 1 Clinical Trial of SGLT2 Antisense Drug
...1 study of ISIS-SGLT2Rx, an antisense drug that inhibits the production of sodium dependent glucose co-transporter type 2 (SGLT2). SGLT2 is the major transporter responsible for glucose re-absorption in the kidney. Decreasing SGLT2 levels promotes glucose excretion in the urine and reduces blood sugar levels, ...Study Shows Machine Perfusion Significantly Improves Transplant Results
... in kidney survival and function when compared to those stored in a traditional "ice box", or cold storage. Unlike the icebox, the LifePort(R) Kidney transporter monitors the temperature and vascular performance of the organ in real time, while preserving it by pumping the kidney continuously with a cold soluti...Ardea Biosciences to Present Data on Lead MEK inhibitor, RDEA119, at EORTC-NCI-AACR Symposium
..., our lead product candidate for the treatment of gout, is being evaluated in a Phase 1 clinical trial and is believed to be an inhibitor of the URAT1 transporter in the kidney, which is responsible for regulation of uric acid levels. We are evaluating our lead MEK inhibitor, RDEA119, in a Phase 1 study in advan...Mouse Anti-Vesicular Glutamate Transporter 2 (VGLUT2) Antibody, Unconjugated from CHEMICON
Description: Vesicular Glutamate Transporter 2 [VGLUT2]...Anti-Monocarboxylate Transporter 2 (MCT2) Polyclonal Antibody, Unconjugated from CHEMICON
Description: Monocarboxylate (lactate) transporter 2...Anti-Glycine Transporter 2, Neuronal (GLYT2) Polyclonal Antibody, Unconjugated from CHEMICON
Description: Glycine Transporter 2, Neuronal (GLYT2). The antiserum has been tested on tissue sections from the central nervous system. The staining pattern obtained with AB1773 corresponds to the pattern described using in situ hybridization with probes to GLYT2 mRNA and to what has been described for glyciner...Anti-Vesicular Monoamine Transporter 2 (VMAT2) Polyclonal Antibody, Unconjugated from CHEMICON
Description: Vesicular Monoamine Transporter 2 (VMAT2). An antibody made to the C-terminal VMAT2 peptide detected a major band at ~55 kDa in postnuclear supernatants of CHO transfected with VMAT2 and not in wild type cells (2). Some additional bands, both higher and lower molecular weight, were also detected an...Rabbit Anti-Human TAP2 Polyclonal Antibody, Unconjugated from Atlas Antibodies
Description:... Antigen peptide transporter 2 (APT2) (Peptide transporter TAP2) (Peptide transporter PSF2) (Peptide supply factor 2) (PSF-2) (Peptide...