Microscopic 'beads' could help create 'designer' immune cells that ignore transplanted organs
AUGUSTA, Ga. The future of organ transplantation could include microscopic beads that create "designer" immune cells to help patients tolerate their new organ, Medical College of Georgia researchers say.
"It's absolutely natural," says Dr. Anatolij Horuzsko, reproductive immunologist at the MC...
New approaches to protecting transplanted organs make first steps toward patients
AUGUSTA, Ga. - Methods used by the body to selectively suppress the immune response may help make organ transplants safer and more effective, according to scientists.
"If you like, what we are trying to do is make every tissue transplant much more like a fetus," said Dr. Andrew L. Mellor, direc...
Circulating fats kill transplanted pancreas cells, study shows
DALLAS Aug. 28, 2007 Dietary restrictions or other strategies that limit fat formation might make pancreatic cell transplants more effective, UT Southwestern Medical Center researchers report.
Using animal models, the researchers discovered that pancreatic islet cells transplanted
into the l...
New Drug Mix to Extend Life of Transplanted Kidneys
It is great news for kidney recipients as well as those on the waiting list. Scientists now announce the extended life spans of transplanted
kidneys// by a priceless two times, through a mix of varied drugs.
Scientists from the University Hospital in Cardiff who detailed their work in an organ ...
Study Reveals Effects of WBCs on Transplanted Kidney
A recent study in genetically engineered mice has revealed that the dreaded white blood cell chemistry known to damage kidneys used for transplants may also help prevent such damage//, according to scientists at Johns Hopkins.
Researchers have long known that when blood flow is cut off and the...
White Blood Cells Can Both Hurt and Help Transplanted Kidneys
In an example of biological irony, the same white blood cell chemistry known to damage kidneys used for transplants may also help prevent such damage, according to a federally// funded study in genetically engineered mice at Johns Hopkins.
Researchers have long known that when blood flow is c...
MRI Can Monitor Transplanted Islets
Magnetic resonance imaging (MRI) could be a safe way to monitor the fate of transplanted
pancreatic islets, says a new study in the September issue of the journal Diabetes. // Researchers from the Martinos Center for Biomedical Imaging at Massachusetts General Hospital (MGH) said that they were abl...
Heart transplanted infants better model for developing AIDS treatment
infants immune system may act as a model for developing better treatment options to patients with AIDS, cancer and other immune disorders. Professor Jeffrey // Plat, Mayo Clinic is to lead a team of researchers which has got a NIH funding of $ 6 million and the research team woul...
Kidneys Can Be Transplanted From Animals Such As Pigs In Future
The idea of transplanting human organs and tissues has captured the imagination of successive generations. The first successful transplantation was a kidney transplantation performed between identical // twins by Joseph Murray and his colleagues.
With the significant progress, it might even be p...
Woman gets cancer from transplanted kidney
For a person with failing kidneys, receiving a transplanted
kidney can be a lifesaver. But in rare cases, the transplanted
organ may pass on cancer to the recipient. Wisconsin researchers report that a transplant recipient whose donor had previously had lung cancer developed cancer herself several...
Transplanted in Medical Technology
Schepens Scientists Identify Key to Integrating Transplanted Nerve
Cells Into Injured Tissue
Discovery promises to make retina, spinal cord and other central
nervous system transplants possible
BOSTON, April 26, 2007 /PRNewswire/ -- Scientists at the
Schepens Eye Research Institute, an affiliate of Harvard Medical
School, have identified a key mechanism for successfully
Stanford Researchers Track Human Stem Cells Transplanted Into Rat
STANFORD, Calif.--(BUSINESS WIRE)--Jun 4, 2007 - Researchers at the
Stanford University School of Medicine have illuminated the path
taken by human neural stem cells that were transplanted
brains of rats and mice, and found that the cells successfully
navigate toward areas damaged by strok...
UPCI Joins ExCell Research Study Using Stem Cells for Leukemia and Lymphoma Patients
...ancies, including leukemia
and lymphoma. StemEx is a graft of expanded stem/progenitor cells taken from
a single unit of umbilical cord blood and then transplanted
with non-expanded cells from the same unit.
"I am extremely pleased UPCI has the opportunity to be a part of this
study," said M...
PARI Pharma Reports Successful Phase Ib Clinical Results for Inhaled Liposomal Cyclosporine A and Gains FDA Orphan Drug Designation for the Prevention and Treatment of Bronchiolitis Obliterans
...tely 60,000 patients worldwide.
"PARI's encouraging results show that it is feasible and well tolerated to deposit relevant amounts of L-CsA into transplanted
lungs. This has the potential to prevent and treat bronchiolitis obliterans in a more efficient way compared to current oral standard treatment. Inha...
Neuralstem's Human Stem Cells Integrate into Nervous System of Rats with Animal Model of ALS
... ROCKVILLE, Md., March 9 /PRNewswire-FirstCall/ -- transplanted
human neural stem cells (hNSCs) developed by Neura...ology reported. This constitutes evidence that the transplanted
cells integrated into the nervous system of the ho...007LOGO )
"This is the first demonstration of transplanted
human neurons synapsing, or making mature structur...
Laser Burn Injuries in One Eye Can Disrupt Protective Immune Privilege in Both Eyes, Study Finds
...ilege, which intervenes in the battle, is also what prevents the eye from rejecting corneal transplants, making them the most common and successful of transplanted
In her laboratory, Stein-Streilein and her team made tiny laser burns in one of the retinas of 15 mice. They then injected either the bu...
Applying Clinical Findings to the Practice of Medicine
...ield of bone tissue engineering and set out to develop orthopaedic biomaterials for treating skeletal disorders. "Bone, after blood, is most commonly transplanted
tissue worldwide," the paper stated.
The team used two strategies - one for contained defects, which are holes contained within the bone, and an...
Fifth U.S. Hand Transplant Patient Heads Home to NY
...eering procedure. Breidenbach and his team are the only surgeons to perform hand transplants in the U.S. To date, there have been a total of 40 hands transplanted
on 32 patients around the world.
Kentuckiana Organ Donor Affiliates (KODA) worked very closely with the Indiana Organ Procurement Organization t...
ViroPharma Announces Discontinuation of Maribavir Phase 3 Study in Liver Transplant Patients
...hese patients, CMV disease can lead to severe conditions such as pneumonitis or hepatitis, or to complications such as acute or chronic rejection of a transplanted
organ. While currently available systemic anti-CMV agents are effective against the virus, their use is limited by toxicities, most notably bone marr...
Rosetta Genomics Reports First Ever In-Vivo Efficacy Data for a Systemic MicroRNA Therapeutic for Liver Cancer
...cientists then used an in-vivo model called
Orthotopic Xenograft, in which an artificial tumor fragment derived from a
human liver cancer cell line is transplanted
into livers of mice, in order to
evaluate the efficacy of systemic microRNA-based treatment in these mice.
Chemically modified antisense oligos (ASOs)...
Transplanted in Medical Definition
...lar inflammation of the bone . 
In 1895, another German doctor, Dr. Karl Czerny did the very first documented breast augmentation when he transplanted
a fatty tumor from the patient’s lumbar region , or lower back, to a breast defect. 
Overview of Current Fat Transfer Techniques ...
Transplanted in Medical Dictionary
... Transplant rejection occurs when a transplanted
organ or tissue is not accepted by the body of...t the immune system of the recipient attacks the transplanted
organ or tissue. This is expected to happen,... ...A protein that contributes to the rejection of transplanted
hearts has been identified by a UCSF research team...
...s a type of medical grafting involving the transplantation of skin . The transplanted
tissue is called a skin graft . More about Skin Grafting : Purpos...pe of organ transplant involving the transplantation of skin . ... The transplanted
tissue is called a skin graft . ... recipient bed, not the skin ...
... Health Article. Save ... Immunosuppressant drugs , which are also called anti-rejection drugs , are used to prevent the body from rejecting a transplanted
organ. ... Immunosuppressant Drugs pictures, video and information at Encyclopedia.com - a ... Immunosuppressant drugs greatly decrease th...
Graft Versus Host Disease
...c bone marrow transplantation in which functional immune cells in the transplanted
marrow recognize the recipient as "foreign" and mount an immuno...ersus - host disease n. A pathological condition in which cells from the transplanted
tissue of a donor initiate an immunologic attack on the Overview: Bar...
... bypass ... graft (grft) Noun ... graft - (surgery) tissue or organ transplanted
from a donor to a recipient; in ... The bone graft is used to fill in...carefully spread on the bare area where it is being transplanted. ... It is transplanted
to the area of the graft . ... Skin grafting . Authoritative facts ab...
...k best for your situation. ... Bone grafts have often played the roles of scaffolds, bridges, spacers, defect ... Autograft, or bone graft transplanted
from one site to another in the same ... Bone graft material can be placed and matured for a few months before placing the implant. ... blood...
Transplanted in Biological News
Device protects transplanted pancreatic cells from the immune system
LA JOLLA, Calif., April 9, 2009Scientists at Burnham Institute for Medical Research (Burnham) and the University of California San Diego (UC San Diego) School of Medicine have demonstrated in mice that transplanted
pancreatic precursor cells are protected from the immune system when encapsulated i...
Studies on imaging and tracking transplanted cells
Tampa, Fla. (Dec. 10, 2008) Successfully monitoring the distribution and fate of transplanted
stem cells through imaging and subsequent tracking would aid clinicians in their ability to evaluate the efficacy of transplanted
cells. Three studies published in the current issue of Cell Transplantat...
Type of stem cell found to reside in transplanted lungs
A new study involving a type of stem cells from the lungs of transplant patients demonstrates for the first time that these progenitor cells reside in adult organs and are not derived from bone marrow, which leads to the possibility that the cells may be able to help with the rejection of donated o...
Stem cells found in adult skin can be transplanted and function in mouse models of disease
Researchers at The Hospital for Sick Children (SickKids) and the University of Calgary have found that stem cells derived from adult skin can create neural cell types that can be transplanted
into and function in mouse models of disease. This research is reported in the June 14, 2006 issue of The J...
Discoveries by UAB and Florida scientists may help transplanted organs survive longer
Scientists may have found a way to dramatically slow organ transplant rejection by as much as several years.
That's the promising implication of an animal study carried out by researchers at the University of Alabama at Birmingham (UAB) and the University of Florida (UF) published in today's (Ma...
NIH stimulus funding supports Emory biomedical scientists
...emory T cells allow the immune system to respond to infections faster and stronger upon a second encounter, but they also play a big role in rejecting transplanted
organs. Scientists will test several molecules found on memory T cells' surfaces as possible handles for manipulating the immune system.
Early rice harvests ease annual famine in Bangladesh
... a yearly famine that occurs in northwest Bangladesh from September to November after the previous season's food has run out and before the harvest of transplanted
rice in December.
According to the Bangladesh Bureau of Statistics, monga affects more than 2 million households in 5 districts that depend on ric...
Ovarian transplantation: First baby is born after a new technique
...e low response to stimulation caused by insufficient vascularisation of the transplanted
"In order for a woman to become pregnant, the ovaries need to ...in a shorter time scale than would be possible if all the tissue were to be transplanted
at the same time.
The researchers have so far utilised this technique wi...
Peripheral nerve repair with fat precursor cells led to wider nerves and less muscle atrophy
...oaded with APCs. No regeneration was observed in any of the rats in which the defect was left untreated," said Marra.
Their results also showed that transplanted
human-derived APCs survived for up to 12 weeks in the injured peripheral nerve and formed a more robust nerve with nerve cells more than double the si...
MITs implantable device offers continuous cancer monitoring
...f we're going to turn cancer from a death sentence to a manageable disease," he said.
In the Biosensors & Bioelectronics study, human tumors were transplanted
into the mice, and the researchers then used the implants to track levels of human chorionic gonadotropin, a hormone produced by human tumor cells.
Transplanted in Biological Technology
Transposagen Creates a Rat Model of the Human Immune System
...white blood cells necessary to prevent invasive bacteria and viruses from causing serious disease. "This new immune deficiency rat model cannot reject transplanted
tissues, even from other species, and will be especially important in cancer and transplantation research," said Dr. Ostertag.
Rat models are s...
Printing New Organs: Foundation Funds Medical Technology That Replicates Human Tissue
...lution. Their 3-dimensional bio-printer lays down bio-ink that fuses into complex tissue, creating new tissue to replace diseased tissue. Rejection of transplanted
tissue is not a concern; the cells that are used can be taken from youthful progenitor cells from the patient to replace the older diseased cells.
Five Cord Blood Transplant Centers in Catalonia and Valencia Join a Study to Test a New Technique to Treat Leukemia and Lymphoma
...al, pivotal marketing authorization trial. StemEx is a graft of
expanded stem/progenitor cells, derived from a single unit of umbilical cord
blood and transplanted
in combination with non expanded cells from the same
unit. StemEx(R) is being developed by a Joint Venture of Gamida Cell and Teva
Celsense, Inc Receives NIH Grant to Translate Cell Imaging Technology for Clinical Use
...l (CRC) and other forms of cancer.
The Cell Sense technology makes transplanted
cells visible by MRI. Therapeutic cells are labeled ex vivo with the Cell S...bel cells ex vivo without the use of transfection agents. Labeled cells are transplanted
into the patient enabling researchers and clinicians to non-invasively trac...
500th Patient Receives Berlin Heart EXCOR Pediatric Ventricular Assist Device
...of the device in 1990. The
patient, an 11-month-old girl, received the device at the Children's Memorial
Hospital in Chicago and has been successfully transplanted
in the meantime.
Alejandra had been diagnosed a few weeks after birth with left
ventricular non compaction and dilative cardiomyopathy, a disea...
STEMCELL Technologies Introduces a New Animal Component-Free, Serum-Free Medium for Culturing Human Mesenchymal Stem Cells
...culture the cells in animal component-free culture systems, in order to minimize the risk associated with disease transmission and immune rejection of transplanted
cells. The availability of MesenCult®-ACF Medium will greatly facilitate advances in efforts to assess the therapeutic relevance of mesenchymal st...
Tolera Therapeutics Granted Orphan Drug Designation for Organ Transplant Rejection Drug
...is designed to safely and specifically target T cells, components of the immune system that play a key role in the rejection, and ultimate failure, of transplanted
organs. Organ transplantation is often the only viable treatment for many end-stage organ diseases.
"We are extremely pleased with this current a...
Amniotic Fluid May Provide New Source of Stem Cells for Future Therapies
The peripheral blood of the transplanted
mice was examined every four weeks, and after 16-1... later, demonstrating the long-term ability of the transplanted
cells to produce new blood cells.
Bone marrow samples from the transplanted
mice were also taken and injected in a second set ...
Frost & Sullivan Recognizes ApaTech's Leadership in Orthopedic Biologics
Traditional autogenous grafts, or autografts, were widely considered the "gold standard" among bone graft materials. Despite the material being transplanted
from the same individual, complications and pain at the affected site have been common. The clinical effectiveness of autografts is considered the pri...
Kidneys for Transplant Function Earlier and Last Longer When Preserved in a Machine Compared to the Traditional Box of Ice
... the New England Journal of Medicine, show that in transplanted
kidneys preserved and transported in a specially d...g on the type of deceased donor,* 15¿50 percent of transplanted
kidneys do not function immediately following tran...n, and the other one to cold storage. Kidneys were transplanted
in recipients across the Eurotransplant area.
Transplanted in Biological Definition
...us is removed from an egg cell and replaced with a nucleus extracted from a cell of the organism to be cloned (currently, both the egg cell and its transplanted
nucleus must be from the same species). As the nucleus contains (almost) all of the genetic information of a lifeform, the "host" egg cell will develo...
...where cells are modified outside the body and then transplanted
back in again) and in vivo (where genes are chan...irectly as well. After modification, the cells are transplanted
back in to the patient where they will hopefully r...produce functional descendants for the life of the transplanted
This technique is best used for di...
...D4 + T cells, is an example of the latter. Immunosuppressive medication intentionally induces an immunodeficiency in order to prevent rejection of transplanted
On the other end of the scale, an overactive immune system figures in a number of other disorders, particularly autoimmune disorders such...
...ated neurons can communicate with other cells when transplanted
into a living animal. The team will first test the...s reported on November 25 , 2004 , that they had transplanted
multi-potent adult stem cells from umbilical cord ...
In the same way that organs can be transplanted
from cadavers , researchers at the Salk Institut...
Transplanted in Biological Dictionary
... of the lips, patient stories, diagnostic guides. Diagnostic checklist, medical tests, doctor questions, and ... Olfactory mucosa autografts were transplanted
... mucosa may contribute to its effectiveness, the 2 cell. types in the olfactory mucosa known to be useful in repair ... balancedfitnss: 30mi...
...micromere at YourDictionary.com ... Micromere Definition | Definition of Micromere at Dictionary.com ... Similarly, when the 1b micromere is transplanted
to the position of 1a, the left ... The 1d micromere in the 1a position develops the left eye in only 2% of ... Near Matches. Ignore Exact. Full ...
... incompatibility ... het-c, -d, -e, and -i were first defined by heterokaryon tests. ... het-c: heterokaryon incompatibility-c. IIL. ... ... of transplanted
BMDCs predominantly derives from heterokaryon formation. ... reprogramming is accompanied by heterokaryon formation and Y chromosome loss ... ...
...or primary culture of hepatocytes ... hepatocytes and the desynchronization and damping of circadian rhythm. ... ... liver transplantation, transplanted
hepatocytes must proliferate efficiently ... Recently, small hepatocytes and oval cells have been proposed as important ... ... had no effect...
...f the transplant is opposite to that of the host. ... The dorsal lip is transplanted
into another gastrula in the ... By transplanting the dorsal blasto...the blastopore, which is ... They demonstrated that dorsal lip material transplanted
to the ventral side of a ... ... starts with the formation of the dor...