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Transmembrane in Medical News

Newly appreciated membrane estrogen receptor important therapeutic target for breast cancer

...ular Endocrinology. This new study by Edward Filardo, MD, and his research team further supports earlier published work by the group that linked the transmembrane receptor, GPR30/GPER-1, to specific estrogen binding, rapid estrogen signaling and breast cancer metastasis. "What is exciting about this new work," ...

Quest Diagnostics Discovers New Genetic Mutations Affecting Cystic Fibrosis Screening

... One in 29 Americans of Northern European Caucasian or Ashkenazi Jewish descent are symptomless carriers of the defective, or mutated, cystic fibrosis transmembrane regulator (CFTR) gene. A child whose parents are both carriers has a one in four chance of developing the disease. "Taken together, these three p...

Hope for preventative treatment for cystic fibrosis lung disease

...e of all symptoms of cystic fibrosis are defects at a certain locations in the genetic makeup a mutation in what is called the CFTR ("Cystic Fibrosis transmembrane Conductance Regulator" gene) leads to loss of salt and water and thus dehydration of the surfaces of the mucous membranes in the lungs, intestines, an...

A new light on the anti-tumor mechanisms of Scutellaria barbata

...microscope. Further investigating the molecular mechanism behind ESB-induced apoptosis, cells treated with ESB underwent a rapid loss of mitochondrial transmembrane potential(delta psi m), release of mitochondrial cytochrome c into cytosol, induction of caspase-3 activity in a dose-dependent manner. This may offe...

Estrogen May Explain Why Women With Cystic Fibrosis Suffer More

...ap has narrowed, largely thanks to more aggressive infection treatment in women. People with cystic fibrosis have mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which reduces the ability of chloride ions to travel across cell membranes, the researchers said. Chloride helps...

2 UCSF scientists recognized for transformative research

...and molecules across the mitochondrial membranes is the foundation of the mitochondrial physiology and a lack of direct methods to study mitochondrial transmembrane transport is likely the most significant barrier to a better understanding of mitochondria," he adds. His goal is to develop a method for the appli...
Transmembrane in Medical Technology

Cystic Fibrosis - Orphan Drug Designation for Innovative Treatment Against Lung Infections by Axentis Pharma AG

...rosis is the most common life-threatening hereditary disease amongst Caucasian populations. The disease is caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene found on chromosome 7. This mutation causes increased secretion deposits on mucous membranes. Lung complications rep...

Dendreon Presents Preclinical Data Demonstrating Activity of TRPM8 Agonist, D-3263, in Benign Prostatic Hyperplasia

... DNDN ) today presented preclinical data demonstrating the potential of D-3263, Dendreon's orally bioavailable small molecule, which targets TRPM8 (a transmembrane cation channel protein), to treat benign prostatic hyperplasia (BPH). D-3263 demonstrated the ability to reduce BPH alone and in combination with fin...

Dendreon Initiates Phase 1 Clinical Trial of Small Molecule Targeting TRPM8 in Cancer

... Phase 1 clinical trial of D3263 in patients with advanced cancer. D3263 is Dendreon's lead small molecule drug candidate designed to target TRPM8 (a transmembrane cation channel protein) in cancer cells and induce cell death. The trial is an open-label, dose-escalation study evaluating the safety and pharmacoki...

Cystic Fibrosis Axentis Pharma Initiates Clinical Trial for Lung Infections

...is the most common life-threatening hereditary disease amongst Caucasian populations. The disease is caused by a mutation in the CFTR (Cystic Fibrosis transmembrane Conductance Regulator) gene found on chromosome 7. This mutation causes increased secretion deposits on mucous membranes. Lung complications represent...

Further Clinical Testing of BZL101 in Advanced Breast Cancer Demonstrates Favorable Efficacy and Toxicity Profiles

...xtract from herba Scutellaria Barbata D. Don of the Lamiaceae family. BZL101 is a compound that induces cell death due to attenuation of mitochondrial transmembrane potential (MTP) leading to the release of reactive oxygen species, causing inhibition of glycolysis and ending with induction of DNA damage and cell d...

PTC Therapeutics Announces Data Supporting Cough Frequency as a New Outcome Measure in Evaluating Treatments for Cystic Fibrosis

... the most common life-threatening genetic disorders worldwide and affects nearly 70,000 adults and children. Patients with CF lack the cystic fibrosis transmembrane conductance regulator (CFTR) protein, a chloride ion channel that maintains proper hydration of epithelial cells in the lungs, pancreas, and liver. Lo...
Transmembrane in Medical Products

Tag-It Cystic Fibrosis ASPE Mix

Description:...ts can be used by high complexity CLIA approved laboratories for detection of up to 70 mutations and 6 variants (polymorphisms) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene....
Company:Tm Bioscience Corporation

Tag-It Cystic Fibrosis ASPE Mix B

Description:...ts can be used by high complexity CLIA approved laboratories for detection of up to 70 mutations and 6 variants (polymorphisms) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene....
Company:Tm Bioscience Corporation

Tag-It Cystic Fibrosis PCR Mix B

Description:...ts can be used by high complexity CLIA approved laboratories for detection of up to 70 mutations and 6 variants (polymorphisms) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene....
Company:Tm Bioscience Corporation

Tag-It Cystic Fibrosis PCR Mix

Description:...ts can be used by high complexity CLIA approved laboratories for detection of up to 70 mutations and 6 variants (polymorphisms) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene....
Company:Tm Bioscience Corporation
Transmembrane in Medical Dictionary

Gastrin

...ood levels of gastrin should be measured. ... The canine and human CCK-B/ gastrin receptors share 90% amino-acid identity and ... in the sixth transmembrane domain of the CCK-B/ gastrin receptor that corresponds ... ... 1,5-benzodiazepine-derivative gastrin /cholecystokinin 2 (CCK-2) receptor ... the...

FSH

... growth, pubertal maturation, and reproductive processes of the human... The follicle stimulating hormone receptor or FSH -receptor (FSHR) is a transmembrane receptor that interacts with the follicle stimulating hormone ( FSH ) and represents a G protein-coupled receptor (GPCR). Its activation is... A...

Calcium channel blockers

...lockers : Normal results ... Nifedipine is a calcium ion influx inhibitor (slowchannel blocker or calcium ion antagonist) which inhibits the transmembrane influx of calcium ions into vascular ... Calcium Channel Blockers : Posttransplantation hypertension has been identified as an independ...
Transmembrane in Biological News

Penn researchers demonstrate a new model for drug discovery with a fluorescent anesthetic

...rkers have shown to bind clinical anesthetics. Researchers noticed a resemblance in the crystal structure of the apoferritin protein to that of the transmembrane region of the superfamily of ligand-gated channels that includes the GABA receptor. Anesthetics are known to positively modulate GABA signaling. ...

Gene decides whether coral relative will fuse or fight

...ellaporta and their interdisciplinary colleagues have identified a key invertebrate allorecognition gene. The gene they identified appears to encode a transmembrane receptor expressed in all tissues capable of allorecognition. It also includes a hypervariable domain and exists in many different varieties that pred...

Protein folding researcher David Baker to receive Sackler Prize in Biophysics

...buted new ways of studying proteins in membranes -- the thin fatty covering that separates the inside of the cell from the external environment. These transmembrane proteins include molecular channels that permit the flow of calcium into and out of the cell, and that are responsible for the passage of neural impul...

Forsyth scientists trigger cancer-like response from embryonic stem cells

...onic stem cell sub-population. These data reveal that key properties of embryonic stem cells can be controlled through bioelectrical signals, identify transmembrane voltage potential as a novel regulator of neural crest function in embryonic development, and demonstrate that potassium flows can be an important asp...

8 National Medals of Science awardees to be honored at gala, then the White House

...ter's and a Ph.D. in Electrical Engineering and Computer Sciences from MIT. Robert Lefkowitz - Duke University For his discovery of the seven transmembrane receptors, deemed the largest, most versatile, and most therapeutically accessible receptor signaling system, and for describing the general mechanism...

Biophysical Society names 2009 award recipients

... Robert Stroud of the University of California, San Francisco, will receive the Anatrace Membrane Protein Award for his outstanding contributions to transmembrane biology, and pioneering new methods allowing membrane proteins to become tractable as structural methods. Stephen H. White of the University of Cal...
Transmembrane in Biological Technology

Debiopharm and MSM Protein Technologies Sign Agreement for Research and Development of Debio 0929, a Novel Oncology Biologic

...ion on MSM, please visit: http://www.msmprotein.com About G-protein Coupled Receptors (GPCRs) GPCRs comprise a large protein family of transmembrane receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. A G-protein is a...

Dendreon Reports First Quarter 2009 Financial Results

...) in the fourth quarter of this year. Presented preclinical data at the AUA meeting announcing that D3263, a small molecule targeting TRPM8 (a transmembrane cation channel protein), reduced the size of the prostate in an animal model of benign prostatic hyperplasia (BPH) alone or in combination with finast...

Dendreon Reports Fourth Quarter and 2008 Year End Financial Results

...D) application with the U.S. Food and Drug Administration (FDA) to evaluate D-3263, the Company's lead small molecule candidate which targets TRPM8 (a transmembrane cation channel protein), in a Phase 1 dose escalation study in cancer. The application was cleared by the FDA in January 2009. "Thi...

New research identifies faster detection of viruses

...target for present-day drug discovery programmes. The interactions between transmembrane protein receptors and their ligands are responsible for viral detection and...eractions is challenging due to the special architecture and consistency of transmembrane proteins in liquids. For the first time, Trinity College Dublin's Profes...

Chronic Lung Disease - Axentis Pharma Attracts Investment Interest

...is the most common life-threatening hereditary disease amongst Caucasian populations. The disease is caused by a mutation in the CFTR (cystic fibrosis transmembrane conductance regulator) gene found on chromosome 7. This mutation causes increased secretion deposits on mucous membranes. Lung complications represent...

Dendreon Reports Third Quarter 2008 Financial Results

...ed to be completed in mid-2009. * Presented preclinical data on the Company's lead small molecule candidate, D-3263, which targets Trp-p8 (a transmembrane cation channel protein also known as Trp-M8), supporting Trp-p8 as a therapeutic cancer target. Dendreon plans to file an Investigational ...
Transmembrane in Biological Products

Rabbit Anti-Human MMP-14 / MT1-MMP Antibody, Unconjugated from Lab Vision

Description:...orm whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, MT3-MMP also known as MMP14, MMP15, MMP16 respectively contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8 amino acid insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and pro...
Company:Lab Vision

MitoLightApoptosis Detection Kit from CHEMICON

Description:... Disruption of the mitochondrial transmembrane potential is one of the earliest intracellular events that occur following induction of apoptosis. The MitoLight Apoptosis Detection Kit utilizes a li...
Company:CHEMICON

MitoLight Mitochondrial Apoptosis Detection Kit from CHEMICON

Description:... Disruption of the mitochondrial transmembrane potential is one of the earliest intracellular events that occur following induction of apoptosis. The MitoLight Apoptosis Detection Kit utilizes a l...
Company:CHEMICON
Transmembrane in Biological Definition

Active transport

... Primary active transport directly uses energy to transport molecules across a membrane. Most of the enzymes that perform this type of transport are transmembrane ATPases . A primary ATPase universal to all cellular life is the sodium-potassium pump , which helps maintain the cell potential . Secondary ...

Apoptosis

... membrane, and belongs to the TNF receptor superfamily [10] . The Fas ligand (FasL, the protein that binds to Fas and activates the Fas pathway) is a transmembrane protein, and is part of the TNF family. The interaction between Fas and FasL results in the formation of the death-inducing signaling complex (DISC), ...

ATP synthase

...is a reversible enzyme. Large enough quantities of ATP cause it to create a transmembrane proton gradient , this is used by fermenting bacteria which do not have...ondrion chloroplast electron transfer chain proton pump transmembrane ATPase External links "ATP synthase - a splendid molecular machi...

ATPase

... solutes across the membrane. (These are called transmembrane ATPases ). transmembrane ATPases import many of the metabolites necessary f...ential . Besides exchangers, other categories of transmembrane ATPase include cotransporters and pumps (however, ...

Ion gradient

...tration side to the low concentration side through transmembrane proteins which can use them as energy. Several dif...stems, the most common one is the proton gradient. transmembrane ATPases or transmembrane proteins with ATPase domains are often used for ma...

Endoplasmic reticulum

...r membrane . The ER is the site of the translation and folding of and transport of proteins that are to become part of the cell membrane (e.g., transmembrane receptors and other integral membrane proteins ) as well as proteins that are to be secreted or " exocytosed " from the cell (e.g., digestive enzym...
Transmembrane in Biological Dictionary

Transmembrane receptor

... Membrane or transmembrane receptors are specialized integral membrane prot...in-coupled receptors (GPCRs), also known as seven- transmembrane domain receptors, 7TM receptors, heptahelical rec...n or protein fraction having a ... Membrane or transmembrane receptors are specialized integral membrane pr...

Transmembrane proteins

... A transmembrane protein is a protein that spans the entire biological membrane. transmembrane proteins aggregate and precipitate in water. Th...traction, although some of them... Membrane or transmembrane receptors are specialized integral membrane prot...

Transduction

...pharmaceutical Association Medical Terms ... 3.1.3 Signal transduction of transmembrane receptors that are ion channels ... Transduction summary with 12 pages...logy,biology terms,biology abbreviations ... 3.1.2 Signal transduction of transmembrane receptors by structural changes ... Signal transduction will involve a...

Thylakoids

...ylakoids (As ... of the thylakoids , as plastocyanin is diffusing in the ... tion of LHC II was measured in isolated thylakoids . ... one to the transmembrane potential of thylakoids de ... thylakoids isolated from leaves is very low as com ... IM in thylakoids from C. reinhardtii and C. sorokini ... ...

Signal transduction

...armaceutical Association Medical Terms ... 3.1.2 Signal transduction of transmembrane receptors by structural changes ... This page is an annotated index of...gy,biology terms,biology abbreviations ... 3.1.2 Signal transduction of transmembrane receptors by structural changes ... The online version of Signal Tran...

Signal Sequence

... The signal sequence is immediately cleaved from the polypeptide once it has been ... This signal sequence processing differs for some ER transmembrane proteins. ... ... that will be completely synthesized in the cytosol do not have a signal sequence . ... secretory protein is a signal se...
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