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Translocations in Medical News

Comprehensive Look at Rare Leukemia Finds Relatively Few Genetic Changes Launch Disease

... The study also reports cryptic chromosomal translocations in 14 percent of patients in this study who, based...ng, appeared to lack such re-arrangements. Cryptic translocations are too small to be detected by conventional testi...8 and NSD1 . These data suggest that chromosomal translocations are more frequent in AML than was previously thoug...

USC researchers identify DNA mutation that occurs at beginning point of T-cell lymphoma

.... Researchers at USC have been working for many years to understand the underlying mechanisms that cause blood cancers. "The goal is to understand translocations in various different forms of lymphoma," Lieber says. "The two papers cover more than half of all human lymphomas. That represents a major step forwar...

NYU School of Medicine pathology researchers solve another mystery in B lymphocyte development

...eepens our understanding of the mechanisms that are in place for preventing translocations during V(D)J recombination that might ultimately lead to leukemias and lymp... and lymphomas are very common cancers, especially in children. Chromosomal translocations involving the antigen receptor loci are a common underlying mechanism. "...

Pilots May Face Greater Cancer Risk

...mes pairs of chromosomes had changed places -- called translocations. Since translocations aren't eliminated from the blood like other forms of chromosomal abnormalit...lots had been flying. Those who'd flown the most had twice the frequency of translocations as those who'd flown the least. The findings suggest that experienced pi...

Researcher Receives Free Flow Cytometer System as First Winner of Accuri(R) Flow Cytometer Creativity Awards Program

... assays to detect direct genomic translocations, an approach that could be applied to a myriad of genomic rearrangements, including detecting specific translocations in certain cancers. She noted, "Flow cytometry offers researchers the chance to innovate in the design of a variety of assays, and I am excited by th...

Researcher Receives Free C6 Flow Cytometer(R) System as First Winner of Accuri Flow Cytometer(R) Creativity Awards Program

... assays to detect direct genomic translocations, an approach that could be applied to a myriad of genomic rearrangements, including detecting specific translocations in certain cancers. She noted, "Flow cytometry offers researchers the chance to innovate in the design of a variety of assays, and I am excited by th...

Microenvironment a main driver of aggressive multi-lineage leukemia disease type

...ons involving the MLL gene fuse with certain partner genes. These so-called translocations result in the MLL gene being rearranged to send instructions to create either AML or ALL. This process can start before birth, and while MLL translocations are associated with 7 percent of AML cases and 10 percent of ALL cases, the...

The good and bad side of anti-cancer compounds

...l use as cancer therapies. Scott Hiebert, Ph.D., professor of Biochemistry and Medicine, and colleagues initially set out to study how chromosomal translocations which happen when chromosomes break and rejoin, creating new genes at the breakpoints cause acute leukemias. He previously had found that a chro...

Leicester scientist announces 'unexpected and exciting advance' in study of cancer type

...ently identified a series of ten novel chromosomal translocations in children and young adults with acute lymphoblastic leukaemia. These translocations arise following breaks within DNA that are repaired incorrectly. Chromosomal translocations play a pivotal role in the development of ALL. Th...

MicroRNAs Can Be Tumor Suppressors

...ing, and perhaps curing, a disease that is responsible for the vast majority of hysterectomies in the Western world." Studying chromosomal HMGA2 translocations that are associated with human tumors, the researchers found that, in normal cells, a microRNA called let-7 binds to the 3' end of the HMGA2 mRNA tran...
Translocations in Medical Products

SYT-SSX t(18;X) Translocations by RT-PCR

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Translocations in Medical Definition

Pathology

...elman syndrome / Prader-Willi syndrome X / Y linked Turner syndrome , Triple X syndrome , Klinefelter's syndrome , XYY syndrome translocations Philadelphia chromosome , Burkitt's lymphoma ...
Translocations in Medical Dictionary

Karyotyping

...):16156-61. Epub 2002 Dec 2. Digital karyotyping . ... Digital karyotyping provides a broadly applicable means for systematic detection ... ... translocations in multiple myeloma with multicolor spectral karyotyping . ... Multicolor spectral karyotyping (SKY) was performed on bone marrow samples from ...
Translocations in Biological News

Comprehensive look at rare leukemia finds relatively few genetic changes launch disease

...es. The study also reports cryptic chromosomal translocations in 14 percent of patients in this study who, based...ng, appeared to lack such re-arrangements. Cryptic translocations are too small to be detected by conventional testi...UP98 and NSD1. These data suggest that chromosomal translocations are more frequent in AML than was previously thoug...

GUMC discovery highlights new direction for drug discovery

...l upon which to design treatment for other disorders caused by the interaction between two proteins, and may be especially useful in cancers caused by translocations of genes, such as sarcomas and leukemias, the researchers say. Agents in use now that work against fusion proteins inhibit a single protein to stop in...

Breast cancer genome shows evolution, instability of cancer

...ancer." "From our standpoint, we are pretty convinced that these genomic translocations may turn out to be prognostic markers and also potential therapeutic target...er at BCM. "This is the first study to comprehensively map these genomic translocations to base pair resolution," Lee said. "I think it's pretty clear that the tec...

Damon Runyon Cancer Research Foundation awards prestigious fellowships to 17 top young investigators

...r Blobel, MD, PhD, at The Rockefeller University, New York, New York, is investigating core structures of the nuclear pore complex (NPC). Chromosomal translocations of NPC proteins are linked to various types of cancer, including myeloid and lymphoid leukemias. Gianna Elena Hammer, PhD , with her sponsor Aver...

MicroRNAs as tumor suppressors

...n and perhaps the cure of a disease that is responsible for the vast majority of hysterectomies in the Western world." Studying chromosomal HMGA2 translocations that are associated with human tumors, the researchers found that in normal cells, a microRNA called let-7 binds to the 3?end of the HMGA2 mRNA transc...

MicroRNAs can be tumor suppressors

...sing, and perhaps curing, a disease that is responsible for the vast majority of hysterectomies in the Western world." Studying chromosomal HMGA2 translocations that are associated with human tumors, the researchers found that, in normal cells, a microRNA called let-7 binds to the 3?end of the HMGA2 mRNA trans...

Role of microRNA identified in thyroid cancer

...er (PTC), the most common form of thyroid cancer, representing about 80 percent of all cases. Although changes in key cell-signaling systems and gene translocations are sometimes present in thyroid tumors, no specific gene mutations have yet been identified that are directly linked to the predisposition of this ty...

Multi-species genome comparison sheds new light on evolutionary processes, cancer mutations

...y lead to the production of new or altered proteins with potential to benefit an organism. In addition to their evolutionary implications, chromosomal translocations are known to contribute to the development or progression of many types of cancer. In their paper, researchers report that the chromosomal abnormal...
Translocations in Biological Technology

Whole Genomes From Microbes to Man

...c variation in populations of organisms, identifying insertions, deletions, translocations and other rearrangements not readily detected by other genome analysis meth...is primarily designed to identify genomic rearrangements, including indels, translocations and repetitive elements, in any genome. As attention shifts from SNPs to in...

Electrophoretic Karyotypes of Wine Strains of Saccharomyces cerevisiae

... of cells per strain; 2) variability in chromosome length observed for otherwise apparently homologous chromosomes; 3) the possibility of translocations or deletions which interfere with band identification if probes containing the rearranged sequences are used; and 4) the possibi...
Translocations in Biological Definition

Chromosome

...ve a small number of unclonable gaps. [1] Chromosomal aberrations Some chromosome abnormalities do not cause disease in carriers, such as translocations , or chromosomal inversions , although it may lead to a higher chance of having a child with an chromosome disorder. Abnormal numbers of chromosomes ...

Down syndrome

...ls throughout the body of the affected person. Other Down syndrome disorders are based on the duplication of the same subset of genes (e.g., various translocations of chromosome 21). Depending on the actual etiology , the learning disability may range from mild to severe. Trisomy 21 results in over- expressi...
Translocations in Biological Dictionary

Translocation

...some ... Translocation ... Other chromosomal translocations may occur more frequently in the ... that carry chromosomal translocations are typically healthy; ... Translocation Dow...esult in a bigger, flawed chromosome. ... Genetic translocations can cause serious disorders, including ... Zoo...

Deletion

...s ... Parental deletion studies were normal ... 22q13.3 deletion syndrome is a microdeletion syndrome suspected in children with ... Unbalanced translocations are characterized by deletion of 22q13.3 and partial ... Risks to family members depend on the mechanism of origin of the deletion . ... Tab...

Chromosome jumping

...acks are 95 percent of a certain chromosome . ... Once an Alu inserts at a chromosome locus, it can copy itself for transposition, ... Jumping translocations (JTs) involve one donor chromosome segment and ... We report a case of JT with the long arm of chromosome 17 (17q) as the ... HHMI's colorf...
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