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Translocation in Medical News

Cepheid Announces European Release of Improved Test for BCR-ABL Chromosomal Translocation Associated With Chronic Myelogenous Leukemia (CML)

Oncology Test Further Highlights Broad Market Applicability of GeneXpert System SUNNYVALE, Calif., June 17 /PRNewswire-FirstCall/ -- Cepheid (Nasdaq: CPHD ) today announced the release of its improved Xpert(R) BCR-ABL Monitor test to be marketed as a CE IVD product under the Euro...

Janet Rowley, MD, A Researcher Funded by The Leukemia & Lymphoma Society, Receives Presidential Medal of Freedom

...r patients with cancer. In 1973, Dr. Rowley showed that the Philadelphia Chromosome associated with chronic myelogenous leukemia (CML) was an abnormal translocation of two chromosomes. Her discovery was a key step in the eventual discovery of Gleevec, a targeted therapy for CML patients. Rowley, 84, is the...

Comprehensive Look at Rare Leukemia Finds Relatively Few Genetic Changes Launch Disease

...n cancer, had that much DNA damage. Even more surprising, 34 percent of patients in this study lacked any apparent CNA, and 28 percent of those with a translocation lacked additional DNA abnormalities. Certain chromosomal re-arrangements are known as translocations. The investigators also found no associat...

USC researchers identify DNA mutation that occurs at beginning point of T-cell lymphoma

...ollows a similar study, published in the December issue of the journal Cell, in which Lieber and colleagues determined how the most common chromosomal translocation in B cell lymphoma occurs. Researchers at USC have been working for many years to understand the underlying mechanisms that cause blood cancers. "...

Long-term L-carnitine supplementation prevents development of liver cancer

...nthesis, in the liver and kidney, and from exogenous dietary sources such as red meat and dairy products. L-carnitine is an essential cofactor for the translocation of long chain fatty acids from the cytoplasmic compartment into mitochondria, where beta-oxidation enzymes are located for ATP production. Despite the...

Medivation Receives FDA Permission to Initiate Phase 3 Trial of MDV3100 in Castration-Resistant Prostate Cancer

...resistant prostate cancer. MDV3100 is a novel small-molecule androgen receptor antagonist that inhibits androgen receptor function by blocking nuclear translocation of the androgen receptor and DNA binding. About Medivation Medivation, Inc. is a biopharmaceutical company focused on the rapid development...
Translocation in Medical Technology

Medivation Announces Positive New Efficacy Data From Phase 1-2 Trial of MDV3100 in Advanced Prostate Cancer Patients

...or with greater binding affinity than bicalutamide; impairs nuclear translocation and blocks DNA binding of the androgen receptor, one of the key steps requi...tor antagonist that inhibits androgen receptor function by blocking nuclear translocation of the androgen receptor and DNA binding. About Medivation Mediv...

Medivation Completes Enrollment of Phase 1-2 Trial of MDV3100 in Castration-Resistant Prostate Cancer Patients

...resistant prostate cancer. MDV3100 is a novel small-molecule androgen receptor antagonist that inhibits androgen receptor function by blocking nuclear translocation of the androgen receptor and DNA binding. About Medivation Medivation, Inc. is a biopharmaceutical company focused on the rapid develo...

Mymetics' HIV Vaccine Achieves Research Breakthrough, Eliciting Protective Antibody Response in Mucosal Tissues of Non-Human Primate Model

...cularly IgA antibodies, with strong potential for preventing in vitro virus translocation across the mucosal barrier and/or to inhibit cell infection, thus preventin... different anatomical compartments and block the early event of HIV translocation at the genito-reproductive and intestine tracts and subsequent infe...

Avalon Pharmaceuticals to Present at the American Association for Cancer Research 2007 Annual Meeting

...ter that will discuss AVN944 will be presented by the lab of Dr. Beverly Mitchell of Stanford University. The poster is titled, "GTP depletion induces translocation of TIF-IA and PAF53, inhibition of pre-rRNA synthesis and dislocation of nucleolar proteins." The presentation cites AVN944 as a compound that has eff...

Mymetics' HIV Vaccine Demonstrates First-Ever Production of Neutralizing IgA Antibodies in Non-Human Primate Model

...cularly IgA antibodies, with strong potential for preventing in vitro virus translocation across the mucosal barrier and/or to inhibit cell infection, thus preventin... different anatomical compartments and block the early event of HIV translocation at the genito-reproductive and intestine tracts and subsequent infec...

DOR BioPharma Announces Issuance of European Patent for Its Oral Multivalent Botulinum Toxin Vaccine BT-VACC

...exposure. The claims in the granted European patent provide protection for the use of certain non-toxic mutants of botulinum toxin that are capable of translocation from the gut to the general circulation for preparation of an oral vaccine. "The grant of the European patent describing the underlying technolog...
Translocation in Medical Products

TEL-AML1, t(12;21) Translocation by RT-PCR

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

t(11;14) IgH-CCND1 Translocation by FISH

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

PML/RARa t(15;17) Translocation by RT-PCR

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

PAX-FKHR Translocation by RT-PCR

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

MLL-AF4, t(4;11) Translocation by RT-PCR

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

E2A-PBX1, t(1;19) Translocation by RT-PCR

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

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Translocation in Medical Dictionary

Translocation

Aspects of the topic translocation are discussed in the following places at Britannica. Assorted References chromosomal disorder ( in chromosomal disorder (congenital); ...can be duplicated three (triploidy) or more (polyploidy) times; or one arm or part of one arm of a single chromosome may be...

Trisomy 13

...s in ... Research into the causes and risk factors for Trisomy 13 . ... A small proportion of trisomy 13 cases result from mosaicism and translocation ... ...
Translocation in Biological News

Comprehensive look at rare leukemia finds relatively few genetic changes launch disease

...n cancer, had that much DNA damage. Even more surprising, 34 percent of patients in this study lacked any apparent CNA, and 28 percent of those with a translocation lacked additional DNA abnormalities. Certain chromosomal re-arrangements are known as translocations. The investigators also found no association ...

Regulation of cell proliferation by the OGF-OGFr axis is dependent on nuclear localization signals

...ered that the efficacy of the Opioid Growth Factor (OGF, [Met5]-enkephalin), a clinically important antitumor agent, is dependent on nucleocytoplasmic translocation and reliant on the integrity of nuclear localization signals in the OGF receptor (OGFr). This discovery, reported in the May 09 issue of Experimenta...

Scripps Research scientists shed light on how DNA is unwound so that its code can be read

...what looks like a vise grip. They then found that RSC creates a little bulge in the DNA that can be propagated around the nucleosome and make possible translocation of the DNA with respect to the histones, exposing the DNA so that it can be read. "Imagine a rubber band wrapped twice around a water glass. The ea...

Immunotherapy in high-risk pediatric sarcomas shows promising response

...ccine." Current studies are underway to test a new version of the vaccine, which utilizes more mature dendritic cells and tumor lysate in lieu of the translocation peptides. Ultimately, effective immunotherapy requires that one is capable of reproducing a strong and sustained immune response to tumor antigens," s...

Global warming experts recommend drastic measures to save species

...atural movement will prevent many species from shifting where they live in response to changes in local climate. They suggest that human-assisted translocation of individuals, often termed "assisted migration" or "assisted colonization," may be necessary to ensure colonization of new geographic regions as par...

Dioxin risk in soil and plant tissues after long-term biosolids application

...detectable levels of dioxins in biosolids led to concerns that farmland application may result in accumulation of dioxins in soil and their subsequent translocation through the human food chain because several congeners of dioxins have extremely high bioaccumulation potential. The USEPA evaluated the risk of dioxi...
Translocation in Biological Technology

Tigris Pharmaceuticals Presents Results of Breast Cancer Research at AACR Annual Meeting

...t, ovarian, lung and renal lines exhibiting particular sensitivity. The mechanism of action of AF is believed to be that treatment with AF results in translocation of the arylhydrocarbon receptor (AhR; a transcriptional regulator of CYP1A1) from the cytoplasm to the nucleus, and its subsequent interaction with th...

Medivation Announces New Positive Efficacy Data From Phase 1-2 Trial of MDV3100 in Castration-Resistant Prostate Cancer Patients

...esistant prostate cancer. MDV3100 is a novel small-molecule androgen receptor antagonist that inhibits androgen receptor function by blocking nuclear translocation of the androgen receptor and DNA binding. About Medivation Medivation, Inc. is a biopharmaceutical company focused on the rapid development...

Japanese Cancer Association and Debiopharm Honour Japanese Research

...plications". EML4-ALK (echinoderm microtubule associated protein like 4 - anaplastic lymphoma kinase) is a fusion protein resulting from a chromosomal translocation present in a relatively large percentage of NSCLCs (non-small cell lung cancers), a disease in which cancer cells form in the tissues of the lung. Thi...

Medivation Announces Presentation of 24-Week Clinical Data of MDV3100 in Castration-Resistant Prostate Cancer Patients

...esistant prostate cancer. MDV3100 is a novel small- molecule androgen receptor antagonist that inhibits androgen receptor function by blocking nuclear translocation of the androgen receptor and DNA binding. About Medivation Medivation, Inc. is a biopharmaceutical company focused on the rapid development of nov...

Biological electron transfer captured in real time

...es. The role of the respiratory chain is to couple electron transfer to the translocation of positively charged protons across the membrane, so that the mitochondria...to ubiquinol. This reaction, as catalysed by Complex I, is linked to proton translocation across the membrane and thus leads to "charging the battery". At a later st...

ESR1 Gene Expression in Oncology and Metabolic Diseases Using the ASCENTATM System Target Validation and Identification of Novel Disease Indications

...(Estrogen Specific Receptor 1) is a member of the nuclear hormone receptor (NHR) family. NHRs bind to steroid hormones in the cytoplasm, causing their translocation to the nucleus and increased affinity for transcriptional elements governing the expression of certain genes (1). NHRs activate genes leading to cell ...
Translocation in Biological Products

Rabbit Anti-JTB Polyclonal Antibody, Unconjugated from Proteintech Group, Inc.

Description:... Homo sapiens jumping translocation breakpoint...
Company:Proteintech Group, Inc.

MHC Volume 1 from Promega

Description:...ies of antigen-presenting cells analysis of MHC class II endocytosis and peptide turnover analysis of signalling via MHC class II molecules peptide translocation into the ER ...
Company:Promega

Rabbit Anti-SKAP55 Polyclonal Antibody, Unconjugated from ABR-Affinity BioReagents

Description:...ocalize with F-actin at the T cell-antigen-presenting cell synapse and promotes the clustering of LFA1 and TCR ligation. TCR engagement induces the translocation of SKAP55 to lipid rafts, where the interactions with Fyn take place. CD45 also plays a very important role in SKAP55/TCR-mediated signaling. SKAP55 ...
Company:ABR-Affinity BioReagents

Goat Anti-PAX3 Polyclonal Antibody, Unconjugated from GeneTex

Description:...ment. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splici...
Company:GeneTex

Canine Pancreatic Microsomal Membranes from Promega

Description:...ins. Processing events such as signal peptide cleavage, membrane insertion, translocation and core glycosylation can be examined by the translation of the appropriat... Applications: Examination of signal peptide cleavage, membrane insertion, translocation and core glycosylation. • Compatible with the TNT® Lysate Systems,...
Company:Promega
Translocation in Biological Definition

Cancer

...nes promote cancer when "switched on" by a mutation, whereas tumor suppressor genes prevent cancer unless "switched off" by a mutation. Chromosomal translocation , such as the Philadelphia chromosome , is a special type of mutation and may involve oncogenes or tumor suppressor genes. In general, mutations in b...

Infertility

...ertility for another third, combined male and female infertility for another 15%, and the remainder of cases are "unexplained" 2 . A Robertsonian translocation in either partner may cause recurrent abortions or complete infertility. Female infertility Factors relating to female infertility are: ...

Patau syndrome

...opies of the chromosome. Patau syndrome due to a translocation can be inherited. An unaffected person can carry a...hromosome. This rearrangement is called a balanced translocation because there is no extra material from chromosome...u syndrome, people who carry this type of balanced translocation are at an increased risk of having children with t...

Phloem

...n by negative pressures (tension) most of the time, movement through the phloem is driven by positive hydrostatic pressures . This process is termed translocation , and is accomplished by a process called phloem loading and unloading . Cells in a sugar source "load" a sieve-tube element by actively transport...

Protein biosynthesis

...The first tRNA is released, but the amino acid that is attached to the first tRNA is now moved to the second tRNA, and binds to its amino acid. This translocation continues on, and a long chain of amino acid (protein), is formed. When the entire unit reaches the end codon on the mRNA, it falls apart and a new...

Proton pump

...quivalents provided by electron transfer or photosynthesis power this translocation of protons. For example, the translocation of protons by cytochrome c oxidase is powered by reducing equivalents pro...
Translocation in Biological Dictionary

Translocation

In genetics, a chromosome translocation is a chromosome abnormality caused by rearrangement of parts between nonhomologous chromosomes. A fusion gene may be created when the translocation joins two otherwise separated genes,... Translocation in plants, transport of food or pestici...

Signal Sequence

... is know as a " signal sequence " or leader peptide. ... The signal sequence is then threaded through a pore called the translocon. ... Upon translocation into that organelle, the signal sequence is removed. ... (proteins that go to the latter have their signal sequence at the C terminus) ... ...

Phospholipid bilayer

...nteractions in bilayer membranes ... measure phospholipid distributions and rates of membrane ... Schematic representation of phospholipid translocation or flip-flop across a bilayer . ... ... phospholipid bilayer by an external agent also alters the lateral organization ... Consider a bila...

Phloem

...ries organic nutrients, ... In trees, the phloem is the innermost layer of the bark, hence the name, derived ... Phloem is responsible for the translocation of Carbohydrates and some other metabolites. It is important to remember however, that Phloem Sap is mostly Water. ... Information about phloem...

Olfactory bulb

...xons and centrifugal projections to the bulb ... We analyzed Mn in lung, liver, olfactory bulb , and other brain regions, and we ... Figure 5. translocation of instilled Mn to olfactory bulb in separate experiments. ... two main types of cells in the olfactory bulb , the mitral and granule cell...

Dicentric

...ddress and/or check the Send me a copy checkbox. ... We report a case of acute promyelocytic leukemia with dicentric chromosome resulting from translocation of chromosomes 11, 17, and 18. Dicentric Y chromosome in mixed gonadal dysgenesis. A Hayek and E Yunis ... The identity of the dicentric ...
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(Date:7/9/2014)... in almost all types of cancer sends the protein ... fuel a tumour,s uncontrolled growth, new research suggests. , ... a molecular trigger responsible for ratcheting up activity of ... makes the building blocks cancer cells need to keep ... called SREBP, controls the flow of messages to the ...
(Date:7/9/2014)... found that fecal transplantation is effective and safe for ... is the result of a study led by Colleen ... Gastrointestinal Medicine at The Women,s Medicine Collaborative. The study ... of print in the American Journal of Gastroenterology ... diff , has increased to epidemic proportions over the ...
(Date:7/9/2014)... There has been a sharp increase in the number ... MyChart, the online, interactive service that allows patients to ... providers, schedule appointments, and renew prescriptions. , Over a ... MyChart each year increased five-fold, while the number ... according to a study by Dr. David Gerber ...
(Date:7/9/2014)... Allergy and Infectious Diseases (NIAID), part of the ... clinical trial of CRS3123, an investigational oral antibiotic ... C. difficile ) infection. CRS3123 (previously known as ... difficile growth while sparing normal intestinal bacteria. , ... 30 healthy men and women ages 18 to ...
(Date:7/9/2014)... , , , , , , ... , , , , , ... a binaural recording using KEMAR, the weapon was an SA80 assault rifle and the microphone is 50m downrange from the firer and approximately 30cm from the ... , , , , ... , , , , , ...
Breaking Medicine News(10 mins):Health News:Signal may send cancer's cellular factories into overdrive 2Health News:Women's Medicine Collaborative examines safety of fecal transplant to treat C. difficile 2Health News:MyChart use skyrocketing among cancer patients, UT Southwestern study finds 2Health News:MyChart use skyrocketing among cancer patients, UT Southwestern study finds 3Health News:NIH launches Phase I clinical trial of novel drug to treat Clostridium difficile infection 2Health News:Fit for the frontline? New study identifies the hearing requirements of British soldiers 2Health News:Fit for the frontline? New study identifies the hearing requirements of British soldiers 3Health News:Fit for the frontline? New study identifies the hearing requirements of British soldiers 4Health News:Fit for the frontline? New study identifies the hearing requirements of British soldiers 5Health News:Fit for the frontline? New study identifies the hearing requirements of British soldiers 6Health News:Fit for the frontline? New study identifies the hearing requirements of British soldiers 7
(Date:7/9/2014)... Cholinergic inhibitors and N-methyl-D-aspartate receptor antagonists can ... fail to affect irreversible cognitive dysfunction and ... brain. Amyloid beta peptide (Aβ) vaccines reduced ... disease (AD) transgenic mouse model, and significantly ... Cao and his team, First Affiliated Hospital ...
(Date:7/9/2014)... copy of its DNA, a fundamental step in the life ... in the human body. While scientists have had an idea ... enzymes that unzip the double-stranded DNA and create "daughter" copiesthey ... works. , Now, researchers at Rockefeller University have built the ... "replication fork"the point where DNA is split down the middle ...
(Date:7/8/2014)... is an increased risk of severe perineal tearing during childbirth ... delivery, suggests a new study published today (9 July) in ... (BJOG). , This study, investigates among women who have had ... delivery in subsequent pregnancies and the recurrence of severe perineal ... childbirth and in some women the tear may be more ...
Breaking Biology News(10 mins):Rockefeller scientists first to reconstitute the DNA 'replication fork' 2Rockefeller scientists first to reconstitute the DNA 'replication fork' 3Rockefeller scientists first to reconstitute the DNA 'replication fork' 4Mode of delivery following a perineal tear and recurrence rate in subsequent pregnancies 2
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