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Transduction in Medical News

Brown researchers make major signal transduction discovery

PROVIDENCE, R.I. [Brown University] The chemical process known as acetylation plays a central role in cytokine receptor signal transduction a fundamental biochemical cascade inside cells that controls the activity of antiviral and tumor-suppressing genes. A team of cell biologists led by Euge...

Keryx Biopharmaceuticals Settles License Dispute With Alfa Wassermann

... adult and pediatric tumor types, both as a single agent and in combination with novel therapies. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell su...

Keryx Biopharmaceuticals Announces Agreement with FDA on a Special Protocol Assessment for Phase 3 Trial of KRX-0401 (Perifosine) in the Treatment of Multiple Myeloma

... adult and pediatric tumor types, both as a single agent and in combination with novel therapies. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell su...

Boehringer Ingelheim to Commence Phase III Study Investigating the Role of BIBW 2992 as First-Line Treatment for Non-Small Cell Lung Cancer (NSCLC) Patients with EGFR Mutations

...arious solid tumors and hematological cancers. The current focus of research includes compounds in three areas: angiogenesis inhibition, signal transduction inhibition and cell-cycle kinase inhibition. BIBW 2992 entered Phase IIb/III clinical development in NSCLC earlier in 2008 and was granted Fast Track...

Adenoviral vector specifically targeted to EphA2 receptor in pancreatic cancer cells

...f native cellular binding sites reduced adenoviral transduction at least 100-fold. Insertion of the YSA peptide in the HI loop restored adenoviral transduction of EphA2R-expressing cells but not of cells lacking this receptor. YSA-mediated transduction was inhibited by addition of synthetic YSA peptide...

Keryx Biopharmaceuticals Inc. Regains Compliance With NASDAQ Listing Requirements

...cancer agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell su...
Transduction in Medical Technology

Cytokine PharmaSciences Initiates Phase I Study of Oral Anti-Inflammatory Agent, CPSI-2364

... time." CPSI-2364 is a chemically-modified form of the synthetic guanylhydrozone, semapimod. Semapimod has been shown to inhibit the signal transduction pathways that lead to the production of nitric oxide and important pro-inflammatory cytokines, including TNF-alpha, IL-1, IL-6, and IL-8. Semapimod h...

Keryx Biopharmaceuticals, Inc. Commences Phase 1 Study of KRX-0401 (Perifosine) in Recurrent Pediatric Solid Tumors at Memorial Sloan-Kettering Cancer Center

...ral, anticancer agent that modulates Akt and several other important signal transduction pathways. Keryx is currently in the process of finalizing late-stage protoc...r survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associate...

Keryx Biopharmaceuticals Announces Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer

...cancer agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell su...

Keryx Biopharmaceuticals Reports Positive Data from a Randomized, Multi-Center, Placebo-Controlled, Phase 2 Combination Study of KRX-0401 (Perifosine) in the Treatment of Advanced Metastatic Colon Cancer

...ancer agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell su...

Semafore's SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, Is Well Tolerated and Demonstrates Activity in Phase I Solid Tumor Patients

...e PI3K/PTEN pathway. About PI3 Kinase Phosphatidylinositol 3 kinases (PI3K) are involved in one of the major pathways of intracellular signal transduction and are important in controlling cell growth/angiogenesis, differentiation, proliferation and survival/apoptosis. Dysregulation of the PI3 kinase sig...

Keryx Biopharmaceuticals Reports Single Agent Phase 2 Data of KRX-0401 (Perifosine) Further Demonstrating KRX-0401's Activity in the Treatment of Advanced Metastatic Renal Cell Cancer

...cancer agent that modulates Akt, a protein in the body associated with tumor survival and growth. KRX-0401 also modulates a number of other key signal transduction pathways, including the JNK and MAPK pathways, which are pathways associated with programmed cell death, cell growth, cell differentiation and cell su...
Transduction in Medical Dictionary

Prolactin

...in and thereby cause higher than ... II. PROLACTIN CHEMISTRY AND MOLECULAR BIOLOGY ... B. Activation of Prolactin -R and the Associated Signal transduction Pathways ... When a mother breastfeeds her baby, she not only nurtures her but provides her ... If the prolactin level comes back normal, then t...

Olfactory

..... Trotier D, MacLeod P. Intracellular recordings from salamander olfactory receptor cells. ... The mechanism of excitatory olfactory receptor transduction has been intensely studied. ... the other hand, studies on olfactory receptor neurons from a wide ... Thus the olfactory granule cells possess...

Macrophage

...ts ... Therefore, the homogeneity of macrophage -tropic patient isolates appeared to be ... Macrophage differentiation is partially restored by transduction with a PU.1 ... mRNA for macrophage -specific genes including M-CSF receptor (Fig 2 A), mannose ... Therefore, the acquisition of macrophage ...
Transduction in Biological News

New insight into the mechanisms of voltage sensing and transduction in biological processes

The voltage sensor of voltage-gated ion channels is a conserved protein domain that senses millivolt changes in transmembrane potential, to regulate ion permeation through the channel. A recently discovered protein, Ci-VSP, has a voltage sensor that is coupled not to an ion channel but to a phosph...

Investigating the development of mechanosensitivity

...nvert it into electrical signals that are conveyed to the brain. Signal transduction has been investigated very thoroughly, which has led to the development of drugs that block the transduction of pain signals to the brain. Very little, however, is known about how stim...

When intestinal bacteria go surfing

...stem - a sort of molecular syringe, through which the bacteria insert entire proteins in the host cell," explains Theresia Stradal, head of the Signal transduction and Motility research group at HZI. Two factors, Tir and EspFU, are brought into the host cell from the bacterium for pedestal formation. Following th...

Magnetic nanoparticles navigate therapeutic genes through the body

...le gene transfer under clinically relevant experimental conditions. For the transduction of human cells, gene carriers were coupled to magnetic nanoparticles and dr...gged into the cells by magnetic field gradients. The efficiency of magnetic transduction turned out to be much higher than the nonmagnetic procedure. An additional ...

Discovering the secret code behind photosynthesis

...tem of communication found in primitive bacteria, may also explain how plants and algae control the process of photosynthesis. Two-component signal transduction systems (TCSTs) have long been recognised as the main way in which bacteria coordinate their responses to changes in their environment. But recent res...

Irritable bowel syndrome can have genetic causes

...in the composition or number of receptors on the cell surface. "The signal transduction in the digestive tract may be disturbed and this may lead to overstimulatio... shows interesting correlations sero-tonin receptors are located on neural transduction pathways involved in pain perception and influence them which could explai...
Transduction in Biological Technology

Revealing the regulating mechanism behind signal transduction in the brain

Leuven, Belgium Our brain consists of billions of cells that continually transmit signals to each other. This dynamic process − which enables us to learn, remember, and so much more − works only when the brain cells make contact correctly, or, in other words, when there is a good 'syn...

In Vivo Signal Transduction Pathway Reporting Systems

New tools to study in vivo functions of new genes and drug candidates Li Xu * Tim Sanchez * ChaoFeng Zheng Stratagene Cloning Systems, Inc. Stratagene's PathDetect in vivo signal transduction pathway reporting systems are designed for specific, rapid and convenient assessment of ...

Signal Transduction Reporting Systems Using Cis-Acting Enhancer Elements

New luciferase vectors for studying signal transduction pathways Li Xu Tim Sanchez Chao-Feng Zheng Stratagene Cloning Systems, Inc. Enhancer elements are the convergent points for many intracellular signal transduction pathways. For simple, rapid and convenient assessment of th...

Optimizing Transfection Conditions for Studying Signal Transduction Pathways

Optimizing Transfection Conditions for Studying Signal Transduction Pathways Obtaining the best results with PathDetect in vivo reporting systems Tim Sanchez Li Xu Mary Buchanan Chao-Feng Zheng Stratagene Stratagenes PathDetect ...

Assess the In Vivo Activation of Signal Transduction Pathways with PathDetect Reporting Systems

A review of products for signal transduction research Assess the In Vivo Activation of Signal Transduction Pathways with PathDetect Reporting Systems Li Xu Tim Sanchez Mary Buchanan Chao-Feng Zheng Stratagene Signal transduction is essential to many cellular pr...

Versatile Reporter Vectors for Monitoring Viral Transduction

Determine retroviral transduction efficiency and gene expression in virtually any target cell line Brenda Rogers Katherine Felts Peter Vaillancourt Stratagene We describe three new ViraPort retroviral reporter vectors: pFB-hrGFP Y , pFB...

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Transduction in Biological Products

Rat Signal Transduction PathwayFinder, PCR Array for expression profiling from SuperArray Bioscience

Description: ...
Company:

Mouse Anti-Cohesin (Scc1 / Rad21) Monoclonal Antibody, Unconjugated, Clone CM110-2C10 from MBL International

Description:... Anti-Cohesin (Scc1/Rad21) Monoclonal Antibody Research Focus: signal transduction Storage: -20C Shipping Temperature: +4C...
Company:MBL International

Mouse Anti-Rat GM130 Monoclonal Antibody, Unconjugated, Clone NN 2C10/1 from ABR-Affinity BioReagents

Description:... GM130 Immunogen: Recombinant purified rat GM130 Family / Subclass 1: Signal transduction Storage: 4 C...
Company:ABR-Affinity BioReagents

293FT Cell Line from Invitrogen

Description:... Normal;heading 1;heading 2;Many mammalian cell types and experimental situations create challenges for standard transfection and other viral transduction systems. ViraPower Lentiviral Expression System overcomes these challenges by efficiently transduci...
Company:Invitrogen

pLenti6/V5 Directional TOPO Cloning Kit from Invitrogen

Description:... Normal;heading 1;heading 2;Many mammalian cell types and experimental situations create challenges for standard transfection and other viral transduction systems. ViraPower Lentiviral Expression System overcomes these challenges by efficiently transduci...
Company:Invitrogen

Antibody MicroArray from Lab Vision

Description:...teins as internal control. Antibodies belonging to many important biological processes such as angiogenesis, apoptosis, cell cycle progression, signal transduction and gene expression are present on these microarrays. A reference chart showing all the antibody names and their respective coordinates on the array i...
Company:Lab Vision
Transduction in Biological Definition

Signal transduction

In biology , signal transduction is any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through seco...

Bacterium

...ied in bacteria: transformation (the transfer of naked DNA from one bacterial cell to another in solution, this can include dead bacteria), transduction (the transfer of viral, bacterial, or both bacterial and viral DNA from one cell to another via bacteriophage) and; bacterial conjugation (the tr...

Bioinformatics

...ves the use of computer simulations of cellular subsystems (such as the networks of metabolites and enzymes which comprise metabolism , signal transduction pathways and gene regulatory networks ) to both analyze and visualize the complex connections of these cellular processes. Artificial life or vir...

Biochemistry

...ensively described. Other areas of biochemistry include the genetic code ( DNA , RNA ), protein synthesis , cell membrane transport, and signal transduction . Contents showTocToggle("show","hide") 1 Development of biochemistry 2 Subdisciplines 3 See also 4 External links ...

Cell biology

...lycolysis Golgi apparatus Lipid bilayer Membrane Mitochondrion Nucleus Organelle Passive transport Ribosome Signal transduction Vesicle Important publications in cell biology External links The Virtual Library of Biochemistry and Cell Biology Institu...

Bioinformatics

...ves the use of computer simulations of cellular subsystems (such as the networks of metabolites and enzymes which comprise metabolism , signal transduction pathways and gene regulatory networks ) to both analyze and visualize the complex connections of these cellular processes. Artificial life or vir...
Transduction in Biological Dictionary

Transduction

Transduction is the process by which DNA is transferred from one bacterium to another by a virus. It also refers to the process whereby foreign DNA is introduced into another cell via a viral vector. This is a common tool... Transduction (biophysics) is the conveyance of energy from a d...

Signal transduction

In biology, ' signal transduction ' refers to any process by which a cell converts one kind of signal or stimulus into another. Most processes of signal transduction involve ordered sequences of biochemical reactions inside the... signal transduction ( ′signəl tranz′dəkshən...

Transmembrane receptor

...eptor tyrosine kinase binding to its ... GO:0007169 : transmembrane receptor protein tyrosine kinase signaling pathway ... 3.1.2 Signal transduction of transmembrane receptors by structural changes ... 4.1 Signal amplification at the transmembrane hormone receptor ... Online Shoppin...

Spermatogonia

...permatocyte 1st order, 4 spermatocyte 2nd Spermatogonia represent a new route to transgenesis in mice ... But the factors influencing retroviral transduction into spermatogonia are not well understood. ... The mitosis of differentiating spermatogonia , the meiosis of spermatocytes, and ... Undiff...

Oocytes

..... In vitro maturation of oocytes . In vitro fertilization. Embryo culture and development ... Oocytes and embryos need to summon many signal transduction mechanisms, ... Abstract and Introduction: The authors discuss their experience with 2 new applications of in vitro maturation for oocyte dono...

Olfactory nerve

...y mucosa of the upper parts of the nasal cavity. The... An olfactory receptor neuron, also called an olfactory sensory neuron, is the primary transduction cell in the olfactory system. receptor neuron' target='_blank'>Full article >>> Aspects of the topic olfactory - nerve are discussed in the...
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