Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats
Dana-Farber Cancer Institute researchers have identified a molecular mechanism in the liver that explains, for the first time, how consuming foods rich in saturated fats and trans-fatty acids causes elevated blood levels of cholesterol and triglycerides and increases one's risk of heart disease and certain cancers. In the Jan. 28 issue of Cell, scientists led by Bruce Spiegelman, PhD, rep...Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
The genome sequence of the parasitic amoeba Entamoeba histolytica, a leading cause of severe diarrheal disease in developing countries, includes an unexpectedly complex repertoire of sensory genes as well as a variety of bacterial-like genes that contribute to the organism's unique biology. The report, which appears in the February 24 issue of Nature, presents the first genome-wide study...Male circumcision reduces risk of HIV transmission from women to men
The first study to examine the probability ofHIV infection per act of heterosexual sex among a population withmultiple sexual partners has found that uncircumcised men have morethan twice the risk of acquiring HIV than do circumcised men.In the study, published in the Feb. 15 issue of The Journal ofInfectious Diseases, now available online, Jared Baeten and colleaguesfrom the United States...Transplantation Of Monkey Embryonic Stem Cells Reverses Parkinson Disease In Primates
The replenishment of missing neurons in thebrain as a treatment for Parkinson disease reached the stage of humantrials over 15 years ago, however the field is still in its infancy.Researchers from Kyoto University have now shown thatdopamine-producing neurons (DA neurons) generated from monkey embryonicstem cells and transplanted into areas of the brain where these neuronshave degenerated i...The transparent organism: EMBLEM and Carl Zeiss give labs a unique look at life
A novel high-tech microscope will be brought to the marketplace, giving laboratories everywhere fascinating new insights into living organisms. EMBLEM Technology Transfer GmbH (EMBLEM), the commercial entity of the European Molecular Biology Laboratory (EMBL), announced today that it has signed a licensing deal with technological leader Carl Zeiss to commercialize a new technology called SPIM (Se...Glutathione-S-Transferase (GST) Colorimetric Assay Kit from Sigma-Aldrich
Description:Biochem/physiol Actions: Glutathione-S-transferases (GSTs) are a group of enzymes important in the detoxification of many xenobiotics in mammals. The enzymes protect cells against toxicants by conjugating the thiol group of the glutathione to electrophilic xenobiotics, and thereby defend cells against the mutagenic, carcinogenic, and toxic effects of the compounds. GST activity is presen...S. cerevisiae Direct Transformation Kit from Wako Chemicals USA, Inc.
Description:This kit is designed for easy transformation of the budding yeast, Saccharoyces sp.. The protocol allows for successful transformation simply by mixing a plasmid DNA and the kit reagents with cultured yeast cells. No complicated steps, such as centrifugation or cell washing, are required. The kit is particularly well suited for high-throughput transformation of a large number of yeast strains gro...S. cerevisiae Direct Transformation Kit from Wako Chemicals USA, Inc.
Description:This kit is designed for easy transformation of the budding yeast, Saccharoyces sp.. The protocol allows for successful transformation simply by mixing a plasmid DNA and the kit reagents with cultured yeast cells. No complicated steps, such as centrifugation or cell washing, are required. The kit is particularly well suited for high-throughput transformation of a large number of yeast strains gro...GenomONE-Neo EX HVJ-E 4 vial(s) Transfection Reagents from Cosmo Bio Co., Ltd.
Description:HVJ (hemagglutinating virus of Japan, also named Sendai virus) Envelope VECTOR KIT is a tool for transfection of molecules by means of membrane fusion. Most efficient transfection are for siRNA (RNAi), Protein, Oligo, cDNA, Antibodies, Vector, and Biomolecule in vitro and in vivo. GenomONE-Neo EX has a high fusing capability in short period of time that benetif sensitive primary cells or tissues...Assess the In Vivo Activation of Signal Transduction Pathways with PathDetect Reporting Systems
Assess the In Vivo Activation of Signal Transduction Pathways withPathDetect Stratagene Signal transduction is essential to many cellular processes, such asgrowth, differentiation, an...Highest Transfection Efficiency of an Endotoxin-Sensitive Mammalian Cell Line
midiprep kit Stratagene EF plasmid midiprep kit, a kit based on anion exchange chromatography, magneticbeads, and cesium ch...Control RT-PCR Primers for Human Gene Transcripts with Varying Abundance
Stratagene We introduce six pairs of control RT-PCR primers that are designed todetect specific human gene transcripts with various expression levels. Theseprimer sets provide insight into whether cDNA synthesis has been effective forall ab...Highest Possible Transformation Efficiencies for High-Throughput Applications
Convenient, time-saving 96Pack Gold competent cells streamline transformation procedures Julie Bonnardel Ronda Allen Bruce Jerpseth Sean Banks...Optimizing Transfection Conditions for Studying Signal Transduction Pathways
Optimizing Transfection Conditions for Studying Signal TransductionPathways in vivo reporting systems Stratagene Stratagenes PathDetect <font face="S...Transdermal HRT not cardioprotective in postmenopausal women with CAD
Transdermal hormone replacement therapy (HRT) does not reduce the risk of cardiac events in postmenopausal women with existing coronary artery disease (CAD). In the PHASE trial (Papworth HRT Atherosclerosis Study), researchers randomized 255 postmenopausal women with angiographically proven coronary artery disease to receive either transdermal HRT--17-beta-estradiol with or without cy...Transdermal HRT not cardioprotective in postmenopausal women with Coronary Artery Disease
Transdermal hormone replacement therapy (HRT) does not reduce the risk of cardiac events in postmenopausal women with existing coronary artery disease (CAD). In the PHASE trial (Papworth HRT Atherosclerosis Study), researchers randomized 255 postmenopausal women with angiographically proven coronary artery disease to receive either transdermal HRT--17-beta-estradiol with or without cy...Infant receives first bloodless liver transplant
An Iowa infant aged 7 months was the first recipient of a bloodless liver transplant in Los Angeles, the United States of America. The seven month old, Aiden Michael Rush, whose parents are Jehovah’s Witnesses are prohibited by their religion to receive transfusions. The boy received 20% of his mother’s liver during the transplantation on February 7th at the children’s hospital i...Liver donors can thrive after transplant
Contrary to belief that donating liver can injure the donor, it is now established without doubt that a living person can donate a part of his liver to a person needing it. And the good news is that the donor would continue to live well and thrive after donating part of his/her liver. Donation of a piece of the liver's right lobe from one adult to another is a relatively new procedure. I...ATG useful in transplant patients as substitute for steroids
Anti-thymocyte globulin (ATG), a compound made from rabbit antibodies appears to be as effective as routine steroids in reducing rejection of transplanted organs without any of the side effects, according to Dr. James Eason of the Ochsner Multi-Organ Transplant Center in New Orleans. In the largest study on steroid-free treatment of liver transplants, Dr. Eason found patients treated with ATG had...2000 series revised ETDRS Translucent Charts
Description:These revised charts incorporate the slight change in the difficulty score for each of the 10 Sloan letters derived from the best corrected visual acuity examinations of 7420 eyes during the ETDRS study. The original charts difficulty scores were derived from the examination of 234 eyes. In addition to the revised arrangement of letters which resulted in the ultimate homogeneity of difficulty per...Reduced 2000 series revised ETDRS Translucent Charts
Description:These revised charts incorporate the slight change in the difficulty score for each of the 10 Sloan letters derived from the best corrected visual acuity examinations of 7420 eyes during the ETDRS study. The original charts difficulty scores were derived from the examination of 234 eyes. In addition to the revised arrangement of letters which resulted in the ultimate homogeneity of difficulty per...AMIA Announces 2008 Summit on Translational Bioinformatics
Program to address a broad range of topics coveringresearch-related issues and best practices in bioinformatics andcomputational biology BETHESDA, Md., June 21, 2007 /PRNewswire-USNewswire/ -- TheAmerican Medical Informatics Association (AMIA) Board of Directors,in support of its strategic plan, has approved the development ofan annual meeting that will explore topics related to translati...NuPathe Reports Positive Phase One Results for NP101 Transdermal Therapy for Acute Migraine
CONSHOHOCKEN, Pa.--(BUSINESS WIRE)--Jun 8, 2007 - NuPathe Inc., aprivately held specialty pharmaceutical company, today announcedpositive results from an initial Phase I study of NP101SmartRelief, a novel treatment for acute migraine being developedby NuPathe. NP101 combines NuPathe's SmartRelief(TM) proprietaryiontophoretic transdermal technology with sumatriptan, the mostwidely prescri...Transurethral resection of the prostate
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