toxicity

New therapy for HIV/AIDS eliminates needles and excessive toxicity

A team led by Johns Hopkins scientists hasfound the first clear evidence that the process behind the human immunesystem's remarkable ability to recognize and respond to a milliondifferent proteins might have originated from a family of genes whoseonly apparent function is to jump around in genetic material. essentially cut...

MetaChip provides quick, efficient toxicity screening of potential drugs

A large, multisite trial designed to examine the safety and preliminary effectiveness of two candidate topical microbicides to prevent HIV infection has opened to volunteer enrollment. The trial, sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, represents a partnership among various research institutions in Africa and the U...

Genomics researchers discover protein deficit that causes drug toxicity

Mayo Clinic researchers have discovered an inherited structural mechanism that can make drugs for some diseases toxic for some patients. The mechanism decreases a protein and in turn causes certain individuals to metabolize thiopurine drugs differently. Thiopurine therapies are used to treat patients with childhood leukemia, autoimmune diseases and organ transplants. The Mayo researchers say thei...

Driver of anthrax toxicity could lead to late-stage therapy

A study in the March 24 Cell reports the discovery of a gene that drives anthrax bacteria's toxic effects. The gene could offer a potential new target for countermeasures against the lethal toxin, according to the researchers. Such therapies might have the potential to protect against anthrax during the late stages of the disease, after antibiotics have lost their therapeutic value, they a...

Mosquito spray increases toxicity of pyrethroids in creek, study finds

A relatively benign compound contained in a widely used group of insecticides can mix with and increase the toxicity of existing pesticides in the environment, according to a new study led by biologists at the University of California, Berkeley. ...

toxicity at Biology Products

In Vitro Toxicity Testing Protocols, Vol 43 from Promega

Description:S. O'Hare & C.K. Atterwill • In vitro toxicity techniques for regular lab use. Ex vivo techniques are also covered with the aim of reducing and refining the use of animals in the future....
Company:Promega

Cytotoxicity Fluorometric (green / red) Assay Kit, LIVE/DEAD® from Molecular Probes (Invitrogen)

Description:LIVE/DEAD® Cell-Mediated Cytotoxicity Kit *for animal cells* *2000 assays*...
Company:Molecular Probes (Invitrogen)

toxicity at Biology Technology

Reliable Assessment of Micronuclei for Genotoxicity Testing in Mice or Rats

Reliable Assessment of Micronuclei for Genotoxicity Testing in Mice orRats Precise and cost-effective micronucleus analysis made easy with theicroFlow Micronucleus Analysis Kit Litron Laboratories, Rochester, NY Mark J. Dycaico<br...

Versatile Transfection Reagent Offers Low Toxicity and Consistent Performance

Stratagene transfection reagent offersimproved, consistent transfections for both adherent cells and cells growing insuspension. In this article, we summarize the results of several experimentsthat characterize the eff...

Low-Toxicity, Lipid-Mediated Transfection of Mammalian Cells

Stratagene Cloning Systems Clonetics Corporation, Walkersville, Maryland LipoTAXI transfection reagent is a novel liposome reagent that offerslow cellular toxicity and high transfection efficiencies for adhe...

High-Efficiency Transfections Achieved with New Low-Toxicity Reagent

Nonliposomal formulation yields high efficiencies in a variety oftransfection conditions Stratagene Introducing foreign DNA into eukaryotic cells requires high-potencytransfections, which demand superior quality transfection reagents that areefficient, have low toxicity, and wor...

LIVE/DEAD Viability/Cytotoxicity Assay for Animal Cells Using the SpectraMax Gemini XS Fluorescence Microplate Reader (MaxLine Application Note #43)

Anne T. Ferguson, Ph.D. Molecular Devices Corporation This application note describes the use of the SPECTRAmax Viability/Cytoxicity Assay Kit for animal cells. This assay uses two fluorescent dyes, calcein AM (cal...

toxicity at Medicine News

B Vitamin protects and lowers toxicity of Arthritis Drug

Rheumatoid arthritis is an autoimmune disease that most often affects women in their 30s and 40s, especially women.The illness causes the immune system to attack the joints, which can cause pain, inflammation and joint destruction. Methotrexate is the standard drug used to treat the condition, but one third of the patients discontinue treatment early due to toxicity.//...

Doctors warned of fluoride toxicity

In the recent Journal of American Dental Association (JADA), doctors are warned against possibility of fluoride toxicity while prescribing fluoride dosage //to patients with oral problems. High concentrations of fluoride dosage are often prescribed to patients to check caries, especially those suffering from mouth cancer. In the recent issue of JADA, authors Frederick C. Eichmiller, N...

Acute Toxicity Of Nano-Scale Zinc Powder: Severe Renal Damage And Anemia

Zinc finds wide use in brass, bronze, die casting metal, alloys, rubber, and paints, etc. In recent years, nanoscale metal powders, because of their unique properties, are being widely used //in the traditional industries, such as dyes, paints, medical diagnosis, sunscreens and cosmetics. Nano Zn powder is used as highly reactive catalyst in organic hydrogen reaction, automobile tail gas...

Herceptin Use May Enhance Cardiac Toxicity, Study

HOUSTON A novel study found that the use of Herceptin in advanced breast cancer patients led to a higher incidence of cardiac toxicity − nearly 28 percent of patients treated with Herceptin// , which no clinical trial has yet reported;The silver lining is that much of the damage to the heart can be remedied with treatment. The study, published online August 14 in the Journal of...

Inherited Genes Linked to Toxicity of Leukemia Therapy

Investigators at St. Jude Children's Research Hospital have discovered inherited variations in certain genes that make children with acute lymphoblastic leukemia (ALL) susceptible to the toxic side effects caused by chemotherapy medications. The researchers showed that these variations, called polymorphisms, occur in specific genes known to influence pharmacodynamics (how drugs work in t...

toxicity at Medicine Products

Irinotecan Toxicity

Description:ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' clients include more than half of the nation's university teaching hospitals and children's hospitals, maj...
Company:ARUP Laboratories

toxicity at Medicine Technology

Publication on Pixantrone Preclinical Studies Demonstrates Reduced Cardiotoxicity Compared to Equiactive Doses of Doxorubicin and Mitoxantrone

Interim results in a randomized phase II/III clinical trialanticipated later this year SEATTLE, June 26, 2007 /PRNewswire-FirstCall/ -- CellTherapeutics, Inc. (CTI) announced the publication of preclinicalstudies, which demonstrate that treatment with pixantrone (BBR2778) resulted in minimal or no significant cardiotoxicity, whiledoxorubicin and mitoxantrone induced significant cardiac da...

toxicity at Medicine Dictionary

Digitalis toxicity

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