Navigation Links
toxicities in Medical News

Fox Chase finds all-biologic regimen efficacious and well-tolerated in elderly lung cancer patients

...ad stable disease by RECIST criteria. The combination appears safe and well tolerated in this patient population with the most commonly encountered toxicities of clinical relevance being high blood pressure, fatigue, loss of appetite and diarrhea. "The observed activity of this regimen in this patient pop...

FDA Approves TYVASO (Treprostinil) Inhalation Solution for the Treatment of Pulmonary Arterial Hypertension

...eutics has agreed to a Post-Marketing Requirement (PMR) to conduct a long-term observational study to evaluate the risk of oropharyngeal and pulmonary toxicities among patients using TYVASO. "We welcome the opportunity to gather further information on TYVASO's safety," continued Dr. Jeffs. We have committed to...

Earlier HIV antiviral treatment can be cost effective in areas of limited resources

... simulate HIV treatment and its associated health and economic outcomes. The model calculated the additional costs of earlier treatment, its potential toxicities and its benefits, including TB prevention. It also calculated how much delaying ART would shorten patients lives and then estimated the cost per extr...

Earlier HIV Treatment Could Save Lives Worldwide

...late HIV treatment and calculate the possible health and economic outcomes. The model determined the additional costs of earlier treatment, potential toxicities and benefits. It also looked at the cost-effectiveness of earlier ART initiation. More information The U.S. Centers for Disease Control and Pre...

Amgen Announces KRAS Safety Update to U.S. Prescribing Information for Vectibix(R) (Panitumumab)

...ortant Product Safety Information Dermatologic Toxicity: Dermatologic toxicities occurred in 89 percent of patients and were severe (NCI-CTC grade 3 and hig...patients receiving Vectibix monotherapy. Withhold Vectibix for dermatologic toxicities that are grade 3 or higher or are considered intolerable. If toxicity does...

Peregrine Pharmaceuticals Completes Planned Patient Enrollment in Bavituximab Phase I Cancer Trial

...tolerability of bavituximab in patients with advanced cancer, to characterize the pharmacokinetic profile of bavituximab and to identify dose-limiting toxicities and the maximum tolerated dose and/or maximum effective dose. The trial enrolled patients with breast, colorectal, pancreatic, liver, prostate, and h...

InteKrin Therapeutics Announces INT131 Phase 2a Results at the 2009 American Diabetes Association Annual Meeting

... of T2DM, while also showing remarkable safety in nonclinical studies of INT131 even at multiples of clinical exposures that far exceed those at which toxicities are observed with TZDs." These Phase 2a study data provided the rationale for a double blind placebo controlled 24 week Phase 2b study of 4 doses...

Pharmasset Initiates Phase 1b Multiple Ascending Dose Clinical Trial of PSI-7851 in Chronic Hepatitis C Patients

...first generation nucleoside polymerase inhibitor, R7128. In vitro studies of PSI-7851 have not shown evidence of any mitochondrial or other cellular toxicities that may be associated with some nucleoside analogs. The half-life of the triphosphate in primary human hepatocytes is approximately 38 hours, which s...

American Academy of Dermatology Issues New Guidelines For the Management of Psoriasis With Systemic Medications

...erance of the medication," said Dr. Pariser. toxicities & Contraindications Because of the known organ toxicities of traditional systemic medications, proper patien...branes of the mouth and anorexia. The most serious toxicities associated with methotrexate are white blood cell ...

2-drug combination appears safe and active in metastatic kidney cancer

...well tolerated in renal cell patients. Two patients developed dose limiting toxicities (one with renal toxicity and one with neutropenia) at the highest temsiroli...rolimus. (Two of the non-renal cell cancer patients developed dose-limiting toxicities early in the trial, after which point the investigators limited enrollment ...
toxicities in Medical Technology

RTA 402 Shown to Protect Animals Against Toxicities of Standard Cancer Treatments

IRVING, Texas--(BUSINESS WIRE)--Jun 29, 2007 - Reata Pharmaceuticals, Inc. today announced the presentation of new preclinical data showing their lead anti-cancer agent, the Synthetic Triterpenoid RTA 402, is effective at protecting against common toxicities caused by traditional cancer treatments....

Vectibix(R) in Combination With Chemotherapy Significantly Improved Progression-Free Survival in First-Line Metastatic Colorectal Cancer

...mportant Product Safety Information Dermatologic Toxicity: Dermatologic toxicities occurred in 89 percent of patients and were severe (NCI-CTC grade 3 and hig...patients receiving Vectibix monotherapy. Withhold Vectibix for dermatologic toxicities that are grade 3 or higher or are considered intolerable. If toxicity does...

Pharmasset Reports Positive Preliminary Antiviral Data With PSI-7851 for the Treatment of Hepatitis C

... polymerase inhibitor, RG7128 (formerly known as R7128). In vitro studies of PSI-7851 have not shown evidence of any mitochondrial or other cellular toxicities that may be associated with some nucleoside analogs. Like RG7128, PSI-7851 has demonstrated pan genotype activity in vitro . About Pharmasse...

Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions

... with great unmet need where our peripherally acting drugs could have significant therapeutic utility without the potential for central nervous system toxicities that plague many centrally acting anti-obesity drugs," continued Dr. Bhanot. "Obesity is just one example of the many therapeutic areas that are amen...

Enrollment in Delcath's Pivotal Phase III Metastatic Melanoma Clinical Trial Achieves Seventy-Five Percent Accrual

...er doses of anti-cancer drugs to a patient's liver while preventing entry of the drugs to the rest of the patient's circulation. This isolation limits toxicities that result from systemic chemotherapy treatments. Patients in the Phase III trial initially are randomized into one of two treatment arms, inclu...

CuraGen Updates CR011-vcMMAE Data at ASCO

...e negative disease. Fifty percent (50%) of patients showed tumor shrinkage. toxicities were similar to those observed in previous studies with CR011-vcMMAE; the m...erse events consisting of rash, alopecia, and pruritus were the most common toxicities in this study. Other adverse events included fatigue, diarrhea, anorexia an...

Proteolix Presents Positive Clinical Data for Carfilzomib in Multiple Myeloma at the 2009 ASCO Annual Meeting

...d who were refractory to treatment with bortezomib, 19 percent achieved a clinical benefit response. Carfilzomib was generally well tolerated and toxicities were manageable. The most common adverse events reported were fatigue, anemia and thrombocytopenia. Of note to this patient population, treatment wi...

Trubion Announces Positive Data From a Phase 1 / 2 Study of TRU-016 for the Treatment of Chronic Lymphocytic Leukemia (CLL)

...ase in spleen size and a significant increase (44%) in hemoglobin. Mild grade 1 or 2 infusion toxicity was observed and there were three dose-limiting toxicities reported that all occurred in different dose cohorts. A maximum tolerated dose has not yet been reached. Also presented at the ASCO Annual Meetin...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

...eversible, and one patient had a fatal heart attack, possibly bevacizumab-related. Grade 3 mucositis occurred in 13% of patients and all other grade 3 toxicities occurred in <10% of patients(11). Early stage development data Abstract #8542: Panobinostat + lenalidomide and dexamethaso...

Video: Partnership Unites UCB with Consumer Product Innovator OXO(R)

...rmed with rituximab or natalizumab; however because of the nature of the adverse events seen with these combinations with TNF blocker therapy, similar toxicities may also result from the use of CIMZIA in these combinations. Therefore, the combination of CIMZIA with anakinra, abatcept, rituximab, or natalizumab ...
toxicities in Medical Dictionary

Iron Overload

... overload , Arthritis, Liver Cancer, Diabetes. Explores the causes, consequences, diagnosis, and management of iron overload which can cause toxicities that often lead to health problems or premature death. ... Why would a primary care doctor want to know about the genetics of iron overlo...

Ethylene glycol

... glycol in rats and mice. Fund. ... Ethylene glycol (EG) is the dihydroxy alcohol derivative of ethane.It was ... Ethylene glycol's major toxicities are a result of it being metabolized to toxic ... Ethylene glycol : human health aspects. ... (ICSC 0270) on ethylene glycol , produced b...
toxicities in Biological News

Key stress protein linked to toxicities responsible for Parkinson's, Alzheimer's

Researchers at the Burnham Institute for Medical Research have discovered a mechanistic link between cellular stress caused by free radicals and accumulation of misfolded proteins that lead to nerve cell injury and death in neurodegenerative disorders such as Alzheimer's and Parkinson's Disease. ...

Ambati study published in PNAS

...siRNA killed these cells by activating an immune receptor called toll-like receptor 3 (TLR3). This was a critical finding, as immune and blood vessel toxicities were not believed to occur with this pharmacologic technique. As a result, siRNA is now recognized as a new class of anti-vascular drugs that could p...

New treatment approach promising for lymphoma patients in the developing world

...ate the more intense treatment, he noted. "Patients on the 2-weekly regimens have to receive injections with 'growth factors' to ensure that severe toxicities to the white blood cells do not occur," he said. "Even so, the cost of these injections per cycle is much lower than that of rituximab. The preliminar...

Galiximab in combination with rituximab in patients with previously untreated follicular lymphoma

...lier Swiss (SAKK) trial using the same schedule with single-agent rituximab. Thirteen percent of patients reported a grade 3 adverse event; no grade 4 toxicities were associated with this combination immunotherapy regimen. Galiximab is an anti-CD80 monoclonal antibody that has been studied as a single-agent...

New research shows no link between aromatase inhibitors and cardiovascular problems

...f AIs. AIs are clearly superior to tamoxifen in terms of reducing the risk of breast cancer recurring. Also, we should not forget the life-threatening toxicities associated with tamoxifen therapy such as venous thromboembolism (VTE) and endometrial cancer, which do not appear to be a problem with AIs. While AIs...

New chemotherapy combo produces side effects, but no extra efficacy, in early breast cancer patients

...n patients with early breast cancer, leads to more toxicities and does not improve the efficacy of treatment, a ...emotherapy regime produced more non-haematological toxicities for example hand-foot syndrome, a skin reaction t...ding capecitabine to docetaxel, and the additional toxicities that it produces, the scientists say that they wou...

Combination therapy improves AIDS-related lymphoma outcome

... HIV-positive patients on HAART while they are treated with chemotherapy for ARL, oncologists are hesitant to expose HIV patients to hypothetical drug toxicities related to combining the therapies. Researchers led by Rudolf Weiss, M.D., of Specialist Practice for Hematology, Oncology and Infectious Diseases in ...

New type of rejection blocker protects kidneys after transplant

... among kidney transplant recipients. "This trial indicates that belatacept should be able to protect transplanted organs from rejection without the toxicities associated with today's standard drugs," Vincenti said. Since standard immunosuppressants damage the kidneys, the new class of drugs also promises ...

Newly discovered genetic disease sheds light on body's water balance

... form." The physicians were reluctant to use other medications that generate increased water loss in the kidneys, as these can have side effects or toxicities in young children. Instead, with Feldman and pediatric endocrinology fellow Eric Huang, MD, Gitelman administered urea, a natural nitrogen compound th...

NCI Researchers Confirm the Effectiveness of Immunotherapy Approach to Treating Melanoma

...treatment-related deaths in this study. The loss of white blood cells, which fight infections, led to the development of infections in seven patients. toxicities related to the chemotherapy and administration of a high dose of IL-2 were easily managed. The results of this study prove that a combination of ch...
toxicities in Biological Technology

NIMOTUZUMAB DEMONSTRATES EFFICACY IN RANDOMIZED HEAD & NECK CANCER STUDY WITHOUT THE TOXICITIES ASSOCIATED WITH OTHER EGFR DRUGS

- Results from a randomized Phase IIb trial reported at 2009 ASCO Annual Meeting - MISSISSAUGA, ON, June 1 /PRNewswire-FirstCall/ - YM BioSciences Inc. (NYSE Amex: YMI , TSX:YM, AIM:YMBA), a life sciences product development company that identifies and advances a diverse portfolio ...

Biomodels Expands Efforts in Cancer Supportive Care, Pulmonary Fibrosis; Preclinical Research Organization Names Dr. Stephen T. Sonis as Partner

...w.biomodels.com ) researchers have identified common mechanisms underlying toxicities that can lead to more rapid pharmaceutical interventions. "Few peo...lopment process, especially to meet the challenges posed by regimen-related toxicities of cancer therapy," he added. Biomodels is internationally known...

YM BIOSCIENCES REPORTS DAIICHI-SANKYO ENROLLS FIRST PATIENTS IN PHASE II, FIRST-LINE LUNG CANCER TRIAL WITH NIMOTUZUMAB

...ab. The addition of nimotuzumab did not add to the toxicities of either regimen, with no Grade III/IV skin toxicities observed. The trial demonstrates that the efficacy...at this efficacy was not accompanied by the severe toxicities reported in patients treated with cetuximab. YM ...

Data Presented at Society of Nuclear Medicine 2009 Annual Meeting Supports Potential of Peregrine's Cotara(R) for the Treatment of Brain Cancer

...tigation Reform Act of 1995. The forward-looking statements involve risks and uncertainties including, but not limited to, the risk that dose-limiting toxicities may be experienced in future stages of the trial that will use higher doses of Cotara or the risk that results from larger trials may not be consiste...

Proteolix Presents Clinical Data from Two Clinical Studies of Carfilzomib in Multiple Myeloma at the 14th Congress of the European Hematology Association

...on with lenalidomide and dexamethasone should provide superior activity to lenalidomide and dexamethasone alone. In addition, the lack of overlapping toxicities and absence of peripheral neuropathy may allow for long-term dosing - and ultimately, sustained clinical benefit." Dr. Wang presented interim dat...

Mersana Reports Preliminary Phase 1 Results of XMT-1001 in Patients with Advanced Solid Tumors

... and seven patients had prolonged stable disease for at least 12 weeks. The study has also demonstrated that XMT-1001 can be safely given to patients. toxicities such as hemorrhagic cystitis and serious diarrhea were not observed in this preliminary assessment. In addition, a favorable pharmacokinetic profile w...

Cimzia(R) (certolizumab pegol) Provides Long-Term Remission and Response Rates in Infliximab-Refractory Crohn's Patients

...rmed with rituximab or natalizumab; however because of the nature of the adverse events seen with these combinations with TNF blocker therapy, similar toxicities may also result from the use of CIMZIA in these combinations. Therefore, the combination of CIMZIA with anakinra, abatacept, rituximab, or natalizuma...

Ascenta Therapeutics Announces Presentation of Promising Results From Clinical Trials of AT-101 in Prostate, Brain, and Lung Cancers at 2009 ASCO Annual Meeting

...1 weeks) in A and 11.7 weeks (range 1.9 - 19.4 weeks) in B, considered by the investigators to be favorable compared to historical controls. Observed toxicities with the combination were consistent with those associated with topotecan. Abstracts of all eleven presentations or publications on AT-101 made...

Trubion Announces Acceptance of Three Presentations on Its TRU-016 Product Candidate at the 2009 ASCO Annual Meeting

...n hematopoiesis, or the production of red blood cells and platelets. Eight of the 10 patients had high-risk genomic features and no dose-limiting toxicities or serious adverse events had occurred. Mild (grade 1-2) infusion toxicity was observed in three patients. Beginning with the 0.3 mg/kg dose, all eigh...

YM BIOSCIENCES REPORTS THIRD QUARTER 2009 OPERATIONAL AND FINANCIAL RESULTS

...ow EGFR levels. For the competing drugs, binding is indiscriminate since they bind to low levels of EGFR and, as a result, these products cause severe toxicities as they interact with healthy tissues. With Erbitux(R) as the leading EGFR-targeting drug on the market and generating more than $1.5 billion in annua...
Other Tags
(Date:9/2/2014)... patients recover from cancer surgery may be influenced ... operations themselves. Family conflicts and other non-medical problems ... Mayo Clinic study has found. Addressing such quality-of-life ... speed their recoveries and save health care dollars, ... colon cancer patients, and found that patients with ...
(Date:9/2/2014)... According to a new report ... global authority in medical device market research, the ... to grow to over €2 billion in 2020. ... the number of procedures for the treatment of ... includes TURP devices, laser BPH devices, brachytherapy, urinary ...
(Date:9/2/2014)... On Saturday, September 6, 2014, The Concilio will present its ... Get Up! Get Moving!®. This event promotes Hispanic family physical ... people of all ages and all sizes. The event, which ... at Kiest Park Recreation Center, 3080 S. Hampton Road, in ... 2007, we have partnered with National Alliance for Hispanic Health ...
(Date:9/2/2014)... Shrewsbury, MA (PRWEB) September 02, 2014 ... the launch of a Free-Tuition Guarantee for its ICD-10 ... is to bring the highest level of confidence to ... as a medical coder, but are faced with the ... delay the implementation of ICD-10 until October 1st, 2015. ...
(Date:9/2/2014)... Amy Norton HealthDay Reporter ... who want to lose weight and boost their heart health, ... fat, a new study suggests. In a small clinical ... follow a low-carbohydrate diet lost more weight over a year ... had bigger improvements in their cholesterol and triglyceride levels, the ...
Breaking Medicine News(10 mins):Health News:Family conflicts, other non-physical worries before cancer surgery raise patients' complication risk 2Health News:European Urological Device Market Is Expected to Grow to over €2 billion by 2020: Led by Coloplast, Wellspect HealthCare, Teleflex, C. R. Bard and Olympus 2Health News:European Urological Device Market Is Expected to Grow to over €2 billion by 2020: Led by Coloplast, Wellspect HealthCare, Teleflex, C. R. Bard and Olympus 3Health News:The Concilio Presents Eighth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 2Health News:The Concilio Presents Eighth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 3Health News:The Concilio Presents Eighth Annual ¡Vive Tu Vida! Get Up! Get Moving!® Event 4Health News:American Healthcare Documentation Professionals Group (AHDPG) Launches Free-Tuition Guarantee for Its ICD-10 Medical Coding Bridge Program 2Health News:American Healthcare Documentation Professionals Group (AHDPG) Launches Free-Tuition Guarantee for Its ICD-10 Medical Coding Bridge Program 3Health News:Low-Carb Beats Low-Fat for Weight Loss, Heart Health: Study 2Health News:Low-Carb Beats Low-Fat for Weight Loss, Heart Health: Study 3
(Date:9/2/2014)... A study published in the September 2014 ... Academy of Child and Adolescent Psychiatry found ... diagnosis had an increased risk of developing diabetes ... data from the nationwide Danish registers, a group ... Psychiatry, Aalborg University Hospital, Denmark, studied 48,299children and ...
(Date:9/2/2014)... Bavaria, the Tithonian Konservat-Lagersttte of lithographic limestone is ... of emblematic fossils from that area (for example, ... found fossil insects in the French equivalent of ... species representing the oldest known water treader. , ... Bavarian outcrops, fewer fossils have been obtained from ...
(Date:9/1/2014)... has improved steadily in recent yearsspurred in large part ... poor and disparities continue to widen among socioeconomic and ... School of Public Health (HSPH). , "The study provides ... efforts by many groups and individuals to improve U.S. ... indicates that these efforts need to be expanded," said ...
Breaking Biology News(10 mins):Risk of diabetes in children and adolescents exposed to antipsychotics 2Exceptionally well preserved insect fossils from the Rh&#244;ne Valley 2Quality of US diet shows modest improvement, but overall remains poor 2Quality of US diet shows modest improvement, but overall remains poor 3
Other Contents