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Towards precise classification of cancers based on robust gene functional expression profiles

Chemists say they have identified a gene that appears to play a key role in the development of type 1 diabetes, also known as insulin-dependent or juvenile diabetes, a disease that affects about one million people in the U.S. and is on the rise worldwide. They described their findings, which they say could lead to new drug interventions and possibly gene therapy, today at the 229th national meeti...

Unchecked DNA replication drives earliest steps toward cancer

Although not widely appreciated as a disease of the genes, cancer is always rooted in genetic errors or problems in gene regulation. Scientists have identified some of the first genetic triggers for cancer as mutations in specific oncogenes or tumor suppressor genes. Full-blown tumors and metastatic cancers, however, often exhibit many genetic mutations, sometimes dozens in a given tumor. An impo...

Virologists make major step towards understanding the process of HIV infection

A working group of virologists headed by Professor Hans-Georg Kräusslich at Heidelberg University Hospitals, jointly with Professor Hanswalter Zentgraf, Division of Applied Tumor Virology of the Deutsches Krebsforschungszentrum (German Cancer Research Center, DKFZ), have been the first to label Human Immunodeficiency Viruses (HIV) for visual investigations without inhibiting the functional charac...

Moffitt-USF head toward first human trials of anti-cancer drug that targets protein AKT

H. Lee Moffitt Cancer Center & Research Institute, working in partnership with the University of South Florida (USF), has discovered a new use for an old, previously discredited anti-cancer drug that could add another weapon in the arsenal against several cancers, including tumors of the breast, ovary, colon, skin and prostate. The compound, tricirbine, was tested at various cancer cen...

Cats' indifference towards sugar explained

Unlike most mammals, cats--both domestic and wild--are indifferent to sweets. A new study in PLoS Genetics explains the molecular mechanism behind their strictly carnivorous behavior. "We took a behavioral question and answered it molecularly," says Joseph Brand, senior author of the study and Associate Director of the Monell Chemical Senses Center. Scattered on mammalian tongues are speci...

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Wisconsin building toward the major leagues of venture capital

That building process reached another milestone with the news that Wiscons...

HP charges toward the living room

Hewlett-Packards decision last week to merge its Imaging and Printing Group and its Personal Systems Group into one Imaging and Personal Systems Group (IPSG) is a major milestone in HPs journey to become consumer technology brand. By combining these two units, HP has a unified and convincing product message for every room in the digital home. That may be the key that turns HPs consume...

Outsourcing fills gaps and drives U.S. back toward innovation

Protesters during the industrial age screamed against rapid automation as a serious threat to jobs and a possible destruction of society. They later protested...

Four steps toward securing more reliable electric power for Wisconsin

MADISON The only thing standing between Wisconsin and a blackout as widespread as last weeks Northeast power outage is our still-sluggish economy. If more people were working and businesses were operating near peak capacity, as they were in the late 1990s, Wisconsins overtaxed transmission grid could shut down in a New York (or Cleveland) minute. A permanently sputtering economy is not...

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Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase

Huntingtons disease is an inherited disease of the nervous system due to the progressive gradual deterioration of the same, initially causing symptoms such as involuntary movements and balance problems and later on leading to declination of functions of speech as well. All these days, until now, it was thought that this disease is due to a mutated form of the protein 'huntingtin' which i...

Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese

Huntingtons disease is an inherited disease of the nervous system due to the progressive gradual deterioration of the same, initially causing symptoms such as involuntary movements and balance problems and later on leading to declination of functions of speech as well. All these days, until now, it was thought that this disease is due to a mutated form of the protein 'huntingtin' which i...

Looking Towards More Effective Leukemia Treatment

Eighty percent of the time childhood acute lymphoblastic leukemia is curable with chemotherapy. The bad news is doctors are not sure // why it doesn’t work for the other 20 percent of patients. Now, new research finds it could be because of a small number of genes that are resistant to drugs used to treat the disease. Researchers tested leukemia cells from 173 children. They looked at...

Attitude Towards AIDS Patients – Time For A Change

It is one of the tragedies of our society that persons infected with HIV/AIDS not only have to bear the burden of their illness - which any person with any illness must do - but also have to face the torment of discrimination and stigma // . Our attitude to the disease rests largely on ignorance regarding the disease inspite of the massive awareness campaigns that has been conducted so f...

Scientists Awarded Appropriately For Contribution Towards Medical Research

Science is usually viewed with awe, not to mention a little fear or suspicion; it is perceived as a realm that most people cannot understand, let alone hope to enter. Such an // approach can be dangerous if they can affect public policy concerning the use of science. If the public is to have a say in developing guidelines for dealing with certain scientific problems, it should fist hav...

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Gene Chips to Detect CYP Variations: A New Step Toward Customized Medical Therapy.

The FDA approval of BiDil for heart failure in African American patients has underscored the concept that two patients can respond differently to the same medication. This concept holds true for a wide variety of everyday medications, and in many cases is due to individual gen...

Novel Human Tissue Transgenic Cancer Model May Offer Significant Advance Toward Accurately Modeling Human Cancer

LOS ANGELES & CAMBRIDGE, Mass.--(BUSINESS WIRE)--Apr 18, 2007 -AVEO Pharmaceuticals, Inc., a biopharmaceutical company focused onthe discovery and development of novel, targeted cancer medicines,presented today findings from its novel human-in-mouse (HIM) tissuetransgenic cancer model system, in which AVEO successfully createdinvasive human tumors that develop over time in mice from prim...