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Topoisomerase in Medical News

Sunesis Announces New Data on Voreloxin for Acute Myeloid Leukemia and Ovarian Cancer Will Be Presented at ASCO

...e derivative, or AQD, a class of compounds that has not been used previously for the treatment of cancer. Voreloxin both intercalates DNA and inhibits topoisomerase II, resulting in replication-dependent, site-selective DNA damage, G2 arrest and apoptosis. Voreloxin is currently being evaluated in a Phase 2 clinic...

Sunesis Reports Financial Results for the First Quarter 2009

...in clinical use for the treatment of breast cancer, including cisplatin and topoisomerase II inhibitors doxorubicin and etoposide. Data also established an enhanced ...y for the treatment of cancer. Voreloxin both intercalates DNA and inhibits topoisomerase II, resulting in replication-dependent, site-selective DNA damage, G2 arres...

Gene alterations associated with response to anthracycline therapy for breast cancer

... Alterations in the topoisomerase II alpha ( TOP2A ) gene were associated with better patient outcomes following anthracycline-based therapy compared with non-anthracycline-based regim...

Biomarkers: What can they tell us

...eo, M.D., Ph.D. Chemotherapy treatment selection based on biomarkers may not yet be a valuable practice. Prior studies have suggested that HER2 and topoisomerase II (TOP2A) might predict sensitivity to particular chemotherapy agents. An interim analysis shows that HER2 and TOP2A have a clinically modest and sta...

CSHL scientists correlate enzyme expression levels with chemotherapy drug response

...ent or short-circuit this process." Regulating topoisomerase through gene "knockdown" The premise of the CS...with the expression of genes involved in producing topoisomerase enzymes. Four shRNAs were identified that specific... Top2A, which codes for production of a particular topoisomerase called...

Sunesis Pharmaceuticals Presents Nonclinical Data on SNS-595 at the Annual Meeting of the American Association for Cancer Research

...mechanism as a site-selective DNA intercalator and topoisomerase poison with selectivity for proliferating cells. T...stance pathways and may have advantages over other topoisomerase poisons," said Daniel C. Adelman, M.D., Senior Vic...SNS-595 in indications such as breast cancer where topoisomerase II poisons are active." Sunesis researchers cond...

DNA with a twist: New company to search for cancer drugs and antibiotics

... enable drug-discovery work in this area including topoisomerase enzymes themselves as well as associated products....nce on the standard gel-based screening method for topoisomerase inhibitors. Inspiralis Ltd will develop the techni...cells rapidly divide in an uncontrolled manner and topoisomerase inhibitors can block this uncontrolled cell divisi...

Class of Chemotherapy Drugs Helps Certain Breast Cancer Patients

...who should get anthracyclines based just on HER2 status. That's because other research has suggested that the overexpression of another gene called topoisomerase II alpha (or topo2) may also play a role in how well anthracyclines work. "The topo2 gene is thought to be the real target of the anthracyclines," sa...

First look at an enzyme target for antibacterial and cancer drugs

...ry (Berkeley Lab) and the University of California (UC) at Berkeley have produced the first three-dimensional structural images of a DNA-bound Type II topoisomerase (topo II) that is responsible for untangling coiled strands of the chromosome during cell division. Preventing topo II from disentangling a cells ...

Sunesis Pharmaceuticals' SNS-595 Shows Clinical Activity in Patients With Relapsed or Refractory Acute Leukemias; Data Presented in Oral Session at 49th Annual Meeting of the American Society of Hematology

...95, a first-in-class naphthyridine analog that intercalates DNA and poisons topoisomerase II causing selective DNA damage, was administered on a weekly or twice week...95, a first-in-class naphthyridine analog that intercalates DNA and poisons topoisomerase II causing selective DNA damage, is currently in a Phase 1b clinical trial ...
Topoisomerase in Medical Technology

Pixantrone in Combination with Chemotherapy Regimens Produces Overall Response Rates of 58-74% with Complete Remission Rates of 37-57% in Relapsed/Refractory Aggressive or Indolent NHL

...andard anthracyclines and the rational design modifications to the chemical compound believed to be responsible for enhanced DNA damage and binding to topoisomerase II enzyme, a key target for anthracycline mediated tumor death. These modifications are also hypothesized by the authors to underlie the drugs' low ca...

Sunesis Pharmaceuticals Announces Presentation of Voreloxin Clinical Data in Patients with Acute Myeloid Leukemia at the 50th Annual Meeting of the American Society of Hematology

...lated to quinolones, a class of compounds that has not been used previously for the treatment of cancer. Voreloxin both intercalates DNA and inhibits topoisomerase II, resulting in replication-dependent, site-selective DNA damage, irreversible G2 arrest and apoptosis. Voreloxin is currently being evaluated in a ...

Sunesis Announces New Data on Voreloxin for Acute Myeloid Leukemia To Be Presented at ASH

...elated to quinolones, a class of compounds that has not been used previously for the treatment of cancer. Voreloxin both intercalates DNA and inhibits topoisomerase II, resulting in replication-dependent, site-selective DNA damage, irreversible G2 arrest and apoptosis. Voreloxin is currently being evaluated as a s...

Sunesis Pharmaceuticals Presents Clinical Trial Data of Voreloxin in Patients with Acute Myeloid Leukemia and Ovarian Cancer at the Chemotherapy Foundation Symposium

...elated to quinolones, a class of compounds that has not been used previously for the treatment of cancer. Voreloxin both intercalates DNA and inhibits topoisomerase II, resulting in replication-dependent, site- selective DNA damage, irreversible G2 arrest and apoptosis. Voreloxin is currently being evaluated in a ...

Sunesis Pharmaceuticals Presents Data from Clinical Trials of Voreloxin (formerly SNS-595) in Patients with Acute Myeloid Leukemia at the 13th Congress of the European Hematology Association

...lated to quinolones, a class of compounds which has not been used previously for the treatment of cancer. Voreloxin both intercalates DNA and inhibits topoisomerase II, resulting in replication-dependent, site-selective DNA damage, irreversible G2 arrest and rapid apoptosis. Voreloxin is currently being evaluated ...

Sunesis Pharmaceuticals Focuses Resources on Development of Voreloxin (Formerly SNS-595)

...lated to quinolones, a class of compounds which has not been used previously for the treatment of cancer. Voreloxin both intercalates DNA and inhibits topoisomerase II, resulting in replication- dependent, site-selective DNA damage, irreversible G2 arrest and rapid apoptosis. Voreloxin is currently being evaluated...

Sunesis Pharmaceuticals Presents Updated Clinical Data From Ongoing Phase 2 Trial of Voreloxin (Formerly SNS-595) in Ovarian Cancer Patients at the 44th ASCO Annual Meeting

...lated to quinolones, a class of compounds which has not been used previously for the treatment of cancer. Voreloxin both intercalates DNA and inhibits topoisomerase II, resulting in replication-dependent, site-selective DNA damage, irreversible G2 arrest and rapid apoptosis. In addition to the ongoing Phase 2 sing...

Sunesis Pharmaceuticals to Present Interim Clinical Data From Voreloxin (Formerly SNS-595) Ovarian Cancer Trial at 44th ASCO Annual Meeting and Acute Myeloid Leukemia Trials at 13th EHA Congress

...lated to quinolones, a class of compounds which has not been used previously for the treatment of cancer. Voreloxin both intercalates DNA and inhibits topoisomerase II, resulting in replication-dependent, site-selective DNA damage, irreversible G2 arrest and rapid apoptosis. Voreloxin is currently being evaluated ...

Sunesis Pharmaceuticals Initiates Phase 2 Clinical Trial of Voreloxin (SNS-595) in Acute Myeloid Leukemia

...lated to quinolones, a class of compounds which has not been used previously for the treatment of cancer. Voreloxin both intercalates DNA and inhibits topoisomerase II, resulting in replication-dependent, site- selective DNA damage, irreversible G2 arrest and rapid apoptosis. The topoisomerase II-associated DNA in...

Significant Anti-Tumor Activity of NKTR-102 in Patients With Refractory Solid Tumors; Interim Data Published in ASCO 2008 Proceedings

...roduced an increase in SN38 exposure that was up to six-fold higher than the exposure previously reported with irinotecan at equivalent doses. SN38, a topoisomerase I inhibitor, is the active metabolite of irinotecan. The ASCO abstract reports interim data on 27 of 32 patients in the first of three dose schedule...
Topoisomerase in Biological News

New book, 'Untangling the Double Helix,' explores enzymes responsible for maintaining genome integrity

...he general readership," wrote Wang. The book will appeal to those with a general interest in molecular biology, the biological and clinical aspects of topoisomerase function, or in the mathematics and physics of topology. Wang starts with the history of the "insuperable" DNA entanglement problem and describes r...

CTRC-AACR San Antonio Breast Cancer Symposium

...h small HER2-positive tumors Evaluation of letrozole as adjuvant endocrine therapy Phase III trials of new, paradigm-shifting clinical agents like topoisomerase When: December 10-14, 2008 Where: Henry B. Gonzales Convention Center San Antonio, TX CTRC-AACR Press Room: Location: Room 217 ...

ESF EURYI award winner aims to stop cancer cells reading their own DNA

...ells much more specifically than traditional chemotherapy, avoiding side effects such as temporary hair loss. Dekker is focusing on an enzyme called topoisomerase IB that plays a key role in some of the molecular motors involved in the processes of DNA and RNA copying during cell division. These are responsible ...

Doing a spin with DNA

... featured on the cover of this issue. The enzyme topoisomerase IB releases the torsion built up in DNA strands. D...ver time as it acted on a single DNA molecule. The topoisomerase clamps onto the DNA, cuts through one of the two D...ivision and under certain conditions even stop it. topoisomerase IB can reduce these torsional forces. The enzym...
Topoisomerase in Biological Technology

Sunesis Reports Financial Results for the Second Quarter 2009

...e derivative, or AQD, a class of compounds that has not been used previously for the treatment of cancer. Voreloxin both intercalates DNA and inhibits topoisomerase II, resulting in replication-dependent, site-selective DNA damage, G2 arrest and apoptosis. Voreloxin is currently being evaluated in a Phase 2 clinic...

AEterna Zentaris Presents Phase 1 Results for AEZS-112 in Patients with Advanced Cancer and Lymphoma at AACR Annual Meeting in Denver

...pharmaceutical company focused on endocrine therapy and oncology, today presented a poster outlining Phase 1 results for its orally-active tubulin and topoisomerase II inhibitor compound, AEZS-112, in patients with advanced solid tumors or lymphoma, which may potentially provide a new therapeutic approach for the ...

AEterna Zentaris To Present Data on Anticancer Compounds AEZS-112 and AEZS-126 at AACR Annual Meeting

...or compound, AEZS-126, as well as a poster on its orally-active tubulin and topoisomerase II inhibitor compound, AEZS-112, at the American Association for Cancer Res...ter outlines Phase 1 results for this orally-active tubulin and topoisomerase II inhibitor compound, in patients with advanced solid tumors and lym...

Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2008 Financial Results

...e derivative, or AQD, a class of compounds that has not been used previously for the treatment of cancer. Voreloxin both intercalates DNA and inhibits topoisomerase II, resulting in replication-dependent, site-selective DNA damage, G2 arrest and apoptosis. Voreloxin is currently being evaluated in a Phase 2 clinic...

Sunesis Pharmaceuticals Provides Year-End Clinical Update on Voreloxin

...lated to quinolones, a class of compounds that has not been used previously for the treatment of cancer. Voreloxin both intercalates DNA and inhibits topoisomerase II, resulting in replication-dependent, site-selective DNA damage, irreversible G2 arrest and apoptosis. Voreloxin is currently being evaluated in a ...

Positive SPA Reply From the FDA for TopoTarget's Pivotal Trial With Belinostat in PTCL

...f the molecular mechanisms of cancer. Focus lies on highly predictive cancer models and key cancer targets (including HDACi, NAD+, mTOR, FasLigand and topoisomerase II inhibitors). TopoTarget has a broad cllinical pipeline with 9 products in development, including belinostat which has shown proof of concept as mon...

Sonus Pharmaceuticals and OncoGenex Technologies complete business combination; OncoGenex Pharmaceuticals to commence trading on NASDAQ Capital Market today

... a treatment in a broad number of cancers; - SN2310 is a novel prodrug of SN-38, which is a potent anti-cancer drug belonging to the class of topoisomerase I inhibitors. SN2310 is designed to enhance the delivery and exposure of SN-38 to the tumor by providing greater prodrug conversion and a lo...

Poniard Pharmaceuticals Appoints Four New Members to Clinical Advisory Board

...s on developing investigational agents and evaluating these compounds in Phase 1 and 2 clinical trials. He has published papers on taxanes and topoisomerase I inhibitors. He currently serves on the American Society of Clinical Oncology (ASCO) Board of Directors and is a member of ASCO's Ethics Comm...

Sonus Pharmaceuticals and OncoGenex Technologies to Merge

... a treatment in a broad number of cancers; - SN2310 is a novel prodrug of SN-38, which is a potent anti-cancer drug belonging to the class of topoisomerase I inhibitors. It is currently in a Phase 1 trial and progress is being made to determine its safety and pharmacokinetic profile, in addition...

AEterna Zentaris to Further Develop Three Follow-up Multi-targeted Cytotoxic Candidates to AEZS-112 as Potential Novel Cancer Treatment

...h Inhibitory Effects on Tubulin Polymerization and topoisomerase II", reviewed results of a pharmacological charact... of action - inhibition of tubulin polymerization, topoisomerase activity as well as antiangiogenic properties - an...ce to the AEZS-112 profile is the inhibition of topoisomerase I by compounds 2 and 3. Moreover, compound 2 displ...
Topoisomerase in Biological Products

Human Topoisomerase II, Alpha from USB Corp.

Description: Source: E. coli containing a clone of the human Topoisomerase II gene. Description: Topoisomerase II alters the topological state of nucleic acids by passing an intact DNA helix through a transient break which generates a separate DNA helix (1,2) . As a result of its double-stranded DNA passage...
Company:USB Corp.

Calf Topoisomerase I from USB Corp.

Description: Source: Calf thymus Description: Topoisomerase I relaxes both positively and negatively supercoiled DNA by a transient breakage and rejoining of phosphodiester bonds (1,2) . Relaxing supercoiled DNA with Topoisomerase I allows molecules to be differentiated by a single nucleotide pair by gel elec...
Company:USB Corp.

Human Topoisomerase II, Alpha from USB Corp.

Description: Source: E. coli containing a clone of the human Topoisomerase II gene. Description: Topoisomerase II alters the topological state of nucleic acids by passing an intact DNA helix through a transient break which generates a separate DNA helix (1,2) . As a result of its double-stranded DNA passage...
Company:USB Corp.

Human Topoisomerase I Wild Type from Calbiochem

Description: Topo I, Wild Type Liquid. In 100 mM KCl, 20 mM Tris-HCl, 1 mM DTT, 200 µM EDTA, 20% glycerol, pH 7.9. AVOID FREEZE/THAW CYCLES. Human DNA topoisomerase I (Topo I) is a monomeric protein of 765 amino acids encoded by a single-copy gene. It catalyzes the relaxation of both positive and nega...
Company:Calbiochem

Vaccinia DNA Topoisomerase I from EPICENTRE Biotechnologies

Description: Topoisomerase I from vaccinia virus is a type I eukaryotic topoisomerase that removes both positive and negative superhelical turns (also called right- and left-handed supercoils) from covalently closed DNA. The product of the reaction is a covalently closed, circular DNA with fewer positive or neg...
Company:EPICENTRE Biotechnologies

Vaccinia DNA Topoisomerase I from EPICENTRE Biotechnologies

Description: Topoisomerase I from vaccinia virus is a type I eukaryotic topoisomerase that removes both positive and negative superhelical turns (also called right- and left-handed supercoils) from covalently closed DNA. The product of the reaction is a covalently closed, circular DNA with fewer positive or neg...
Company:EPICENTRE Biotechnologies

HTP Zero Blunt TOPO PCR Cloning Kit for Sequencing MultiShot E. coli from Invitrogen

Description:...e most effective technology available for cloning PCR products. TOPO TA Cloning and Zero Blunt TOPO vectors are supplied linearized and activated with topoisomerase I. This enables 5-minute, bench-top ligation and yields >=95% recombi...
Company:Invitrogen

HTP Zero Blunt TOPO PCR Cloning Kit for Sequencing MultiShot StripWell E. coli from Invitrogen

Description:...e most effective technology available for cloning PCR products. TOPO TA Cloning and Zero Blunt TOPO vectors are supplied linearized and activated with topoisomerase I. This enables 5-minute, bench-top ligation and yields >=95% recombi...
Company:Invitrogen

Zero Blunt TOPO PCR Cloning Kit with One Shot Mach1 T1 Phage-Resistant Chemically Competent E. coli from Invitrogen

Description:...or high-efficiency (>=95%) cloning of blunt-end PCR products amplified with proofreading thermostable polymerases. The kit includes the linearized and topoisomerase I-activated pCR-Blunt II-TOPO vector for 5-minute bench-top ligations without ligase (1). The pCR-Blunt II-TOPO vector also features:...
Company:Invitrogen

Zero Blunt TOPO Kit for Sequencing with One Shot Mach1 T1 Phage-Resistant Chemically Competent E. coli from Invitrogen

Description:...-TOPO vector provides blunt ends for cloning PCR products amplified with proofreading thermostable polymerases. Each vector is supplied linearized and topoisomerase I-activated enabling 5-minute bench-top ligation yielding recombinants (1). Both vectors feature:...
Company:Invitrogen

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Topoisomerase in Biological Dictionary

Topoisomerase

Topoisomerase I solves the problem caused by tension generated by winding/unwinding of DNA. ... See also topoisomerase inhibitor ... Eukaryotic type II topoisomerase cannot introduce supercoils; it ... In cancers, the topoisomerase IIalpha is highly expressed in highly prolifera...

Ribonucleotides

... Ribonucleotides located within the 4 bp cleavage stagger stimulate topoisomerase ... The positional effect of ribonucleotides on topoisomerase II-mediated cleavage ... Ribonucleotides are difficult to activate ...

Relaxed DNA

...in. If a DNA segment... ... twisting it about the other strand, to relax DNA to a thermodynamic equilibrium. Once DNA is relaxed , topoisomerase reconnects broken strands. Structure ... ... with the amount of relaxed DNA to get you going and ... Relaxed , modified pBR-322 1000 ug -High...

Recombinase

... Cre recombinase , often abbreviated to Cre, is a Type I topoisomerase from P1 bacteriophage that catalyzes site-specific recombination of DN...fic DNA inversion in the Salmonella ... Cre Recombinase is a Type I topoisomerase from bacteriophage P1 that catalyzes ... Is the Cre Recombinase contro...

Gyrase

...ntain a second type IIA topoisomerase, ... Type I topoisomerase - Type II topoisomerase ( gyrase , topoisomerase IV) ... gyrase One of the type II topoisomer...

Endoreduplication

...ine the level of endoreduplication in epidermal cells ... Key words: Endoreduplication , gradient of gibberellic acid, lipid bodies, ... DNA topoisomerase VI Is Essential for Endoreduplication in Arabidopsis ... Endoreduplication is a common process in eukaryotes that involves DNA ... ... E exp...

DNA gyrase

... a unique combination of a classical type I DNA topoisomerase ... DNA gyrase is distinct from all other ...n DNA gyrase . ... DNA gyrase is a type II topoisomerase responsible for the manipulation of the ... Am... supercoiling and re ... trapping of gyrase and topoisomerase IV on DNA probably ... gyrase removes negativ...
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