Isis Reports That ISIS 301012 is Well Tolerated in Patients Treated for Five Or More Months
- Twelve of Sixteen FH Patients in an Ongoing Open-Label Extension Study
Have Been Dosed With ISIS 301012 for Approximately Five Months or More, and Four Have Been Dosed for More Than Six Months
- Isis Will Host a Conference Call on Monday, October 8, at 8:00 a.m. E.T. ...
Cervical Cancer Vaccine Well Tolerated
Reactions such as hives called 'idiosyncratic,' study finds
THURSDAY, Dec. 4 (HealthDay News) -- Reactions to the vaccine designed to protect against cervical cancer are rare, and young women can tolerate subsequent doses.
That's the assessment of Australian researchers who analyzed...
Radiation Therapy for Prostate Cancer Tolerated Well by Elderly Patients
Researchers from the University of Pittsburgh Medical Center treated 33 prostate cancer patients, over age 80, with external beam radiation therapy. // Patients received the same radiation doses that patients in their 50s and 60s receive.
Results of the study show the elderly patients had a five...
Orexigen(R) Therapeutics Announces Second Quarter 2009 Financial Results
...in the frequency and strength of food cravings and an increased ability to control their eating compared to placebo.
Contrave was generally well tolerated
by patients across the COR Phase 3 program. The COR program data continue to be analyzed and compiled for submission to relevant scientific conference...
Bionovo Presents Positive Results from Phase 1B Trial of Bezielle for Metastatic Breast Cancer
... University. The primary objective of the study was to identify the maximum tolerated
dose of Bezielle and to determine the safety, feasibility and preliminary e...udy medication was excellent with 90% of prescribed doses taken. A maximum tolerated
dose, as defined in study protocol, was never established despite dose esca...
Lexicon Initiates Phase 2 Clinical Trial of LX2931 in Patients With Rheumatoid Arthritis
...xicon. "LX2931 has demonstrated potent anti-inflammatory activity in preclinical models of arthritis and inflammation and, importantly, has been well tolerated
in combination with methotrexate, the current standard of care first-line therapy."
LX2931 inhibits sphingosine-1-phosphate (S1P) lyase, an en...
HIV integrase inhibitor effective for patients beginning antiretroviral treatment
...'s HIV/AIDS clinical trials unit and vice-chair of medicine dealing with Grady Memorial Hospital.
"These results provide an additional potent, well tolerated
treatment option for newly diagnosed patients with HIV infection," says Lennox.
Raltegravir, a HIV integrase inhibitor, is overall as effective ...
Fox Chase finds all-biologic regimen efficacious and well-tolerated in elderly lung cancer patients
...r initial data, the combination appears to be well tolerated
and efficacious, though we'll have to wait and see...on lacking standard cytotoxic agents may be better tolerated
by these patients, potentially without comprising ...criteria.
The combination appears safe and well tolerated
in this patient population with the most commonly ...
Advanced targeted therapies effective as first-line treatment for lung cancer
...ncerous and non-cancerous cells alike, targeted therapies are designed to inhibit only cancer cell replication and tumor growth and are generally well tolerated
"The studies presented at the WCLC confirm that targeted therapies are on the forefront of treatment innovation and show improved eff...
SnoringIsntSexy.com Tops 21,000 Site Visits for Second Month in a Row
... the public to the fact that oral appliance therapy , in the hands of an experienced dentist, is an alternative to nasal CPAP where CPAP is not well tolerated
or where the patient prefers it to CPAP."
Snoring Isn't Sexy, LLC boasts membership of 50 dentists with practices in the United States and C...
tolerated in Medical Technology
OPAXIO(TM) Combined with Alimta(R) Well Tolerated in Dose-Ranging Study of Patients with Advanced Non-Small Cell Lung Cancer
SEATTLE, Aug. 3 /PRNewswire-FirstCall/ -- Cell Therapeutics, Inc. (CTI) (Nasdaq and MTA: CTIC) announced results from a study released by Dartmouth-Hitchcock Medical Center at the International Association for the Study of Lung Cancer (IASLC) 13th World Conference on Lung Cancer. Th...
Semafore's SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, Is Well Tolerated and Demonstrates Activity in Phase I Solid Tumor Patients
Clinical Data Presented at the 2009 ASCO Meeting
INDIANAPOLIS, May 30 /PRNewswire/ -- Semafore Pharmaceuticals, Inc., a privately held cancer drug discovery and development company, today presented data from a Phase I clinical trial of its vascular targeted pan-PI3K/mTORC1/2 inhibitor, SF1126...
Novel VELCADE(R) (Bortezomib) for Injection Based Four-Drug Combination Was Well Tolerated In Previously Untreated Multiple Myeloma Patients
SAN FRANCISCO, Dec. 7 /PRNewswire/ -- Millennium: The Takeda Oncology
Company today reported the Phase I results from a randomized, multi-center,
Company-sponsored Phase I/II study of VELCADE, dexamethasone, cyclophosphamide
and lenalidomide (VcDCR) in patients with previously untreated multiple
Data Show Aerovance's Aerovant(TM) Inhalation Powder is Well Tolerated in Asthma Patients
BERKELEY, Calif., Oct. 7 /PRNewswire/ -- Aerovance Inc. today reported
pharmacokinetic (PK) and safety data from a Phase I trial of its Aerovant
inhalation powder that demonstrate good tolerability with no evidence of
local irritancy following asthma patients' inhalation of a single 10 mg
IDM Pharma Announces Phase 2 Follow-Up Data Showing IDM-2101 is Well Tolerated With Positive Survival Trend in Non-Small Cell Lung Cancer Patients
- Data presented at 44th American Society of Clinical Oncology (ASCO)
annual meeting further supports improvement in median survival vs. external controls -
IRVINE, Calif., June 2 /PRNewswire-FirstCall/ -- IDM Pharma, Inc.
(Nasdaq: IDMI ) today announced follow-...
Data Presented at AAN Show That Lacosamide Significantly Reduced Pain and was Generally Well Tolerated in Patients With Diabetic Neuropathic Pain
UCB announces clinical data presented at the 60th Annual Meeting of the American Academy of Neurology (AAN) in Chicago
SMYRNA, Ga., April 16 /PRNewswire/ -- UCB presented efficacy and safety
results from pooled analyses of Phase II and III double-blind, randomized,
Update From Mipomersen Extended Dosing Study Continues to Show That Mipomersen Is Well Tolerated and Maintains Activity in Patients Treated for Up to 16 Months
Isis Will Host a Conference Call on Monday, April 14, at 8:30 a.m. E.T. at http://www.isispharm.com
CARLSBAD, Calif., April 14 /PRNewswire-FirstCall/ -- Isis
Pharmaceuticals, Inc. (Nasdaq: ISIS ) announced additional results from its
ongoing Phase 2 open-label extensio...
IDM Pharma Announces IDM-2101 Updated Phase 2 Results Show Treatment Well Tolerated With Positive Survival Trend in Lung Cancer Patients
- Patients on IDM-2101 showed an improvement in median survival vs. parallel external controls -
IRVINE, Calif., Nov. 2 /PRNewswire-FirstCall/ -- IDM Pharma, Inc.
(Nasdaq: IDMI ) today announced updated results from the Phase 2 study of
its investigational agent IDM-210...
Isis Reports Strong Financial Results and Highlights for Second Quarter of 2009
...-011 plus docetaxel of 23.8 months compared to 16.9 months for patients treated with docetaxel alone.
OncoGenex reported that OGX-427 was well tolerated
as a monotherapy in a Phase 1 study and demonstrated declines in circulating tumor cells and evidence of reduction in tumor markers.
Radius' Investigational Bone Anabolic Agent, BA058, Increased Bone Mineral Density (BMD) at Key Fracture Sites in Phase 2 Clinical Trial in Postmenopausal Osteoporosis
...orteo(R) group and boosted femoral neck BMD by 4.1 percent compared with 2.2 percent for the Forteo(R) group.
BA058 was generally safe and well tolerated
in this study, with adverse events similar between the BA058 and placebo/Forteo(R) groups. In addition, the occurrence of hypercalcemia was half that ...
tolerated in Medical Products
Prolieve™ Thermodilatation System
Description:...oms of BPH. This dual-action thermodilatation technology simultaneously heats the prostate while dilating the prostatic urethra. The treatment is well tolerated
by patients and most patients do not require post-treatment catheterization....
Company:Boston Scientific Corporation
Bledsoe Aligner OA Brace
Description:...pplies force only when needed, so greater force can be applied without cutting off circulation.
Lightweight Lightest brace on the market today, better tolerated
Brace Construction Made of super alloy aluminum for longer life and easy to conform to patients leg.
Convenience Simple single lever adj...
Company:Bledsoe Brace Systems
Aspen® CTO Cervicothoracic Bracing System
Description:... The Aspen® CTO combines highly effective immobilization of the cervical and upper thoracic spine with a level of comfort that makes it well tolerated
by patients. Research has shown substantially progressive immobilization in going from a stand-alone cervical collar, to a two-post device, and then o...
Company:Aspen Medical Products
Description:... surgeon to see capsule clearly. Auroblue is a sterile preparation of trypan blue combined with sodium chloride and buffer solution. Auroblue is well tolerated
following intraocular injection into the anterior chamber of the eye during cataract surgery....
Features:... LARGE AREA TREATED
AND NON-INVASIVE TREATMENT
HIGH EFFICACY AND SPEED (8.3 CM2/S)
SAFETY OF BOTH THE PATIENT AND THE OPERATOR
MINIMUM RUNNING COSTS
INTEGRATED SKIN C...
Company:DEKA Research & Development Corp.
Early flexion and extension
Facility for gradual extension or flexion where required
Immediate Pronation and Supination
by the patient ...
tolerated in Medical Dictionary
..... The boy's physician suspected cystic hydatid disease, and a serum sample was ... A hydatid cyst enlarges slowly and is generally well tolerated
by an infected ... hydatid n. A cyst formed as a result of infestation by larvae of the tapeworm Echinococcus granulosus ... Which is the be...
...he hip joint a negative pressure exists which contributes to the ... maintain hips in abduction, active assisted and knee flexion exercises as tolerated
... Hip - Definition of Hip at Dictionary.com a free online dictionary with ... of a garment) extending to the hips ; hiplength: hip boots....
... an infant ... The 1-minute Apgar score measures how well the newborn tolerated
the ... This scoring system (named after its creator, Virginia Apgar... an infant ... The 1-minute Apgar score measures how well the newborn tolerated
the ... ...
...lthy. ... ... 1952 by Dr. Virginia Apgar at Columbia University's Babies Hospital. ... The 1-minute APGAR score assesses how well the infant tolerated
the birthing process. ... Apgar score summary with 5 pages of encyclopedia entries, essays, summaries, research information, and more. ... Apga...
tolerated in Biological News
Anti cancer virotherapy well tolerated in first human administration, research finds
An international medical conference here heard that an Australian developed anti-cancer therapy based on the use of a common cold virus to control cancer cell growth has begun safety testing in human subjects.
The research was presented to the third International Meeting on Replicating Oncolytic...
Study shows cancer vaccines led to long-term survival for patients with metastatic melanoma
...unced promising data from a clinical study showing patient-specific cancer vaccines derived from patients' own cancer cells and immune cells were well tolerated
and resulted in impressive long-term survival rates in patients with metastatic melanoma whose disease had been minimized by other therapies.
Funxional successfully completes initial clinical trial of FX125L, an anti-inflammatory drug with a novel mechanism of action
...named Broad Spectrum Chemokine Inhibitors ( BSCIs ).
The Phase I, single ascending dose study was conducted in the United States. FX125L was well tolerated
at all doses studied and no serious adverse events or subject withdrawals were observed. The pharmacokinetics of FX125L was linear over the wide dose ...
DuoCort: New chronotherapy for adrenal insufficiency
...ency or Addisons disease, presented at a scientific congress in June confirmed the findings in the phase I study and showed the new therapy to be well tolerated
and safe. Endocrinology Professor and Chief Medical Officer of DuoCort, Gudmundur Johannsson says, We are very pleased with the outcome of the Phase ...
Microparticle immune response modifier shows broad effects against recurrent or metastatic cancer
...sis and metastatic disease," said Simon Wilkinson, Innate Therapeutics' chief executive officer. "To date, MIS416 has shown itself to be safe and well tolerated
in these patients. Extensive toxicity studies of the drug in animals have also shown excellent safety with those treated showing no adverse effects at...
Novel lung cancer vaccine shows promise in fighting early-stage lung cancer
...acebo vaccines. The preliminary research shows that the treatment was well tolerated
by patients and the MAGE-A3-treated patients seemed less likely to have rec... Earlier phases of the study indicate the immunotherapy treatment was well tolerated
Right whale sedation enables disentanglement effort
...ulted in a marked switch from the expected evasiveness. An hour after injection of sedatives, the animal no longer evaded boat approaches, but instead tolerated
repeated close approaches by a disentanglement boat to allow removal of 90 percent of the remaining rope. Veterinarians on the team calculated the dos...
Gene therapy corrects sickle cell disease in laboratory study
...ect sickle cell disease with genetic therapy to produce fetal hemoglobin. We think that increased fetal hemoglobin expression in patients will be well tolerated
and the immune system would not reject the hemoglobin, in comparison to other approaches."
While Persons believes that the mouse experiments will l...
Calcium and vitamin D may not be the only protection against bone loss
...osses of calcium in the urine over a three month period," said Dr. Dawson-Hughes. "This intervention warrants further investigation as a safe and well tolerated
supplement to reduce bone loss and fracture risk in older men and women."
Powerful online tool for protein analysis provided pro bono by Stanford geneticist
... an amino acid that has changed a lot in evolution is much less likely to be bad than a mutation that affects an amino acid in which evolution has not tolerated
any change. "This type of analysis will be key in the interpretation of your personal genome sequence, when not if that becomes commonplace," said S...
tolerated in Biological Technology
Clinical Data Show Long-Acting Human Growth Hormone ARX201 is Safe and Well Tolerated
Long-Acting hGH Analogue Requires Only Weekly Dosing
SAN DIEGO, Nov. 13 /PRNewswire/ -- Ambrx Inc. today announced Phase
I/II clinical trial data demonstrating that ARX201, the company's
long-acting human growth hormone (hGH) analogue developed in collaboration
with Merck Serono, normalized ...
InterMune Reports Second Quarter 2009 Financial Results and Business Highlights
... & Co. Ltd. in Japan.
Pirfenidone was safe and generally well tolerated
in both CAPACITY studies. There was no difference in SAEs and fewer deaths...reductions over the dosing period in all cohorts. The combination was well tolerated
over 14 days, with no treatment-related serious adverse events (SAEs), dose...
OncoGenex Reports Second Quarter 2009 Financial Results
during an oral presentation at the 2009 ASCO Annual Meeting.
Preliminary results as of April 2009 showed that OGX-427 was well
as a monotherapy. In addition, OGX-427 demonstrated declines
in circulating tumor cells at all doses evaluated as well as evidence
Shire plc: Core Portfolio of Products Delivers 20% Sales Growth
...s were positive, and achieved statistically significant
improvements in the primary endpoint. Velaglucerase alfa was also found
to be well tolerated
with no drug related serious adverse events
reported in this trial.
- On August 3, 2009 Shire announced that it had received approval from
Pharmacy Compounds Liquid Mupirocin for the Chronic Sinusitis Patient
...unit dosed vials, it may easily be used for sinus irrigation or sinus nebulization. ASL and many prescribing physicians find this treatment to be well tolerated
among patients, producing excellent results. Physicians may call ASL Pharmacy® at 866-552-7579 to learn more about the dosing and uses for compo...
DOR BioPharma Receives FDA Orphan Drug Designation for orBec(R) for the Treatment of Chronic Gastrointestinal GVHD
...ct against the lethal effects of exposure to ricin toxin, botulinum toxin and anthrax. DOR's ricin toxin vaccine, RiVax(TM), has been shown to be well tolerated
and immunogenic in a Phase 1 clinical trial in normal volunteers.
For further information regarding DOR BioPharma, Inc., please visit the Compa...
Anadys Pharmaceuticals Reports Second Quarter 2009 Financial Results and Program Highlights
...ata from the healthy volunteer portion of the Phase I clinical trial of ANA773 in HCV were reported at the EASL conference. ANA773 was generally well tolerated
with no serious adverse events. Plasma drug levels were proportional to dose, and there was a dose-dependent induction of well-recognized interferon ...
Transave Enters Into Cooperative Research Agreement With NIH To Study ARIKACE(TM) In Nontuberculous Mycobacteria
...st 30,000 patients suffering with NTM lung disease in the United States. Current treatment requires lengthy multi-drug regimens that are often poorly tolerated
and not very effective, especially in patients with severe disease or in those who have failed prior treatments. Few clinical trials are under way to...
PTC Therapeutics Initiates Phase 2 Clinical Trial of PTC299 in Patients with Neurofibromatosis Type 2
...ients with metastatic breast cancer, Kaposi's sarcoma, and other solid tumors."
In previous Phase 1 clinical studies, PTC299 was generally well tolerated
by healthy volunteers who received single or multiple doses, with no serious, dose-limiting or definitively drug-related adverse events reported. All...
Study Published in Child and Adolescent Psychiatry and Mental Health Demonstrated Once-Daily Vyvanse(R) (lisdexamfetamine dimesylate) CII Provided Significant Improvement of ADHD Symptoms for Children at 13 Hours After Administration
...aking Vyvanse. Your health care provider may stop Vyvanse treatment if a problem is found during these check-ups.
Vyvanse was generally well tolerated
in clinical studies. The most common side effects reported in studies of Vyvanse were: children - decreased appetite, difficulty falling asleep, st...
tolerated in Biological Definition
Varies from tolerated
to prohibited for medical use:
Salvia divinorum (prohibited in Australia , tolerated
Varies from prohibited for non-medical use to prohibited for...