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Tobramycin in Medical News

PARI Pharma Receives 2nd ODD From EMEA; Moves Inhaled Tobramycin - eFlow Technology Program Forward

MUNICH and MONTEREY, Calif., May 7 /PRNewswire/ -- PARI Pharma GmbH received an Orphan Drug Designation (ODD) by the European Commission based on a positive recommendation by the EMEA for inhaled PARI Tobramycin 100 delivered via a customized Investigational eFlow Nebulizer System. This is the se...

PARI Pharma Completes Successful Clinical Trials for Tobramycin 100 & Investigational eFlow for CF

MONTEREY, Calif., Nov. 10 /PRNewswire/ -- PARI Pharma GmbH has successfully completed Phase I and Phase II clinical trials comparing its proprietary PARI Tobramycin 100 (150mg/1.5mL) formulation delivered via a customized Investigational eFlow Nebulizer System to TOBI (tobramycin 300mg/5mL) de...

AlphaRx Presents Positive Preclinical Data on Zysolin(TM) Inhalable Nanoparticles at Controlled Release Society Annual Meeting

...linical results which demonstrated that an inhaled tobramycin nanoparticle (Zysolin(TM)) formulation was a more ...when compared to inhaled and injected conventional tobramycin solutions. The data was presented recently in an o...consistently increased survival rate to 50% over a tobramycin treatment group, wherein all untreated animals die...

Zysolin(TM) Pre-clinical Data Supports Once-a-day Dosing in Humans

... AlphaRx's inhaled tobramycin nanoparticle formulation provides 300% more av...ough in the development of Zysolin(TM), an inhaled tobramycin nanoparticle formulation utilizing the company's p...ivo." About Zysolin(TM) Zysolin(TM) is a tobramycin compound, encapsulated in AlphaRx's Nano Drug Deli...

China Sky One Medical, Inc. Obtains Production Rights for Two Additional Drugs

... chronic rhinitis, sinusitis and allergic rhinitis; -- Taurine eye drops for the treatment of acute and chronic conjunctivitis; -- tobramycin eye drops for the treatment of acute infection on eyelids; -- Compound Zinc Sulfate eye drops for the treatment of acute and chronic conjun...

AlphaRx Provides Corporate and Development Update

...Company will make a go/no go decision based on the outcome on these studies which will be available by mid-July. Zysolin(TM), a specially-formulated tobramycin nano-particulate formulation, intended for the treatment of severe pneumonias caused by gram negative pathogens such as Psedomonas Aeruginosa. The Com...

Experts Release New Cystic Fibrosis Guidelines

...atments and rated their effectiveness. Those with the strongest, most consistent results were given an "A" grade recommendation. They are: Inhaled tobramycin -- an antibiotic -- to suppress chronic Pseudomonas aeruginosa infections in CF patients with moderate to severe disease, to improve lung function a...
Tobramycin in Medical Technology

Cystic Fibrosis - Liposomal Tobramycin Receives Second Orphan Drug Designation Within Weeks

ZURICH, July 16 /PRNewswire/ -- An innovative treatment for infections of the respiratory tract in cystic fibrosis patients has received a second orphan drug designation in the US only weeks after a first designation was granted. The recent designation relates to Burkholderia cepacia pathogens...

Cystic Fibrosis - Orphan Drug Designation for Innovative Treatment Against Lung Infections by Axentis Pharma AG

...ory diseases. In the case of Fluidosome-tobramycin, the interaction between tobramycin and the microbial cell is triggered when the liposomes attach to the outer cell membrane. tobramycin then leaches into the inner cell compartment, which leads to rapid cell dea...

Mpex Pharmaceuticals Presents New Data on MP-376 in Cystic Fibrosis

...oxacin potency was least affected compared to tobramycin or aztreonam. -- Activity in anaerobic environme...terial activity against P. aeruginosa whereas tobramycin activity was decreased by 1-2 logs in the pre...l anti-inflammatory effects were not observed with tobramycin or aztreonam. "We believe that taken together th...

Cystic Fibrosis Axentis Pharma Initiates Clinical Trial for Lung Infections

...e product ARB-CF0223 ­ also known as Fluidosome(R) tobramycin ­ is a liposomal formulation of tobramycin, delive...l receive a twice-daily 300 mg dose of the current tobramycin formulation over 28 days; another eight will be gi... Fluidosome tobramycin(R), the interaction between tobramycin and the microbial cell is triggered when the lipos...

Gilead Announces Presentation of Positive Phase III Data on Aztreonam Lysine for Inhalation in Patients With Cystic Fibrosis

...with aztreonam lysine for inhalation following a 28-day treatment course of tobramycin inhalation solution in people with CF who have pulmonary P. aeruginosa. Pat...e trial was 26.2 years. Participants had received more than five courses of tobramycin inhalation solution, on average, in the previous year (mean value = 5.33 co...

Gilead Announces Achievement of Primary Efficacy Endpoint in Second Phase III Study of Aztreonam Lysine for Inhalation in Patients With Cystic Fibrosis

...dy designed to assess the safety and efficacy of a 28-day treatment course with aztreonam lysine for inhalation following a 28-day treatment course of tobramycin inhalation solution in people with CF who have pulmonary P. aeruginosa. Patients were randomized to receive 28 days of treatment with 75 mg of aztreon...

Ceragenix Compound Shows Promise for Treating Lethal Cystic Fibrosis Infections

...therapy used to treat Pseudomonas infections in cystic fibrosis patients is tobramycin but there are an increasing number of tobramycin resistant strains of Pseudomonas. There is an urgent need for the developme...
Tobramycin in Medical Products

Simplex™ P Bone Cement with Tobramycin

Description: Simplex™ P with Tobramycin is the original Simplex™ P Bone Cement formula, with the addition of 1g of tobramycin. By maintaining the original formula, surgeons can expect the superior performance characteristics of Simplex™ P Bone Cement, while ensuring safe and optimal delivery o...
Company:Stryker Corporation
Tobramycin in Biological News

Two-pronged model could help foil tough cystic fibrosis infections

...the DMS researchers reported that it took far more tobramycin to destroy biofilm pockets than can be delivere...s, they determined that up to 10 times the maximum tobramycin dosage was needed. They were also studying iron ov...n poisoning or overload can enhance the ability of tobramycin against Pseudomonas infection. "The beauty is...
Tobramycin in Biological Technology

Chronic Lung Disease - Axentis Pharma Attracts Investment Interest

...d product ARB-CF0223 - also known as Fluidosome(R) tobramycin - is expected to generate a peak annual turnover o... Fluidosome(R) tobramycin, the interaction between tobramycin and the microbial cell is triggered when the liposomes attach to the outer cell membrane. tobramycin then penetrates into the inner cell compartment of...

Nektar Announces Closing of Sale of Specific Pulmonary Delivery Assets to Novartis for $115 Million

...tely 140 Nektar personnel, as well as certain intellectual property and manufacturing methods, including manufacturing and royalty rights to Novartis' tobramycin inhalation powder (TIP) program. Nektar continues to own its Bayer HealthCare-partnered program NKTR-061 (Amikacin Inhale) and royalties from t...

Prominent Physician Achieves Success Using Topical Sinus Medications via Pulsitile Irrigation

... blowing 6. The patient is instructed to not blow their nose for the next hour Which medications should be used? Dr. Grossan initially began with tobramycin added to 200 cc of saline. Today he often cultures the infection and adds the appropriate medications accordingly. For fungal infections, he use antif...

Cystic Fibrosis - Axentis Pharma Takes Over Patents and Continues Development of Innovative Platform Technology

...rominent example of such diseases is cystic fibrosis (mucoviscidosis). The company is in final preparation to initiate a phase II clinical trial using tobramycin liposome formulation against lung infections in Cystic Fibrosis patients. About the patent families The inventions which have now been acquired by...

Nektar Receives Patent Covering Pulmonary Targeted Antibiotics

... U.S. Patent Encompassing tobramycin Inhalation Powder and Other Aminoglyc...mpositions and methods for creating and delivering tobramycin Inhalation Powder (TIP) and other aminoglycoside a...tellectual property position on dry powder inhaled tobramycin and compositions of other aminoglycoside antibioti...

Cystic Fibrosis: License Agreement Boosts Development of Therapy Against Lung Infections

...eady been tested successfully in a phase I single-dose inhalation study. No significant adverse events were observed when the liposomal formulation of tobramycin was compared with the currently marketed formulation in 24 healthy volunteers who were treated in a crossover fashion. About Cystic Fibrosis Cysti...

Immunoassay of Theophylline by fluorescence polarisation

...ed which contained the following concentrations of eleven different drugs: gentamicin at 5 g/mL theophylline at 17.8 g/mL tobramycin at 6.5 g/mL quinidine at 2.6 g/mL phenytoin at 12 g/mL digoxin at 2.2 ng/mL salicylate at 220 g/mL a...
Tobramycin in Biological Definition

Antibiotic

...es Amikacin Dibekacin Gentamicin Kanamycin Neomycin Netilmicin Paromomycin Sisomycin Streptomycin tobramycin Beta-lactam ring antibiotics Carbapenems Ertapenem Imipenem Meropenem Cephalosporins and cephamycins ...
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