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Tlr3 in Medical News

The Sage Group Widens Strategic Role to Assist HemispherX Biopharma in Pandemic Influenza Initiatives as Pacific Rim/Japan Treatment/Prevention Programs Accelerate

...d the scheduled Prescription Drug User Fee Act action date of May 25, 2009 on the New Drug Application for Ampligen(r) (Poly I Poly C12U), a selective tlr3 modulator, for the management of Chronic Fatigue Syndrome. About The Sage Group, Inc. Sage is a senior-level health care, international, t...

Gene Linked to 'Dry' Macular Degeneration

... silver lining in the form of a mutated version of tlr3 -- a so-called "inactive" or "less active" tlr3 -- that suppresses this retinal death process, see..., the treatment appears to simultaneously activate tlr3 -- resulting in a 60 percent spike in retinal cell...

Nventa presents HspE7 data at international HPV conference

...y Peter Emtage, Ph.D., Vice President of Research and Development at Nventa. Results: Data from the study not only confirmed that the addition of the tlr3 agonist Poly IC potently alters the magnitude of the antigen-specific CD8 effector arm, but also that adding this moiety acts to push the immune respo...

Toll-like Receptor (Tlr3) Attachment Leads To Lethal Encephalitis

...aperitonially challenge with a lethal dose of WNV, tlr3 mice were more resistant to infection than wild ty...al burden in the peripheral blood was increased in tlr3 mice compared with wild type mice. Analysis blood ...inflammatory cytokines in wild type, compared with tlr3 mice early in infection. The results indicate that...
Tlr3 in Medical Technology

Recent siRNA Research Publications Support Silence Therapeutics Combined Development Approach

...a global leader in the RNAi space." Footnotes: Kleinman et. al., Nature(1), "Sequence-and target-independent angiogenesis suppression by siRNA via tlr3 | doi: 10.1038/nature06765; Received published online 26 March 2008." Kim et. al., Molecules and Cells(2), Vol. 24, 247, 2007: "Immune Activation by...
Tlr3 in Biological News

Ambati study published in PNAS

...d by specifically degrading intracellular messenger RNA bound for protein-forming machinery. Furthermore, this finding strengthens their finding that tlr3 positioned on the cell surface is responsible for mediating the toxic side-effects of siRNA. In concert with Sandro De Falco and Arturo Brunetti, rese...

Scripps research scientists solve structure of a critical innate immune system protein

...epeats (LRRs). The structure reveals details of tlr3 that have never been seen before, an essential ste...tains distinguishing CpG dinucleotides motifs . tlr3 in Detail Likewise, tlr3 recognizes double-stranded RNA, which is the form ...
Tlr3 in Biological Technology

Quark Pharmaceuticals Presented At ARVO Data Showing That PF-04523655 Enters Retinal Cells And Elicits Its Pharmacologic Effect Via Target Gene Knock-Down Without Activating TLR3

FREMONT, Calif., May 11 /PRNewswire/ -- Quark Pharmaceuticals, Inc., a development-stage pharmaceutical company discovering and developing novel RNA interference (RNAi)-based therapeutics, today announced that Elena Feinstein, M.D., Ph.D., Chief Scientific Officer, presented a study titled, "PF-04...

Nventa Biopharmaceuticals Announces Third Quarter 2008 Financial Results and Recent Corporate Highlights

... dosing range for Phase 2 development and that our tlr3 agonist may have application in both therapeutic a...ty that we will not be successful in licensing our tlr3 agonist to other vaccine developers; risks associa...ely manner and that we will be able to license our tlr3 agonist. In the event that any of these assumpti...

Vaxart Demonstrates Efficacy of Oral Avian Flu Vaccine in Preclinical Studies

...t that enhances immune response to a foreign protein). Vaxart uses an adjuvant that works through a "toll-like receptor" (TLR). Vaxart determined that tlr3 is much more active in the gut than other TLR pathways that have been used for injected vaccines, making this the only TLR adjuvant approach likely to...

MultiCell Technologies Relocates Corporate Headquarters

... for the treatment of relapsing-remitting MS. MCT-465 for the treatment of tlr3 positive breast cancers. MCT-475 for the treatment of tlr3 positive cervical cancers. MultiCell also sells and/or licenses immortaliz...

MultiCell Technologies To Increase Focus on Therapeutic Candidates

... for the treatment of relapsing-remitting MS. MCT-465 for the treatment of tlr3 positive breast cancers. MCT-475 for the treatment of tlr3 positive cervical cancers. MultiCell also sells and/or licenses immortaliz...

MultiCell Technologies Signs Worldwide Exclusive License Agreement With Corning Incorporated

... the treatment of relapsing-remitting MS. -- MCT-465 for the treatment of tlr3 positive breast cancers. -- MCT-475 for the treatment of tlr3 positive cervical cancers. For more information about MultiCell Technologi...
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