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Titration in Medical News

Clinical guidelines for the manual titration of PAP in OSA patients published in JCSM

WESTCHESTER, Ill. Positive airway pressure (PAP) devices are used to treat patients with sleep-related breathing disorders, including obstructive sleep apnea (OSA). Following the diagnosis of OSA, a polysomnogram (PSG), also known as an overnight sleep test, is conducted, during which PAP is adj...

Snoring Isn't Sexy, LLC Announces Commendation Program to Honor Sleep Physicians Who Work with Dentists to Manage Sleep Breathing Disorders

...ea. "Dentists depend upon physicians to conduct sleep studies, to make diagnoses, and to interpret results from in-office testing during the titration phases of oral appliance therapy." said Dr. Barsh, Founder and President of Snoring Isn't Sexy, LLC. "We are pleased to commend those sleep...

-Contrave(R) Obesity Research Phase 3 Program Meets Co-Primary and Key Secondary Endpoints; Exceeds FDA Efficacy Benchmark for Obesity Treatments-

...and eating control, as well as HbA1c in the COR Diabetes trial. Patients were randomized to receive either placebo or Contrave, BID, with a four week titration period. COR-I (NB-301): A trial designed to assess the safety, tolerability and efficacy of Contrave16 and Contrave32 versus placeb...

FDA Approves SAMSCA(TM) (tolvaptan), the First and Only Oral Vasopressin Antagonist to Treat Patients With Clinically Significant Hypervolemic and Euvolemic Hyponatremia

...itors, anuric patients Too Rapid Correction of Serum Sodium Can Cause Serious Neurologic Sequelae - During initiation and after titration monitor patients to assess serum sodium concentrations and neurologic status. Subjects with SIADH or very low baseline serum sodium concentrations ma...

FDA Approves Lamictal(R) ODT(TM) Orally Disintegrating Tablets

...Tablets to the ODT formulation, the recommended dose of Lamictal ODT matches the dose of Lamictal Tablets. For patients new to Lamictal , Patient titration Kits containing five weeks of treatment will be available. Lamictal ODT will also be available in four Maintenance Packs, one Pack for each dose st...

New Analyses from 16-Year Follow-up Trial with Betaseron(R) Demonstrated that Early and Sustained Treatment of Multiple Sclerosis Patients Enrolled in the Trial Affected Their Long-term Outcomes

...ost commonly reported adverse reactions are lymphopenia, injection-site reaction, asthenia, flu-like symptom complex, headache and pain. Gradual dose titration and use of analgesics during treatment initiation may help reduce flu-like symptoms. BETASERON should be used with caution in patients with depress...

Arena Pharmaceuticals Announces Positive Lorcaserin Pivotal Phase 3 Obesity Trial Results: Meets All Primary Efficacy and Safety Endpoints

...ithout co-morbid conditions and overweight patients (BMI 27 to less than 30) with at least one co-morbid condition. The trial did not include any dose titration or run-in period. Patients were randomized in a 1:1 ratio to lorcaserin or placebo at baseline. At Week 52, 856 patients taking lorcaserin were re-ran...

Less costly, more accessible and as effective: Simplified treatment for sleep apnea

...sults of patients thus diagnosed and treated to those who underwent standard sleep medicine pathways, including laboratory-based polysomnography, CPAP titration and physician management of the patient. They assessed the patients' sleepiness on the validated Epworth Sleepiness Scale (ESS) and set the minima...

Marinus Pharmaceuticals, Inc. Announces Positive Results of its Phase 2 Clinical Trial of Ganaxolone as Adjunctive Therapy in Adults With Partial Onset Seizures

... ganaxolone arm met the primary endpoint showing a statistically significant reduction of mean weekly seizure frequency vs. the placebo arm during the titration and maintenance period (P<0.0251). In addition, the patients in the ganaxolone arm also showed an improvement on percent reduction in seizure freq...

Hospira's Precedex(R) Phase IV Study Published in the Journal of the American Medical Association

...e IV trial incorporated new standard elements of sedation practice, including a light-to-moderate sedation target, delirium assessment, and study drug titration or interruption every four hours and as part of a daily arousal assessment. "This multicenter study is one of the largest to compare two differ...
Titration in Medical Technology

Labopharm to Present Poster on Dose Titration of Once-daily Tramadol at 3rd International Forum on Pain Medicine

- Article Discussing Pharmacokinetics and Dose Proportionality of Company's Once-Daily Tramadol to be Published in Biopharmaceutics Journal - LAVAL, QC, June 29, 2007 /PRNewswire-FirstCall/ - Labopharm Inc. today announced that it will present a poster discussing the dose titration of its once-dai...

FDA Approves Tekturna HCT(R) as Initial Treatment in Patients Unlikely to Achieve Their Blood Pressure Goals With a Single Agent

...ial. All patients randomized to the combination groups received the combination treatment of Tekturna HCT at assigned doses as initial therapy without titration from monotherapy. The antihypertensive effect of Tekturna HCT were largely manifested within 1 week. The maximum antihypertensive effect was generally...

Data Demonstrates Long-Term Reduction In Seizure Frequency With Novel Once Daily Anti-Epileptic Zebinix(R)

... to three concomitant anti-epileptic drugs. During the trials, patients were randomised to various dosages of ESL or placebo and after a 2-week titration period, were assessed over a 12 week maintenance period, with continued follow-up over a one year open-label period. Efficacy Over the 1...

Studies Show AFRESA(R) Controls Post-Meal Sugar Levels With Less Weight Gain and Hypoglycemia Risk for Diabetes Patients

...r of limitations, including the risk of severe hypoglycemia, the likelihood of weight gain, inadequate post-meal glucose control, the need for complex titration of insulin doses in connection with meals and the need for injections. Additionally, current therapies do not mimic the natural time-action profile of...

Arena Pharmaceuticals Announces Lorcaserin Data Demonstrating Highly Significant Categorical and Absolute Weight Loss and Improvements in Secondary Endpoints Associated with Cardiovascular Risk

...ithout co-morbid conditions and overweight patients (BMI 27 to less than 30) with at least one co-morbid condition. The trial did not include any dose titration or run-in period. Patients were randomized in a 1:1 ratio to lorcaserin or placebo at baseline. At Week 52, 856 patients taking lorcaserin were re-ran...

AFRESA(R) Phase 3 Pulmonary Function Safety Data in Patients with Diabetes Presented at ADA

...r of limitations, including the risk of severe hypoglycemia, the likelihood of weight gain, inadequate post-meal glucose control, the need for complex titration of insulin doses in connection with meals and the need for injections. Additionally, current therapies do not mimic the natural time-action profile of...

Video: UCB Launches Vimpat(R) in the U.S. for Add-On Treatment of Epilepsy in Adults

...f Vimpat(R) and by 12% with 400 mg/day of Vimpat(R), compared with 6% for placebo. Patients began experiencing a reduction in seizures during the titration phase and maintained or had improved seizure control throughout the studies. The most common adverse events (>10 percent in the Vimpat(R)-treated g...

New Data Shows Blood Pressure Reduction Therapy with BENICAR(R) and BENICAR HCT(R) Effectively Reduces Blood Pressure in Elderly Patients to Target Blood Pressure

...he safety and BP-lowering efficacy of the proposed titration of olmesartan medoxomil and olmesartan medoxomil/h...eater than or equal to 90 mm Hg, at which time the titration schedule was resumed. The primary endpoint wa...35/85, <130/80 & <120/80 mm Hg), at each titration period and study end and a subgroup analysis by ag...

New Data Shows AZOR(R) (amlodipine and olmesartan medoxomil) Significantly Improves 24-Hour Ambulatory Blood Pressure

...stepwise amlodipine and olmesartan medoxomil-based titration regimen provided mean 24-hour ambulatory reduction...stepwise amlodipine and olmesartan medoxomil-based titration regimen to maintain BP reductions over 24 hours. T... that an amlodipine and olmesartan medoxomil-based titration regimen can be an effective tool for treating hype...

Results From Phase 3 EQUATE Trial of VIVUS' Qnexa Highlighted at European Congress on Obesity

...phentermine/92 mg topiramate CR), the respective phentermine and controlled-release topiramate constituents, or placebo. Patients had a four-week dose titration period followed by 24 weeks of treatment. Subjects were asked to follow a hypocaloric diet representing a 500-calorie/day deficit and advised to imple...
Titration in Medical Products

CritiView

Features:...ing: Early identification / warning of the bodys critical metabolic imbalances or tissue viability of a patient A sensitive therapy titration tissue based monitor and as end point of resuscitation. ...
Company:CritiSense

Ensemble & Enguard Mennens' Central Nurse Station

Features:...phical trends, numerical charts, arrhythmia analysis, ST watch, ST all-lead analysis, calculations, heart rate variability, all ECG lead display, drug titration and calculation ...
Company:Mennen Medical Corp.

Gemini PC-1 Single-Channel Infusion System

Features:...ides sequential delivery of infusion programs and automatically switches to primary infusion upon completion of secondary program. Rapid Rate On-Line titration - Enables rapid rate adjustments without interrupting flow. Panel Lock - Added safety feature that prevents inadverdent changes to infusion program. ...
Company:ALARIS Medical Systems, Inc.

OUTLOOK® SAFETY INFUSION SYSTEM

Features:...er ID ensures an authorized clinician administers infusion therapy to prevent unauthorized tampering Provides set-based free-flow protection Decreases titration errors Dose rate calculator eliminates the need for manual calculations that can induce errors The use of DoseGuards with facility determined dose lim...
Company:B. Braun Medical Inc.

FlexStation II and FlexStation II384

Features:...ilizing consumable pipette tips to completely avoid cross-contamination of precious compounds Assay Development / Lead Optimization Automixing and titration functions Integrated Dual Scanning Monochromator with Fluidics Assay Optimization Real-Time Kinetic Data from Functional Assays Total integratio...
Company:Bucher Biotec AG

SleepStyle 238

Features:... Fully integrated system Ambient Tracking Plus Compliance Maximizer software titration Maximizer software Leak compensation ...
Company:Fisher & Paykel Healthcare

SleepStyle 233

Features:... Fully integrated system Ambient Tracking Plus titration Maximizer software ...
Company:Fisher & Paykel Healthcare

SleepStyle 236

Features:... Heated humidification delivery titration Maximizer software Leak compensation ...
Company:Fisher & Paykel Healthcare

SleepStyle 231

Features:... Heated humidification delivery titration Maximizer software ...
Company:Fisher & Paykel Healthcare

SleepStyle 232

Features:... Heated humidification delivery Compliance Maximizer software titration Maximizer software ...
Company:Fisher & Paykel Healthcare
Titration in Biological Technology

Novel Once Daily Anti-Epileptic Zebinix(R) Approved in the European Union

... to three concomitant anti-epileptic drugs. During the trials, patients were randomised to various dosages of ESL or placebo and after a 2-week titration period, were assessed over a 12 week maintenance period, with continued follow-up over a one year open-label period. Efficacy Over the 1...

Perceptive Informatics Reaches Key Milestone Marking 10 Million IVRS Interactions In Support of Clinical Trials

...inPhone IVR/IWR platform, provide key features including a broad range of validated randomization methods, automated inventory control, dispensing and titration management, emergency code break capabilities and real-time supply reporting. The ClinPhone IVR/IWR solution is part of Perceptive's extensive e...

Epilepsia Study Demonstrates New Add-on Antiepileptic Drug Vimpat(R) (lacosamide) Significantly Reduces Partial-Onset Seizures in Adults With Epilepsy

...e III study, patients began experiencing a reduction in seizures during the titration period and maintained or improved seizure control throughout the study. Vim...0 mg/day or placebo (along with prior AEDs), followed by a four-week forced titration period. Patients were started on either placebo or Vimpat(R) 100 mg/day. ...

Multiple Vimpat(R) (lacosamide) Studies Presented at American Epilepsy Society Annual Meeting

...50 mg twice daily) during the initial week of treatment, followed by weekly titration in 100 mg/day increments to the assigned targeted dose. This patien...in the intent-to-treat analysis, including those who dropped out during the titration period, also demonstrated statistically significant reductions in seizure f...

Beyond Seizure Control in the Treatment of Epilepsy With New Anti-Epileptic Drug, Zebinix(TM)

...ti-epileptic drugs.(8) During the trials, patients were randomised to various dosages of eslicarbazepine acetate or placebo and after a 2-week titration period, were assessed over a 12 week maintenance period, with continued follow-up over a one year open-label period.(2)-(11) Efficacy ...

Halozyme Therapeutics Begins Phase 2 Clinical Trial of Insulin With rHuPH20 in Type 1 Diabetic Patients

...d, open label, liquid meal Phase 2 study is designed to collect data on at least 20 patients who complete the study. The study allows for insulin dose titration and each patient will receive a minimum of four and up to three additional study drug injections that include Humalog and Humulin R with and without r...

Titrators Market to Reach $315 Million by 2015, According to New Report by Global Industry Analysts, Inc.

...ators comprising both automatic and manual, to reach $315 million by 2015. San Jose, California (PRWEB) October 27, 2008 -- titration is one of the most widely used methods for accurately determining the chemical composition of laboratory and industrial solutions. The technique is on...

Sanofi Aventis : New Study Results Support the "Basal Plus" Strategy With LANTUS(R) and APIDRA(R) to Improve Blood Sugar Control in Patients With Type 2 Diabetes

...R and OPAL show us that a basal plus strategy is an option for insulin intensification for Type 2 Diabetes insufficiently controlled despite optimized titration of LANTUS(R) combined with oral antidiabetic drug therapy." The ELEONOR study also confirmed that in a large proportion of patients with secondary f...

Eisai/Pfizer's Aricept Owns a Dominating 42.4% Patient Share for First-Line Treatment of Alzheimer's Disease

...erase inhibitors (AChEIs) largely because of their familiarity with the agent, while neurologists cite Aricept's side-effect/safety profile and easier titration (the dosing schedule needed for a patient to receive full therapeutic doses of a drug). The report finds that, in first-line treatment, Aricept hold...

YM BioSciences provides update on AeroLEF(TM) clinical development program

...ment for the treatment of moderate to severe pain, including cancer pain. In contrast to fixed-dose approaches to opioid delivery, where a significant titration period is often required to determine the suitable dose for the patient, AeroLEF(TM) is being developed as a non-invasive delivery system designed to ...
Titration in Biological Products

Immunohistochemistry - Gene Discovery from Paragon BioServices

Description:... This service involves the optimization of immunostaining. The optimization includes titration of the primary antibody, selection and optimization of secondary reagents (e.g. Alk. Phos., HRP, fluorescence, or biotinylated conjugates), optimizati...
Company:Paragon BioServices

Pyrex brand narrow mouth graduated erlenmeyer flask, student grade from Sigma-Aldrich

Description:... Heavy-duty rim. Especially recommended as a titration flask. Corning5100. capacity 250 mL Special grade: student grade...
Company:Sigma-Aldrich

Custom Epitope Peptide Microarray from LC Sciences

Description:...plate. Perform multiple concentration bindings on the same chip to generate titration curves. Paraflo Technology These are not spotted arrays. The Paraflo mic...sults Analyte samples of varying concentration may be used to obtain their titration curve. Established microarray analysis software is used to extract detectab...
Company:LC Sciences

Custom Peptidomimetic Microarray from LC Sciences

Description:...peptide microarray is equivalent to 40 or more experiments using a 96-well plate. Perform multiple concentration bindings on the same chip to generate titration curves. Paraflo Technology These are not spotted arrays. The Paraflo microfluidic technology enables on-chip synthesis ensuring high probe quality,...
Company:LC Sciences

Custom Phosphopeptide Microarray from LC Sciences

Description:...peptide microarray is equivalent to 40 or more experiments using a 96-well plate. Perform multiple concentration bindings on the same chip to generate titration curves. Paraflo Technology These are not spotted arrays. The Paraflo microfluidic technology enables on-chip synthesis ensuring high probe quality,...
Company:LC Sciences
Titration in Biological Dictionary

Zona pellucida

...he fertilization process; usually remains around the The zona pellucida is the spherical glycoprotein shell that sur ... caused by direct titration of zona pellucida binding sites is suggested as an ... the structure and function of the extracellular zona pellucida . ... In mice and huma...
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(Date:8/28/2014)... -- Scientists have identified the developmental on-off switch for ... produce more than two-thirds of the world,s naturally derived ... to see whether it is possible to manipulate this ... , The study, appearing August 28 in Cell ... molecule called cyclic-di-GMP and a larger protein called BldD ...
(Date:8/28/2014)... systems are good examples of complex systems. Their ... networkincluding water for cooling, transport to supply fuel, ... step in the network chain is interconnected with ... dependent. A team of UK-based scientists has studied ... The findings have been published in EPJ B ...
(Date:8/28/2014)... . Cars, planes ... of sophisticated assembly lines. Mobile assembly carriers, on to which ... assembly lines. In the case of a car body, the ... a precise spatial and chronological sequence, resulting in a complete ... of such an assembly line at molecular level has been ...
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