Natural Killer Cells May Help Protect Against New Strains of Influenza Virus
..., help control influenza virus early during an infection. Specifically, the studies demonstrate that NK cells are essential in controlling lung virus titers
early during an influenza virus infection and that NK cell function decreases with old age.
Dr. Ritz: "NK cells are among the earliest responders...
Novavax Reports Fourth Quarter and 2008 Year-End Financial Results
... reported previously, the vaccine demonstrated strong neutralizing antibody titers
across all three doses tested, exhibiting increasing antibody titers
with the escalation of the dose. The new data showed that the vaccine also...
BioCryst Reports Positive Results From a Phase 2 Study of Intravenous Peramivir for Outpatient Influenza
...aseline in composite symptom score, time-weighted change in
influenza virus titers
from baseline to two days following infusion,
pharmacokinetics and safety.
...een peramivir 600 mg and placebo in time-weighted change in
influenza virus titers
from baseline to two days following infusion
(p=0.0027). Peramivir was gene...
A potential approach to treatment of hepatitis B virus infection
...up a chronic HBV infection model by culturing hepatocyte HL7702 cells with HBV-positive serum without washing off input virus as conventional. HBV DNA titers
inside the infected cells represent the final viral amount including the infected DNA without being degraded and the newly synthesized HBV DNA. In thi...
Study finds unique HIV vaccine formula elicits strong immune responses
... the finding of neutralizing antibodies in this study as a major step forward.
Previously, we didnt know where to start. The neutralizing antibody titers
in our study are still relatively low, but, these results are promising and open the door for future efforts to optimize HIV vaccine formulations in o...
Study Finds Single Dose of Iomai Patch With Pandemic Flu Vaccine Achieves Protective Levels
...United States for the avian
influenza H5N1 virus requires two 90-microgram doses, administered 28 days
apart, to achieve hemagglutinin inhibition (HI) titers
equal to or greater
than 40 in 44 percent of vaccinated individuals.
"During an influenza pandemic, public health officials will face two
Antibody responses in patients with Lyme arthritis
.... Among non-antibiotic-treated patients, antibody titers
to Borrelia burgdorferi remained high throughout a...biotic-responsive arthritis, the level of antibody titers
to Borrelia burgdorferi and most outer-surface pro...biotic-refractory arthritis, the level of antibody titers
to Borrelia burgdorferi and most outer-surface ant...
Prion Disease Agent Causes Heart Damage
...e blood of the same mice used in the heart study. "This is the first system in which prion disease agents were found reproducibly and reliably at high titers
in the blood," notes Oldstone.
In the future, this finding could help scientists answer basic questions such as how prions travel in the bloodst...
Titers in Medical Technology
DSM Announces Yield Boosts of 5-10 Fold With XD(R) Technology for Mammalian Manufacturing Platforms
...D(R) Technology boosts bioreactor productivity and titers
of mammalian cell culture processes by 5-10 fold f...y offers the opportunity to substantially increase titers
in a very short time without changing the cell lin... XD(R) Technology offers a substantial increase in titers
and reactor output and has the potential to increa...
Novavax Presents Favorable Results from Phase I/IIa Pandemic Influenza Vaccine Program at World Health Organization Conference
...tudy, the vaccine demonstrated strong HAI antibody titers
against the H5N1 A/Indonesia strain. The study eva...5 mcg, or 90 mcg of vaccine or a placebo. The HAI titers
to the vaccine strain increased with increasing do...bjects achieved a four-fold or greater rise in HAI titers
when compared to baseline and...
Novavax Announces Top Line Results of Phase IIa Clinical Trial for Its Seasonal Influenza VLP (Trivalent) Vaccine Candidate
...ination groups, seroprotection rates (i.e., percentage of subjects with HAI titers
greater than or equal to 40) for the vaccine strains ranged from 95 to 97% ...ave antibodies to these strains before vaccination. The geometric mean HAI titers
were strong and increased with dose. High HAI titers, similar to those see...
Vical Pandemic Influenza Vaccines Achieve T-Cell Responses and Cross-Clade Reactivity in Humans
...d previously reported that the monovalent vaccine achieved potentially protective levels of antibody responses (H5 hemagglutination inhibition, or HI, titers
of at least 40 and at least a four-fold increase from baseline) in at least 50% and up to 67% of evaluable subjects in a 100-subject Phase 1 trial. In...
U.S. Navy and U.S. Army to Develop Dengue DNA Vaccine Formulated With Vical's Vaxfectin(R) Adjuvant
...afe and well-tolerated at both the
1 mg low dose and 5 mg high dose tested, but even at the high dose induced
only low levels of neutralizing antibody titers
in less than half of the
animals. Under a Collaborative Research and Development Agreement (CRADA)
with Vical, the NMRC developed a tetravalent dengue...
Vical Expands Applications of Vaxfectin(R) Adjuvant for Infectious Disease and Cancer Vaccines; 80% to 100% of High-Dose Responders in H5N1 Clinical Trials Still Responding at 6 Months
pandemic influenza DNA vaccines achieved potentially protective levels of
antibody responses (H5 hemagglutination inhibition, or HI, titers
least 40 and at least a four-fold increase from baseline) in at least 50%
and up to 67% of evaluable subjects in the higher dose cohorts in a
Vical Announces Breakthrough for Pandemic Influenza DNA Vaccines With Preliminary Human Data
...es (defined as hemagglutination inhibition, or HI, titers
least 40; responses ranged from 40 to 640) i...es. Responders were
those subjects achieving H5 HI titers
of at least 40 and achieving at least
a four-fold ...kpiled by the U.S. government was approved with HI titers
40 or more in 44% of subjects by Day 56.
BioCryst Announces Initiation of Phase II Study of Intramuscular Peramivir for the Treatment of Seasonal Influenza
...ry endpoint of BioCryst's Phase II trial is improvement in
time to alleviation of symptoms in patients. Secondary endpoints include
reduction in viral titers
and safety and tolerability. The trial is
expected to enroll approximately 320 patients and will be conducted in the
Alba Therapeutics Announces the Presentation of Results of a Phase IIa Clinical Trial for Larazotide Acetate for the Treatment of Celiac Disease at the Digestive Disease Week Conference
...to Day 21 showed dose dependent prevention of increase in LAMA across the 4 and 8 mg treatment groups * Changes in PGWBI scores and anti-tTG titers
were not significant over the time course of this study * An unexpected enrollment effect resulted in a fall in intestinal permeability from...
Novavax Reports Positive Results from Preclinical Studies of its VLP-based Trivalent Seasonal Influenza Vaccine Candidate
.../strain which is the standard dose for currently licensed split and
subunit influenza vaccines. The vaccine candidate also induced protective
against a drifted strain in approximately 50% of ferrets
inoculated. A separate toxicology study conducted in rabbits showed the
trivalent vaccine was...
Titers in Medical Products
Autoimmune Hepatitis Panel Pluswith Reflex to Titers
Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
MBL Mannan Binding ELISA Kit
Description:...ssive treatment, recurring infections and autoimmune dieseases. Kit 030 designed especially for patients with autoimmune diseases giving rise to high titers
of rheumatoid factors or heterophile antibodies that may interfere with MBL ELISA based on antibody capture....
Fisher Sure-Vue® RF Rapid Latex Test Kit
Features:... CLIA Complexity: Non-waived
Can be used to both screen for levels of RF in serum greater than 10IU/mL and determine titers
of RF in serum in IU/mL using the semi- quantitative technique
Test results in two minutes
Test kit includes latex reagent, disposable slides (six-...
Titers in Medical Dictionary
...lso used to determine: ... VACCINE ANTIBODY titers
. Reprinted with permission from Antech News - November ... Determination of serum antibody titers
is one method commonly used to assess ... Antibody titers
vs. Annual Vaccination. Richard B. Ford, DVM, MS....
Titers in Biological News
Penn-Wistar team gains insight into HIV vaccine failure
.... The blood samples, which came from individuals with both high and low nAb titers
and thus varying degrees of pre-existing neutralizing antibodies to Ad5, ha...dy. From their current Ad5 assay, the team found no correlation between nAb titers
at baseline and CD4 T-cell frequency.
"Ad-specific CD4 T-cells are exce...
Influenza vaccine causes weaker immune response for children of rural Gabon than in semi-urban areas
...(poorer in rural areas). Following vaccination, influenza virus HI antibody titers
increased in both the rural and the semi-urban schoolchildren, but reache...d significantly higher levels in the semi-urban schoolchildren. The highest titers
were seen in semi-urban children not infected with helminths.
Titers in Biological Technology
Novavax Announces Selection of a Respiratory Syncytial Virus Vaccine Candidate for Advanced Preclinical Studies
...grams with and without adjuvant. The study showed that the RSV-F vaccine induced neutralizing antibody responses at all doses evaluated. The highest titers
were observed with vaccine formulations that contained an aluminum-based adjuvant. Following vaccination, mice were exposed to live RSV through the n...
Preclinical Proof-of-Concept Studies Published for Novavax Seasonal Influenza Virus-Like-Particle Vaccine
...15 mcg/strain, the dose used for currently licensed vaccines, developed HAI titers
greater than or equal to 1:40. This level of antibody has been shown to be...nfluenza vaccines. In addition, approximately 50% of ferrets developed HAI titers
greater than or equal to 1:40 against drifted H3N2 strains from the 1999, 2...
Genomatica Produces Pure BDO From Natural Sugars
...ith the "blueprint," Genomatica researchers then updated the microorganisms using a range of different state-of-the-art genetic techniques to increase titers
and reduce by-products. With significantly reduced by-products and using expertise from the traditional chemical industry, Genomatica's process engin...
Novavax Announces Enrollment in the Second Phase II Study of its Seasonal Influenza VLP Vaccine Candidate
... H1N1, and B influenza strains showed that the trivalent VLP vaccine candidate induced robust immune responses as measured by hemagglutinin inhibition titers
against both vaccine and drifted strains.
According to the Centers for Disease Control and Prevention (CDC), seasonal influenza affects 15 to 60...
PharmAthene Presents Data for SparVax(TM), a Novel Vaccine for the Prevention and Treatment of Anthrax Infection, at the 12th Annual Conference on Vaccine Research
...enic following the 3-dose series with response rates of approximately 90%. There were no significant differences in either TNA or ELISA geometric mean titers
(GMT) between the vaccine groups 14 days after the third vaccination. A strong immunologic memory response was observed at both 6 months and 12 months...
PharmAthene Presents Data for SparVax(TM) and Valortim(R), a Novel Vaccine and Anti-Toxin for the Prevention and Treatment of Anthrax Infection at the 7th Annual ASM Biodefense Meeting
... measured by ELISA on day 14 after the third dose. The data showed that the titers
were significantly higher on one regimen (by almost x5) than those on the other regimen. No significant differences in GM titers
were observed between groups that received different dose levels. An antige...
NOVAVAX and the University of Massachusetts Medical School Announce Preclinical Study Results for a Respiratory Syncytial Virus ('RSV') Vaccine Candidate
...r a placebo. The antibody responses to
the RSV VLPs were robust and higher than the antibody responses to inactivated
or live RSV. Further, antibody titers
increased with higher VLP doses.
Subsets of mice that had been immunized with either RSV VLPs via
intraperitoneal inoculation or live RSV via ...
Savient's Pegloticase Data in Treatment-Failure Gout Patients Presented at 72nd Annual Meeting of the American College of Rheumatology Conference
...d control remained relatively constant during extended therapy with pegloticase.
- Neutralizing antibodies and clinically relevant titers
of anti pegloticase IgE were not present in any of the patients with continued use of pegloticase out to as long as 18 months.
BioEnergy International, LLC Acquires Assets of OmniGene Bioproducts, Inc.
...B5), and the
amino acid methionine. In all cases, the organisms and processes developed
by OBI's scientists have set records for the highest published titers
their respective products. For more information visit
BioEnergy International, LLC is a p...
Peregrine Pharmaceuticals Reports Financial Results for Fiscal Year 2008
...rmacokinetics of bavituximab in patients co-infected with HCV and HIV.
Patient cohorts are receiving ascending doses of bavituximab. HCV and HIV
and other biomarkers are being evaluated.
-- In August 2007, Peregrine announced that the first GBM brain cancer
patient had been administered Cotar...
Titers in Biological Products
Anti-gp64 Antibody, Unconjugated from Novagen
Description:...ace of infected cells as early as 8-24 hours post-infection. This forms the basis of the FastPlax Titer Kit, which allows determination of baculovirus titers
in just 25-48 hours. The FastPlax Antibody can also be used to detect gp64 on Western blots....
FastPlax Titer Kit from Novagen
Description:... The FastPlax Titer Kit is designed for determination of baculovirus titers
in just 2448 hours instead of 46 days as in other methods. Classical determination of baculovirus titer has relied on the appearance of plaques, but t...
from QED Bioscience Inc.
Description:...gh titer IgG responses.
2. Test bleeds are evaluated by ELISA; bleeds are available to the client for testing.
3. The animals with the highest titers
for selected for fusion.
Estimated completion time: 10-14 weeks ($1,845.00)
PHASE II: FUSION
1. Spleen ...
Company:QED Bioscience Inc.