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Thymus in Medical News

Stimulating Thymus Reactivates T-Cell Production

Finding may provide benefit for HIV, bone marrow transplantation patients FRIDAY, Feb. 22 (HealthDay News) -- It's possible to stimulate the thymus gland to produce new immune system T-cells in adults infected with HIV, U.S. researchers say. HIV infection destroys T-cells, which lea...

Fluorescent probes may permit monitoring of chemotherapy effectiveness, Stanford study shows

...place to deal with viral infections, or just to complete their normal life cycle. Cells lining the gut, for example, or immune cells in the spleen and thymus are meant to live only a couple of days. "You lose three-quarters of a million cells per second in your body due to apoptosis," noted Guy Salvesen, Ph...

Rare disorder gives modelers first glimpse at immune system development

... DURHAM, N.C. -- Children born without thymus glands have given Duke University Medical Center r...tional Biology, tracked three young patients after thymus tissue transplantation to measure the growth of a ...th all of its diversity. Duke University pioneered thymus transplantation for children born with DiGeorge Sy...

Viral Genetics Has Option Under Issued Key Patent for Cancer Drug

...ral Genetics, Inc. is a biotechnology company that discovers and develops immune-based therapies for HIV, AIDS and other autoimmune diseases using its thymus nuclear protein compound (TNP). The company recently entered into an Exclusive License Agreement with the University of Colorado and V-Clip Pharmace...

CORRECTION: Viral Genetics Pursues Promising New Therapy for Lyme Disease With Grant from Time for Lyme, Inc.

...ral Genetics, Inc. is a biotechnology company that discovers and develops immune-based therapies for HIV, AIDS and other autoimmune diseases using its thymus nuclear protein compound (TNP). The company recently entered into an exclusive license agreement with the University of Colorado and V-Clip Pharmace...

Five UCSF Scientists Elected to National Academy of Sciences

... to the pancreatic beta cells, which are destroyed by the immune system in type I diabetes; he found, for example rare tolerance-inducing cells in the thymus that express the beta-cell specific insulin gene. As a graduate student, Hanahan developed high efficiency plasmid transformation methods and E. c...

UBC research finds molecular "key" to successful blood stem cell transplants

...w blood. The stem cells then need to travel to the thymus - an organ near the heart - and produce T-cells, a...nts is the failure of stem cells to repopulate the thymus and generate T-cells. Without T-cells the patient ...identified a molecule called S1P that can tell the thymus to "open the gates" and accept more stem cells. ...

Scripps Research cancer biology department awarded more than $8 million in new research grants

...upport Petrie's work understanding regrowth of the thymus in adults and the elderly. Decreases in T cell im... cells (which form the supportive framework of the thymus and other organs). Using an experimental model of thymus regrowth, Dr. Petrie and his colleagues will seek ...

AAI honors Chen Dong for breakthrough T lymphocyte research

...ther Th1 or Th2 pathways. It was black and white, one or the other," Dong said. T cells are lymphocytes, a type of white blood cell produced by the thymus equipped with receptors that recognize and bind to antigens, pieces of invading organisms presented to the T cells by dendritic cells. The bound antig...

Dendritic cells ensure immune tolerance

...tic cells, even the first, central screening of autoreactive T cells in the thymus runs only at reduced efficiency," reports Vhringer. "In these animals, the thymus releases T cells that react to the body's own material. These are then acti...
Thymus in Medical Technology

Researchers Train the Immune System to Deliver Virus That Destroys Cancer in Lab Models

...ncer has spread. Dr. Vile and colleagues theorized that they could control the spread of cancer through the lymphatic system (bone marrow, spleen, thymus and lymph nodes) by manipulating the immune system. Researchers zeroed in on immature T-cells from bone marrow, programming them to respond to spe...
Thymus in Medical Definition

Autoimmune regulator

... AIRE , is a human gene which is expressed in the thymus . It causes transcription of a wide selection of...e set of self-antigens, such as insulin , in the thymus . [3] This expression then allows maturing thy...jection of an Immunological Self-Shadow Within the thymus by the Aire Protein. Science 298 (5597), 1395-1401...

Central tolerance

...the host). In mammals the process occurs in the thymus (T cells) [2] [3] and bone marrow (B cell...ional sources of antigen are made available in the thymus by the action of the transcription factor AIRE . ....html ^ Sprent J, Kishimoto H (2001). "The thymus and central tolerance". Philos Trans R Soc Lond B...

Thymocyte

...ytes are T cell precursors which develop in the thymus . The processes of beta-selection, positive select...on 2 Events during maturation 2.1 thymus Settling 2.2 Beta selection 2.3 Po...lso fail, autoimmunity may arise. thymus Settling Thymocytes are ultimately derived from...
Thymus in Medical Dictionary

Thymus

In human anatomy, the thymus is an organ located in the upper anterior portion of the chest cavity just behind the sternum. The main function of the thymus is to provide an area for T lymphocyte maturation, and is vital in... thymus n. , pl. -muses . A small glandular organ that...

Myasthenia gravis

...oline receptors at... What is the role of the thymus gland in myasthenia gravis ? ... Myasthenia...hich symptoms include ... What is the role of the thymus gland in myasthenia gravis ? ... Myasth...ia gravis may be associated with tumors of the thymus (an ... The hallmark of myasthenia gravis ...

Mediastinum

...right and left pleuræ in and near the median ... The Posterior Mediastinum (Figs. ... In the superior mediastinum look for remnants of the thymus gland (142/N207) ... The bifurcation of the trachea lies in the superior mediastinum . ... Define the boundaries of the posterior mediast...

Glands

...re the hypothalamus, ... Glands are either. formed in the ... The extremely large salt glands dominate the skull space lateral to ... The thymus glands can be located by tracing along ... In fact, the adrenal glands naturally produce more cortisol during stress. ... Endocrine glands...

Endocrine glands

...ction to Endocrinology & Endocrine Surgery. Endocrinology Overview. Thyroid Gland ... Learn about endocrine glands . An Overview of the thymus ... gland help regulate the functions of other endocrine glands . ... Multiple Endocrine Neoplasia Type 1 ... The endocrine system does n...

DiGeorge Syndrome

... syndrome — Comprehensive overview covers causes, symptoms, treatment of this chromosomal disorder. ... with DiGeorge syndrome , the thymus ... Overview: Conditions associated with DiGeorge syndrome are the other 22q11 deletion syndrome (22q11DS) known as the velocardiofacial s...

Colds and flus

...wn. ... Colds and flus are caused by viruses. Or ... Tips on Preventing Colds and Flus ... If prone to colds and flus , consider thymus extract (animal glandular) or a ... A common misperception is that colds are associated with winter weather. But research shows that people act...
Thymus in Biological News

Children's Hospital of Pittsburgh of UPMC scientists identify enzyme important in aging

...em into old age by maintaining the function of the thymus throughout life, according to researchers studying... of UPMC, reports that the novel mouse model has a thymus that remains intact throughout its life. In all ma...ay have the ability to restore the function of the thymus in old age, or perhaps by intervening at an early ...

They are young and need the job: A second chance for dangerous T-cells

... 10 June 2009) During their development in the thymus gland, a kind of 'T-cell school', every T-cell is ...re is also a constant production of T-cells in the thymus that may recognize and attack the body's own struc... been reprogrammed during their development in the thymus so that they can no longer cause any damage. In fa...

Novocell awarded seminal stem cell patent

...cell is developing for use as a cell therapy for diabetes, but also other endoderm lineage-derived tissues and organs such as lungs, intestine, liver, thymus and thyroid. "This composition patent is a milestone achievement for Novocell and is the culmination of extensive research that opened the door t...

Fireflies and jellyfish help illuminate quest for cause of infertility

...lved." The research, funded by the Wellcome Trust, identified cells producing prolactin throughout the body. This included the pituitary gland, the thymus an organ in the chest which helps protect against autoimmunity the spleen and inflammatory cells in the abdominal cavity. ...

Genetic study shows direct link between vitamin D and MS susceptibility 'gene'

...e immune system, to perform its regular tasks. The thymus produces an army of T cells, which identify invadi...body's own cells or proteins. Ordinarily, the thymus will regulate the T cells and delete those that po... during early life might impair the ability of the thymus to delete these T cells, which then go on to attac...

Identification of protein able to stimulate production of T-cells

...archers determined that elevated levels of Wnt4 led to a marked increase in the number of white blood cell progenitors, and of immature T cells in the thymus in particular. Conversely, they found that deletion of the Wnt4 gene and lack of the corresponding protein was associated with a decrease in the n...

Immune police recognize good and bad guys in the body

...ognize in the thymus. They also reported that most Tregs that mature in the thymus retain their regulatory properties and do not later convert to nave T cells as was previously believed. This finding emphasized the role of the thymus as the primary site where Tregs differentiate and acquire their unique inhi...

Mice stressed in simulated weightlessness show organ atrophy

... Rutgers researchers should look at the spleen and thymus the organs responsible for most of the animals immune cells. If stress affects the spleen and thymus so that they atrophy, the immune system becomes im...We had no basis to expect this, but the spleen and thymus of the OPN-deficient animals remained normal where...

'Nurse cells' make life and death decisions for infection-fighting cells

...gan in the upper portion of the chest. Loss of the thymus results in severe immunodeficiency and increased s...infection. The function of T cells produced by the thymus is to recognize harmful invaders. Once invaders ha...rse cells are performing a much bigger role in the thymus than we thought." Thymic nurse cells were giv...

Thymus transplants gives hope to babies with fatal immune disease

...turn three in September, thanks in large part to a thymus transplant she received at Duke University Medical... show that 75 percent of the babies who received a thymus transplant were alive after one year. The recipien.... However, about 1 percent of these babies have no thymus at all, a situation that ends in death, usually by...
Thymus in Biological Technology

Viral Genetics Creates Subsidiary to Develop Cancer Therapy

...no, California, Viral Genetics discovers and develops drug therapies to treat infectious, autoimmune, and immunological deficiency disorders using its thymus nuclear protein compound (TNP). The company recently entered into an Exclusive License Agreement with the University of Colorado and V-Clip Pharmaceut...

Viral Genetics Retires Nearly $3.5 Million Convertible Debt and Provides Updates on Capital Structure and Stock Issuances

...ral Genetics, Inc. is a biotechnology company that discovers and develops immune-based therapies for HIV, AIDS and other autoimmune diseases using its thymus nuclear protein compound (TNP). The company recently entered into an Exclusive License Agreement with the University of Colorado and V-Clip Pharmaceut...

Viral Genetics Information Now Available Through OTCIQ.com and Pink Sheets Website

...ral Genetics, Inc. is a biotechnology company that discovers and develops immune-based therapies for HIV, AIDS and other autoimmune diseases using its thymus nuclear protein compound (TNP). The Company recently licensed technology developed by M. Karen Newell, PhD from the University of Colorado , that app...

CuraGen and TopoTarget Announce Initiation of an NCI-sponsored Phase II Clinical Trial of Belinostat for Thymoma and Thymic Carcinoma

...esident and Chief Executive Officer of CuraGen Corporation. About Thymoma and Thymic Carcinoma Thymoma and thymic carcinoma are rare tumors of the thymus with fewer than 1000 patients diagnosed in the United States per year. Histologically the tumors are of epithelial origin and can be classified as wel...

A Large-Scale Research Project by a Dutch Consortium Addressing a Global Problem

... therapies to activate and manipulate the immune system, through two platforms: use of temporary sex steroid suppression to effect rejuvenation of the thymus and bone marrow, with resulting enhancement of T cell function and immune responsiveness; and the development of adjuvanted virosomes for vaccines bas...

EFFECTS OF INSTRUMENT RESOLUTION ON ASSESSMENT OF DNA PURITY

...1700 (fixed bandwidth, 1nm), and the UV-1240 (fixed bandwidth ,5nm). Calf thymus DNA and Bovine serum albumin were obtained from Sigma Chemical Company, St....strated in Figure 1. In this figure, a sample of approximately 73 g/mL calf thymus DNA in physiological buffer was measured using a Shimadzu UV-2401 spectroph...

Use of the DCode System to Detect the Food-Borne Bacterial Pathogen Listeria monocytogenes

... intensity of the reaction product was determined in a fluorescence spectrometer at 435 nm using an excitation wavelength of 360 nm. Calf thymus DNA was used as a standard. POLYMERASE CHAIN REACTION PCR was performed with a Bio-Rad Gene Cycler using PfuTM or P...

The Bio-Rad Silver Stain, Rev E

...B, Anal Biochem 148, 357364 (1985) 84. Wahl AF et al., Immunoaffinity purification and properties of a high molecular weight calf thymus DNA α-polymerase, Biochemistry 23, 18951899 (1984) 85. Welte K et al., Purification and biochemical characterization of ...

Whole Gel Eluter Purification of a Functional Multiprotein DNA Replication Complex, Rev A

...Silver Stain Plus kit (Bio-Rad). DNA POLYMERASE α ASSAY DNA polymerase α activity was assayed with an activated calf thymus DNA template (Sigma Co.) according to published procedures, 2 using [ 32 P]dTTP in place of [ 3 H]dTTP in the assay. ...

Quantitation of DNA for Automated Sequencing Using the VersaFluor Fluorometer

...rying DNA concentrations made by serial dilution of control calf thymus DNA. All dilutions were made in 2 ml of 1 g/ml Hoechst 33258 dye...g the upper range value at 10,000 RFU using 10 l of 1 mg/ml calf thymus DNA and using 2 l of the sample DNA in 2 ml of the 1 g/ml Hoechs...
Thymus in Biological Products

Rapid-Screen Arrayed cDNA Library Panels Master Plates -Mouse Thymus from OriGene Technologies

Description: The Rapid-Screen cDNA Library Panels were designed for full-length gene cloning and require just three sets of PCRs to identify the desired cDNA clone. The first PCR analysis is performed in a 96-well "Master Plate," where each well contains plasmid DNA from 5,000 clones. Having identified the posi...
Company:OriGene Technologies

Rat CXCL7 (NAP-2) ELISA development Kit, DuoSet from R&D Systems

Description:...This DuoSet ELISA Development kit contains the basic components required for the development of sandwich ELISAs to measure natural and recombinant rat thymus Chemokine-1 in cell culture supernates and serum. Each kit contains sufficient materials to run ELISAs on approximately fifteen 96-well plates, provid...
Company:R&D Systems

DNA Quantitation Kit (Hoechst) from Bio-Rad

Description:...with a VersaFluor or other fluorometer. The kit quantitates dsDNA in the range of 10 ng per ml to 5 micrograms per ml and contains Hoechst 33258, calf thymus DNA standard, and assay buffer for 750 standard 2 ml reactions....
Company:Bio-Rad

Calf Topoisomerase I from USB Corp.

Description:... Source: Calf thymus Description: Topoisomerase I relaxes both positively and negatively supercoiled DNA by a transient breakage and rejoining of phosphodiester bonds (1...
Company:USB Corp.
Thymus in Biological Definition

Antigen

... In order to keep the cytotoxic cells from killing cells just for presenting normal proteins, they run through a test cycle (negative control in the thymus ) just after their production. Only those CTL that do not react to normal body protein fragments are allowed to enter the bloodstream. ...

Immune system

...system (only found in vertebrates [1] ), composed of four lymphoid organs ( thymus , lymph nodes , spleen and submucosal lymphoid nodules) and the group mo...d by T cells , also called T lymphocytes (T means they develop in the thymus ). There are two major types of T cells: Cytotoxic T cells (T C c...

Immunology

...e to be part of the immune system. The key organs of the immune system are thymus , spleen , bone marrow , lymph vessels , lymph nodes and secondary lym...tissues such as tonsils and adenoids ) and skin . The major organs, the thymus and spleen, are examined histologically only post-mortem during autopsy ...

T cell

...lay a large role in the immune response . The abbreviation "T" stands for thymus , the organ in which their final stage of development occurs. There are m... These cells lose either their CD4 molecules or CD8 molecules and leave the thymus via postcapillary venules. Hormonal substances (thymosin, interferon &gam...
Thymus in Biological Dictionary

Uracil

...aturally occurring pyrimidine derivative. Originally discovered in 1900, it was isolated by hydrolysis of yeast nuclein that was found in bovine thymus and spleen, herring sperm, and wheat germ. It is... uracil n. ( Abbr. U ) A pyrimidine base, C 4 H 4 N 2 O 2 , that is an essential constituent...

Thymus gland

... In human anatomy, the thymus is an organ located in the upper anterior porti...just behind the sternum. The main function of the thymus is to provide an area for T lymphocyte maturation. The thymus also... ...

Thoracic cavity

...cavity , you can add more facts here " ... OPENING THE THORACIC CAVITY ... ARTERIES OF THE THORACIC CAVITY ... Thoracic cavity opened, thymus gland removed properly. Brachiocephalic Artery ... Gray, Henry. 1918. Anatomy of the Human Body. V. Angiology. 4. The Thoracic Cavity ... The ...

T lymphocytes

...ferentiate ... T cell n. Any of the lymphocytes that mature in the thymus and have the ability to recognize specific peptide antigens through the...ns such ... " T " lymphocytes are so called because of the role that the thymus gland plays in ... Immunobiology is intended as an introductory text fo...

Nuclein

...in (n&oomacr;'klē-ĭn, ny&oomacr;'-) n. ... mus), so it was named thymus nuclein . ... nuclein and protein further. ... Because of the acid beh..... was isolated by hydrolysis of yeast nuclein that was found in bovine thymus and ... Except where noted otherwise, data are given for ... This fun DN...

Lymphocytes

...d in the blood, lymph, and lymphoid tissues, constituting approximately 25 percent of white T cell n. Any of the lymphocytes that mature in the thymus and have the ability to recognize specific peptide antigens through the receptors on their lymphocytes . monocytes ... consist of lymphocyt...

Endocrine glands

...blood by endocrine glands . ... (Click to enlarge) endocrine gland endocrine glands A. thyroid B. pituitary gland C. pineal gland D. thymus E ... Some endocrine glands respond directly to ... 1 Introduction To The Endocrine System. 2 Types of Glands . 3 Hormones and Types ... The...

Ductless glands

... glands endocrine gland , ductless gland any of the glands of the endocrine system that secrete hormones directly into the ... gland , thymus — a ductless glandular ... Ductless Glands . From LoveToKnow 1911. DUCTLESS GLANDS , in anatomy. ... of the histology of this as well as of...

Cell-mediated immunity

...ectly attacking foreign antigens. T lymphocytes participate in... ... Immunity . Cell - mediated Immunity . Humoral ... but sensitized in the thymus and constitute the basis of cell - mediated immunity . ... Cell - mediated immunity ... Cell - mediated immunity summary with 11 pages o...

CDNA array

.... Software and methods for oligonucleotide and cDNA array data analysis ... The cDNA array experiment compared gene expression in the thymus of the mutant ... ...
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