Upside-down world: DNA protecting protein helps cancer drug to kill cells

...tment of colorectal cancer. But precisely how the drug kills cancerous cells was not well understood. It was generally thought that as an inhibitor of thymidylate synthase the compound worked by starving cells of the thymidine needed to make DNA. First author on the paper Christophe Kunz and his colleagues i...

What are simple ways to judge the efficacy of 5-fluorouracil in colonic neoplasm?

...chemotherapeutical drug. It exerts its antitumor effect through competitive thymidylate synthase (TS) inhibition. thymidylate synthase (TS) catalyses deoxyuridine-5-monophosphate (dUMP) to 2-deoxythymy...

Studies suggest key correlation between lung cancer subtype and treatment outcomes

...majority of the patients on the trial. The retrospective analysis was driven by preclinical data that suggested patients with a lower expression of thymidylate synthase (TS) enzyme show an increased efficacy when treated with ALIMTA. , The histological type of NSCLC is determined by how the cancerous cells ...

Thymidylate in Medical Technology

ADVENTRX Announces Preliminary Response Rate Data From Discontinued Phase 3 Trial of CoFactor(R)

...otherapeutic agent 5-fluorouracil. Compared to leucovorin, CoFactor creates more stable binding between the active form of 5-FU and the target enzyme, thymidylate synthase. CoFactor bypasses the metabolic pathway required by leucovorin to deliver the active form of folate, potentially allowing 5-FU to work more ...

ADVENTRX Announces Completion of Patient Enrollment in Phase 2 Clinical Trial of CoFactor(R) for the Treatment of Advanced Breast Cancer

...used cancer chemotherapeutic agent 5-FU. Compared to leucovorin, CoFactor creates more stable binding of the active form of 5-FU to the target enzyme, thymidylate synthase (TS). CoFactor bypasses the metabolic pathway required by leucovorin to deliver the active form of folate, potentially allowing 5-FU to work ...

Studies Suggest Key Correlation Between Lung Cancer Subtype and Treatment Outcomes

...that suggested patients with a lower expression of thymidylate synthase (TS) enzyme show an increased efficacy wh...r human colon cancer cells is associated with thymidylate synthase overexpression. Biochem Pharmacol 20...s higher messenger RNA and protein levels for thymidylate synthase. Cancer 2006; 107:1589-96. (5) National ...

ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer

...cancer chemotherapeutic agent 5-FU. In comparison to leucovorin, CoFactor creates more stable binding of the active form of 5-FU to the target enzyme, thymidylate synthase (TS). CoFactor bypasses the metabolic pathway required by leucovorin to deliver the active form of folate, allowing 5-FU to work more effecti...

ADVENTRX to Present CoFactor Multiagent Therapy Data at AACR Annual Meeting

...otherapy 5-fluorouracil (5-FU). In comparison to leucovorin, CoFactor creates more stable binding of the active form of 5-FU to the target enzyme, thymidylate synthase (TS). CoFactor bypasses the metabolic pathway required by leucovorin to deliver the active form of folate, allowing 5-FU to work more eff...

Adventrx Announces Positive Data From Multidrug Therapy With CoFactor

...chemotherapy 5-fluorouracil (5-FU). In comparison to leucovorin, CoFactor creates more stable binding of the active form of 5-FU to the target enzyme, thymidylate synthase (TS). CoFactor bypasses the metabolic pathway required by leucovorin to deliver the active form of folate, allowing 5-FU to work more effecti...

CuraGen Presents Update on Clinical Development Program for Belinostat

...range 2 - 8 cycles), with 2 patients currently on treatment, and no objective responses noted. No consistent effect has been seen on the expression of thymidylate synthase (TS) in peripheral blood mononuclear cells from this population. Enrollment of patients is continuing into the 1000 mg/m2/d belinostat and 50...

Thymidylate in Biological Technology

ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer

...cancer chemotherapeutic agent 5-FU. In comparison to leucovorin, CoFactor creates more stable binding of the active form of 5-FU to the target enzyme, thymidylate synthase (TS). CoFactor bypasses the metabolic pathway required by leucovorin to deliver the active form of folate, allowing 5-FU to work more effecti...

Oragene is compatible with TaqMan SNP genotyping

...ragene works well with TaqMan SNP Genotyping Assays. SNPs in the thymidylate synthetase and apolipoprotein E genes were reliably detected. ...n plots Figure 1 shows the allelic discrimination plot for the thymidylate synthetase assay and Figure 2 shows the plot for the apolipoprot...

Oragene and DNA sequencing with ABI PRISM

... kit. Primer design PCR primers for the human thymidylate Synthase (TYMS) gene were designed based on the publicly availab...t program. All 5 samples correctly aligned to the original human thymidylate Synthase gene sequence. Figure 1 shows a representative ABI PRIS...

Oragene and Whole Genome Amplification with GenomiPhi

...electrophoresis for a 560 bp fragment of the human thymidylate synthetase gene. SNP genotyp... A TaqMan SNP Genotyping Assay for the thymidylate synthetase (TYMS) gene was obtained fro...ure 3 shows an allelic discrimination plot for the thymidylate synthetase assay. The plot is presented...

Thymidylate in Biological Products

Mouse Anti-Thymidylate Synthase Monoclonal Antibody, Unconjugated, Clone 3A7.A11 from Abcam

Description:... Mouse monoclonal [3A7.A11] to thymidylate Synthase ( Abpromise for all tested applications). entrezGeneID: 7298 SwissProtID: P04818...
Company:Abcam

Chicken Anti-DCTD (dCMP deaminase) Polyclonal Antibody, Unconjugated from GenWay Biotech, Inc.

Description:... DCTD_HUMAN GI Number: 4503277 Accession Number: NP_001912.1 MW: 20016 Description: FUNCTION: Supplies the nucleotide substrate for thymidylate synthetase. CATALYTIC ACTIVITY: dCMP + H 2 O = dUMP + NH 3 . SUBUNIT: Homohexamer. SIMILARITY: Belongs to the Diseases: Benign Tumor; Leukemia; Escher...
Company:GenWay Biotech, Inc.