Thrombin

Haemacure and Angiotech Enter License, Distribution and Supply Agreements for Haemacure's All-Human Fibrin Sealant and Thrombin Products

HAE:TSX Haemacure Completes US$2.5 Million Bridge Financing from Angiotech MONTREAL, June 3 /PRNewswire-FirstCall/ - Haemacure Corporation (TSX:HAE), a Montreal-based specialty bio-therapeutics company, announces that Haemacure and Angiotech Pharmaceuticals, Inc. (NASDAQ: ANPI , T...

Haemacure Reports on Strategic Collaboration with Angiotech Pharmaceuticals, Inc. and Second Quarter 2009 Financial Results

...ution and supply rights related to Haemacure's all-human fibrin sealant and thrombin products, both of which are currently in development. Bridge Financing...aise in order to complete the development and launch our fibrin sealant and thrombin products on the market, said Joseph Galli, Chairman and Chief Executive Off...

Schering-Plough Reports Financial Results for 2009 First Quarter

...isease who have failed prior therapy. (Announced March 11) Reported on a Phase II study published in The Lancet of the company's novel oral thrombin receptor antagonist (TRA), which showed no increase in TIMI major and minor bleeding and was well tolerated when given with standard platelet therapy....

Frost & Sullivan Commends Nycomed for Excellence in Product Differentiation Innovation

...e bioactive mechanism of action of human coagulation factors fibrinogen and thrombin with a collagen patch for mechanical support." TachoSil effectively fu...attendant safety concerns related to the bovine protein Aprotinin or bovine thrombin which carries the risk of allergic reactions, autoimmune syndromes and tran...

Final Patient Completes Treatment In Boehringer Ingelheim's RE-LY(R) Study, The Largest Atrial Fibrillation Outcomes Trial To Date

...e long-term efficacy and safety of the oral direct thrombin inhibitor dabigatran etexilate with the current st...ate Dabigatran etexilate is a direct reversible thrombin inhibitor (DTI), in a new class of oral anticoagul...cifically and selectively blocking the activity of thrombin (both free and clot-bound), the central enzyme in ...

Investigational Drug May Help Avert Blood Clots

...ppears able to uncouple two important functions of thrombin in the formation of blood clots and that it might ...ntrol bleeding and blot clot formation during PCI. thrombin is a protein in the blood that activates platelets... clump together to form the scaffolding of a clot. thrombin also helps produce fibrin, a protein that plays an...

Redesigned protein accelerates blood clotting

...mical stability by 30 percent increase. It reduced the ability of A2 to break away from factor VIIIa by 800 percent, and brought about an increase in thrombin generation capacity of 220 percent. "Moving forward, we are excited about this line of work because we have identified further changes that promi...

ThermoGenesis Introduces New Cell Separation Technology for Veterinary Use at Major Equine Convention

...hrough independent distributors in Europe and South America. -- The thrombin Processing Device(TM) (TPD(TM)) is a sterile blood processing disposable that prepares activated thrombin from a small aliquot of plasma in less than 30 minutes. The CE-Marked TPD i...

Haemacure's Human Fibrin Sealant Demonstrates Effectiveness in Skin Graft Fixation Proof-of-Concept Study for Burn Injury

...strongly suggest that the use of Haemacure's fibrin sealant, with a reduced thrombin concentration, may provide advantages over staples and sutures, the current... effectiveness of tissue fixation, rather than hemostasis. As a result, the thrombin concentration of the fibrin sealant was reduced to provide additional time ...

ThermoGenesis Announces Management Transition; Provides Update on Operational Milestones

...rough independent distributors in Europe and South America. -- The thrombin Processing Device(TM) (TPD(TM)) is a sterile blood processing disposable that prepares activated thrombin from a small aliquot of plasma in less than 30 minutes. The CE-Marked TPD i...

Thrombin in Medical Technology

Schering-Plough's Investigational Oral Thrombin Receptor Antagonist Meets Primary Endpoint in a Newly Published Study

A Phase II Study Published in The Lancet of Fast-Tracked Antiplatelet Agent Showed No Increase in TIMI Major and Minor Bleeding and was Well Tolerated When Given With Standard Platelet Therapy KENILWORTH, N.J., March 12 /PRNewswire-FirstCall/ -- Results of a Schering-Plough Corporation (NYSE:...

Nuvelo Initiates Phase 1 Clinical Trial of Thrombin Inhibitor, NU172

SAN CARLOS, Calif., Jan. 30 /PRNewswire-FirstCall/ -- Nuvelo, Inc. (Nasdaq: NUVO ) today announced that it has enrolled the first patient in a single-center, Phase 1 trial to determine the safety, tolerability and pharmacokinetics of escalating doses of NU172, a thrombin-inhibiting aptamer, i...

The Lancet Publishes Major Phase 3 Study on Novel Oral Direct Thrombin Inhibitor

Study results outline dabigatran etexilate as potential thromboprophylaxis therapy for patients undergoing total hip replacement surgery RIDGEFIELD, Conn., Sept. 13 /PRNewswire/ -- Boehringer Ingelheim today announced that the September 15 issue of The Lancet will publish results from the R...

Study Shows Plasma-Derived Human Thrombin Equivalent to Bovine Thrombin in Achieving Hemostasis in Surgery

Results presented at the 6th Annual Meeting of the Society for the Advancement of Blood Management (SABM). Separate study presented at SABM finds EVICEL* Fibrin Sealant (Human) more effective than manual compression in achieving hemostasis in vascular ...

Schering-Plough Announces Presentation of Phase II Trial Results for Novel Oral Thrombin Receptor Antagonist at the 2007 Annual Meeting of The American College of Cardiology/i2 Summit

KENILWORTH, N.J., March 12, 2007 /PRNewswire-FirstCall/ -- Schering-Plough Corporation announced today that results of the Phase II trial of its novel oral thrombin receptor antagonist (TRA) SCH 530348 will be presented at the 2007 annual Scientific Sessions of the of Cardiology (ACC.07)/Innovatio...

New Study Using Combination of Bioengineered Skin and Stem Cells Shows Promise in Treatment of Non-Healing Wounds

... advantage of the immediate polymerization, or 'gluing,' of stem cells in fibrinogen when mixed with thrombin," said Dr. Falanga. "Both fibrinogen and thrombin are naturally occurring substances in blood which, when mixed to form fibrin, are normally involved in the formation of a clot. In this case, the two ...

ThermoGenesis Announces MXP Involvement in New Regenerative Medicine Initiatives

...through independent distributors in Europe and South America. The thrombin Processing Device(TM) (TPD(TM)) is a sterile blood processing disposable that prepares activated thrombin from a small aliquot of plasma in less than 30 minutes. The CE-Marked TPD i...

ProFibrix Steps up Recombinant Fibrinogen Program With PER.C6(R) License From Crucell

...commercial, clinical and scientific experience in the hemostasis field. Fibrocaps, the company's lead product, is based on a mixture of fibrinogen and thrombin and is a unique dry powder topical tissue sealant that stops acute and severe bleeding after trauma injury or during surgery. Fibrocaps has major adva...

Schering-Plough Highlights R&D Pipeline Progress, Innovation and Breadth of Research Projects

...Highlights In reviewing the company's portfolio, presenters highlighted the following projects in the company's pipeline: thrombin Receptor Antagonist (TRA), a novel antiplatelet agent that can potentially prevent the formation of deadly blood clots without adding a significant bl...

Nuvelo Announces Positive Phase 1b Proof-of-Concept Data With Anticoagulant NU172

...novel drugs for acute cardiovascular disease, cancer and other debilitating medical conditions. Nuvelo's development pipeline includes NU172, a direct thrombin inhibitor which has completed Phase 1 development for use as a potential short-acting anticoagulant during medical or surgical procedures; and NU206, ...

Thrombin in Medical Products

Thrombin Time with Reflex to Thrombin Time 1:1 Mix

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

STA THROMBIN 2

Description: Determination of the Thrombin Time by STA Analyzers. Freeze-dried human thrombin (1.5NIH units/mL) with calcium....
Company:Diagnostica Stago, Inc.

STA THROMBIN 10

Description: Determination of the Thrombin Time by STA Analyzers. Freeze-dried human thrombin (1.5NIH units/mL) with calcium....
Company:Diagnostica Stago, Inc.

BD Vacutainer® Specialty Tubes - Thrombin

Description: BD Vacutainer® Specialty Tubes - Thrombin...
Company:BD Diagnostic Systems

Pefakit TDT

Description:... Assay for Determination of Initial thrombin Formation...
Company:Centerchem, Inc.

STA STACHROM AT III

Description:... Colorimetric Assay of Antithrombin III Activity by STA© Analyzers. Bovine thrombin ~12NIH units/mL, freeze-dried....
Company:Diagnostica Stago, Inc.

STA FIBRINOGEN 5

Description:... Quantitative determination of Fibrinogen by STA Analyzers (Clauss Method). Freeze-dried human thrombin (~100NIH units/mL) with heparin inhibitor and calcium....
Company:Diagnostica Stago, Inc.

FIBRI-PREST AUTOMATE 2

Description:... Quantitative determination of Fibrinogen (Clauss Method). Freeze-dried human thrombin (~100NIH units/mL) with heparin inhibitor and calcium....
Company:Diagnostica Stago, Inc.

CROSSEAL*

Description:... is ineffective or impractical. CROSSEAL* Fibrin Sealant (Human) delivers a unique formulation of human Biologically Active Component (BAC) and human thrombin with a high-precision, needle-free application device. It may be sprayed to cover the wound with a transparent layer providing good visualization, and...
Company:Ethicon, Inc.

ActCel Hemostatic Gauze

Description:... hemostatic agent registered with the FDA to help control bleeding from open wounds and in body cavities. The material contains no chemical additives, thrombin or collagen and is hypoallergenic. When it comes in contact with blood, it expands to 3-4 times its original size and converts to a gel that dissolves...
Company:ActSys Medical, Inc.

More>>

Thrombin in Medical Dictionary

Vasodilation

...ldosterone • hypertension • renin • ultrasonics • vasodilation ... BK promotes vasodilation ,1 exerts antiproliferative effects,2 inhibits thrombin ... Although BK is known to cause vasodilation through the B2 receptor and through ... Britannica online encyclopedia article on vasodilation ...

Protein C

... Protein C is a major physiological anticoagulant. It is a vitamin K-dependent serine protease enzyme (EC 3.4.21.69) that is activated by thrombin into activated protein C (APC). The activated form degrades Factor Va and... Protein C deficiency is a rare genetic trait that predisposes t...

Fibrinogen

...or the coagulation of blood and is converted to fibrin by the action of thrombin in fibrin n. An elastic, insoluble, whitish protein produced by the action of thrombin on fibrinogen and forming an interlacing fibrous network in the FIBR...

Fibrin

...ectin on ... As shown by immunohistochemistry, fibrin deposition and increased vWF expression ... When injury occurs to a blood vessel wall, thrombin (a coagulation enzyme) is formed in the first stage of a complicated series of steps called the coagulation ... ...

Thrombin in Biological News

Findings released from 1 of the largest percutaneous coronary intervention trials ever

...ter/NewYork-Presbyterian and chairman of the Cardiovascular Research Foundation, has shown that heart attack patients who were administered the direct thrombin inhibitor bivalirudin during primary angioplasty had a reduced rate of adverse clinical events, a lower rate of major bleeding, and a lower mortality ...

American Chemical Society's Weekly PressPac -- Nov. 7, 2007

... blood clot responsible for some strokes and most heart attacks, the scientists say. ARTICLE #2 FOR IMMEDIATE RELEASE Anti-Helicobacter pylori and thrombin Inhibitory Components from Chinese Dragon's Blood, Dracaena cochinchinensis DOWNLOAD HTML http://pubs.acs.org/cgi-bin/sample.cgi/jnprdf/2007/70/i...

Polymer aids in blood clotting, pointing way to new treatment

...hampaign. The inorganic compound accelerates two parts of the coagulation cascade -- the contact-activation pathway and factor V, a protein that forms thrombin -- leading to fibrin and clots. Finally, he said, polyphosphate delays the breakdown of clots, which causes renewed bleeding. "The net effect is ac...

Thrombin in Biological Technology

Angiotech Enters License, Distribution and Supply Agreements for Fibrin and Thrombin Technologies with Haemacure Corporation

Angiotech to Provide $2.5 Million Bridge Facility to Haemacure VANCOUVER, June 3 /PRNewswire-FirstCall/ - Angiotech Pharmaceuticals, Inc. (NASDAQ: ANPI , TSX: ANP), a specialty pharmaceutical and medical device company, announced today the completion of a collaboration transaction with Haem...

Angiotech Pharmaceuticals, Inc. announces financial results for the second quarter ended June 30, 2009

...ith Haemacure Corporation. In June 2009, we announced that we had entered into license, distribution, development and supply agreements for fibrin and thrombin technologies with Haemacure Corporation ("Haemacure"). The collaboration provides us with access to technology for certain of our surgical product can...

Schering-Plough Reports Financial Results for 2009 Second Quarter

...cal. The company noted that the "Five Stars" in its product pipeline, highlighted at its November 2008 R&D Update meeting, continued to advance: thrombin receptor antagonist (TRA), in Phase III for atherothrombosis; SIMPONI (golimumab), a subcutaneous treatment for certain inflammatory diseases; SAPHRIS...

ARCA biopharma to Present at 27th Annual JPMorgan Healthcare Conference

...novel drugs for acute cardiovascular disease, cancer and other debilitating medical conditions. Nuvelo's development pipeline includes NU172, a direct thrombin inhibitor which has completed Phase 1 development for use as a potential short-acting anticoagulant during medical or surgical procedures; and NU206, ...

Nuvelo Shareholders Approve Issuance of Common Stock Pursuant to Merger Agreement With ARCA biopharma

...novel drugs for acute cardiovascular disease, cancer and other debilitating medical conditions. Nuvelo's development pipeline includes NU172, a direct thrombin inhibitor which has completed Phase 1 development for use as a potential short-acting anticoagulant during medical or surgical procedures; and NU206, ...

Nuvelo Announces Positive Results from Phase 1 Clinical Trial of NU206 in Healthy Volunteers

...novel drugs for acute cardiovascular disease, cancer and other debilitating medical conditions. Nuvelo's development pipeline includes NU172, a direct thrombin inhibitor which has completed Phase 1 development for use as a potential short-acting anticoagulant during medical or surgical procedures; and NU206, ...

Soliris(R) Reduced Measures of Thrombosis and Inflammation, and Decreased Indicators of Pulmonary Hypertension, in Studies of Patients with PNH

...utive Officer of Alexion. Blood Markers of thrombin Generation and Inflammation Research title...lts in Rapid and Sustained Decreases in Markers of thrombin Generation and Inflammation in Patients with PNH" ...r to determine the effect of Soliris on markers of thrombin generation and inflammation among eight patients w...

Nuvelo and ARCA biopharma Advance Toward Completion of Merger

...novel drugs for acute cardiovascular disease, cancer and other debilitating medical conditions. Nuvelo's development pipeline includes NU172, a direct thrombin inhibitor which has completed Phase 1 development for use as a potential short-acting anticoagulant during medical or surgical procedures; and NU206, ...

Johnson & Johnson Announces Definitive Agreement to Acquire Omrix

...t products for various surgical applications. ETHICON currently has exclusive distribution rights in the U.S. and the European Union for EVITHROM(TM) thrombin Topical (Human) and EVICEL(TM) Fibrin Sealant (Human), two active, biologic-based hemostats manufactured by Omrix. ETHICON and Omrix are also partner...

ARCA biopharma to Present at JMP Securities Healthcare Focus Conference

...novel drugs for acute cardiovascular disease, cancer and other debilitating medical conditions. Nuvelo's development pipeline includes NU172, a direct thrombin inhibitor which has completed Phase 1 development for use as a potential short-acting anticoagulant during medical or surgical procedures; and NU206, ...

Thrombin in Biological Products

STag Thrombin Purification Kit from Novagen

Description: Request Info...
Company:Novagen

Tunicamycin, Streptomyces lysosuperficus from Calbiochem

Description:...dic protein-carbohydrate linkages. Active in vitro against Gram-positive bacteria, yeasts, fungi, and viruses. Inhibits the expression of functional thrombin receptors on human T-lymphoblastoid cells. Also inhibits thrombin-induced Ca 2+ mobilization in cells. Purity: ≥95% by HPLC (A+B+C+D). Soluble i...
Company:Calbiochem

Thrombin from Novagen

Description:... Restriction Grade thrombin is a highly purified preparation qualified to spec...ative for HBsAg and for antibodies to HIV and HCV. thrombin is supplied as a solution in 50% glycerol and includes 10X thrombin Cleavage Buffer and a Cleavage Control Protein. RT...
Company:Novagen

Thrombin in Biological Dictionary

Dimer

...> Publications > Clinical Laboratory News > 2009 > April ... thrombin converts fibrinogen into soluble fibrin monomer. ... thrombin also activates factor XIII, which in the presence of calcium, ... Dimeri...