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Thioredoxin in Medical News

Researchers Report Combined Molecules in Red Wine by Far Exceed the Biological Activity of Plain Resveratrol, Consistent With the Composition of Longevinex(R)

...tal Cell Research. For more information about Longevinex(R), please visit www.longevinex.com Reference: Red wine triggers cell death and thioredoxin reductase inhibition: effects beyond resveratrol and SIRT1. Experimental Cell Research 2009 Mar 4. [Epub ahead of print] ...

Major 'missed' biochemical pathway emerges as important in virtually all cells

... Duke Department of Biochemistry. The research explains that the enzymes thioredoxin 1 and thioredoxin 2 remove nitric oxide from the amino acid cysteine within mammalian cells, ...

Scientists identify new leads for treating parasitic worm disease

...cted with Schistosoma maintained in laboratory conditions, shows that an oxadiazole compound was effective in inhibiting a crucial worm enzyme, called thioredoxin glutathione reductase (TGR). Furthermore, in tests of laboratory mice infected with Schistosoma, this compound killed the parasite in all of its stage...
Thioredoxin in Medical Technology

Pharmacyclics Announces Promising Results From Phase 2 Clinical Trial of Xcytrin in Recurrent, Metastatic Non-Small Cell Lung Cancer

...ent pathways in cells and inhibit oxidative stress related proteins such as thioredoxin reductase. Its multifunctional mode of action, including its magnetic reson...ts with brain metastases from NSCLC. The target for Xcytrin is the enzyme thioredoxin reductase, which is frequently over expressed in lung cancer cells. This en...

Pharmacyclics Announces Interim Results From Two Ongoing Phase 2 Trials Supporting Potential of Xcytrin Plus Chemotherapy to Treat Recurrent Non-Small Cell Lung Cancer

...ent pathways in cells and inhibit oxidative stress-related proteins such as thioredoxin reductase. Its multifunctional mode of action, including its magnetic reson...with standard chemotherapy regimens. The target for Xcytrin is the enzyme thioredoxin reductase, which is frequently overexpressed in lung cancer cells. This enz...
Thioredoxin in Biological News

American Chemical Society's Weekly PressPac -- Jan. 16, 2008

...earchers note. MTS ARTICLE #1 FOR IMMEDIATE RELEASE Broccoli: A Unique Vegetable That Protects Mammalian Hearts through the Redox Cycling of the thioredoxin Superfamily DOWNLOAD PDF http://pubs.acs.org/cgi-bin/sample.cgi/jafcau/asap/pdf/jf0728146.pdf DOWNLOAD HTML http://pubs.acs.org/cgi-bin/sampl...

'Electronic switch' opens doors in rheumatoid joints

...ersitys Faculty of Biological Sciences reveal that thioredoxin works in a different manner: it activates an ion c...fessor Beech likens to an electronic on-switch. thioredoxin is naturally present in cells and is secreted to h...ry diseases cause the production of high levels of thioredoxin in fact with rheumatoid arthritis, its striking h...

Chloroplast f and m Thioredoxins Discovered in Nonphotosynthetic Tissues

...localized in the cytosol and are thought to function in seeds in maturation and germination, in plant reproduction, and in other signaling pathways. thioredoxin h is also thought to be a mobile element in plants transported through the phloem or directly from cell to cell through plasmodesmata and thus may act...

A search for biomarkers for early detection of colorectal cancer

...chers at the Zhejiang University, Hangzhou have discovered that mimecan and thioredoxin Domain-Containing Protein 5 (TXNDC5) were differentially expressed in color...rticle describing this work entitled Differential Expression of Mimecan and thioredoxin Domain-Containing Protein 5 in Colorectal Adenoma and Cancer: A Proteomic S...

USC researchers determine mechanism of action of chemotherapy drug

...n enzyme-thioredoxin reductase-that is an important component in the cell's antioxidant system, as well as important in DNA synthesis. In other words, thioredoxin reductase is key to the replication and survival of cells, and its inhibition ultimately leads to cell death. "Our studies showed that MGd induces ...

Computational Tool Predicts How Drugs Work In Cells, Advancing Efforts To Design Better Medicines

...lgorithm predicted, and subsequent experiments verified, that PTSB acted on thioredoxin and thioredoxin reductase, findings that not only validate the tool’s capability but could ...
Thioredoxin in Biological Technology

Oncothyreon announces clinical data from three product candidates presented at American Society of Clinical Oncology (ASCO) Annual Meeting

... and final results from two Phase 1b trials of the thioredoxin inhibitor PX-12 in advanced cancer patients. ...ed. PX-12 was shown to lower levels of circulating thioredoxin in patients whose starting levels were at least th...rsible inhibitor of the redox protein thioredoxin. thioredoxin is involved in the first unique step in DNA synthe...

Oncothyreon announces presentations at American Society of Clinical Oncology (ASCO) Annual Meeting

... Molecular Therapeutics - Saturday May 30, 8:00 AM to 12:00 PM Level 2, West Hall C - "Results from phase Ib studies of PX-12, a thioredoxin inhibitor in patients with advanced solid malignancies" - Abstract # 2571, Poster Session: Developmental Therapeutics: Cytoto...

Oncothyreon initiates Phase 1b trial of PX-12 in patients with advanced metastatic cancer

...trial of PX-12 in 38 patients with advanced metastatic cancer showed that PX-12 was well tolerated and produced a decrease in plasma concentrations of thioredoxin that was significantly correlated with increased patient survival. Fifteen of the 38 patients achieved stable disease of up to 322 days. Oncothyreon i...

Data for Oncothyreon's PX-12 and PX-866 presented at AACR Annual Meeting

...8. PX-12 PX-12 is an irreversible inhibitor of thioredoxin (Trx)-1, a protein that is over-expressed in many ...bout PX-12 PX-12 is an irreversible inhibitor of thioredoxin (Trx-1), a protein that regulates many transcripti...nd produced a decrease in plasma concentrations of thioredoxin that was significantly correlated with increased p...

Oncothyreon highlights corporate and clinical objectives for 2008

...X-12 exploring a more-prolonged infusion regimen is currently expected to begin in the second quarter of 2008. PX-12 is an irreversible inhibitor of thioredoxin (Trx-1), a protein that regulates many other proteins including hypoxia inducible factor (HIF)-1 alpha, vascular endothelial growth factor (VEGF) and ...
Thioredoxin in Biological Products

Chicken Anti-Human Thioredoxin domain containing 9 Polyclonal Antibody, Unconjugated from Abcam

Description: Chicken polyclonal to Thioredoxin domain containing 9 ( Abpromise for all tested applications). Antigen: Full length protein (Human) Entrez Gene ID: 10190 Swiss Protein ID: O14530...
Company:Abcam

Origami(DE3) Glycerol Stock from Novagen

Description:... Origami host strains are K-12 derivatives that have mutations in both the thioredoxin reductase (trxB) and glutathione reductase (gor) genes, which greatly enhan...lin-resistant plasmids and are ideal for use with pET-32 vectors, since the thioredoxin fusion tag further enhances the formation of disulfide bonds in the cytopla...
Company:Novagen

Origami(DE3)pLysS Glycerol Stock from Novagen

Description:... Origami host strains are K-12 derivatives that have mutations in both the thioredoxin reductase (trxB) and glutathione reductase (gor) genes, which greatly enhan...lin-resistant plasmids and are ideal for use with pET-32 vectors, since the thioredoxin fusion tag further enhances the formation of disulfide bonds in the cytopla...
Company:Novagen

Rabbit Anti-Peroxiredoxin 1 Polyclonal Antibody, Unconjugated from GeneTex

Description:...rx6 belonging to 1-Cys Prx subgroup, the other five 2-Cys Prx isotypes have the thioredoxin-dependent peroxidase (TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20-30 kilodalton in molecular size and vary in subcellular localization: Prx1, 2, and 6 ...
Company:GeneTex

HRV 3C Protease from Novagen

Description:... The pET expression vectors pET-47b(+) through pET-50b(+) incorporate the HRV 3C protease cleavage site in combinations with His•Tag, S•Tag, thioredoxin (Trx•Tag™), glutathione-S-transferase (GST•Tag™), and NusA (Nus•Tag™) sequences. The combination of pET-47b(+) to pET...
Company:Novagen
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