AGA Institute presents cutting-edge research during DDW
...estions Facing our Field? R. Sandler (11:25 a.m.)
The Clinical Plenary session presentations (Monday, June 1, 8 - 10 a.m. CDT, Room B1) include:
therapy is associated with a three-fold decrease in the incidence of advanced colorectal neoplasia in IBD patients with longstanding extensive colitis...
Molecular science could further improve leukemia survival, say St. Jude researchers
... to find out who those patients are who are at risk so we can spare them from toxicity.
For instance, a genetic alteration affects an enzyme called thiopurine
methyltransferase. Children with this alteration cannot metabolize a certain anti-cancer drug, and the active metabolite of the drug can accumulate in...
Thiopurine in Biological News
St. Jude projects 90 percent cure rate for ALL
...g-term side effects of treatment. For example, a St. Jude team lead by Evans demonstrated that patients who lack the enzyme TPMT are more sensitive to thiopurine
chemotherapy drugs and are more likely to suffer damage to the body's blood-producing cells. Evans subsequently discovered the genetic cause and devel...
Genomics researchers discover protein deficit that causes drug toxicity
...d in turn causes certain individuals to metabolize thiopurine
drugs differently. thiopurine
therapies are used to treat patients with childhoo...as shown before that the aggresome plays a role in thiopurine
metabolism, and it's a significant contribution," ...
Thiopurine in Biological Technology