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Thiol in Medical News

Engineering chimeric polypeptides to illuminate cellular redox states

...ajor obstacle to a FRET-based redox sensor. The researchers designed the linker sequence such that in its reduced state the linker is an α-helix. thiol groups, strategically placed throughout the linker, sense the redox potential of the environment and form disulfide bonds upon oxidation. Under ox...

Immunosuppressive Action Of Fungal Metabolite - Gliotoxin

...s with a minimal effect on depletion of internal Ca2+ stores. Finally, gliotoxin induced intracellular production of superoxide possibly through a thiol redox cycling, which appeared to mediate suppressive effects on mast cell activation. ...

Protein Carbonyl Level Causes Oxidative Protein Damage In Diabetics

...teins. Researchers from the Department of Biochemistry and Nephrology, Medical Faculty, Akdeniz measured reactive carbonyl derivates (PCO), protein thiol (P-SH), and reduced glutathione (GSH) levels in Type 2 diabetic (DM) and diabetic hemodialysed patients (DHD) and in healthy control participants. ...
Thiol in Biological News

Nonstick and laser-safe gold aids laser trapping of biomolecules

...chnology), an approach that is mechanically stronger than the protein-based bonding techniques typically used in biology. The JILA scientists used six thiol bonds instead of just one between the DNA and the gold posts. These bonds were mechanically strong enough to withstand high-force laser trapping and c...

Chloroplast f and m Thioredoxins Discovered in Nonphotosynthetic Tissues

...-called redox-regulated reactions, TRXs can transfer hydrogen to convert a disulfide bridge formed between two cysteine amino acids to their unbridged thiol forms. These TRX-responsive disulfide bridges have regulatory functions in numerous cellular processes, including regulatory cascades related to enzy...
Thiol in Biological Technology

Efficient Primary Structure Elucidation of Disulfide-bridged Peptides

...ere cleaved with immobilised trypsin to eliminate disulfide exchange during digestion, and iodoacetamide was added as a scavenger to alkylate any free thiol groups that may have been formed during cleavage. The tryptic peptides were separated by RP-HPLC and the disulfide-containing peptides were identified...

Quantification of the Purinergic Receptor P2X3 using ICAT and Orthogonal 2D LC-MS/MS with an Ion Trap Mass Spectrometer

...mentation of MS-based methods for quantitative protein profiling. The ICAT procedure relies on the selective alkylation of the free thiol groups of cysteines with either a d 0 - or d 8 - ICAT followed by proteolysis, affinity enrichment of the labeled peptides, and ...
Thiol in Biological Products

Contact Printing Kit with Printing Surface, Stamp & Thiol from Platypus Technologies

Description: Platypus Contact Printing Kit contains choice of Printing Surface (3 glass slides coated with 100 /500/1000 Angsroms of Gold over Ti adhesion layer, 1 silicon wafer coated with 1000 Angstroms of Gold over TI adhesion layer, or 3 plain glass slides), PDMS Stamps (3 PDMS micropatterned stamps with se...
Company:Platypus Technologies

Tritirachium album Proteinase K from USB Corp.

Description:... Working Concentration: 0.05 - 1 mg/ml Activators: Stimulated by 0.2 - 1% SDS or 1 - 4M urea (8) Inactivated by PMSF (1) ; Not inactivated by EGTA, thiol reagents or trypsin/chymotrypsin inhibitors (1) Form: Lyophilized powder Purity: Tested for contaminating ribonucleases and deoxyribonucleases....
Company:USB Corp.

Dithio-bis(2-nitrobenzoic acid) BioChemica from AppliChem GmbH

Description:... a synthetic substrate, replacing the natural substrate acetylcholine. This enzyme hydrolyses the substrate to yield acetate and thiocholine. The free thiol group of thiocholine reacts with DTNB included in the assay mixture, producing the yellow 4-nitrothiolate. The release of this yellow anion is followe...
Company:AppliChem GmbH

Glutathione-S-Transferase (GST) Colorimetric Assay Kit from Sigma-Aldrich

Description:... in mammals. The enzymes protect cells against toxicants by conjugating the thiol group of the glutathione to electrophilic xenobiotics, and thereby defend c...is suitable for the broadest range of GST isozymes. Upon conjugation of the thiol group of glutathione to the CDNB substrate, there is an increase in the abs...
Company:Sigma-Aldrich
Thiol in Biological Definition

Disulfide bond

...ir side chains, they normally do so through a disulfide bond. The particular side chain involved is the sulfhydryl group (- S H ). Oxidation of the thiol group yields a disulfide (S-S) bond. The presence of S-S then helps to maintain the tertiary structure of the protein. An amino acid that commonly f...
Thiol in Biological Dictionary

Disulfide bridge

... In chemistry, a disulfide bond is a covalent bond, usually derived by the coupling of two thiol groups. The linkage is also called an SS-bond or disulfide bridge . The overall connectivity is therefore C-S-S-C. The terminology... In chemist...
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