Study reveals candidate targets for anti-retroviral therapeutics
The increased frequency of drug resistance in isolates of the AIDS virus, HIV, makes identification of new antiviral targets an urgent necessity. Host genes required to support the replication of HIV are a potential source of such novel targets, but relatively few appropriate target genes have been identified in animal cells thus far. A new study, conducted by Dr. Suzanne Sandmeyer and colleagues...Tetanus toxin found to have therapeutic properties
A team of researchers from the Department of Biochemistry and Molecular Biology and the Institute of Neuroscience at the Universitat Autònoma de Barcelona has discovered that tetanus toxin, which causes tetanus, could be extremely useful as a therapy against psychological disorders such as depression, anxiety and anorexia, and to slow the progress of neurodegenerative disorders such as Parkinson'...Dendritic cells offer new therapeutic target for drugs to treat MS and other autoimmune disease
Scientists at the Johns Hopkins Kimmel Cancer Center have found that a gene pathway linked to a deadly form of leukemia may provide a new way to treat autoimmune diseases, including multiple sclerosis. Their tests in cell cultures and mice suggest that blocking the pathway by interfering with a blood cell growth gene, known as FLT3, targets an immune system cell often ignored in favor of T-cell t...Greasing interferon's gears may pave way to greater therapeutic benefits, fewer side effects
nterferon -- a critical protein that mediates the body's defense against a wide variety of infectious agents and tumors -- may soon have greater therapeutic value as the result of a new study by researchers at Washington University School of Medicine in St. Louis. "Essentially, we found a way to grease the gears that drive the interferon signal," says Michael J. Holtzman, M.D., the Selma...New Therapeutic Target Identified In Inherited Brain Tumor Disorder
With preliminary results from a study in Botswana, Harvard School of Public Health researchers have found that people with HIV-1 subtype C in resource-poor settings, who receive antiretroviral (ARV) therapy, can achieve comparable results to those in the developed world. A fully supported health care delivery system and infrastructure help ensure this success, according to data published in Novem...GPCR SpliceArray Service from ExonHit Therapeutics Inc.
Description:The binding specificity and signaling of the members of the GPCR family are known to be modified by alternative splicing--which has important implications for drug research. With GPCR SpliceArrays you can perform a classical expression profiling and at the same time detect the different alternatively spliced forms of the gene that are expressed in the samples under study. The GPCR SpliceArray mon...Apoptosis Pathway SpliceArrays from ExonHit Therapeutics Inc.
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Description:Through its SpliceArray service, ExonHit can design custom microarrays to detect alternative splicing events starting with your gene list. Proprietary algorithms are used to identify splice events and design microarray probes from high quality, spliced cDNAs aligned to the human genome. Each splice event contained in a custom SpliceArray is profiled with a patent protected combination of six exo...Ion Channel SpliceArray Service from ExonHit Therapeutics Inc.
Description:The binding specificity and signaling of the members of the GPCR family are known to be modified by alternative splicing--which has important implications for drug research. With GPCR SpliceArrays you can perform a classical expression profiling and at the same time detect the different alternatively spliced forms of the gene that are expressed in the samples under study. The GPCR SpliceArray mon...Microarray expression profiling service from ExonHit Therapeutics Inc.
Description:SpliceArray Services is a microarray service provider that supports industrial and academic researchers. We are a Certified Servive Provider of Agilent, and we provide expression profiling services on all Agilent catalogue arrays. Gene expression reports are delivered via CD....Biologist who cloned Dolly the sheep believes therapeutic cloning will gain acceptance
Wilmut, a biologist with the <a href="http://www.re...Canadian firm buys Proventiv Therapeutics, makes ex-Bone Care exec CEO
Proventiv was founded in S...Quintessence Biosciences forms cancer therapeutic advisory board
MADISON Announced last week by President and Chief Executive Officer , the board will consist of distinguished...Tetanus causing toxin has therapeutic properties
Tetanus toxin, that causes the disease tetanus, have therapeutic properties that can be effective// against mental disorders like anxiety disorder, depression and anorexia. Researchers of the Universitat Autònoma de Barcelona in Spain have discovered the beneficial effects of the tetanus toxin by isolating a harmless part of the toxin called the carboxy-terminal domain. This part of th...Understanding Chronic Infections May Help in Developing Therapeutic Vaccines
Vaccines for prophylaxis are well known. Famous vaccines include the ones against tetanus, polio, diphtheria, measles, // mumps etc.; Therapeutic vaccines to cure a condition are more recent innovation. The current vaccines tested in this area include the ones against HIV and hepatitis. The therapeutic vaccines aim to enhance the immune system's ability to combat an infectious agent, such as a vi...Therapeutic cloning by regenerating stem cells from heart muscles
Professor Hiroaki Matsubara and colleagues from Kyoto University Hospital has regenerated stem cells from cardiac muscle cells. The cardiac muscle cells were obtained from the heart tissue// of human volunteers. The researchers injected the regenerated stem cells from humans into the heart of the mouse, which had a damaged heart muscle and blood vessels, the scientists found that the therapy heal...Therapeutic Genes Transferred By Viral Vector Through T Cell Masking
Dr. Richard Vile, Mayo Clinic Molecular Immunologist and his team has found a new virus based gene therapy delivery system for the treatment of cancer, inflammation and autoimmune diseases. The new delivery system acts as a “T // cell Therapeutic hitchhiker”, by which the Therapeutic virus containing the required genes are transferred into the T cells in the immune system, as the T cells are the...Therapeutic Monoclonal Antibody Production Is More Profitable Than Small Molecule Drugs
New study has suggested that therapeutics based on monoclonal antibodies (mAbs) are fare more likely to be commercially successful than their small molecule predecessors. According to a study completed by // consultancy Propagate Pharma, about half the mAbs launched so fare appear to be profitable. That means mAbs are recouping more in revenues than their estimated $1 billion to $1.8 billion cost...2089 TENNIS ELBOW STRAP WITH THERAPEUTIC GEL PAD
Description:An excellent preventative/thera-peutic device for wearing during sports or construction activity. Helps dampen vibration and shock often transmitted during periods of repetitive motion. Provides relief from painful symptoms of tennis elbow. Gel pad is easily detachable from the brush lined encircling strap, and can be cooled or heated for therapy....2422 KNEED-IT© THERAPEUTIC KNEE GUARD
Description:Targets the physiological causes of minor knee pain like arthritis, tendonitis and chondromalachia Anatomic design works in concert with the motion of the knee, applying pressure to the joint liner and patellar tendon and assisting in the relief of minor knee pain. Semi-rigid plastic support with high density foam padding molds itself around soft tissues for customized support. Well padded enci...BRO-YL2 Therapeutic Bronchoscope
Description:Fujinon's therapeutic fiberoptic bronchoscopes offers a generous 2.6mm operating channel with a slim outside diameter. The large channel allows for improved suction and easier passage of cytology brushes. The scope is fully submersible for easier cleaning....Lyphochek Therapeutic Drug Monitoring Control (TDM)
Description:Lyphochek Therapeutic Drug Monitoring Control (TDM) contains over 40 analytes with assayed values at three clinically significant levels....Liquichek Therapeutic Drug Monitoring Control (TDM)
Description:Liquichek Therapeutic Drug Monitoring Control (TDM) is a liquid assayed control containing a comprehensive menu of therapeutic drugs, as well as many common ligands. Available in three levels....Monitoring Options Expand for Therapeutic Agents and Drugs of Abuse
In keeping with the recent proliferation of rapid, easy-to-use diagnostic tests, many assays and collection products have entered the marketplace to help clinicians assess dosage appropriateness of therapeutic drugs and to screen for the presence of drugs of abuse. Some of these products require laboratory support while many simple test kits are suitable for point of care use by medical profe...CV Therapeutics Identifies Potential Anti-Diabetic Mechanism of Action for Ranexa
-- New Preclinical Information May Correlate with Clinical HbA1cReductions Observed in Phase 3 CARISA and MERLIN TIMI-36 ClinicalTrials -- PALO ALTO, Calif., July 9, 2007 /PRNewswire-FirstCall/ -- CVTherapeutics, Inc. announced today that researchers have completedpreliminary preclinical studies showing that ranolazine increasedglucose stimulated insulin secretion in pancreatic beta cells...