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Terminus in Medical News

New role discovered for molecule important in development of the pancreas

...ene to orchestrate gene expression with these proteins. Specifically, Stoffers was curious about the function of one end of the Pdx1 protein the C terminus whose role in beta-cell development was not known and yet is mutated in certain diseases. Her team, led by MD-PhD candidate Jennifer Oliver-Krasinsk...

Two Scientists Honored with MetLife Foundation Awards for Medical Research in Alzheimer's Disease

...rm basis for the currently prevailing b-amyloid hypothesis. The Iwatsubo group has focused on the mechanisms of y-secretase complex that cleaves the C terminus of Ab, and demonstrated that PS, APH-1, nicastrin and PEN-2 are the essential set of proteins that comprise the y-secretase complex. Recently, his gro...

New Mechanism for Nutrient Uptake Discovered

...called C-terminus, of the protein Arabidopsis ammonium transporter AtAMT1;1, located at the surface of the cell membrane, acts as a switch. "The terminus is an arm-like feature that physically grabs a neighboring short-chain molecule, binds with it, and changes the shape of itself and its neighbor there...

The cancer-fighting gene

...o acids that comprises a complex, three-dimensional structure.Scientists have been focusing their investigations on the two ends of the protein, the C terminus and the N terminus.The focus of Glover’s work has been the C-terminus, which consits of a pair of related structures, called BRCT repeats. BRCT ...
Terminus in Biological News

AGU journal highlights -- Dec. 31, 2008

...glaciers. Seismic events traced back to glaciers during the same time period have been interpreted to have resulted from calving events at the glacier terminus or surging events lubricated by subglacial meltwater. To learn more, Nettles et al. conducted geodetic studies at Helheim Glacier, one of Greenland's ...

AGU journal highlights -- Oct. 16, 2008

...lmost unmodified Circumpolar Deep Water (CDW); though cold, this deep water is several degrees above freezing and drives rapid melting of the floating terminus of the Pine Island Glacier. To learn more, Thoma et al. model ocean circulation in the Amundsen Sea. They find that influx of CDW is related to region...

New mechanism for nutrient uptake discovered

...-called C-terminus, of the protein Arabidopsis ammonium transporter AtAMT1;1, located at the surface of the cell membrane, acts as a switch. "The terminus is an arm-like feature that physically grabs a neighboring short-chain molecule, binds with it, and changes the shape of itself and its neighbor there...

A new molecule discovered in the battle between plants and disease

...psis thaliana (G. Pearce, A. Huffaker, C.A. Ryan, submitted). The peptide is encoded by a gene at the locus At5g64900 and is derived from the carboxyl terminus of a 92 amino acid precursor, proAtPep1, a scenario commonly found in both animal and plant peptide precursors. No physiological role was known for At...
Terminus in Biological Technology

Fundamentals of Fermentation: Techniques For Benchtop Fermentors

....) All tubing connected to ports that have their terminus within the vessel below the liquid level (i.e. the...oculum. The shake flask is connected to the port terminus using aseptic techniques, and then the clamps are ...is disconnected. At this point, the harvest port terminus must be covered up again with sterile cotton and f...

RNA Interference and Gene Silencing: History and Overview

...The active RISC then targets the homologous transcript by base pairing interactions and cleaves the mRNA ~12 nucleotides from the 3' terminus of the siRNA (3 , 18 , 27 , 29 )...

Sequence-Validated and Expression-Tested Human cDNA in a Dual Expression Vector

...on, and tandem consensus sequences for optimal translation initiation in both systems. The c-myc epitope and HIS6 purification tags at the carboxy terminus of the expressed protein allow proteins to be detected and purified, respectively. The tags can be separated from the protein encoded by the cDNA ...

Expression and Purification of Recombinant Proteins That Have Native Amino Acid Sequence

...the expressed protein. Because EK cleaves at the C terminus of its recognition target, which is also the N terminus of the inserted polypeptide sequence, cleavage o...ows efficient cleavage of all sequences at the N terminus of the polypeptide of interest and produces prot...

Efficient Cleavage of Fusion Proteins to Yield Native Amino Termini

...rokinase, an efficient, sitespecific protease that cleaves at the carboxy terminus of its recognition target. Cleavage of fusion proteins that contain the e...ned to fuse the 5-amino-acid EK target site to the natural amino terminus of the JNK protein. The PCR product was inserted into the affini...

New Mammalian Two-Hybrid System Detects Protein-Protein Interactions

...iption activation domain we used for pCMV-AD is derived from the carboxyl terminus of the mouse NF- k B p65 protein. 9 The p65 activation domain has been r... 72 to 390 of murine p53 were fused in frame to the carboxyl (C) terminus of the GAL4-DNA binding domain (pBD-53), and amino acids 84 and ...
Terminus in Biological Products

Rabbit Anti-Smac / DIABLO, C Terminus Antibody, Unconjugated from BACHEM

Description: Smac/DIABLO (CT) - IgG for Western Blotting, Host: Rabbit Family: Smac/DIABLO...
Company:BACHEM

Goat Anti-PPP2R5D Polyclonal Antibody, Unconjugated from GeneTex

Description:... Goat polyclonal to PPP2R5D Immunogen: Peptide with sequence KRAEEFLTASQEAL, from C terminus of the protein sequence according to NP_006236...
Company:GeneTex

Rabbit Anti-IL-23 P19 Polyclonal Antibody, Unconjugated from Abcam

Description:... Rabbit polyclonal to IL23 P19 ( Abpromise for all tested applications). Antigen: Synthetic 16 amino acid peptide from near the amino terminus of human IL23 P19 Entrez Gene ID: 51561 Swiss Protein ID: Q6NZ80...
Company:Abcam

Goat Anti-ICEBERG Polyclonal Antibody, Unconjugated from IMGENEX

Description:... Peptide-affinity Purified Polyclonal Antibody to ICEBERG Peptide with sequence EEDPQLASKMGLH, from C terminus of the protein sequence according to NP_067546...
Company:IMGENEX

Goat Anti-MAML1 / Mastermind Polyclonal Antibody, Unconjugated from IMGENEX

Description:... Peptide-affinity Purified Polyclonal Antibody to MAML1 / Mastermind Peptide with sequence VLPTCPMAEFALPR, from N terminus of the protein sequence according to NP_055572....
Company:IMGENEX

Goat Anti-SMAD7, MADH7 Polyclonal Antibody, Unconjugated from IMGENEX

Description:... Peptide-affinity Purified Polyclonal Antibody to SMAD7 Peptide with sequence SSCPCWLEVIFNSR, from C terminus of the protein sequence according to NP_005895....
Company:IMGENEX

Goat Anti-MLH3 Polyclonal Antibody, Unconjugated from GeneTex

Description:... Goat polyclonal to MLH3 Immunogen: Synthetic peptide: RQSLQQSMPPCEPP (Human) from C terminus of the protein sequence according to NP_055196....
Company:GeneTex

Rabbit Anti-ETR3 Antibody, Unconjugated from ABR-Affinity BioReagents

Description:... Immunogen: C terminus [VQLKRSKNDSKPYC] of cardiac elav-type RNA-binding protein (ETR-3) Storage: -20 C, Avoid Freeze/Thaw Cycles...
Company:ABR-Affinity BioReagents

Goat Anti-HA1 Polyclonal Antibody, Unconjugated from Abcam

Description:... Goat polyclonal to HA1 ( Abpromise for all tested applications). Antigen: Synthetic peptide: TLGSCRERQPEFV from the C terminus of human HA1. Entrez GeneID: 23526 Swiss Protein ID: O78181...
Company:Abcam

Poly A Polymerase from Invitrogen

Description:... Poly A Polymerase catalyzes the addition of AMP to the 3' hydroxyl terminus of RNA. Poly A Polymerase can add poly(C) and poly(U) to RNA but does so with much-reduced efficiency....
Company:Invitrogen

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Terminus in Biological Definition

Biopolymer

...s the study of the shapes of biopolymers. The convention for a protein is to list its constituent amino acid residues as they occur from the amino terminus to the carboxylic acid terminus. The convention for a nucleic acid sequence is to list the nucleotides as they occur from the 5' end to the 3' end ...

Electron transfer chain

...s part of the Krebs cycle and does not pump protons, and Complex V uses the electrochemical potential generated to create ATP . Complex IV is the terminus of the electron transfer chain , where oxygen from the lungs is reduced by electrons and hydrogen protons (provided by NADH and/or FADH2 ) to ma...

Polymerase chain reaction

...owever it should be chosen empirically for individual conditions. Inner self-complementary hairpins of >4 and of dimers >8 should be avoided. 3' terminus is extremely case sensitive - it must not be complementary to any region of the other primer used in the reaction and must provide correct base matchi...

Protein

...ion. The two ends of the amino acid chain are referred to as the carboxy terminus (C-terminus) and the amino terminus (N-terminus) based on the nature of the free group on each extremity. ...
Terminus in Biological Dictionary

N Terminus

The N - terminus refers to the start of a protein or polypeptide terminated by an amino acid with a free amine group (-NH2). The convention for writing peptide sequences is to put the N - terminus on the left and write the sequence from N - to C- terminus . When the protein is......

Carboxyl Terminus

The C- terminus of a protein or polypeptide is the end of the amino acid chain terminated by a free carboxyl group (-COOH). The convention for writing peptide sequences is to put the C-terminal end on the right and write the sequence from N- to C- terminus . The N- terminus refers ...

C Terminus

The C - terminus of a protein or polypeptide is the end of the amino acid chain terminated by a free carboxyl group (-COOH). The convention for writing peptide sequences is to put the C -terminal end on the right and write the sequence from N- to C - terminus . C-terminus Please he...

Amino Terminus

The N- terminus refers to the start of a protein or polypeptide terminated by an amino acid with a free amine group (-NH2). The convention for writing peptide sequences is to put the N- terminus on the left and write the sequence from N- to C- terminus . When the protein is... Th...

Polyprotein

...rther processed into structural and nonstructural ... Polyprotein processing activity of the NS3 protease is required for NS4A ... ... at the N terminus of the polyprotein and transfected the derived T7 RNA ... reading frame codes for a polyprotein from which structural proteins VP0, VP3, ... ...

Origin of replication

...S phase than at others, but the ... In order to be replicated, each origin of replication must be bound by: ... ... locate the origin and terminus of . replication in microbial ... The origin of replication is. predicted at position 4040 kbp rather than at position zero. ... ... DNA ...

N-terminus

... The N - terminus refers to the start of a protein or polypeptid...for writing peptide sequences is to put the N - terminus on the left and write the sequence from N - to C- terminus . When the protein is... The C-...

Kinase

...ural ... T4 Polynucleotide Kinase catalyzes the transfer and exchange of P<sub>i</sub> from the γ position of ATP to the 5' -hydroxyl terminus of double- and single-stranded ... Kinase Inhibitors have experienced an era of intense discovery research and the ... A decade ago, kinase inh...

C-terminus

... The C - terminus of a protein or polypeptide is the end of the...the right and write the sequence from N- to C - terminus . The N- terminus refers to the start of a protein or polypeptid...

Concatemer

...Concatemer " ... In cells expressing the concatemer , amphetamine analogs promoted GABA efflux and ... The concatemer was tagged on its amino terminus with CFP, which afforded the ... Next message: Concatemer Chain Reaction (CCR ... process, known under the name of concatemer chain reaction (...

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