Combination therapy boosts effectiveness of telomere-directed cancer cell death
Sometimes apotential target for a drug seems very promising on paper; things areoften very different in reality. Its the case of telomerase inhibitorsto treat cancer; they are supposed to strip the "immortal" (able todivide indefinitely) aspect of cancer cells. Yet, something in the cellseems to block their function, preventing them to inhibit completelythe...Tiny roundworm's telomeres help scientists to tease apart different types of aging
The continual and inevitable shortening of telomeres, the protective "caps" at the end of all 46 human chromosomes, has been linked to aging and physical decline. Once they are gone, so are we. But there are more ways than one to grow old. Researchers at Salk Institute for Biological Studies demonstrate for the first time that the roundworm Caenorhabditis elegans succumbs to the trials of...Chromosome Ends Trigger DNA Damage Response For Telomere Protection
Researchers from the Salk Institute for Biological Studies have suggested that a localized DNA damage response at telomeres after replication is essential for recruiting the //processing machinery that promotes formation of a chromosome end protection complex. Telomeres, the ends of linear chromosomes, represent a problem for the control of genome stability and the DNA damage machinery...Telomere Plays an Important Role in Ageing
According to a study conducted by the British scientist it was found that telomeres present in the cell reduces in size when the cell divides.// Hence it is thought that the telomeres play a very important role in the ageing process. The study compared the length of telomeres of 1,552 female twins in Britain between the age of 18 and 75. The participants were also adjusted for other fac...Got a Short Telomere-Watch Your Heart
Long telomeres may equal longer lives, if recent studies prove conclusive.// Scientists claim to have found a new predictive marker for heart disease, the telomere or strand of DNA found at the ends of the chromosome. Nilesh Samani and his team who published a report in the british medical journal, The Lancet, detailed their experiments on 1500 men, in the age group 45 to 64.<...