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Telomerase in Medical News

Secrets of Telomerase Revealed

Researchers unlock active region of enzyme involved in cancer, aging MONDAY, Sept. 1 (HealthDay News) -- Researchers have revealed the structure of the active region of telomerase, an enzyme involved in both cancer and aging. Telomerase works by adding repeats of a short DNA sequen...

Urine testing for telomerase enzyme for bladder cancer diagnosis

Dr Maria Aurora Sanchini and her colleagues from Italy have found a new urine test which detects bladder cancer// in people with high-risk of cancer occurrence. The test which is proved to be 90% accurate is used to measure the level of the enzyme telomerase in urine of patients. The results of the...

RevGenetics Releases Its New Science-Based Telomere Health Supplement Formulation for DNA and Chromosome Health

... What Astral Fruit does is activate the enzyme telomerase by using a natural herbal extract. telomerase is a naturally occurring activity that the immune ...vates when preparing to combat infection. However, telomerase also repairs cellular damage in the cells' chromos...

AIDS Drug Slows Spread of Deadly Childhood Brain Cancer

...al of Cancer reports that ABC (Abacavir) suppresses the enzyme telomerase. telomerase activity appears to be essential for certain tumor survival and growth, suc...ation appeared better tolerated by patients than other drugs used to target telomerase in trials, and ABC's safety record in long-term AIDS treatment would make i...

Also in the March 24 JNCI

... Human Cytomegalovirus Stimulates telomerase Activity in Tissue Culture Cells Infection with... cytomegalovirus (HCMV) triggers expression of the telomerase reverse transcriptase (hTERT) gene in both normal ...ar. Several other cancer-related viruses stimulate telomerase activity, which promotes cell proliferation and im...

Immune cells from patients with rheumatoid arthritis have prematurely aged chromosomes

...enetic information after repeated cell division. telomerase adds short repeated DNA sequences to the ends of c...e of the very few cells in adults that can turn on telomerase when stimulated, probably because they have to div...nts with rheumatoid arthritis make 40 percent less telomerase enzyme when stimulated. The cells came from 69 pat...

Testes stem cell can change into other body tissues, Stanford/UCSF study shows

...ciated with pluripotency. The cells could also be induced to differentiate into decidedly non-testicular neural cell precursors and they expressed the telomerase enzyme essential to keep pluripotent cells young and unspecialized. However, when the researchers examined the cells' patterns of methylation a modif...

The 2009 Leibniz Prize: Eleven new scientific discoverers

...ph was able to show that telomere shortening ultimately leads to a shorter lifespan and that the occurrence of liver cirrhosis depends on the level of telomerase activity, for example. Rudolph's finding that telomere shortening has two contradictory effects on the occurrence of cancer is especially important: O...

Experts to share how research is tackling cancer

...tial people in recognition of her research, which has revealed why cancer cells keep growing. "Professor Blackburn's discovery of a protein called telomerase is considered the holy grail of cancer research. Her research has allowed us to understand how cancer cells keep growing over time, which has opened u...

Breast Cancer Vaccines Look Promising

...called antigens to trigger an immune response against cancer cells already in the body. In her study, Domchek used pieces of a protein called human telomerase reverse transcriptase (hTERT) peptide to vaccinate 19 women with breast cancer that had spread. The peptide is nearly universally overexpressed in hu...
Telomerase in Medical Technology

Geron's Telomerase Inhibitor Cancer Drug Demonstrates Good Pharmacokinetics and Tolerability in Phase I/II Trial

MENLO PARK, Calif.--(BUSINESS WIRE)--Jun 12, 2007 - Geron Corporation's (Nasdaq:GERN) telomerase inhibitor cancer drug, GRN163L, has demonstrated good pharmacokinetics and tolerability in its ongoing Phase I/II trial involving patients with chronic lymphocytic leukemia (CLL), according to data pres...

A Milestone in Cancer Genetics: deCODE Discovers First Common Genetic Variants Affecting the Risk of Many Types of Cancer

...ciated with increased risk of BCC and also with risk of cancer of the lung, bladder and prostate. Rs 2736089 is located in the gene encoding the human telomerase reverse transcriptase (TERT), which directs the addition of repeat DNA sequences to the ends of chromosomes. Importantly, the risk of these different ...

Vical Receives Milestone Payment from Merck & Co., Inc. Triggered by Planned Initiation of Investigational Cancer DNA Vaccine Trial

...rial of an investigational plasmid DNA (pDNA) cancer vaccine. The candidate vaccine is based on Vical's DNA gene delivery technology and encodes human telomerase reverse transcriptase (hTERT). hTERT is the subject of separate license agreement. "The breadth of applications for Vical's gene delivery tec...

Telomerase Presentations at the AACR 2007 Annual Meeting

...y referenced multiple presentations on the role of telomerase and telomeres in cancer at this year's American As...ere approximately 80 presentations on telomere and telomerase biology reflecting the growing body of evidence supporting the importance of telomerase as a universal cancer target for drug and vaccine ...

Research Indicates Geron's Human Embryonic Stem Cell-Based Therapeutic for Spinal Cord Injury Evades Direct Attack by the Human Immune System

...ing spinal cord injury, heart failure, diabetes and HIV/AIDS. The company is advancing an anti-cancer drug and a cancer vaccine that target the enzyme telomerase through multiple clinical trials. Geron is also the world leader in the development of human embryonic stem cell-based therapeutics, with its spinal c...

Geron Corp. Licensee TA Sciences Announces Landmark 7/07/07 Teleconference to Answer Questions About TA-65, Their Telomerase Activator With Proven Age Management Benefits

... NEW YORK, June 15, 2007 /PRNewswire/ -- telomerase Activation Sciences, Inc. (T.A. Sciences) recently...measurable and positive anti-aging benefits from a telomerase Activator. Statistically significant results were ... of the vast, powerful, and tangible benefits of a telomerase Activator in human aging. This trial has been inva...

Research Documents Scalable Production, Survival Following Engraftment and Positive Impact on Cardiac Function in Infarcted Rats for Geron's Human Embryonic Stem Cell-Based Therapeutic for Heart Failure

...ing spinal cord injury, heart failure, diabetes and HIV/AIDS. The company is advancing an anti-cancer drug and a cancer vaccine that target the enzyme telomerase through multiple clinical trials. Geron is also the world leader in the development of human embryonic stem cell-based therapeutics, with its spinal c...
Telomerase in Biological News

Stowers Institute's Baumann Lab identifies key step in maturation pathway of telomerase

The Stowers Institute's Baumann Lab has discovered an important step in the maturation pathway of telomerase, the enzyme that replenishes the sequences that are lost at chromosome ends with every cell division. The findings were published today in the Advance Online Publication of Nature . Te...

A little telomerase isn't enough

With seed money from Johns Hopkins Institute of Cell Engineering, a Johns Hopkins geneticist and her team have discovered a critical link between the health of stem cells and the length of the chromosome ends within them. Chromosome ends, or telomeres, are repetitive stretches of DNA that protect...

Telomeres resemble DNA fragile sites

...for a considerable amount of time. The only other known replication problem posed by telomeres was solved in 1985 when it was shown that the enzyme telomerase elongates telomeres, which shorten during every cell division. The second problem posed by telomeres, the so-called end-protection problem, was solved...

UT Southwestern researchers identify gene linked to inherited form of fatal lung disease

...d TERT and TERC. These two genes are normally responsible for producing the telomerase enzyme, which elongates the lengths of DNA at the ends of chromosomes, call... familial IPF. Up to 40 percent have short telomere lengths and evidence of telomerase dysfunction. "But we were still left with a big question mark," Dr. Garc...

Researchers use chemical from medicinal plants to fight HIV

..., the T-cells fighting that virus can't keep their telomerase turned on forever," Effros said. "They turn off, a... Previous studies have shown that injecting the telomerase gene into T-cells can keep the telomeres from shor... in traditional Chinese therapy and which enhances telomerase activity in other cell types. They tested TA...

Novel anti-cancer mechanism found in long-lived rodents

...t lived as long as we humans do needed to suppress telomerase activity to guard against cancer. telomerase helps cells reproduce, and cancer is essentially r...grey squirrel that live for 24 years or more? With telomerase fully active over such a long period, why isn't ca...

Landmark study opens door to new cancer, aging treatments

...p researchers in their efforts to design effective telomerase inhibitors, says Emmanuel Skordalakes, Ph.D., assi...rdalakes says. "That means a drug that deactivates telomerase would likely work against all cancers, with few si...cts." The study elucidates the active region of telomerase and provides the first full-length view of the...

UCLA study identifies mechanism behind mind-body connection

...ne remains elevated in the bloodstream for long periods of time, though, it wears down the immune system. We are testing therapeutic ways of enhancing telomerase levels to help the immune system ward off cortisol's effect. If we're successful, one day a pill may exist to strengthen the immune system's ability t...

UGA researchers discover mechanism that explains how cancer enzyme winds up on ends of chromosomes

...ers have known for some time that an enzyme called telomerase is crucial to cancer's progress. Now, for the firs...ar biology and genetics at UGA, "and the fact that telomerase keeps these telomeres growing when it should be in...rucial for the proliferation of cancer. That makes telomerase a very promising target for a potential drug to st...

Researchers find way to make tumor cells easier to destroy

...eat also enhances the activity of an enzyme called telomerase in cancer cells," he says. "Telomerase helps prote...of them to survive. We used compounds that inhibit telomerase and showed that cancer cells then become easier to...yperthermia and radiation used in combination." telomerase repairs the ends of chromosomes by maintaining sta...
Telomerase in Biological Technology

Lytix Biopharma and KAEL-GemVax Announce Joint Clinical Trial to Combine LTX-315 and GV1001 Cancer Immunotherapy

...s that trigger activation of the immune system. On the other hand GV1001, a telomerase peptide vaccine in phase III trials, is one of the best documented anti-can...1001, a vaccine directed against the catalytic subunit of human telomerase. telomerase is a universal tumour antigen expressed in 85-90% of cancer tissues. ...

Former Telomolecular CEO Clarifies SEC Settlement

...ncer. Mr. Sarad said the company was the first to deliver active human telomerase and synthetic DNA nanocircles to human cells and observe significant signs of telomere regeneration that was not observed when delivering inactive telomerase or linear strands of the same DNA. Studies performed by UCLA suggest that t...

hNT BlueNeurons Express b-Galactosidase at High Levels

...(CNS) neurons, hNT neurons* ( figure 1 ). In the course of RAinduced differentiation, NT2 cells lose neuroepithelial markers and telomerase activity, acquire many neuronal markers, begin to express glutamate receptor channels, change the metabolism of amyloid precurso...
Telomerase in Biological Products

TRAPEZE® RT Telomerase Detection Kit from CHEMICON

Description: The TRAPeze RT Telomerase Detection Kit is a highly sensitive in vitro assay for the fluorometric detection and real time quantification of telomerase activity. It incorporates refinements to the original TRAPeze assay and adds the ability to quantitate telomerase activity using fluorescence energy...
Company:CHEMICON
Telomerase in Biological Definition

Cancer

...ls are less likely to go into apoptosis (programmed cell death) when damaged by therapy. There are more mutations that make a tumor more malignant. telomerase mutations remove additional barriers, extending the number of times a cell can divide. Other mutations enable the tumor to grow new blood vessels t...

Cell division

...orter with each division and eventually can no longer protect the chromosome. Cancer cells, on the other hand, are "immortal." An enzyme called telomerase allows them to continue dividing indefinitely. See also Cell cycle Cell growth External link How Cells Divide: Mitosis vs....
Telomerase in Biological Dictionary

Telomerase

Telomerase is an enzyme that adds specific DNA sequence repeats to the 3' end of DNA strands in the telomere regions, which are found at the ends of eukaryotic chromosomes. The telomeres contain condensed DNA material, giving... telomerase ( ) n. An enzyme that is found in the ...
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