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Combination therapy boosts effectiveness of telomere-directed cancer cell death

Sometimes apotential target for a drug seems very promising on paper; things areoften very different in reality. Its the case of telomerase inhibitorsto treat cancer; they are supposed to strip the "immortal" (able todivide indefinitely) aspect of cancer cells. Yet, something in the cellseems to block their function, preventing them to inhibit completelythe...

TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas

The genes TEL2 and MYC cooperate with each other to promote pediatric cases of the immune system cancer B-cell lymphoma. This finding, from investigators at St. Jude Children's Research Hospital, is published in the current issue of Molecular Cell Biology (MCB). B-cell lymphoma is a cancer in which the antibody-producing cells (B lymphocytes) multiply uncontrollably and crowd out other blo...

Emergence of cancer as major cause of childhood death in developing countries is not being adequately addressed

The emergence of cancer as a major cause of death among children in developing regions of the world is not being adequately addressed by national or international health organizations and charities, according to investigators at St. Jude Children’s Research Hospital. This growing rate of pediatric cancer is occurring as the number of children dying from infectious diseases is being reduced throug...

Biochemists report discovery of structure of major piece of telomerase; implications for cancer

UCLA biochemists have determined the three-dimensional structure of a major domain of telomerase, the enzyme that helps maintain telomeres ?small pieces of DNA on the ends of chromosomes that act as protective caps -- allowing DNA ends to be copied completely when cells are replicated. This is the first major piece of telomerase for which the structure is known. Telomerase plays a key rol...

Leprosy genome tells story of human migrations, French researchers report in Science

A French genetics study comparing strains of leprosy-causing bacteria has revealed some surprises about how the pathogen evolved and how it was spread across the continents by human migrations. The research, led by scientists at the Pasteur Institute in Paris, appears in the 13 May issue of the journal Science, published by AAAS, the nonprofit science society. The findings indicate that t...

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Rainbow trout Vitellogenin EIA Kit from Cayman Chemical

Description:Detection of the yolk protein Vtg in plasma from juvenile or male fish is a simple and sensitive biomarker for endocrine disrupting chemicals (EDCs) with estrogenic effects in fish. Quantification of Vtg has become an accepted screening test for the estrogenic effects of EDCs in fish. The Vtg (rainbow trout) EIA kit is a double-antibody immunometric (sandwich) EIA for analyzing Vtg in plasma samp...
Company:Cayman Chemical

Rainbow trout Vitellogenin EIA Kit from Cayman Chemical

Description:Detection of the yolk protein Vtg in plasma from juvenile or male fish is a simple and sensitive biomarker for endocrine disrupting chemicals (EDCs) with estrogenic effects in fish. Quantification of Vtg has become an accepted screening test for the estrogenic effects of EDCs in fish. The Vtg (rainbow trout) EIA kit is a double-antibody immunometric (sandwich) EIA for analyzing Vtg in plasma samp...
Company:Cayman Chemical

LNA-ISH Cytogenetics - Human centromere alpha satelliteISH probes from Exiqon

Description:Exiqons LNA technology enables sensitive, fast and specific detection of chromosomal sequences directly on intact chromosomes. Related Conte...
Company:Exiqon

Telomerase Gel-based assay Assay Kit, TRAPeze from CHEMICON

Description:...
Company:CHEMICON

Telomerase Fluorometric Assay Kit, TRAPeze from CHEMICON

Description:...
Company:CHEMICON

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Tel at Biology Technology

Fully automated DNA purification and efficient multiplex PCR for analysis of microsatellite loci

Marion Schmidt, Holger Engel, Markus Sprenger-Hauels, Corinna Kppers, Gaby Schulte, Silke Zobel, and Dirk Lffert QIAGEN GmbH, Hilden, Germany Microsatellites highly polymorphic DNA markers comprised of nucleotides that are repeated in tandem arrays and distributed throughout the geno...

Isolation of Low Molecular Weight Digestion Products of the Human Platelet Thromboxane A2 Receptor, Rev A

Joseph W. Turek and Guy C. Le Breton, Department of Pharmacology,University of Illinois at Chicago, College of Medicine, Chicago, IL 60612.Address correspondence to: Joseph W. Turek, 835 South Wolcott, Departmentof Pharmacology M/C 868, University of Illinois at Chicago, Chicago, IL 60612.E-mail: jturek1@icarus.uic.edu Introduction...

Telecom issues are among focus of upcoming western Wisconsin conference

It will be part of the , which will build upon discussions at a December 2004 kickoff luncheo...

Debate over `intelligent design' is a not-so-wise diversion from science education

- The day an archeologist finds a fossil cat or dog in Precambrian rock is the day Charles Darwin's evolution theory is disproved. But that hasn't happened. In fact, the Earth's fossil records tell a consistent scientific story through the ages: Today's living species descended -- with modification -- from common ancestors that lived in our anci...

When its parts pull together, Wisconsin can tell a compelling economic story

MILWAUKEE If you ask visitors from Spain, Lithuania or Hong Kong what they know about Wisconsin, chances are good the answers will have something to do with beer, brats, cheese or the Green Bay Packers. But how much would they know about our biotechnology? Not much, if anything. However, its vital to Wisconsins economic future that people far outside our borders learn more about the sta...

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Tel at Biology Definition

Microsatellite

Tandemly Re...

Tel at Biology Dictionary

Vitelline membrane

that surround an oocyte and that will form the <a href="/ ?q=/ Biology-Dictionary/ fertilization" class=...

Telson

of amphibians that extended from the Carboniferous...

Telophase

and that lasts until the <a href="...

Telomere

Full...

Telomerase

Clon...

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Tel at Medicine News

“Don’t fear long haul flights!” Vascular surgeon tells travelrs

Dr. John Scurr, a vascular surgeon at London's Middlesex Hospital, advices passengers, who fly long haul flights, that there is nothing to fear. The death of a woman on board an airliner, while she was flying a long distance flight, has sparked off this sudden debate that long flights can be fatal to many people. Dr. Scurr says this fear is unfounded and that people are just ove...

TELITHROMYCIN - the proven effective new drug for cap

Community acquired pneumonia other wise known as CAP has been a therapeutic challenge to most of the practising physicians. This is mainly due to the growing resistance of the bacteria causing them to the available antibiotics. Telithromycin (Ketek), a new ketolide antibiotic, is highly effective in treating patients with pneumococcal bacteraemia associated with community-acquired pneumo...

Chromosome Ends Trigger DNA Damage Response For Telomere Protection

Researchers from the Salk Institute for Biological Studies have suggested that a localized DNA damage response at telomeres after replication is essential for recruiting the //processing machinery that promotes formation of a chromosome end protection complex. Telomeres, the ends of linear chromosomes, represent a problem for the control of genome stability and the DNA damage machinery...

Telomerase Vital In Maintaining Ability of Stem Cell to Multiply

Carol Greider, Ph.D., director and professor of molecular biology and genetics in the Johns Hopkins Institute of Basic Biomedical Sciences and colleagues have found that the length of telomeres is important// in ensuring that stem cells are able to divide indefinitely. Telomeres are the ends of the chromosomes that protect genetic information while the chromosome is undergoing division....

Smoking can depreciate intellegence

Smoking in old age appears to be linked to intellectual impairment over the age of 64, research has found. A team from the Institute of Psychiatry in London carried out a community survey of an area of England They studied more than 630 people aged 65 and over. Smoking and drinking habits were recorded at the beginning of the study. The volunteers' intellectual powers were also asses...

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Miniature Telescopes

Description:Karl Storz borescopes are rigid endoscopes for general applications and are equipped with our proven Hopkins lens system. The diameters of borescopes, i.e. rigid endoscopes, range between 1 mm and 10 mm, with viewing directions from 0 up to a 120 retrospection, and image angles ranging between a zoom lens and wide angle view. Endoscopes with working lengths of 1.5 meters and longer are available...
Company:Karl Storz GmbH & Co. KG.

Stellate Harmonie E

Description:The Stellate Harmonie workstation is a medical device designed to handle the intense processing loads, high quality video capability, and archiving demands of the EEG laboratory. Advanced recording and review functions A framework that helps organize workflow and the collection, evaluation and archiving of data A centralized database and powerful search capability keeps track of every patient ent...
Company:Stellate Systems Inc.

Stellate Notta

Description:An ambulatory recorder can help the patient be more comfortable and at ease as well as increasing an EEG laboratory's recording capacity....
Company:Stellate Systems Inc.

Stellate Harmonie S

Description:State-of-the-art sleep recording and analysis...
Company:Stellate Systems Inc.

Hertel Exophthalmometer

Description:Hertel exophthalmometer is used for precise exophthalmos measurements (e.g. exophthalmic goiter)....
Company:Richmond Products, Inc.

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Tel at Medicine Technology

New Study Shows That Extending Prophylaxis With Clexane / Lovenox (enoxaparin Sodium Injection) to 5 Weeks is More Effective Than 10 Days for Reducing the Risk of Venous Thromboembolism (VTE) in Acutely ill Medical Patients With Reduced Mobility

EXCLAIM is the First International Study to Show That ExtendedThromboprophylaxis Reduces VTE Risk in Acutely-ill Medical PatientsWith a Statistically Significant 44% PARIS, July 8, 2007 /PRNewswire-FirstCall/ --Sanofi-aventisannounced today the results of the EXCLAIM (EXtended CLinicalprophylaxis in Acutely Ill Medical patients) study, which showedthe benefit of extended prophylaxi...

New Data Presented on Micardis (Telmisartan) Tablets in Hypertensive Patients With Type 2 Diabetes

RIDGEFIELD, Conn., June 18, 2007 /PRNewswire/ -- Today, resultsfrom AMADEO*, one of a series of studies comparing two angiotensinreceptor blockers (ARBs) in hypertensive patients with diabeticnephropathy, were presented at the 17th annual European Meeting onHypertension in Milan, Italy. The randomized, double-blind, forced titration, parallel group,multicenter study included 860 hy...

New Study Shows That telmisartan has Greater Renoprotective Potential Thanlosartan in Hypertensive Patients With Type 2 Diabetes

MILAN, Italy, June 15 /CNW/ - Today AMADEO, one of thefirst studies to compare the protective potential of twoangiotensin receptor blockers in hypertensive patients withdiabetic nephropathy, was presented at the European Societyof Hypertension, Milan. The results from this study show that telmisartan reduces proteinuria to a significantly greater extentthan losartan.(1)...

Geron Corp. Licensee TA Sciences Announces Landmark 7/07/07 Teleconference to Answer Questions About TA-65, Their Telomerase Activator With Proven Age Management Benefits

NEW YORK, June 15, 2007 /PRNewswire/ -- Telomerase ActivationSciences, Inc. (T.A. Sciences) recently announced the results ofthe Pivotal 2005 Anti-Aging Trial of TA-65, the first human trialever to show demonstrated, measurable and positive anti-agingbenefits from a Telomerase Activator. Statistically significantresults were found in those taking TA-65 across several keyconditions of agi...

Geron's Telomerase Inhibitor Cancer Drug Demonstrates Good Pharmacokinetics and Tolerability in Phase I/II Trial

MENLO PARK, Calif.--(BUSINESS WIRE)--Jun 12, 2007 - GeronCorporation's (Nasdaq:GERN) telomerase inhibitor cancer drug,GRN163L, has demonstrated good pharmacokinetics and tolerability inits ongoing Phase I/II trial involving patients with chroniclymphocytic leukemia (CLL), according to data presented today byAlan Colowick, M.D., M.P.H., the company's president, oncology, atthe Pan Pacific Ly...

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Telephone Triage

Please help in articles on <a href="http:/ / www.google.com/ search?...

Tel at Medicine Dictionary

Telangiectasia

s bleed readily an...

Platelet

hemophilia<...

Platelet count

A can be affected by...

Patella

(the kneecap) and attach it to the <a h...

Mittelschmerz

(womb). This occurs about 2 wee...

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