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Taxol in Medical News

Surveyed Experts Indicate That the Combination of Sutent and Taxol Has Advantages Over the Combination of Avastin and Taxol in the Treatment of Metastatic Triple-Negative Breast Cancer

Sutent/Taxol Will Earn Decision Resources' Clinical Gold Standard Status for the Indication by 2012, According to a New Report from Decision Resources WALTHAM, Mass., April 22 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and hea...

Weekly Doses of Taxol Prolonged Lives of Breast Cancer Patients

Finding should change standard of care, which is 4 doses every 3 weeks, researchers say WEDNESDAY, April 16 (HealthDay News) -- Women who take the drug Taxol weekly after receiving chemotherapy for 12 weeks live longer and live longer without a recurrence of their breast cancer, compar...

Orthocare Innovations Receives Prestigious R&D 100 Award for Computerized Prosthesis Alignment System

...974), the fax machine (1975), the liquid crystal display (1980), the printer (1986), the Kodak Photo CD (1991), the Nicoderm antismoking patch (1992), taxol anticancer drug (1993), lab on a chip (1996), and HDTV (1998). About Orthocare Innovations Orthocare Innovations is a medical device re...

UCF researcher's nanoparticles could someday lead to end of chemotherapy

... toxic, whole-body chemotherapies. Perez and his team used a drug called taxol for their cell culture studies, recently published in the journal Small , because it is one of the most widely used chemotherapeutic drugs. taxol normally causes many negative side effects because it travels throughout th...

'Green chemistry' could ease manufacture, boost usefulness of cancer drug

...lecular biology, studies enzymes that assemble the taxol molecule in Taxus plants. "This process is like pa...lker said. "Under our process, the construction of taxol uses a biological assembly line where each enzyme ...ts on the molecular frame to create new-generation taxol molecules. This can lead to more effective drug va...

Scientists honored for contributions to cancer fight

...m of action of Taxol, as an inhibitor of cell division due to its interaction with microtubules, led to clinical trials of this drug in the mid-1980s. taxol is now involved in the first line of treatment in many cancers, including ovarian, breast and non-small cell lung cancer. The drug has been administer...

New method to overcome multiple drug resistant diseases developed by Stanford researchers

...e, who is a co-author on the paper. "Overcoming taxol resistance is big. It's huge," said Nelson Teng, ...ine-Taxol complex still has to break apart for the taxol to do its job against the cancer cell. Wender's gr...bond the researchers used to hold the arginine and taxol together. Once the arginine-Taxol complex is insid...

Avastin Added to Chemo Helps Women With Advanced Breast Cancer

...udies have found that adding Avastin (bevacizumab) to the chemotherapy drug taxol (paclitaxel) in women with advanced breast cancer actually doubled progress...docetaxel). Taxotere is more commonly used outside the United States, while taxol is more commonly used in the United States. This phase III trial involve...

Avastin Added to Chemo Helps Women With Advanced Cancer

...udies have found that adding Avastin (bevacizumab) to the chemotherapy drug taxol (paclitaxel) in women with advanced breast cancer actually doubled progress...docetaxel). Taxotere is more commonly used outside the United States, while taxol is more commonly used in the United States. This phase III trial involve...

Mitosis gets harder thanks to new gene discovery

...er cells, then stopping them from dividing is a useful way of doing this. Several cancer treatments block cell division by targeting microtubules, taxol is a well known example. It is even possible that RASSF7 might be a future drug target. During the different phases of mitosis the pairs of chromos...
Taxol in Medical Technology

Clinical Results From EntreMed's Panzem NCD and Taxol Breast Cancer Study Presented at ASCO

Safety, Efficacy and Markers Demonstrated in Combination Trial ROCKVILLE, Md., June 06, 2007 /PRNewswire-FirstCall/ -- EntreMed, Inc. , a clinical-stage pharmaceutical company developing therapeutics primarily for the treatment of cancer and inflammatory diseases, announced the presentation of int...

Another LNA-based RNA Inhibitor Enters Clinical Trials

... LNA-based PIK3CA antagonist" "EZN-3042, a novel locked nucleic acid oligonucleotide against survivin, inhibits survivin expression and confers taxol sensitivity" "EZN-3920, an LNA antisense oligonucleotide RNA antagonist, down modulates HER3 expression and PI3K/Akt signaling pathway and enha...

Access Pharmaceuticals Announces Positive ProLindac(TM) Phase 2 Ovarian Cancer Clinical Trial Results

...c. As previously announced, we are currently planning a number of combination trials, looking at combining ProLindac with other cancer agents, such as taxol and gemcitabine, in multiple solid tumor indications including colorectal and ovarian." Access has previously announced that it has licensed ProL...

RAD001 Shows Potential to Reverse Resistance to Herceptin(R)* in Metastatic Breast Cancer Patients, Leading to Phase III Trial

...mg) and weekly RAD001 (30 mg, 50 mg and 70 mg) regimens in combination with taxol (80 mg/m2 IV over 60 min on days 1, 8 and 15 every 28 days) and Herceptin (.... Internationally, Herceptin is a registered trademark of Roche. ** taxol is a registered trademark of Bristol-Myers Squibb Company. *** Nave...

Access Pharmaceuticals Presents Favorable Ovarian Cancer Data and Clinical Update on ProLindac(TM) Development at Prestigious International Symposium

...lans for Phase 2 combination trials where we intend to look at multiple solid tumor types with ProLindac in combination with other cancer agents, like taxol and gemcitabine." ProLindac is currently in a Phase 2 dose-escalating monotherapy trial in recurrent ovarian cancer. Access believes that ProLindac'...

Kosan's Second-Generation Hsp90 Inhibitor, Alvespimycin, Shows 42% Clinical Benefit in Phase 1 HER2-Positive Metastatic Breast Cancer Trial

...) (bortezomib) is a registered trademark of Millennium Pharmaceuticals, Inc. Herceptin(R) (trastuzumab) is a registered trademark of Genentech, Inc. taxol (R) (paclitaxel) is a registered trademark of Bristol-Myers Squibb ...

Additional New Data from Satraplatin SPARC Phase 3 Investigational Trial Presented at ASCO Annual Meeting

...le for analysis; a total of approximately 40 patients are expected to be enrolled in the study. This preliminary analysis showed that satraplatin plus taxol appears to have activity in this treatment setting. In an effort to reduce myelosuppression in the study, the satraplatin dose has been lowered to 70 ...

Additional New Data from Satraplatin SPARC Phase 3 Investigational Trial Presented at ASCO Annual Meeting

...le for analysis; a total of approximately 40 patients are expected to be enrolled in the study. This preliminary analysis showed that satraplatin plus taxol appears to have activity in this treatment setting. In an effort to reduce myelosuppression in the study, the satraplatin dose has been lowered to 70 ...

Pro-Pharmaceuticals Updates Progress of Clinical Trials & Davanat 505 (b)(2) Filings

... In other pre-clinical studies, DAVANAT(R) also improved activity of other FDA-approved chemotherapeutics, such as Oxaliplatin, Cisplatin, Avastin(R), taxol and Doxorubicin. "We are also continuing our clinical development plan for DAVANAT(R) in combination with 5-FU and other chemotherapy and biological...
Taxol in Biological News

UCSB scientists show how certain vegetables combat cancer

...man tumor cells by a mechanism similar to the way that the anticancer drugs taxol and vincristine inhibit cell division during mitosis. Mitosis is the proces..." said Wilson. It is also possible that it could be used as an addition to taxol and other similar drugs to increase effective killing of tumor cells withou...

Yale undergrads' Amazon trip yields a treasure trove of diversity

...hytes remain relatively unstudied by scientists, however their potential value was illustrated more than a decade ago when the blockbuster cancer drug taxol was isolated from a fungal endophyte collected from a Pacific Yew tree. Already, the Yale undergraduates have found at least two endophytes with so...

How chemo kills tumors: research to reduce side effects

...ol, has been used clinically for many years because they are highly effective. However, as in all chemotherapy, there are side effects. In the case of taxol these include peripheral neuropathies which can lead to permanent nerve damage and loss of sensation in fingers. In addition little is known about ...

Gut research yields new anti-cancer approach

...ght to the market by Bristol-Myers Squibb in 1993, taxol had annual sales of $1.6 billion at its peak in 2000. Unfortunately, taxol and other standard, anti-tubulin drugs failed in c... breast and lung cancer, the tumor types for which taxol is most used, nearly 100 percent of these tumors e...

Researchers image molecular motor structural changes

... cancer. For example, the drug Taxol, which is used to treat breast and ovarian cancers, works by stabilizing microtubules. But the problem with using taxol as a general inhibitor of cell division is that it works on all dividing cells, not just those involved in tumors or cancers, and so causes unwanted s...

Injection may prevent infertility in men receiving cancer chemotherapy

... testes examined and weighed. The researchers found that a single dose of taxol had induced significant testicular weight loss compared with the control group. An injection of AS101 a day before that of taxol prevented the Taxol-induced weight loss. "Tissue analysis of the teste...

Buckyballs boost antibody's chemotherapy payload

...o melanoma tumors, and work at Rice has shown that taxol can be chemically attached to a buckyball. "The idea that we can potentially carry more than one taxol per buckyball is exciting, but the real advantage ...potential to carry multiple drug payloads, such as taxol plus other chemotherapeutic drugs," said Rice's Lo...

Cellular scale drug delivery from the inside out

...and would break the bonds on the caps and release the drugs. In this way, only cancer cells could be targeted with powerful chemotherapy drugs such as taxol or doxorubicin, while the nanospheres inside the normal cells would remain capped and therefore not cause unwanted side affects by damaging healthy ce...

Measuring Enzymes At End Of Cancer Pathway Predicts Outcome Of Tarceva, Taxol

...rapy Tarceva and the widely used chemotherapy drug taxol are effectively killing tumor cells. They say that...T # 459 Profile CDK to Predict Effectiveness of taxol A different research team, headed by Naoto Ueno...n the Tarceva finding - then the chemotherapy drug taxol appears to effectively kill breast cancer cells. ...

Chemists create 'Superbowl' molecule; May lead to better health

... atoms, particularly those of medicinal value, Sherburn says. "I'm sure that we will be able to encapsulate compounds such as [the anticancer drug] taxol in the near future," he says, but cautions that the superbowl molecule has not yet been tested in animals or humans. Until then, no one knows yet when...
Taxol in Biological Technology

Strong Double-Digit Net Sales Growth and Solid Earnings Growth Highlight First Quarter for Bristol-Myers Squibb Company

... 108 45 140% 29 17 71% 59% Oncology Erbitux 187 160 17% 185 158 17% N/A taxol 94 111 (15)% - 4 (100)% N/A Sprycel 66 21 ** 20 10 100% 49% Ixempr...

Avastin Used in Combination with Drugs from Bristol-Myers Squibb Has Advantages in Survival Rates Over the Current Sales-Leading Therapy for Advanced Ovarian Cancer

... Avastin Used in Combination with taxol and Paraplatin Will Become the Clinical Gold Standard Treatment by 2011, According to a New Report from Decision Resources...

The Coming of Biotech Generic Pharmaceuticals

...s area is the time and amount of money spent on the development of the drug taxol (Bristol-Myers Squibb). This drug was not going anywhere in the NCI until B...pes of cancer to a point where annual sales reached $1.6 billion before the taxol patent expired. The NCI recouped very little back from Bristol-Myers Sq...

Drug innovation beats marketing, patents and mergers

...cer. According to BusinessWeek , Avastin could soon become the largest-selling cancer drug. This is a claim previously held by Bristol-Myers Squibb's taxol before its patent expired. Avastin could reach $2 billion in sales this year. Genentech's stock has split four times since 1987 (1987, 1999, 2000 a...

Enhancing Ruggedness and Full-Scan MS Sensitivity Using Ion Sweep Technology

...nalysis for paclitaxel (Taxol) (m/z 854). taxol is present in a nine component test mixture ...pectrum without the use of Ion Sweep gas. taxol is barely visible in the baseline of the ... is reduced, allowing better detection of the taxol peak in the base peak chromatogram. Furth...
Taxol in Biological Definition

Tubulin

... centrioles and may play a role in forming the mitotic spindle during mitosis. Pharmacology Tubulins are targets for anticancer drugs like taxol . The anti- gout agent colchicine binds to tubulin and inhibits microtubule formation, arresting neutrophil motility and decreasing inflammation...
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