Targeting

Researchers discover stem cell 'guide' that may be key for targeting neural stem cell treatments

UC Irvine School of Medicine researchers have discovered how new neurons born from endogenous neural stem cells are sent to regions of the brain where they can replace old and dying cells, a finding that suggests how stem cell therapies can be specifically targeted to brain regions affected by neurodegenerative diseases or by stroke. Associate Professor Qun-Yong Zhou and graduate student K...

Targeting a key enzyme with gene therapy reversed course of Alzheimer's disease in mouse models

Silencing Alzheimer's: targeting a key enzyme with gene therapy reversed course of disease in mouse modelsIn mice, that had been genetically engineered to develop Alzheimer's disease, scientists were able to reverse the rodents' memory loss by reducing the amount of an enzyme that is crucial for the development of Alzheimer's disease. "What we are showing is a proof of principle that stopp...

Pain killer fights breast cancer by targeting key enzyme

A pain–killing medication appears to halt the production of an enzyme that is key to a common form of breast cancer, a new study using tissue cultures suggests. The drug is called nimesulide. In laboratory experiments on breast cancer cells, scientists found that derivatives of nimesulide stopped the production of aromatase, the enzyme implicated in estrogen-dependent breast cancer. This f...

'Best of both worlds' -- Targeting a single gene could inhibit bone decay and stimulate bone growth

Researchers at the University of Pennsylvania’s School of Medicine have found by targeting the function of a single gene that it is possible to inhibit bone decay while simultaneously stimulating bone formation. This concept may lead to drug treatments for osteoporosis and other bone diseases. Senior author Yongwon Choi, PhD, professor of Pathology and Laboratory Medicine at the University of Pen...

Targeting tumors the natural way

By mimicking Nature's way of distinguishing one type of cell from another, University of Wisconsin-Madison scientists now report they can more effectively seek out and kill cancer cells while sparing healthy ones. The new tumor targeting strategy, presented today (March 25) at the annual national meeting of the American Chemical Society, cleverly harnesses one of the body's natural antibod...

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Rabbit Anti-Conjugated Quinaldic Acid Polyclonal Antibody, Unconjugated from Advanced Targeting Systems

Description:Anti-Conjugated Quinaldic Acid...
Company:Advanced Targeting Systems

Targeting at Biology Technology

A Screen of shRNAs Targeting Tumor Suppressor Genes to Identify Factors Involved in Paclitaxel Sensitivity

Diana Ji, Stacy L. Deeds, and Edward J. Weinstein RNA interference methodologies have been utilized in small to large scale screening projects. The technology has allowed researchers to perform gene-silencing experiments in timeframes and target cells previously not possible. While siRNA screens have become fairly common, large scale screening wi...

Targeting at Biology Dictionary

Gene targeting

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Pharmaceutical companies are targeting patients

TV viewers are right if they are feeling bombarded by commercials. Drug company advertising aimed at ordinary people instead of doctors tripled in the U.S. between 1996 and 2000 to nearly $2.5 billion a year. Advertisements targeting consumers account for 15% of U.S. spending to promote medications, up from almost 9% in 1996.// Spending that targets doctors - including visits from sale...

Novel Technique For Targeting Small-Cell Lung Cancer

Small-cell lung cancer (SCLC), accounting for about 20% of all lung cancers, is a particularly aggressive form of malignancy// with about 80% of cases presenting in advanced stages. Early, accurate detection of SCLC, before it becomes systemic, is essential for successful treatment. Tumor targeting with specific carriers is a promising approach that can significantly enhance the diagnost...

Targeting PARP1 Is Effective In Protecting HD Cells from Damage

According to a study conducted by the researchers at the MassGeneral Institute for Neurodegenerative Disease (MIND) it was found that inhibitor of an enzyme known as Poly //(ADP-ribose) polymerase (PARP1) is very effective in protecting Huntington’s disease affected cells from undergoing damage. By targeting this enzyme new drugs can be developed to treat Huntington's disease (HD) and o...

Ad Campaign Targeting Republicans On Medicare Prescription Drug Program

A $500,000 television and radio ad campaign blaming GOP lawmakers for not seeking lower prices for the Medicare prescription drug program has been launched by the// Association of Trial Lawyers of America on Tuesday. The ad campaign accusing the lawmakers for blocking provisions that would have required Medicare to negotiate with drug companies for the best prescription cost has been...

By Targeting Specific Germs, Hospital Hopes to Improve Pneumonia Treatment

By analyzing patient characteristics and the particular bacteria causing some patients to develop pneumonia during hospital stays// , Wake Forest University Baptist Medical Center has developed treatment guidelines to more effectively target the germs. “We matched the best antibiotic combination to each patient’s characteristics and the particular bugs that we have in our hospital,” sa...

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Gene Therapy Eradicates Pancreatic Cancer in Preclinical Trial Targeting System's Success in Mouse Model Reported in Cancer Cell

HOUSTON, July 9, 2007 - A molecularly engineeredtherapy selectively embeds a gene in pancreatic cancer that shrinksor eradicates tumors, inhibits metastasis, and prolongs survivalwith virtually no toxicity, researchers from The University ofTexas M. D. Anderson Cancer Center report in the July 9 edition ofCancer Cell. "This vehicle, or vector, is so targeted and robust in itscanc...

Pieris Progresses Development of its Proprietary Biotherapeutics Platform: Successful Demonstration of Dual Targeting With Duocalin(R) Technology

FREISING-WEIHENSTEPHAN, Germany, June 21, 2007 /PRNewswire/ --Pieris AG, a bio-pharmaceutical company developing Anticalins(R), anovel class of targeted human protein therapeutics, announced todaythat its proprietary Duocalin(R) technology has successfullydemonstrated dual targeting potential. Commenting on this development, Dr Andreas Hohlbaum, Director ofScience and Preclinical D...

Targeting Specific Mutations Reveals Promising New Approach to Treating Genetic Disorders; Preclinical Data Published in Nature

PTC124 Targets Nonsense Mutations; Addresses Underlying Cause ofGenetic Disorders and Restores Protein Function SOUTH PLAINFIELD, N.J., April 23, 2007 /PRNewswire/ -- Newpreclinical data published online in the current edition of thejournal Nature show that PTC124, an investigational new drugdesigned to bypass nonsense mutations, was efficacious in apreclinical model of Duchenne muscular...

Abraxis BioScience Presents Pre-Clinical Findings That Support Role of SPARC Expression in Cancer and the Role of the Nanoparticle Albumin Bound (nab) Technology Platform in Targeting the Pathway

LOS ANGELES--(BUSINESS WIRE)--Apr 19, 2007 - Abraxis BioScience,Inc. (NASDAQ:ABBI), an integrated, global biopharmaceuticalcompany, announced results from two pre-clinical studies thatsupport the role of SPARC (secreted protein acidic and rich incysteine) expression in cancer and Abraxis' nanoparticlealbumin-bound (nab(TM)) tumor-targeting technology at the 98thAmerican Association for Canc...

Micromet and MedImmune Present Data From Preclinical Study of New BiTE Molecule Targeting CEA

GAITHERSBURG, Md. and CARLSBAD, Calif., April 18, 2007/PRNewswire-FirstCall/ -- Micromet, Inc. and MedImmune, Inc. todayannounced data from a preclinical study in which BiTE(R) moleculestargeting carcinoembryonal antigen (CEA) were shown to preventsubcutaneous tumor growth and formation of lung metastases. Anestablished marker for tumor progression, CEA is frequentlyexpressed on breast,...

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