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Tacrolimus in Medical News

Waters Drives Efficiency in the Clinical and Research Laboratory and Showcases New MassTrak Systems at AACC 2009

...the U.S. Food and Drug Administration (FDA) for a first-of-its-kind commercially available kit specifically designed to quantify the immunosuppressant tacrolimus in kidney and liver transplant patients by LC/MS/MS. About Waters Corporation ( www.waters.com ) Waters Corporation creates bus...

Patent pending for pain-free method of monitoring drug levels in transplant patients

...rgan rejection after transplantation. She is also researching the use of saliva for monitoring the concentration of two other immunosuppressive drugs, tacrolimus and sirolimus. "Routine concentration measurement for these agents is essential for their efficacious and safe use. This is currently done through ...

American Academy of Dermatology Issues New Guidelines For The Management of Psoriasis With Topical Therapies

...cal therapies for psoriasis - including corticosteroids, vitamin D analogues, combination calcipotriene/betamethasone propionate ointment, tazarotene, tacrolimus and pimecrolimus - the Academy's guidelines address patient expectations, method of application, use of concurrent therapies, length of use, applicati...

Immune Response May Hinder Stem Cell Treatments

... would also cause an immune response." Medicating the mice with normal immune systems with a combination of two common anti-rejection compounds -- tacrolimus and sirolimus -- allowed those cells to survive for up to 28 days, the team said. More information The U.S. National Institutes of Health has...

'Multi-target' immune therapy improves outcomes of severe lupus nephritis

...th a combination of immunosuppressant drugs." One group of patients received this "multi-target" therapy, consisting of the immunosuppressant drugs tacrolimus and mycophenolate mofetilcommonly used as anti-rejection drugs in transplant patientsplus a steroid. The other group received standard treatment with...

Cell-Mediated Immunity and Anti-HLA Antibody Tests Provide Insight to Immune Response in Renal Transplant Patients

...Living donor kidney transplants using alemtuzumab pre-conditioning and tacrolimus monotherapy: 5 year experience. Abstract no. 137 presented at the ...0 living donor kidney transplants using alemtuzumab induction and tacrolimus monotherapy: 3 year follow-up. Abstract no. 221 presented at the Ameri...

Multiple Independent Studies Report on Use of Cylex's Immune Cell Function Assay in Postoperative Monitoring of Kidney, Liver, and Heart Transplant Recipients

...gh (C0) levels more than cyclosporine (CSA) or tacrolimus (TAC) -- a safeguard for our many long-term no...ring to assist in the weaning of recipients to tacrolimus monotherapy. -- "Monitoring of immune function f...nsplants with alemtuzumab preconditioning and tacrolimus monotherapy, including the role of the Cylex ImmuK...

Study concludes no racial disparities in long-term outcomes in recipients of liver transplants

...mmunosuppressant drug used during that era (cyclosporine from 1984-1993 and tacrolimus from 1994-2007). The use of the modern immunosuppressant drug tacrolimus substantially reduced the risk of acute rejection, graft loss and patient d...

FDA Approves Additional Indication for Astellas' MYCAMINE(R)

...can be used concomitantly with a number of other drugs, including the HIV protease inhibitor ritonavir and the transplant medications cyclosporine and tacrolimus with no alteration in the pharmacokinetics of MYCAMINE. Patients should be monitored for sirolimus, nifedipine or itraconazole toxicity if receiving t...

Gentler chemotherapy before stem cell transplant causes long-term remission of follicular lymphoma

...s. "Even elderly patients can have this done." Patients received fludarabine, cyclophosphamide and rituximab for three days before transplantation. tacrolimus and methotrexate were used to prevent graft-vs.-host disease. Follicular lymphoma is a Non-Hodgkin lymphoma, with about 12,000 new cases diagnosed ...
Tacrolimus in Medical Technology

Living Donor Kidney Transplants Using Alemtuzumab Pre-Conditioning and Tacrolimus Monotherapy: Long-Term Safety and Efficacy

The results of these studies will be presented during the American Transplant Congress in Boston , MA May 30 - June 3, 2009 COLUMBIA, Md., May 31 /PRNewswire/ -- The results of two large studies presented by researchers from the Starzl Transplant Institute at the University of P...

Emerging Therapies Could Help Ease The Chronic Symptoms of Atopic Dermatitis For Adults and Children

...neurin inhibitors, which includes the FDA-approved tacrolimus ointment and pimecrolimus cream. Recently, several...with the application of topical corticosteroids or tacrolimus ointment, applying topical calcineurin inhibitors ...e recent studies demonstrate that applying topical tacrolimus ointment two to three times per week successfully ...

Precise Low-Dose Drug Monitoring Essential for Long-Term Kidney Transplant Success

...Study Highlights Performance of Abbott's ARCHITECT tacrolimus Assay, Only Automated Transplant Monitoring Test t...isking rejection. "Successful low-dose regimens of tacrolimus and other anti-rejection medications require highl...with the utmost confidence to the physician that a tacrolimus blood level of 3 ng/mL is exactly right and not 5,...

CellCept(R) and a Reduced Level of CNI Shows Trend Towards Preservation of Kidney Function Versus a Standard-Dose CNI

...haracteristics did not differ among treatment groups with living donors accounting for approximately 50 percent of grafts. Eighty-two percent received tacrolimus (Tac) and 18 percent cyclosporine (CyA). CNI doses and levels were significantly lower in the reduced level of CNI. CellCept doses were greater in CyA...

University of Miami Team Confirms Value of Monitoring Cell-Mediated Immunity Pre- and Post-Transplant in Management of Kidney Transplant Recipients

...Patients undergoing kidney transplantation were immunosuppressed post-transplant and their immunosuppressed state was maintained with a combination of tacrolimus (Prograf(R)) and low-dose steroids. A total of 2,096 specimens were drawn from 339 transplant patients, and additional samples were provided by normal...

Prospective Microbial Analysis of Bronchoalveolar Lavage Fluids with Immune Function Testing Can Distinguish Between Fungal Colonization and Fungal Disease In Lung Transplant Recipients

...prospectively monitored and classified for episodes of infection according to standardized criteria. All patients received alemtuzumab induction and tacrolimus suppression to prevent organ rejection. Results of ImmuKnow assays of CMI were included in the analysis if and when they were obtained within 30 days ...

Isotechnika's independent data monitoring committee conducts review of phase 2b kidney transplant trial

...rial is defined as non-inferiority in biopsy proven acute rejection (BPAR) episodes in patients receiving ISA247 for six months as compared to the tacrolimus control which is currently the North American leading transplant drug in this class. Additionally, kidney function and other laboratory parameters...

Isotechnika Announces Interim Three Month Data from Phase 2b Kidney Transplant Trial

...ps compared to a 9% rate of acute rejection in the tacrolimus group, which is being dosed optimally. As par...receiving ISA247 for six months as compared to the tacrolimus control which is currently the North American lead...g/kg twice daily compared with the fourth group, a tacrolimus (0.05 mg/kg twice daily) control arm. Patients in ...

LifeCycle Pharma Announces Positive Phase I Clinical Results for its Transplantation Product Candidate, LCP-Tacro

...al program of LCP-Tacro, a proprietary, once-daily tacrolimus tablet. A series of Phase I trials, involving mo...approximately 5-10% per year. About LCP-Tacro: tacrolimus is a leading immunosuppressive medication to preve... compared to both Astellas' twice daily version of tacrolimus (Prograf(R)) and its modified-release version of...

Anacor Clinical Study of AN2728, a Novel Anti-Inflammatory Compound, Shows Efficacy in Psoriasis

...e trial were divided into six sections, and each of those sections was treated with a different therapy: AN2728 ointment, AN2728 cream, betamethasone, tacrolimus (Protopic) and vehicle cream and ointment. Using ultrasound, researchers measured the thickness of the inflammatory infiltrate in the psoriatic plaque...
Tacrolimus in Biological News

Immunosuppressant further linked to birth defects

...y describes a 25-year-old Spanish woman who had undergone two kidney transplants. Following the second transplant she took the immunosuppressant drugs tacrolimus and MMF. Two years later she became pregnant and MMF was discontinued at 10 weeks gestation, while tacrolimus, one of the drugs that has been studied ...

New compound reduces stroke damage

... treatments, neuroprotective agents have also generated as much interest as thrombolytic therapies. The immunosuppressive drug FK506 (also known as tacrolimus or Prograf®) is often administered to patients receiving transplants to prevent organ rejection. Dervatives of the drug are also commonly used in the ...

Cyclosporine inhibits hepatitis C virus in vitro

...n for patients transplanted for HCV infection and may offer an advantage to tacrolimus in those patients undergoing IFN-based therapy," the authors report. In add...fect than either one alone." Of note, considerably more patients taking tacrolimus had to reduce or stop the therapy due to side effects. Also of possible sig...
Tacrolimus in Biological Technology

Astellas Receives FDA Approval for Use of Prograf(R) (Tacrolimus) in Conjunction With Mycophenolate Mofetil (MMF) in Kidney Transplant Recipients

...f. Coma and delirium also have been associated with high plasma concentrations of tacrolimus. In post marketing experience, patients treated with tacrolimus have been reported to develop posterior reversible encephalopathy syndrome (PRES). If PRES is suspected or diagnosed, immediate reduction of immunosup...

A new LC/MS/MS Research Method for Rapid Quantitation of Five Immunosuppressant Drugs, including Mycophenolic Acid (MPA)

... application note in this series describes an LC/MS/MS method for the simultaneous determination of four immunosuppressant drugs: Cyclosporin A (CsA), tacrolimus (TAC, aka FK-506), Sirolimus (SIR, aka Rapamycin) and Everolimus (EVE, aka RAD-001) (1, 2). The method is based on a simple and robust hardware config...
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