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TPO in Medical News

3SBio Inc. Files for SFDA Approval for TPIAO Label Extension for the Treatment of ITP

...alf of these patients resistant to conventional steroid treatment. TPIAO represents a new approach for the treatment of ITP, by stimulating the tpo receptor, which is intended to have the effect of directly increasing platelet production to outpace platelet destruction by the immune system. The r...

JCI online early table of contents: July 10, 2008

.... Lnk was found to regulate HSC quiescence by binding a signaling protein known as JAK2 after it was activated following binding of the soluble factor tpo to its receptor Mpl. The authors therefore hypothesize that in the absence of the inhibitory molecule Lnk, TPO-initiated signaling from Mpl to JAK2 go...

Naturally-occuring protein may be effective in limiting heart attack injury and restoring function

...team has shown that administering a single dose of tpo to rats during a heart attack decreased the extent...ound that a single cardioprotective treatment with tpo did not increase platelet count. This novel finding suggests the cardioprotective actions of tpo are separate from its ability to increase platelet...

New ADDHERE(TM) Adhesive Tie Layer Bonds Acrylic Cap Layers to Substrates of Thermoplastic Polyolefin (TPO) in Production of Sheet for Use in Thermoforming

... image, and surface durability to high-performance tpo sheet stock MANSFIELD, Texas, Oct. 22 /PRNewswir...elletized material that can be co- extruded with a tpo substrate, to which acrylic film rollstock can be ...h of the three materials - acrylic, tie layer, and tpo - from the melt phase to produce a multi-layer she...

Antifolate Drugs may Be Effective in Treating P Vivax Malaria

... Researchers of HealthNet tpo Malaria and Leishmaniasis Control Programme in Pakistan, have revealed that antifolate drugs may be effective in treating P vivax malaria. To...
TPO in Medical Technology

Long-term Follow Up Interim Data Show Nplate(TM) Increased and Sustained Platelet Counts in Adult Chronic ITP Patients

... thrombopoietin (TPO), a natural protein in the body. Nplate stimulates the tpo receptor, which is necessary for growth and maturation of bone marrow cells...ncy or Myelodysplastic Syndromes (MDS) -- Nplate stimulation of the tpo receptor on the surface of hematopoietic cells may increase the risk for he...

GSK Reports PROMACTA(R) (eltrombopag) Significantly Increased Platelet Counts and Reduced Bleeding in Long-Term Study of Patients With Chronic ITP

...nd monitor closely. Bone Marrow Reticulin Formation and Risk for Bone Marrow Fibrosis: PROMACTA is a thrombopoietin (TPO) receptor agonist and tpo receptor agonists increase the risk for development or progression of reticulin fibers within the bone marrow. Prior to initiation of PROMACTA, examin...

Nplate(TM) (Romiplostim) Receives Positive Opinion for Marketing Authorisation in the European Union

...butes of both peptides and antibodies, but is distinct from each. Nplate works similarly to TPO, a natural protein in the body. Nplate stimulates the tpo receptor, which is necessary for growth and maturation of bone marrow cells that produce platelets. The CHMP positive opinion is based on data...

FDA Approves Promacta(R) (Eltrombopag), the First Oral Medication to Increase Platelet Production for People With Serious Blood Disorder

...e Marrow Fibrosis: PROMACTA is a thrombopoietin (TPO) receptor agonist and tpo receptor agonists increase the risk for development or progression of retic... Malignancies and Progression of Malignancies: Stimulation of the tpo receptor on the surface of hematopoietic cells may increase the risk for he...

Long-Term Safety and Efficacy Data on Promacta(TM) (Eltrombopag) Presented at American Society of Hematology Annual Meeting

...ide thrombopoietin receptor agonist. Blood. 2007: 109:4739-4741. (7) Erickson-Miller, C., Delorme, E., et al Biological Activity and Selectivity for tpo Receptor of the Orally Bioavailable, Small Molecule TPO receptor Agonist, SB-497115. Blood. 2004; 104:796a. (8) Study TRA105325 protocol. (9) Buss...
TPO in Biological Technology

3SBio Inc. Announces Unaudited Fourth Quarter and Fiscal Year 2007 Results

...ter 2006 to RMB29.8 million (US$4.1 million). -- Net revenue from our protein-based therapeutic recombinant human thrombopoietin products, or tpo products, marketed under our TPIAO brand, increased 99.3% over the fourth quarter 2006 to RMB11.7 million (US$1.6 million). -- Operating inco...
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