Lorus Therapeutics Provides an Update on Progress in Virulizin(R) Development Program
...ulizin(R), a novel immunotherapy agent,
expression in monocytes/macrophages in vitro and i...esulted in a
significant induction of the cytokine tnfalpha
in tumors in a mouse model
of malignant melanoma. ... activity towards cancer
cells was demonstrated.
is a protein that is produced by cells of the immu...
Using Validated siRNAs in Functional Genomic Assays
...Validated siRNA targeting the
receptor (TNFR) can be used to identify gene produ...translocation triggered with ligands distinct from tnfalpha
was expected to occur normall...anslocation of NF-kappaB
in response to tnfalpha
treatment was dramatically reduced.
Aggressive cutaneous T-cell lymphomas after TNFalpha blockade.
Pharmacologic blockade of TNFalpha
has been a highly effective approach to ... a humanized murine antibody, bind TNFalpha
and block its interaction with cell ...
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and IL-18 with myocardial infarction and ...