Effects Of Age-related Vascular Diseases Can Be Reduced By Inactivating TNFa
A new study investigating the potential beneficial effects of TNFa
inhibition in vascular aging//, "Vasculoprotective effects of anti-TNFa treatment in aging," appears in the January issue of The American Journal of Pathology.
This study shows hope for significantly reducing vascular aging by...
PRA International to Present Key Challenges for Safety Professionals at the World Drug Safety Congress: PRA Experts discussing REMS at Washington DC Conference
...tly in effect, focusing on dermatology, oncology and immune disorders. PRA has implemented programs in support of novel drugs and biologicals, such as tnfa
blockers, as well as mature products such as antiepileptic drugs.
About PRA International
PRA International is a global Clinical Research Org...
Effect of tumor necrosis factor a inhibitors on heart failure risk in RA Patients
...icated in cardiovascular disorders. Inhibition of tnfa
has opened promising new treatment options for RA ...prevent joint damage. However, in cardiac trials, tnfa
inhibitors have shown no more positive effects on ...isk -- and sometimes less -- than placebo.
inhibition prevent heart failure in RA patients --...
How 'IAP antagonist' chemicals kill tumors
...pathway that produces another protein, called tumor necrosis factor (TNFa). tnfa
comes back and binds its receptor, triggering unimpeded apoptosis and killi... through their action on cIAP1, resulting in NF-"B activation, which drives tnfa
production and initiates tumor cell death. Silke noted that the congruence ...
Pathway links inflammation, angiogenesis and breast cancer
... and doctoral student Dung-Fang Lee, and colleagues works like this:
activates IKK , which as a kinase works by attaching phosphate groups to ot...tween obesity and heightened cancer risk. Obese mammals have high levels of tnfa
secreted by their fat cells.
For Hung, the Cell paper is part of an ongo...
Textile City Tirupur in Tamil Nadu Tops in Pollution Generation
...waiting for a good judgement from the Chennai High Court and if we are not happy with the judgement, we will stage a massive protest,' said Kandasamy, tnfa
Meanwhile, about a hundred dyeing units have been closed down, as they failed
to meet the standards fixed by the Tamil Nadu Pollu...
Synthetic compound promotes death of lung-cancer cells, tumors
In addition to aiding in cell death, tnfa
also is known, paradoxically, to sometimes play a ... able to exploit certain cancer cells that secrete tnfa
and usurp this pro-survival signal to promote cell.... Wang said, adding that detecting the presence of tnfa
in a patient could serve as a marker to indicate t...
A new jump start for aging blood vessels
...e investigated the potential beneficial effects of tnfa
inhibition in vascular aging, making this the firs..., they confirmed that in advanced aging, increased tnfa
levels were associated with significant impairment...ulation of blood pressure.
Second, blocking tnfa
via chronic etanercept treatment decreased cell de...