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TNF in Medical News

Does the Crowded TNF Market Really Need Two New Agents? Rheumatologists Provide Insight in the Wave One Report of LaunchTrends(TM): SIMPONI and CIMZIA

EXTON, Pa., July 31 /PRNewswire/ -- BioTrends Research Group, Inc. announces the release of the wave one LaunchTrends (TM): SIMPONI and CIMZIA report. The survey was completed by U.S. Rheumatologists in late June 2009. While awareness of both new TNF antagonists is relatively h...

Study Shows Increased Out-of-Pocket Expenses May Negatively Influence Initiation of TNF Blocker Therapy

Prime Therapeutics to present findings at AMCP Conference in April ST. PAUL, Minn., April 21 /PRNewswire/ -- Prime Therapeutics (Prime), a thought leader in pharmacy benefit management, today announced the results of its study, "Association Between Tumor Necrosis Factor (TNF) Blocker Out-of...

TNF Blockers May Help Some With Rheumatoid Arthritis

...exate were randomly assigned to receive either the tnf blocker infliximib (Remicade) or the conventional ... methotrexate alone, followed by the addition of a tnf blocker only in patients who have an inadequate re...od and Drug Administration on Tuesday ordered that tnf blockers carry an updated "black box" label to war...

Amgen and Wyeth Statement on FDA Announcement About Tumor Necrosis Factor (TNF) Blockers

...e 2008 pertaining to cases of malignancy in pediatric patients exposed to a tnf blocker. As a result of this review, the FDA has required strengthened warn...and support the continued evaluation of the potential risks and benefits of tnf blockers for patients who are prescribed these therapies. Both companies m...

Certain Arthritis, Crohn's Drugs May Raise Kids' Cancer Risk: FDA

...DA announced that it has completed its analysis of tnf blockers and has concluded that there is an increa...he boxed warning for these products," she said. tnf blockers already carry FDA-mandated warning label...he case of a woman with Crohn's disease who took a tnf blocker and then developed lung cancer. When she c...

Professor Bruce Beutler Joins aTyr Pharma's Scientific Advisory Board

...ccessful class of biotherapeutics ever developed: recombinant inhibitors of tnf that are used to treat inflammatory diseases such as rheumatoid arthritis. ...is of inflammation and innate immunity, Dr. Beutler discovered the key role tnf plays in the inflammatory response. About aTyr Pharma aTyr Pha...

News briefs from the July issue of CHEST

...moking cessation process. Results showed that smoking cessation resulted in significant reductions in circulating tumor necrosis factor (TNF), soluble tnf receptors I and II, and soluble vascular cell adhesion molecule-1 (VCAM-1). Researchers conclude that there are rapid consequences of smoking cessatio...

Global Autoimmune Disease Therapeutics Market to Reach $50 Billion by 2015, According to a New Report by Global Industry Analysts

...ed, and subsequently higher number of patients receiving therapy. Leading biological drugs in the present day treatment of autoimmune diseases include tnf inhibitors, such as Enbrel, Humira and Remicade. New products in the market, such as Rituxan and Orencia made significant inroads by addressing therap...

New Immune Approach for Treatment of Alzheimer's Disease

... , will present the latest data on a revolutionary new immune approach for treatment of Alzheimer's disease. Dr. Tobinick's presentation, entitled tnf modulation for treatment of Alzheimer's Disease, will review the remarkable results which have been documented using perispinal administration of etan...

Once Monthly Dosing: How Much of a Competitive Advantage is it? Rheumatologists Provide Insight in the Baseline Report of LaunchTrends(TM): SIMPONI(TM)

... On the downside, SIMPONI is a new addition to an already crowded market of tnf agents with a similar mechanism of action and a lack of any clear clinical ...ab) for Rheumatoid Arthritis on May 14th, bringing yet another once monthly tnf agent into the mix. In addition to the recent launches of SIMPONI and CIMZ...
TNF in Medical Technology

R788 in TASKi3 Clinical Trial Does Not Meet Efficacy Endpoints in RA Patients Who Had Previously Failed Biologic Therapies - Results Incongruent

...o controlled, parallel dose clinical trial involving 219 RA patients in the U.S. who had failed to respond to at least one biologic treatment (such as tnf inhibitors). The patients were randomly assigned to two cohorts and thus received R788 orally in a 100 mg bid (twice daily) dose or placebo for a per...

SIMPONI(TM) (golimumab) Receives Positive Opinion From CHMP for Once-Monthly Subcutaneous Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

...lonal antibody that targets and neutralizes excess tnf alpha, a protein that when overproduced in the bod...stic infections have been observed with the use of tnf antagonists including SIMPONI. Some of these infe... latent tuberculosis infections. The use of tnf blocking agents including SIMPONI has been associa...

New Analysis Shows Efficacy of SIMPONI(TM) (golimumab) in Anti-TNF Experienced Rheumatoid Arthritis Patients

...pha agents and reason for discontinuation of prior tnf inhibitor. Ninety-five percent confidence interva...ha agent was also examined to assess the impact of tnf inhibitor types (P75 receptor-fusion protein versu...ents who are carriers of this virus and are taking tnf blocker medicines, such as SIMPONI(TM). Some of t...

Two-Year Data Show Patients Receiving SIMPONI(TM) (golimumab) Experienced Sustained Improvement in Signs and Symptoms of Psoriatic Arthritis and Ankylosing Spondylitis

...ents who are carriers of this virus and are taking tnf blocker medicines, such as SIMPONI(TM). Some of t... If you take SIMPONI(TM) or other tnf blockers, your risk for developing lymphoma or oth...t failure can occur or get worse in people who use tnf blockers like SIMPONI(TM). Your doctor will monit...

TNFerade(TM) Phase III Data Presented at ASCO

...ein with potent and well-documented anti-cancer effects, for direct injection into tumors. After administration, TNFerade stimulates the production of tnf alpha in the tumor. TNFerade has been granted Fast Track product designation by the U.S. Food and Drug Administration (FDA) for its proposed use in th...

Video: Partnership Unites UCB with Consumer Product Innovator OXO(R)

...the development of lymphoma. The potential role of tnf blocker therapy in the development of malignancies...re (CHF) and new onset CHF have been reported with tnf blockers. CIMZIA has not been formally studied in ... and institute appropriate therapy. Use of tnf blockers, including CIMZIA, may increase the risk ...

ESBATech's Antibody Fragment Enters Phase I/IIa Clinical Development in Osteoarthritis with the Potential for Disease-Modifying Activity

...driven by episodes of local inflammation and thus, tnf alpha represents a highly promising target. tnf alpha is excessively generated in OA by chondrocyt...which cannot be achieved by the currently marketed tnf inhibitors. With ESBA105, we observe a very effici...

Longevity Seekers Advised to Consume Modest Doses of Red Wine Molecules in Dietary Supplements (Longevinex(R)) Rather than Mega-Dose Resveratrol Alone

...nhibition of tumor necrosis factor (TNF), an inflammatory factor. Excessive tnf leads to inflammation, while too little impairs the immune system, says Sardi. "We know that over-inhibition of tnf in humans increases the risk for lymphoma (cancer that originates in lympho...

Roche and FDA Agree on Pathway Towards U.S. Approval of ACTEMRA(R) (tocilizumab)

... patients with moderate to severe RA who have either responded inadequately to, or who were intolerant to, previous therapy with one or more DMARDs or tnf antagonists. In these patients, RoActemra can be given as monotherapy in cases of intolerance to methotrexate or where continued treatment with methot...

CIMZIA(R) (Certolizumab Pegol) Provides Rapid and Sustained Relief from Signs and Symptoms of Rheumatoid Arthritis for Two Years

... reactivation in patients receiving treatment with tnf blockers such as CIMZIA. However, active tuberculo...erculosis and histoplasmosis are endemic. Use of tnf blockers, including CIMZIA may increase the risk o...CIMZIA and institute appropriate therapy. Use of tnf blockers, including CIMZIA, has been associated wi...
TNF in Biological News

Johnson & Johnson honors 2008 recipients of the Dr. Paul Janssen Award for Biomedical Research

...tients treated globally. "It is very pleasing that our research defining tnf as a good therapeutic target for rheumatoid arthritis has subsequently led to tnf blockade in Crohn's disease, psoriasis, ankylosing spondylitis and ulcerati...

New genes found for inflammatory bowel disease in children

... in the biological pathway of a protein called tumor necrosis factor (TNF). tnf is a cytokine, a chemical messenger that plays a key role in the harmful in...tments for IBD use monoclonal antibodies that selectively bind to a type of tnf involved in the disease (Among those drugs are infliximab, adalimumab and c...

Preventing tuberculosis reactivation

...necrosis factor alpha (TNF) is a protein that facilitates cellcell communication during an inflammatory immune response. Animal models have shown that tnf is vital for control of TB infection. However, anti-TNF treatments are common therapies for treating autoimmune diseases, and this can cause an unwant...

Study reveals a key to blood vessel growth and possible drug target

...r regression and cell death. Next, through a series of genomic analyses and biochemical studies, the team discovered the critical role of birc2 and tnf in blood vessel health in the zebrafish embryo. They showed that birc2 is needed for the formation of the tumor necrosis factor receptor complex 1, a...

JCI table of contents: Aug. 9, 2007

... to suggest that the extent of cardiomyocyte apoptosis is a critical factor in determining whether or not adverse cardiac remodeling occurs. TITLE: tnf provokes cardiomyocyte apoptosis and cardiac remodeling through activation of multiple cell death pathways AUTHOR CONTACT: Douglas L. Mann Baylor...

Infection 'alarm' yields clues to immune system behavior

...terial intruder or toxin in the body. They produce tnf to carry a message about this health threat to nei...them to join in the fight. To send this message, a tnf molecule latches onto the surface of a neighboring...cellular signaling system. "You could think of the tnf molecule, which sounds the alarm, as a very weak r...

Studies reveal how plague disables immune system, and how to exploit the process to make a vaccine

...ria. In mouse and human macrophages, version rV10, missing amino acids 271 through 300, triggered only small amounts of IL-10 and had little effect on tnf secretion. Mice immunized twice over six weeks with rV10 developed antibodies that protected them from many times the lethal dose of the bacteria. ...

New component of the 'brakes' on nerve regeneration found

...er of the same family of receptor proteins--called tnf receptors--as p75. Their experiments revealed that...nd colleagues, "The implication that more than one tnf receptor member may be involved in myelin inhibiti...ating CNS injury." They cited studies showing that tnf receptors are expressed in many types of cells in ...
TNF in Biological Technology

Cimzia(R) (certolizumab pegol) Provides Long-Term Remission and Response Rates in Infliximab-Refractory Crohn's Patients

...the development of lymphoma. The potential role of tnf blocker therapy in the development of malignancies...re (CHF) and new onset CHF have been reported with tnf blockers. CIMZIA has not been formally studied in ...IA and institute appropriate therapy. Use of tnf blockers, including CIMZIA, may increase the risk ...

Health Canada Approves SIMPONI(TM) (golimumab) for Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

...ive for latent tuberculosis infections. The use of tnf blocking agents has been associated with reactivat...phomas have been observed in patients treated with tnf blocking agents, including SIMPONI. The incidence ...re (CHF) and new onset CHF have been reported with tnf blockers. Cases of CHF in patients with known card...

Frost & Sullivan Recognizes ESBATech's Innovation in Developing Antibody Fragments for Biologic Therapeutics

...non-aggregating antibody fragment being evaluated in treating a number of indications including ocular disease. ESBA105 is directed against human tnf alpha - a cytokine that has been identified as the cause of many inflammatory conditions including uveitis, a group of inflammatory diseases affecting...

New Data Suggest CIMZIA(R) (Certolizumab Pegol) Active in Treating Moderate to Severe Crohn's Patients With Fistulizing Disease

... reactivation in patients receiving treatment with tnf blockers such as CIMZIA (R) . However, active ...talities, have been reported in patients receiving tnf blockers, including CIMZIA (R) . Infections ...s and histoplasmosis are endemic. Use of tnf blockers, including CIMZIA(R) may increase the ris...

ACTEMRA(R) (tocilizumab) Studies to be Featured at American College of Rheumatology Annual Scientific Meeting

...T's session], "Tocilizumab Rapidly and Significantly Improves Outcomes in Patients with Rheumatoid Arthritis Who Have Inadequate Response to tnf Antagonists" (Presenter: Paul Emery, M.D.) -- October 27, 3:00 pm - 3:15 pm PDT, Room 307 [Oral Presentation during the RA Treatment: Biol...

Johnson & Johnson Honors 2008 Recipients of The Dr. Paul Janssen Award for Biomedical Research

...shed in clinical trials and through experience with more than one million patients treated globally. "It is very pleasing that our research defining tnf as a good therapeutic target for rheumatoid arthritis has subsequently led to TNF blockade in Crohn's disease, psoriasis, ankylosing spondylitis and u...

Clarification on Press Release Issued Earlier Today: Targeted Genetics Confirms Positive, Interim Phase 1/2 Study Findings

...cs. "We believe the data suggest that tgAAC94 has the potential to improve disease symptoms that are refractory to other therapies, including systemic tnf antagonists." Patients in this Phase 1/2 study continue to be followed for safety and measures aimed to assess functional improvement in treated joi...

Professors Marc Feldmann and Sir Ravinder Maini Named Winners of the 2008 Dr. Paul Janssen Award for Biomedical Research

...s revealed rapid and dramatic improvement of rheumatoid disease activity with anti-TNF therapy, which led to development of several anti-TNF drugs. As tnf is also involved in other chronic inflammatory diseases, the pioneering work of Feldmann and Maini has led to the routine use of anti-TNF therapy for ...

Genmab A/S - Notice to Convene Annual General Meeting

...arly soluble cytokine receptors, as pharmacologic regulators of inflammation. He was instrumental in the development of Enbrel, a soluble receptor for tnf marketed by Amgen and Wyeth Ayerst for the treatment of rheumatoid arthritis. He received a Ph.D. in genetics from the University of Wisconsin in 1976...

Synvista Therapeutics to Develop Topical Formulation of ALT-2074 for the Treatment of Psoriasis

...te plaque psoriasis. TNF-alpha is an established target for drug development in psoriasis and other autoimmune diseases. The effectiveness of approved tnf antagonists may relate to their demonstrated ability to inhibit the induction of cell adhesion molecules and consequent migration of pro-inflammatory ...
TNF in Biological Definition

Apoptosis

...ied extrinsically induced apoptotic processes: the tnf and the Fas pathways. Keep in mind, however, that ...step of these pathways. Tumor necrosis factor ( tnf ), a 157 amino acid inter-cellular signaling molec...ceptors for TNF: TNF-R1 and TNF-R2. The binding of tnf to TNF-R1 has been shown to fire-off the pathway t...
TNF in Biological Dictionary

Biologics

...The Peters Bieling As They Take You Through The Studio And Make A 'Biologic' Painting. Bielings Website: Http://Www.Bielings.Com Biologics (BRMs, tnf Blockers, Biologic DMARDs) drug information, dosage, side ... Do Biologics Prevent Joint Damage and Deformity? ... Find Biologics and more Nutr...

Adenosine deaminase

...ihop ... Direct association of adenosine deaminase with a T cell ... Co-treatment with adenosine deaminase did not reverse the ATP effect on tnf ... "Complete sequence and structure of the gene for human adenosine deaminase . ... "Three new adenosine deaminase mutations that def...
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