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TLR9 in Medical News

JCI online early table of contents: Jan. 12, 2009

...provided new insight into how drugs that stimulate tlr9 might be beneficial, by showing that they inhibit ...ore have immense clinical potential. In the study, tlr9 was found to be highly expressed by a defined popu...D known as 1-alpha,25VitD3. In vitro, induction of tlr9 was mainly regulated by 1-alpha,25VitD3, and human...

JCI online early table of contents: April 8, 2008

... VIROLOGY A pox on TLR9: the immune molecule tlr9 is crucial to prevent lethal poxvirus infection in... Nordic GmbH, Germany, have identified the protein tlr9 as central to immune defense against infection with some poxviruses in mice. In the study, tlr9 was shown to be essential for mice to mount protec...

Dynavax to Present at CIBC World Markets and Acumen BioFin Rodman and Renshaw Healthcare Conferences

...es Corporation discovers, develops, and intends to commercialize innovative tlr9 agonist-based products to treat and prevent infectious diseases, allergies,... approaches that alter immune system responses in highly specific ways. Our tlr9 agonists are based on immunostimulatory sequences, or ISS, which are short ...

Dynavax Announces Third Quarter 2007 Financial Results and Updates 2007 Financial Outlook

...es Corporation discovers, develops, and intends to commercialize innovative tlr9 agonist-based products to treat and prevent infectious diseases, allergies,... approaches that alter immune system responses in highly specific ways. Our tlr9 agonists are based on immunostimulatory sequences, or ISS, which are short ...

Dynavax and Merck & Co., Inc. Announce Partnership to Develop HEPLISAV(TM), an Investigational Hepatitis B Vaccine Currently in Phase 3

...es Corporation discovers, develops, and intends to commercialize innovative tlr9 agonist-based products to treat and prevent infectious diseases, allergies,... approaches that alter immune system responses in highly specific ways. Our tlr9 agonists are based on immunostimulatory sequences, or ISS, which are short ...

New Round of Lupus Research Institute Awards Brings Promise of More Breakthroughs

... B cell depletion therapy in mice Gregory Barton, PhD University of California, Berkeley The role of ubiquitin-mediated downregulation of TLR7 and tlr9 in lupus Loren Erickson, PhD University of Virginia The Role of Nba2 in Plasma Cell Differentiation Nir Hacohen, PhD Massachusetts General Hosp...

Dynavax to Present at Bear Stearns 20th Annual Healthcare Conference

...es Corporation discovers, develops, and intends to commercialize innovative tlr9 agonist-based products to treat and prevent infectious diseases, allergies,... approaches that alter immune system responses in highly specific ways. Our tlr9 agonists are based on immunostimulatory sequences, or ISS, which are short ...

Hope For Patients With Inflammatory Bowel Disease

...o two different groups of mice that appeared similar but were from different genetic strains. Reactions were different in the two strains of mice. The tlr9 activators inhibited the severity of experimental colitis but had no effect on the other group of mice. To understand why the mice reacted differen...
TLR9 in Medical Technology

Idera Pharmaceuticals Announces Presentations of Preclinical Data on New Potential Oncology Applications of its TLR9 Agonists at AACR

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Apr 18, 2007 - Idera Pharmaceuticals, Inc. (AMEX: IDP) today announced two presentations of data for two new potential applications in oncology of its novel agonists of Toll-like receptor 9 (TLR9) at the Annual Meeting of the American Association for Cancer Resear...

Dynavax Presents New Analysis of TOLAMBA(TM) Data at ACAAI Meeting

...es Corporation discovers, develops, and intends to commercialize innovative tlr9 agonist-based products to treat and prevent infectious diseases, allergies,... approaches that alter immune system responses in highly specific ways. Our tlr9 agonists are based on immunostimulatory sequences, or ISS, which are short ...

Coley Pharmaceutical Group and Pfizer Nominate Additional Anti-Cancer Compound for Clinical Development

...ator in the area of cancer, has nominated a second tlr9 agonist compound discovered by Coley for future cl... programs for PF-3512676, Coley's lead therapeutic tlr9 agonist drug candidate, for the treatment of cance... and develop a variety of pharmacologically unique tlr9 agonist compounds demonstrates our dexterity in dr...

Coley Pharmaceutical Group Receives $3.0 Million Milestone Payment from GlaxoSmithKline

...disease-free survival. The $3 million development milestone was triggered by the initiation of this Phase III trial. VaxImmune is Coley's proprietary tlr9 agonist designed to induce both an enhanced antibody response and a potent killer T cell immune response when used in conjunction with vaccines in ord...

Dynavax Begins TOLAMBA(TM) Environmental Exposure Chamber Study

...es Corporation discovers, develops, and intends to commercialize innovative tlr9 agonist-based products to treat and prevent infectious diseases, allergies,... approaches that alter immune system responses in highly specific ways. Our tlr9 agonists are based on immunostimulatory sequences, or ISS, which are short ...

Dynavax's HEPLISAV(TM) Hepatitis B Vaccine Maintains Full Immunogenicity at 50 Weeks in Phase 3 Trial

...es Corporation discovers, develops, and intends to commercialize innovative tlr9 agonist-based products to treat and prevent infectious diseases, allergies,... approaches that alter immune system responses in highly specific ways. Our tlr9 agonists are based on immunostimulatory sequences, or ISS, which are short ...

MedImmune Highlights Advances in Inflammatory Disease Pipeline With Series of Data Presentations

...ntribute to the pathology of a range of disorders such as joint inflammation and sepsis." Data presented at AAI include: -- "Regulation of tlr9 dependent DNA Immune complex mediated cell activation by High Mobility Group Box Protein 1 (HMGB1) and Receptor for Advanced Glycation...
TLR9 in Biological News

Scripps research scientists solve structure of a critical innate immune system protein

...saccharide, a chemical component of the cell walls of certain bacteria like Neisseria meningitides--one of the leading causes of bacterial meningitis. tlr9 recognizes bacterial DNA that contains distinguishing CpG dinucleotides motifs . TLR3 in Detail Likewise, TLR3 recognizes double-stranded RNA, w...
TLR9 in Biological Technology

Dynavax Issued Landmark Patent Covering Second-Generation TLR9 Agonists

BERKELEY, Calif., Aug. 16 /PRNewswire-FirstCall/ -- Dynavax Technologies Corporation (Nasdaq: DVAX ) today announced that the U.S. Patent Office has issued the company a broad composition of matter patent covering the company's proprietary second-generation TLR9 agonists. The claims cover a ...

Dynavax Reports Progress in Lupus Program With Inhibitor of TLR7 and TLR9

Animal Model Shows Disease Progression Can Be Prevented BERKELEY, Calif., Nov. 26 /PRNewswire-FirstCall/ -- In a paper appearing online in the December issue of The European Journal of Immunology (Vol. 37, Issue 12), Dynavax scientists report the results of studies made possible under ...

Dynavax to Present at UBS 2007 Global Life Sciences Conference

...es Corporation discovers, develops, and intends to commercialize innovative tlr9 agonist-based products to treat and prevent infectious diseases, allergies,... approaches that alter immune system responses in highly specific ways. Our tlr9 agonists are based on immunostimulatory sequences, or ISS, which are short ...
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