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TIMI in Medical News

Daiichi Sankyo and Lilly Receive U.S. FDA Approval for Effient(TM)

...-TIMI 38 investigator Elliott Antman, M.D., professor of Medicine at Brigham and Women's Hospital (BWH) in Boston and senior investigator with the BWH timi Study Group. "Prasugrel is an important new option for patients with ACS who are managed with PCI. Prasugrel was associated with a significantly high...

Schering-Plough Reports Financial Results for 2009 First Quarter

... Reported on a Phase II study published in The Lancet of the company's novel oral thrombin receptor antagonist (TRA), which showed no increase in timi major and minor bleeding and was well tolerated when given with standard platelet therapy. (Announced March 12) Initiated the first-in-human ...

Prasugrel Receives Unanimous Approval Recommendation from FDA Advisory Committee

...am and Women's Hospital (BWH) in Boston and senior investigator with BWH's timi Study Group. "In a large head-to-head trial, TRITON, showed that prasugrel ...g was compared to the benefit of reduced heart attack, there were five more timi major bleeding events, but 22 fewer heart attacks for every 1,000 patients ...

Phase II Trial of Experimental Anti-Coagulant Reports Safety and Outcomes Data

...spirin plus a thienopyridine. Regarding the safety endpoint, a composite of timi major bleeding, timi minor bleeding and any bleeding requiring medical attention, the researcher...

Cholesterol-Lowering Drugs May Ease Irregular Heartbeat

...rofessor of medicine at Harvard Medical School and a cardiologist at Brigham and Women's Hospital, Boston. Cannon is also a senior investigator in the timi (Thrombolysis in Myocardial Infarction) Group, which has done studies on statins and atrial fibrillation. "It would be nice to see a larger number ...

Ranexa(R) Significantly Reduces Ischemia in Women in MERLIN TIMI-36 Study

...atic documented arrhythmias was observed in women between the ranolazine and placebo groups. The data were presented today by Dr. Jessica Mega of the timi Study Group at the American Heart Association Scientific Sessions in Orlando, Florida. "Women were very well represented in the MERLIN TIMI-36 study ...

Ranexa(R) Significantly Reduces Incidence of CV Death, MI or Recurrent Ischemia in MERLIN TIMI-36 Patients With Elevated BNP

... (>80pg/ml) level of b-type natriuretic peptide (BNP) in the MERLIN TIMI-36 study (p=0.009). The data were presented today by Dr. David Morrow of the timi Study Group at the American Heart Association Scientific Sessions in Orlando, Florida. Ranolazine is believed to exert its anti-ischemic effects thro...

Singulex Announces Presentation on Monitoring of Cardiac Biomarker to Assess Transient Myocardial Ischemia at the American Heart Association Scientific Sessions

...rdiovascular medicine at BWH. He was instrumental in the development of the timi Biomarker Program at BWH, and his research at timi focuses on risk stratification and the management of acute coronary syndrom...

In Landmark Phase III Head-to-Head Study, Prasugrel Statistically Superior to Clopidogrel in Reducing Risk of Heart Attack

...dose clopidogrel as an antiplatelet therapy to support patients undergoing coronary stenting," said Elliott Antman, M.D., senior investigator with the timi Study Group at Harvard Medical School and director of the Samuel A. Levine Cardiac Unit at Brigham and Women's Hospital in Boston. "With the data from...

Sanofi-aventis Announces a Good Third Quarter Performance; Increase in 2007 full-year earnings growth guidance

...rward-looking information or statements. Recent Events September 2, 2007 Announcement of one-year findings from the ExTRACT- timi 25 and STEEPLE studies confirming a clear net clinical benefit for Lovenox(R) versus unfractionated heparin ...

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TIMI in Medical Technology

New Analysis Evaluated Impact of Genetic Variation on Response to Prasugrel

...pectively (P=0.48). The results also showed that rates on non-CABG-related timi major or minor bleeding did not significantly differ by genetic variant amo...Physician at Brigham and Women's Hospital in Boston and Investigator at the timi Study Group. "We wanted to test if these genetic variants have a similar ef...

Schering-Plough Announces Results of the Early ACS Trial

...bleeding were observed in the study group, with 118 patients experiencing a timi major bleeding event, compared to 83 in the delayed provisional group (p=0....us adverse events through 120 hours. Bleeding was measured according to the timi and GUSTO bleeding scales. About INTEGRILIN(R) (eptifibatide) Injecti...

Schering-Plough's Investigational Oral Thrombin Receptor Antagonist Meets Primary Endpoint in a Newly Published Study

...t-Tracked Antiplatelet Agent Showed No Increase in timi Major and Minor Bleeding and was Well Tolerated Wh.... The primary endpoint was measured using the timi bleeding scale. timi major bleeding is defined as any intracranial (hea...

Diabetes Patients with High Triglycerides and Low HDL Cholesterol Get the Most Benefit From Fenofibrate Treatment: New Data From the FIELD Study

...s Care 32:493-498. 2. Miller M, Cannon CP, Murphy SA et al, PROVE-IT timi 22 Investigators. Impact of triglyceride levels beyond low-density lipoprotein cholesterol after acute coronary syndrome in the PROVE-IT timi 22 trial. J Am Coll Cardiol 2008; 51: 724-30. 3. Barter PJ, Gotto AM...

MGuard(TM) Coronary Stent System Approved in Israel

... with acute STEMI who received the MGuard stent with no additional distal embolization or aspiration device. The primary endpoint is ST resolution and timi flow, and follow up is up to six months. The study's primary endpoints are complete resolution of ST-segment elevation and restoration of flow through...

Daiichi Sankyo Initiates Phase III Trial of Its Investigational Factor Xa Inhibitor, DU-176b, in Patients With Atrial Fibrillation

...lely by Daiichi Sankyo. The Phase III global study, Effective Anticoagulation with Factor Xa Next Generation in Atrial Fibrillation (ENGAGE-AF timi 48), will compare DU-176b with warfarin in preventing stroke and systemic embolic events (SEE) in patients with atrial fibrillation. The primary safe...

Daiichi Sankyo and Lilly Respond to Speculation on Status of Prasugrel New Drug Application

...d risk of serious bleeding with prasugrel overall, some of which may be life threatening. Overall, for every 1,000 people treated, there were six more timi major bleeding events, but 23 fewer heart attacks in patients taking prasugrel compared with patients taking clopidogrel(i). The risk of cardiovascula...

Head-to-Head Study Showed Prasugrel Statistically Superior to Clopidogrel in Reducing Recurrent Cardiovascular Events

...e threatening. Overall, for every 1,000 people treated, there were six more timi major bleeding events, but 23 fewer heart attacks in patients taking prasug...rent bleeding events occurred infrequently among patients with at least one timi non-CABG major or minor bleeding (17 in the prasugrel group and 13 in the c...

ATHENA Clinical Results with Dronedarone (Multaq(R)) Highlighted at the World Cardiology Congress

... a landmark trial, that marks a paradigm change for the management of atrial fibrillation," said Prof Christopher Cannon, a Senior Investigator in the timi Study Group at Brigham and Women's Hospital, Harvard Medical School, who was not involved in the study. "Atrial fibrillation is a very common disease,...

ATHENA Clinical Results for Dronedarone (Multaq(R)) Highlighted at the World Cardiology Congress

... a landmark trial, that marks a paradigm change for the management of atrial fibrillation," said Prof Christopher Cannon, a Senior Investigator in the timi Study Group at Brigham and Women's Hospital, Harvard Medical School, who was not involved in the study. "Atrial fibrillation is a very common disease,...
TIMI in Biological Technology

Sanofi-aventis Announces Second Quarter 2009 Results

...the ACTIVE-I study evaluating irbesartan in patients with atrial fibrillation will be presented on September 1. Results from the SEPIA-ACS1 timi 42 phase II trial, evaluating the efficacy and tolerance of otamixaban (an intravenous selective anti Xa factor) in patients with acute coronary syndr...

Multiple Types of Heart Attacks Reduced by Prasugrel in TRITON-TIMI 38 Trial

...rent heart attacks," said David A. Morrow, M.D. M.P.H., Associate Professor of Medicine at Harvard Medical School and a Senior Investigator with the timi Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA. Investigators classified 1,218 heart atta...

InspireMD Announce the Completion of Enrollment for the MAGICAL Trial (MGuard(TM) in Acute Myocardial Infarction) at EuroPCR '09. Results Will be Presented May 21st by Dr. Dariusz Dudek at the InspireMD Cocktail Reception Debate Chaired by Prof. Martin Le

...e ST segment resolution measured 60 minutes post procedure and incidence of timi 3 flow after PCI. Main secondary endpoints are myocardial blush grade and M...I patients using MGuardTM seems highly safe and effective". To date, timi flow 3 is 91%, MBG 3 (Myocardial Blush Grade) is 74%, Complete ST Resolutio...

MGuard(TM), InspireMD's Novel Coronary Stent System, was Celebrated by World Leading Interventional Cardiologists at the Transcatheter Cardiovascular Therapeutics (TCT) in Washington DC, USA, October 12-17 2008

... an MGuardTM stent which covered the entire thrombus, preventing defragmentation and massive embolization. The final result was very good with a final timi 3 flow and a very good myocardial blush. I think that the MGuardTM stent system helped us to achieve very good results in a very difficult set up." ...

Daiichi Sankyo, Lilly Submit New Drug Application for Investigational Antiplatelet Drug, Prasugrel, with U.S. Food and Drug Administration

...ery 1,000 patients treated with prasugrel as compared with clopidogrel, there were 22 fewer patients with heart attacks and five more non-CABG-related timi major bleeds. "Given the overall results from TRITON, this submission is particularly meaningful considering that cardiovascular disease is the lead...

Circulation Publishes MERLIN TIMI-36 Data Showing Safety and Anti-Arrhythmic Effects of Ranexa(R)

...i-arrhythmic agent in treating ventricular arrhythmias," said Benjamin Scirica, a cardiologist at Brigham and Women's hospital, an investigator at the timi Study group and lead author of the study. These data represent the first clinical report of the effect of ranolazine to reduce the incidence of cardi...

New Study Findings Confirm CLEXANE(R)/LOVENOX(R) Long-Term Clinical Benefit in Patients Suffering From Acute Coronary Syndrome

...is in the STEMI patient population," noted ExTRACT timi 25 principal investigator Dr. Elliott Antman, M.D., Senior Investigator timi Study Group, Director, Samuel A. Levine Cardiac Un...nvestigator of the ExTRACT-TIMI 25 study. ExTRACT timi 25 was a major randomized clinical trial that supp...

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