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TAT in Medical News

Patients Beyond Borders Thailand Edition to Launch in September

...national tourism industry and its related sectors. tat also supplies information on tourist destinations ...ct travelers to Thailand. For nearly 50 years, tat has played a significant role in national tourism ...tions available. Thirty-five local and 22 overseas tat offices disseminate Thailand tourism information w...

Bumrungrad Launches 2009 Great Chefs Program - Top local Chefs Design Menus Based on 'Amazing Thailand'

... CEO. "This year, we wanted to connect these expert chefs to what's special about Thailand--for example, great beaches and delicious seafood. The tat campaign offers a natural tie-in." The participating hotels include: Swissotel Le Concorde Bangkok, Pan Pacific Bangkok, Sofitel Centara Gran...

Study sheds light on causes of HIV dementia

...rasad and colleagues compared the sequences of the tat protein of the two clades and noted a key difference. Where the clade B tat protein contained the amino acid cysteine at a specific position in the tat protein, the clade C...

Selenium may slow march of AIDS

...ey protein known as Tat, is the likely culprit. tat is one of about 14 odd proteins produced by HIV du...at the virus needs to sustain itself. In addition, tat also plays a key role in helping the virus replicate. One of the proteins that targets tat is a selenoprotein known as TR1. "Since HIV ta...

Researchers identify toehold for HIV's assault on brain

... neurons. Researchers discovered the receptor that tat uses to attack neurons, and they were able to reverse the effects of tat in the laboratory by blocking the receptor. The...tright dementia. Gelbard's team discovered that tat works through the ryanodine receptor to sicken neu...

Illinois Radiologists Self-Edit Reports, Reduce Turnaround Time with SpeechQ for Radiology(TM)

...to the appropriate radiologist for review and signature. With SpeechQ, average report turnaround time has been reduced from 61/2 hours to 3 hours, and tat for STAT and ED reports is now five minutes. Dr. James Studlo, medical director of Imaging Services and chief of the medical staff at Provena Mercy,...

Anti-parasite drug may provide new way to attack HIV

...N. In a series of experiments, Kims team observed that the presence of HIV tat in infected macrophages lowers PTEN levels by 40 percent, enabling the PI3K... inhibits PI3K/Akt pathway, and thus, promises to counter the effect of HIV tat on PTEN, Kim said. The treatment was first identified in Germany in the ear...

amfAR announces inaugural Mathilde Krim Fellowship Awards for AIDS research

... cell protein, P-TEFb, which interacts with a segment of the virus called Tat. Dr. DOrso plans to elucidate the precise details of the process whereby tat and P-TEFb bind together and the structure of these protein complexes. Understanding the process of assembly and the shape taken by these proteins whe...

FDA Approves New Roche West Nile Virus Blood Screening Test

...nce of a new threat to the U.S. blood supply. Although mosquito-borne transmission remains the predominant mode of WNV transmission, identification of tat underscored the need for WNV screening of donated blood. In June 2003, blood-collection agencies implemented investigational WNV nucleic acid-amplific...

Working Up Potential Living Liver Donors

...acts on his or her psyche, decision and satisfaction, as well as on the outcome of the potential recipient. Researchers, led by Professor Sheung tat Fan of the University of Hong Kong, sought to analyze and report the experiences of donor workups at their center, which performs many more transplant...

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TAT in Biological News

High blood sugar's impact on immune system holds clues to improving islet cell transplants

... AUGUSTA, Ga. A biological tit for tat may hold clues to improving the success of islet cell transplants intended to cure type 1 diabetes, according to a Medical College of Georgia scientis...

Researchers discover how stealthy HIV protein gets into cells

...gs appears this month in Angewandte Chemie. The tat protein transduction domain of the HIV virus has s...roperties. First, it is a tiny part of the overall tat protein, containing only 11 amino acids. Second, a...components and are designed to keep things out. tat is extremely good at getting through cell membrane...

Researchers reveal HIV peptide's possible pathway into the cell

...sts have known that a positively charged, 11-amino-acid chain of HIV (HIV-1 tat protein) can do the nearly unthinkable X cross through the cell membrane. Sometimes referred to as an "arrow protein," HIV-1 tat pierces the cell membrane and carries a cargo though the cell membrane. ...

Scientists find potential 'off-switch' for HIV virus

...ous studies by others, they have proposed that the tat protein and the enzymes that modify it serve as a ...ecular Biology. "Understanding how to activate the tat resistor to interrupt the reactions leading to vir...s in a loop. First, one of HIV's genes creates the tat protein, which is part of the chemical signal for ...

HIV protein enlisted to help kill cancer cells

...ish Hospital. "A portion of the HIV protein called tat can transport biologically active compounds into cells. tat is small, but it can move massive molecules. You could almost hook tat up to a train, and...

A simple feedback resistor switch keeps latent HIV from awakening

...ription. HIV's transcriptional activator, the tat gene, is encoded in the HIV genome. Once tat is transcribed, it can rapidly increase transcript...at ultimately lead to viral replication. Thus, the tat protein acts like a molecular switch, making it a ...

Hopkins study suggests commercially available antibiotic may help fight dementia in HIV patients

...ng so. The study looked at two proteins, called tat and gp120, that are part of the virus that causes ...dy's lead author. HIV is the only virus that makes tat and gp120, which are produced during its normal li...ents for this complication. According to Rumbaugh, tat and gp120 are believed to cause dementia by reduci...

Random gene expression may drive HIV into hiding

...of HIV's replication machinery: a gene called Tat. tat facilitates transcription of HIV's entire genome, ...eates a positive-feedback loop: If a little bit of tat is around, then the HIV genome is transcribed effi...l, it is copied into DNA, and then a little bit of tat is made before the virus integrates into the host ...

Ancient immune defense mechanism is no match for HIV-1

...n function as a suppressor of RNA silencing (SRS). tat helps HIV-1 to elude the cell's natural RNAi defen...te animals," explains Dr. Jeang. "Our finding that tat is an SRS also helps explain the long-standing bio...vation that when HIV-1 is engineered to be lacking tat but contains alternative transcriptional activator...

An HIV Protein Plays a Surprising Role in Gene Activation

... work with human cell lines and find evidence that tat can also stimulate PIC assembly. While most transcription factors bind to DNA, tat binds to an area at the end of newly emerging vira...ransactivation response element (TAR). Once bound, tat recruits a cellular complex called P-TEFb (consist...

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