Synthase

Food additive may one day help control blood lipids and reduce disease risk

...ed a strain of mice that could not make fatty acid synthase in the liver. When humans or animals eat, we take in sugars. Fatty acid synthase converts those sugars to fatty acids in the liver,...m. "To our surprise, animals missing fatty acid synthase in the liver were just like animals that couldn't ...

Unique Collaboration Between TB Alliance and Tibotec To Accelerate Tuberculosis Drug Development

... Sheet. Accessed from http://www.who.int/tb/publications/2008/factsheet_april08.pdf . (VI) Andries et al. A Diarylquinoline Drug Active on the ATP synthase of Mycobacterium tuberculosis Science 14 January 2005: Vol. 307. no. 5707, pp. 223 - 227. Media Contacts Global Alliance for TB D...

Upside-down world: DNA protecting protein helps cancer drug to kill cells

...orectal cancer. But precisely how the drug kills cancerous cells was not well understood. It was generally thought that as an inhibitor of thymidylate synthase the compound worked by starving cells of the thymidine needed to make DNA. First author on the paper Christophe Kunz and his colleagues inactivate...

Genetic variants predict recurrence of bladder cancer, patient survival

...cent over four years. In this study of 596 patients at M. D. Anderson, 46 percent of those who had a common genotype of the inducible nitric oxide synthase (iNOS) gene experienced a recurrence after receiving maintenance BCG therapy. Only 22 percent of patients with the variant-containing genotypes had a ...

Also in the March 24 JNCI

...ssofficers@mail.nih.gov , 301-496-6641 Overexpression of Fatty Acid synthase Promotes Prostate Cancer in Mouse Models Fatty acid synthase (FASN) can act as a prostate cancer oncogene in mouse models. FASN, a ke...

Scientists Gain Insight Into Blood Cancer's Progression

...to a deadlier stage. The finding may improve patient outcomes, they said. The researchers found that when a molecular off-switch called glycogen synthase kinase (GSK) 3 beta becomes faulty in chronic stage CML cells, it fails to turn off another protein called beta-catenin. This enables pre-leukemia ste...

Synthase in Medical Technology

Trius Antibiotics to be Highlighted in 18 Presentations at ICAAC/IDSA

...f a Novel Series of Pyrimidine Antibacterials Targeting Methionyl-tRNA synthase (MetRS) -- F1-335: In Vitro Activity of Rx100472 Against Clinically Impor...re Guided Design of Pyrimidine Antibacterials Targeting Methionyl-tRNA synthase (MetRS) Copies of these posters will be available on the Trius website fol...

In Blood Vessel Stents, Innovative Materials Allow Better Control, Delivery of Gene Therapy

...o allow peak release of the vector when it can have the maximum benefit." The adenovirus vector carries genes that code for inducible nitric oxide synthase (iNOS), a protein that controls cell damage in blood vessels. In the current study, the iNOS reduced restenosis by 56 percent in the carotid arteries ...

ADVENTRX Announces Completion of Patient Enrollment in Phase 2 Clinical Trial of CoFactor(R) for the Treatment of Advanced Breast Cancer

...chemotherapeutic agent 5-FU. Compared to leucovorin, CoFactor creates more stable binding of the active form of 5-FU to the target enzyme, thymidylate synthase (TS). CoFactor bypasses the metabolic pathway required by leucovorin to deliver the active form of folate, potentially allowing 5-FU to work more effe...

Synvista Therapeutics' Alagebrium Shows Potential for use in Treating Diabetes-Related Gastrointestinal Complications

...monstrating the ability of its compound, alagebrium, to reduce serum levels of advanced glycated end-products (AGEs) and restore neuronal nitric oxide synthase (nNOS) activity in rats with diabetes. Loss of gastrointestinal nNOS activity is one of the major putative mechanisms for the development of diabetic ...

Studies Suggest Key Correlation Between Lung Cancer Subtype and Treatment Outcomes

...linical data that suggested patients with a lower expression of thymidylate synthase (TS) enzyme show an increased efficacy when treated with ALIMTA.(3,4) The h...LIMTA) in WiDr human colon cancer cells is associated with thymidylate synthase overexpression. Biochem Pharmacol 2003; 66:431-38. (4) Ceppi P, Volan...

ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer

...therapeutic agent 5-FU. In comparison to leucovorin, CoFactor creates more stable binding of the active form of 5-FU to the target enzyme, thymidylate synthase (TS). CoFactor bypasses the metabolic pathway required by leucovorin to deliver the active form of folate, allowing 5-FU to work more effectively. CoF...

Synthase in Medical Products

Uroporphyrinogen I Synthase

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Hydroxymethylbilane Synthase

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Synthase in Biological News

Advance in understanding cellulose synthesis

...le fluorescent molecules, and found that cellulose synthase moves along "tracks" defined by the microtubules. ...ooked at how the association between the cellulose synthase complexes and microtubules begins. The scientists were able to watch individual cellulose synthase complexes as they were delivered to the plasma mem...

MSU discoveries upend traditional thinking about how plants make certain compounds

...usly unsuspected way." The two newly identified genes, neryl diphosphate synthase 1 (NDPS1) and phellandrene synthase 1 (PHS1), cause the tomato plant to make the new enzymes that produce the m...

Computational model examines the pathways of Alzheimer's that strikes at the young

...udy entitled A Computational Model of the Role of Presenilin-1 and Glycogen synthase Kinase-3 in Familial Alzheimer's Disease. They will present their findings ...teins presenilin-1 (PS1) (a mutated gene found in familial AD) and glycogen synthase kinase (GSK-3) (a protein) and amyloid beta (Aβ) plaque (amino acids t...

Computational model examines the pathways of Alzheimer's that strikes at the young

...udy entitled A Computational Model of the Role of Presenilin-1 and Glycogen synthase Kinase-3 in Familial Alzheimer's Disease. They will present their findings ...teins presenilin-1 (PS1) (a mutated gene found in familial AD) and glycogen synthase kinase (GSK-3) (a protein) and amyloid beta (Aβ) plaque (amino acids t...

Pulmonary hypertension in children may result from reduced activity of gene regulator

...erful dilator. There's also more asymmetric dimethyl arginine, or ADMA, which inhibits nitric oxide production, making bad matters worse. Nitric oxide synthase uses arginine to make nitric oxide and ADMA, an arginine analogue, can bind to the nitric oxide precursor so it instead becomes a source for free radi...

SNPs affect folate metabolism in study of Puerto-Rican adults

...folate uptake and retention: folate hydrolase (FOLH1), folate polyglutamate synthase (FPGS), γ-glutamyl hyrdolase (GGH), proton-coupled folate transporter ...ns were studied: methylenetetrahydrofolate reductase (MTHFR) and methionine synthase (MTR). SNPs are variations in the sequence of nucleotides, or building ...

Synthase in Biological Technology

FASgen Diagnostics, LLC Announces Production and Investment Agreement With Tetracore, Inc.

... antibodies. The tests measure the over-expression of the enzyme fatty acid synthase (FAS), which is found in virtually all solid tumor cancers. FASgen's FAS-de...ns Hopkins who have been studying the role of over expression of fatty acid synthase in cancer. That work has been underway for more than 15 years. FASgen Diagn...

Celadrin(R) Research Unveiled at Nutrigenomics 2008 Meeting in Paris, France

...iscovery organization for the pharmaceutical and biotechnology industries. In these in vitro studies, Celadrin(R) was shown to inhibit the thromboxane synthase enzyme using prostaglandin G2 (PGG2) and prostaglandin H2 (PGH2) as substrates. Thromboxane is a very strong facilitator of inflammation and local tis...

New approach may render disease-causing staph harmless

...id in Staph. He also knew that many compounds already had been developed to block the human enzyme. I thought there was a good chance that squalene synthase inhibitors developed early on as cholesterol lowering agents might also work on this other pathway, he said. Current cholesterol-lowering drugs like s...

ADVENTRX Announces Fast Track Designation Granted By the FDA For CoFactor For the Treatment of Metastatic Colorectal Cancer

...therapeutic agent 5-FU. In comparison to leucovorin, CoFactor creates more stable binding of the active form of 5-FU to the target enzyme, thymidylate synthase (TS). CoFactor bypasses the metabolic pathway required by leucovorin to deliver the active form of folate, allowing 5-FU to work more effectively. CoF...

A DELFIA Assay for Inhibition of PARP

...in, increase apoptosis in cancer cells, prevent infiltration of neutrofils and subsequent inflammation, and to suppress the production of nitric oxide synthase in macrophages 3,4 . In response to low to moderate levels of DNA damage, PARP is activated and NAD levels in the cells decrease. Experiments with PAR...

Oragene and DNA sequencing with ABI PRISM

... Primer design PCR primers for the human Thymidylate synthase (TYMS) gene were designed based on the publicly available DNA se...ll 5 samples correctly aligned to the original human Thymidylate synthase gene sequence. Figure 1 shows a representative ABI PRISM sequenc...

Synthase in Biological Products

Mouse Anti-Thymidylate Synthase Monoclonal Antibody, Unconjugated, Clone 3A7.A11 from Abcam

Description: Mouse monoclonal [3A7.A11] to Thymidylate Synthase ( Abpromise for all tested applications). entrezGeneID: 7298 SwissProtID: P04818...
Company:Abcam

Nitric Oxide Synthase Radiometric Assay Kit from Cayman Chemical

Description: The NOS assay kit measures NOS activity by monitoring the conversion of radiolabeled arginine to citrulline. This assay is simple, sensitive, and specific for NOS activity and can be used with both crude and purified enzyme preparations. The kit includes sufficient materials and reagents for 50 tot...
Company:Cayman Chemical

Mouse Anti-Bovine Complex V (F1F0 ATP Synthase) Heart Mitochondria Monoclonal Antibody, Unconjugated, Clone 12F4AD8AF8 from MitoScience LLC

Description:...tochondria. Also included are 2 mg of bovine heart mitochondria for control immunocapture. The Complex V immunocapture kit allows isolation of the ATP synthase complex (E.C. 3.6.3.14) from small amounts of tissue. This facilitates subsequent analysis of assembly state and activity. Thus the enzyme retains oly...
Company:MitoScience LLC

Mouse Anti-Human ALAS2 Monoclonal Antibody, Unconjugated, Clone 6C1 from Novus Biologicals

Description:... Mouse monoclonal antibody to ALAS2 - aminolevulinate, delta-, synthase 2 (sideroblastic/hypochromic anemia)...
Company:Novus Biologicals

Synthase in Biological Definition

ATP synthase

An ATP synthase ( EC 3.6.3.14) is a general term for an enzyme that can synthesize adenosine triphosphate (ATP) from adenosine diphosphate (ADP) and inorganic phosphate by utilizing some form of energy. The overall reaction sequence is: ADP + P i → ATP ATP syntha...

Adenosine triphosphate

...P can be produced by various cellular processes, most typically in mitochondria by oxidative phosphorylation under the catalytic influence of ATP synthase or in the case of plants in chloroplasts by photosynthesis . The main fuels for ATP synthesis are glucose and fatty acids . Initially glucose i...

ATPase

...ered active transport . ATP synthetase The ATP synthetase (or ATP synthase ) of mitochondria and chloroplasts is an anabolic enzyme that harness... protons against their thermodynamic gradient. External links "ATP synthase - a splendid molecular machine" ...

Chemiosmotic hypothesis

...nd FADH 2 to create a proton gradient across the mitochondrial membrane and that this energy was used by a reversible proton pump , the ATP synthase , to create ATP . This was a radical proposal at the time, and not well accepted. The prevailing view was that the energy of electron transfer was st...

Citric acid cycle

...H 2 O ) H 2 O IX. L - Malate 9. Malate dehydrogenase Oxidation NAD + NADH + H + X. Oxaloacetate 10. Citrate synthase Condensation XI. Acetyl-CoA The sum of all reactions in the citric acid cycle is: Acetyl-CoA + 3 NAD + + F...

Ion gradient

...s used for driving the molecular motor enzyme ATP synthase to make the necessary conformational changes requ...dients are also be made by bacteria by running ATP synthase in reverse, this is used to drive flagellas. The F 1 F O ATP synthase is a reversible enzyme. Large enough quantities of...

Synthase in Biological Dictionary

Selfing

...nuals as a trade-off ... If selfing also shortens the time between flower maturation and ovule ... ... plant rapd sativa scar selfing synthase tetrahydrocannabinol thc by xico ... posted to colonization evolution plant selfing by biomcgary on 2007-08-23 22:26: ... (more formally, I w...

Pseudogene

...embles a gene but cannot be transcribed. ... A pseudogene structure in 5S DNA of Xenopus laevis" ... The discovery of a functional nitric oxide synthase (NOS) pseudogene compels us to understand pseudogenes in a new light. It confirms earlier clues suggesting that ... Pseudogene nonfunctionality...

Gene product

...ding and ... Often, annotating a new gene product reveals relationships in an ontology that ... In addition, gene products such as chitin synthase can be annotated to nodes of ... This includes gene product information, with a link to the database providing ... The species from which t...

Electron transport chain

.... ... The electron transport chain is the most complex and productive pathway of cellular respiration. ... Electron Transport Chain ATP synthase ... V. THE ELECTRON TRANSPORT CHAIN AND OXIDATIVE PHOSPHORYLATION. Introduction ... Some electron carriers of the transport chain accep...

Cristae

... membrane of a mitochondrion. They are studded with proteins, including ATP synthase and a variety of cytochromes. The maximum surface for chemical reactions ...on folds inwards, forming the cristae . ... evidence that subunits of ATP synthase are involved in cristae formation. ... Plant glossary explains basic b...

Chloroplast

...s the evolution of mitochondria and chloroplasts in eukaryotes. ... The Chloroplast Genome ... 6 genes encoding parts of the chloroplast ATP synthase ... ... is directed at understanding how the genetic machineries in the chloroplast and nucleus communicate to produce a chloroplast that is ...