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Survivin in Medical News

Isis Highlights New Clinical Data on Anti-Cancer Antisense Drugs Featured at ASCO

...esented new data from a Phase 1 study of LY2181308 in patients with cancer. The new data confirmed that LY2181308 penetrates tumor tissue and reduces survivin mRNA and protein levels in tumor cells. In addition, Dr. Azeem Saleem, CRUK Senior Clinical Research Fellow, University of Manchester, presented resu...

New findings may improve treatment of inherited breast cancer

...cer initiation or progression has been identified. survivin is an apoptosis inhibitor that is dramatically ele... many types of tumors. Research has suggested that survivin may serve to maintain the tumor and promote growth...ntaining SIRT1 expression, which in turn inhibited survivin expression. When BRCA1 was not functioning properl...

Turned-off cannabinoid receptor turns on colorectal tumor growth

...that CB1 increases cancer cell death by stifling a protein called survivin. survivin is overexpressed in nearly every human tumor but is barely detectable in normal tissue, DuBois noted. Overexpression of survivin is associated with poor outcome and reduced apoptosis in colorectal cancer ...

Isis Reports Financial Results and Highlights for First Quarter of 2008

...se drug to enter clinical development for the treatment of asthma. o Lilly has advanced an antisense drug, LY2181308, which targets survivin for the treatment of cancer, into Phase 2 trials. -- Ibis Biosciences o Ibis, Isis' majority-owned subsidiary, has developed and is com...

Isis Reports Financial Results and Highlights for Fiscal year 2007

... OGX-427 that targets Hsp27 for cancer treatment. * Lilly expects to begin Phase 2 clinical studies of LY2181308 that targets survivin for cancer treatment. * The broad therapeutic potential of antisense drugs enables Isis to discover drugs that are outside of Isis' core focus...

Lilly Showcases Pipeline Opportunities to Wall Street, Sets 2008 Financial Guidance and Outlines Transformation Strategy

...ancer and melanoma, with new Phase II studies now initiated for ovarian cancer and soft-tissue sarcoma. Phase II trials are set to begin for survivin ASO, an antisense molecule targeted at solid tumors that Lilly is developing with its partner, ISIS Pharmaceuticals; a second antisense mole...

A new chemotherapeutic target for hepatocellular carcinoma

... of HCC. The immunohistochemical expression of survivin in liver tumor specimens obtained from 17 patients was studied. In addition, to determine the survivin expression in response to anti-cancer drugs in early stage HCC, the survivin expression was determined after treating HCC cells...

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Survivin in Medical Technology

Isis Reports Strong Financial Results and Highlights for Second Quarter of 2009

...i Lilly and Company recently completed its Phase 1 study of LY2181308 and presented data confirming that LY2181308 penetrates tumor tissue and reduces survivin mRNA and protein levels in tumor cells. Isis and its collaborators highlighted new antisense therapeutic programs and targets to...

Another LNA-based RNA Inhibitor Enters Clinical Trials

...rug (IND) application for the use of the LNA-based survivin inhibitor. survivin is a key protein that controls cancer growth by pl...ting the programming that controls cell death. The survivin inhibitor was developed using the Locked Nucleic A...

Paper in Molecular Cancer Therapeutics Reports that a Novel Combination of Alfacell's ONCONASE(R) and Rosiglitazone Induces a Synergistic Apoptotic Effect in Several Cancer Cell Lines

...sed cell viability and increased cell apoptosis in several cancer cell lines, including lung, breast, prostate and ovarian, due to decreased Fra-1 and survivin expression. The results also suggest that combined therapeutic use may overcome the resistance produced in some cancer cells by the activation of surv...

Avalon Pharmaceuticals to Present at the American Association for Cancer Research 2007 Annual Meeting

...inhibitors for the beta-catenin and aurora pathways now in late stage lead candidate optimization. Avalon also has discovery programs on modulators of survivin function and a drug discovery program targeting the MYC oncoprotein, one of the most important and previously intractable cancer targets. The company ...

Avalon Updates the AVN944 Phase I Hematologic Malignancies Trial

...inhibitors for the beta-catenin and aurora pathways now in late stage lead candidate optimization. Avalon also has discovery programs on modulators of survivin function and a drug discovery program targeting the MYC oncoprotein, one of the most important and previously intractable cancer targets. The company ...
Survivin in Biological News

Hebrew University researchers neutralize tumor growth in embryonic stem cell therapy

...yos, but it is almost completely absent from mature normal tissues. The survivin gene is especially highly expressed in undifferentiated human embryonic stem cells and in their derived tumors. By neutralizing the activity of survivin in the undifferentiated cells as well as in the tumors, the researchers wer...

Researchers develop gene therapy to reverse pulmonary arterial hypertension

...d in both human and animal lung arteries with PAH. survivin is an inhibitor of apoptosis--or programmed cell d...n PAH. The team members believe that as in cancer, survivin drives excessive cell growth in the PAH lung blood...PAH, but not in normal human blood vessels, making survivin a very attractive target for selective interventio...
Survivin in Biological Technology

Santaris Pharma - Interim Report for the Period 1 January to 30 June 2009

...ical trial in solid tumors with the LNA-based drug survivin targeting cancer. SPC4955-ApoB inhibitor ...study in various solid tumors for EZN/SPC3042, the survivin inhibitor, in the 1st quarter of 2009. In a...esting this candidate - EZN3042, an LNA-based survivin inhibitor, being developed for the treatment...

First Patient Dosed in Phase I Clinical Trial of Tigris Pharmaceuticals' GGTI-2418

... hypophoshorylation of the tumor suppressor Rb. GGTase I inhibitors also induce apoptosis by a mechanism involving downregulation of the expression of survivin and suppression of the activation of PI3K/Akt. About Tigris Pharmaceuticals, Inc. Tigris Pharmaceuticals, Inc. is a privately held biopharmac...

FDA Accepts Investigational New Drug (IND) Application for Tigris Pharmaceutical's GGTI-2418

... hypophoshorylation of the tumor suppressor Rb. GGTase I inhibitors also induce apoptosis by a mechanism involving downregulation of the expression of survivin and suppression of the activation of PI3K/Akt. About Tigris Pharmaceuticals, Inc. Tigris Pharmaceuticals, Inc. is a privately held biophar...

Tigris Pharmaceuticals Files IND Application for GGTI-2418

... hypophoshorylation of the tumor suppressor Rb. GGTase I inhibitors also induce apoptosis by a mechanism involving downregulation of the expression of survivin and suppression of the activation of PI3K/Akt. About Tigris Pharmaceuticals, Inc. Tigris Pharmaceuticals, Inc. is a privately held biopharmac...

Isis Reports Financial Results and Highlights for Second Quarter of 2008

... refractory prostate cancer -- Eli Lilly and Company reported positive Phase 1 clinical trial results for LY2181308, targeting survivin -- Atlantic Healthcare received U.S. orphan drug designation for alicaforsen for the treatment of pouchitis -- Altair Therapeutics advanced A...

DermTech Names Herbert A. Fritsche, Ph.D., Chief of Clinical Chemistry at M.D. Anderson Cancer Center to Company's Scientific Advisory Board

...ogesterone receptors), more recently, tests for circulating DNA (promoter regions of tumor suppressor genes for prostate cancer detection), urine mRNA survivin for bladder cancer detection and circulating tumor cell assays for establishing prognosis of patients with metastatic cancers. Dr. Fritsche received...

Matched siRNAs and Assays: Ambion + Applied Biosystems = RNAi Success

...n Figure 5. A Silencer Validated siRNA targeting survivin mRNA was transfected into cells. survivin siRNA reduced survivin mRNA levels in these cells by 80% compared to cell...

Confirming RNAi Effects Is Now Easier Than Ever

... Figure 1. Knockdown of survivin with a Silencer Validated siRNA and Verification... a Silencer Validated siRNA targeting survivin (BIRC5) or Silencer Negative Control #1 in ...sing a TaqMan Gene Expression Assay for survivin (Hs00153353_m1). Data shown here represent ...

Measuring Gene Silencing Effects by RT-PCR Without RNA Isolation

... were transfected with scrambled control (red ) and gene specific siRNAs to cdc-2, GAPDH and survivin (blue ). 18S rRNA was used as a reference standard for quantitation. The 18S rRNA signal was...
Survivin in Biological Products

Rabbit Anti-Survivin DEx3 Polyclonal Antibody, Unconjugated from Abcam

Description:... Rabbit polyclonal to survivin DEx3 ( Abpromise for all tested applications). entrezGeneID: 332 SwissProtID: O15392...
Company:Abcam
Survivin in Biological Dictionary

Caspase

...cysteine ... the apoptosome (regulated by cytochrome c and the Bcl-2 family) which activates caspase -9. ... An anti-apoptotic protein human survivin is a direct inhibitor of caspase -3 and -7" ... Caspase -2 induces apoptosis by releasing proapoptotic proteins from ... Caspase a...
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