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Suppressor in Medical News

Promising biomarker and candidate tumor suppressor gene identified for colorectal cancer

Researchers have identified a new candidate tumor suppressor gene in colorectal cancer and examined its use as a potential biomarker in stool samples, according to a new study published online June 17 in the Journal of the National Cancer Institute . In the study, Manon van Engeland, Ph.D., of...

Gene helps protect tumor suppressor in breast cancer

HOUSTON - Scientists at The University of Texas M. D. Anderson Cancer Center have discovered a gene that protects PTEN, a major tumor-suppressor that is reduced but rarely mutated in about half of all breast cancers. The gene Rak helps protect and regulate PTEN, which also is important in sever...

Tumor suppressor may attenuate fibrotic disease

New research reveals a critical cellular signaling pathway that is responsible for generating excess connective tissue in multiple organs, similar to what is seen in human patients with scleroderma. The study, published by Cell Press in the February issue of the journal Developmental Cell , also ...

Oncogene inhibits tumor suppressor to promote cancer: Study links B-RAF and LKB1

Scientists have uncovered an interesting connection between two important protein kinase signaling pathways that are associated with cancer. The research, published by Cell Press in the January 30th issue of the journal Molecular Cell , may direct new therapeutic strategies for multiple types of ...

Cell biologists identify new tumor suppressor for lung cancer

Cancer and cell biology experts at the University of Cincinnati (UC) have identified a new tumor suppressor that may help scientists develop more targeted drug therapies to combat lung cancer. The study, led by Jorge Moscat, PhD, appears in the January 2009 issue of Molecular and Cellular Biol...

CSHL scientists trace causal link between a tumor suppressor gene and liver cancer

Scientists at Cold Spring Harbor Laboratory (CSHL) have taken the search for cancer-causing genes an important step forward. In a newly published paper, they confirm that a gene called DLC1 is a tumor suppressor. They have demonstrated in living mice that its deletion, inactivation or loss precipi...

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Suppressor in Medical Technology

Gene Marker May Improve Odds of Stem Cell Therapies for Disease

...decrease, in several genes involved in stem cell self-renewal and DNA repair, including Rb1 and p107 gene expression. However, pRB2/p130, a tumor suppressor gene first identified by Antonio Giordano, Director of the Sbarro Institute for Cancer Research and Molecular Medicine at the College of Science and T...

Late-Breaking Data Highlighting Research Advances in Several Blood Disorders to Be Presented At the American Society of Hematology Annual Meeting

...atment of anemia, and the discovery of a new tumor suppressor gene in patients with myeloproliferative disorders...fety concerns. TET2 is a Novel Tumor suppressor Gene Inact i vated in Myeloproliferative Neop... time. This research unveiled a new tumor suppressor gene called TET2 (Ten-Eleven Translocation-2), w...

Data Suggest CEL-SCI's CEL-2000 Vaccine Prevents or Retards Permanent Damage of Rheumatoid Arthritis

...t of T-cell function with primarily effector T-cell functions (T Lymphocyte; helper/effector T lymphocyte, type 1 or 2 [Th1 or Th2], cytotoxic [Tc] or suppressor [Ts]). Therefore, it would appear that the L.E.A.P.S.(TM) construct represents a chimeric peptide with bi-functional behavior. About CEL-SCI: CEL-...

Exelixis Reports Positive Clinical Pharmacodynamics Data for PI3K/mTOR Inhibitor XL765 at ASCO

...anslation machinery and hence, cell growth. PI3K is activated in human cancers by elevated receptor tyrosine kinase activity, by deletion of the tumor suppressor PTEN, or by mutation of its catalytic domain. mTOR is activated by growth factors via PI3K and AKT, but is also activated in a PI3K-independent fashio...

Presentation of Data on Progen's Cancer Epigenetic Targets Platform

...ed to specifically demethylate histone proteins (demethylates Lysine 4 of histone H3) and plays an important role in the regulation of specific cancer suppressor genes. LSD-1 inhibitors prevent the action of LSD-1, causing increased levels of histone methylation, resulting in the reactivation of the cancer supp...

Data Show SuperGen's MP-470 is Safe in Humans

...afe in humans (Abstract No. 4083). Entitled, "MP-470, a potent oral Rad51 suppressor is safe and tolerable in first-in-human study," the poster highlights data ...ponsible for repair of DNA double strand breaks. "This is the first Rad51 suppressor that has advanced into Phase 1 clinical trials," said Dr. Gregory Berk, Sup...
Suppressor in Medical Definition

Pathology

... leukemia Treatment Surgery - Chemotherapy - Radiation therapy - Immunotherapy - Experimental cancer treatment Misc. Tumor suppressor genes / oncogenes - Staging / grading - Carcinogenesis - Carcinogen - Research - Paraneoplastic phenomenon - ICD-O - List of oncology-re...

Ocular oncology

... leukemia Treatment Surgery - Chemotherapy - Radiation therapy - Immunotherapy - Experimental cancer treatment Misc. Tumor suppressor genes / oncogenes - Staging / grading - Carcinogenesis - Carcinogen - Research - Paraneoplastic phenomenon - ICD-O - List of oncology-re...
Suppressor in Medical Dictionary

Von Hippel-lindau Disease

...ates JR, et al; Von Hippel - Lindau disease : a genetic study. ... The von Hippel - Lindau disease (VHL) gene is a putative tumor suppressor gene ... Von Hippel - Lindau (VHL) disease is an autosomal dominant tumor syndrome, in ... Von Hippel - Lindau syndrome (VHL) is...

Von Hippel-Lindau

...ed at the beginning of the 20th ... The Von Hippel - Lindau tumor suppressor protein is encoded by the VHL gene and ... The von Hippel - Lindau Tumor suppressor Gene and Kidney Cancer" ... Article describes von Hippel - Lindau d...

Tissue

...X offers a large selection of antibody reagents to factors that are involved in the cascade of number of key factors including oncogenes and tumor suppressor ... Multiple organ normal and diseased tissue microarray, single core per case, 10 ... Test slides ( tissue arrays with catalog numbers endin...

Pancreatic carcinoma

...ancreatic cancer Cancer ... What is Pancreatic Carcinoma ? Alternative names. Causes. Symptoms & Signs. Exams ... Alterations of tumor suppressor gene p16INK4a in pancreatic ductal carcinoma " ... The molecular genetics of pancreatic ductal carcinoma " ... ...

Immune System

...ct the body from bacterial, parasitic, The immune system rallies its defenses from the cellular level, everywhere in ... there is an excess of suppressor cells and the immune system shuts down. ... When the immune system is functioning properly, it protects the body against ... If the immun...
Suppressor in Biological News

Tumor suppressor gene in flies may provide insights for human brain tumors

SINGAPORE and DURHAM, N.C. In the fruit fly's developing brain, stem cells called neuroblasts normally divide to create one self-renewing neuroblast and one cell that has a different fate. But neuroblast growth can sometimes spin out of control and become a brain tumor. Researchers at Duke-NU...

Skin cancer study uncovers new tumor suppressor gene

National Institutes of Health (NIH) researchers have identified a gene that suppresses tumor growth in melanoma, the deadliest form of skin cancer. The finding is reported today in the journal Nature Genetics as part of a systematic genetic analysis of a group of enzymes implicated in skin cance...

Design of a compound that stabilizes the main natural suppressor of tumors

This press release is available in Spanish . An interdisciplinary team of researchers, headed by Ernest Giralt at the Institute for Research in Biomedicine (IRB Barcelona) and Javier de Mendoza at the "Institut Catal d'Investigaci Qumica" (ICIQ, Tarragona), have discovered a substance with ...

Two suppressor molecules affect 70 genes in leukemia

COLUMBUS, Ohio By restoring two small molecules that are often lost in chronic leukemia, researchers were able to block tumor growth in an animal model. The research, using human chronic lymphocytic leukemia (CLL) cells, also showed that loss of the two molecules affects 70 genes, most of whic...

La Jolla Institute discovers novel tumor suppressor

SAN DIEGO (August 3, 2009) La Jolla Institute for Allergy & Immunology researchers studying an enzyme believed to play a role in allergy onset, instead have discovered its previously unknown role as a tumor suppressor that may be important in myeloproliferative diseases and some types of lymphoma...

Novel regulatory mechanism identified for key tumor suppressor p53

Collaborating scientists from The Wistar Institute in Philadelphia and The Vienna Biocenter in Austria have identified a novel mechanism involved in normal repression of the p53 protein, perhaps the single most important molecule for the control of cancer in humans. The new molecular pathway des...

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Suppressor in Biological Technology

Fat droplet nanoparticle delivers tumor suppressor gene to tumor and metastatic cells

Dr. Esther Chang describes the most recent developments in human trials of the first systemic, non-viral, tumor-targeted, nanoparticle method designed to restore normal gene function to tumor cells while completely bypassing normal tissue April 21 at an American Association of Anatomists (AAA) sci...

A Screen of shRNAs Targeting Tumor Suppressor Genes to Identify Factors Involved in Paclitaxel Sensitivity

Diana Ji, Stacy L. Deeds, and Edward J. Weinstein RNA interference methodologies have been utilized in small to large scale screening projects. The technology has allowed researchers to perform gene-silencing experiments in timeframes and target cells prev...

CEL-SCI Files Patent Application to Support Company's Treatment for More Virulent Strain of H1N1 Swine and Other Influenza Viruses

...t of T-cell function with primarily effector T-cell functions (T Lymphocyte; helper/effector T lymphocyte, type 1 or 2 [Th1 or Th2], cytotoxic [Tc] or suppressor [Ts]). The L.E.A.P.S. vaccine constructs are chimeric peptides which combine antigen specificity with immune response modulation. CEL-SCI Corpor...

CEL-SCI Developing Immune-Based Treatment Against Swine and Other H1N1 Flu Viruses Using Proprietary L.E.A.P.S. Technology

...t of T-cell function with primarily effector T-cell functions (T Lymphocyte; helper/effector T lymphocyte, type 1 or 2 [Th1 or Th2], cytotoxic [Tc] or suppressor [Ts]). The L.E.A.P.S. vaccine constructs are chimeric peptides which combine antigen specificity with immune response modulation. CEL-SCI Corpor...

First Patient Dosed in Phase I Clinical Trial of Tigris Pharmaceuticals' GGTI-2418

... cycle arrest by a mechanism involving induction of the CDK inhibitors p21waf and p27kip, CDK2 and CDK4 inhibition and hypophoshorylation of the tumor suppressor Rb. GGTase I inhibitors also induce apoptosis by a mechanism involving downregulation of the expression of survivin and suppression of the activation ...

CEL-SCI's L.E.A.P.S. Technology Shows Potential to Treat Swine Influenza in Preclinical Studies

...t of T-cell function with primarily effector T-cell functions (T Lymphocyte; helper/effector T lymphocyte, type 1 or 2 [Th1 or Th2], cytotoxic [Tc] or suppressor [Ts]). The L.E.A.P.S. vaccine constructs are chimeric peptides which combine antigen specificity with immune response modulation. CEL-SCI Corpora...
Suppressor in Biological Products

Tumor Suppressor Sampler Kit from BD Biosciences Pharmingen

Description: Tumor Suppressor Sampler Kit 10 mu g each...
Company:BD Biosciences Pharmingen

Rat Anti-Kinase Suppressor Of Ras Monoclonal Antibody, Unconjugated, Clone MINT/1/4 from GeneTex

Description: Rat Antibody to Kinase Suppressor Of Ras Recognises the kinase suppressor of Ras (KSR). Immunogen: Recombinant human KSR protein Specificity: human kinase supressor of Ras...
Company:GeneTex

Anti-UbcH7 Antibody, Unconjugated from CHEMICON

Description:... involved in both the degradation of non-""N-end rule"" protein substrates and of certain N-a -acetylated proteins as well as the degradation of tumor suppressor protein p53....
Company:CHEMICON

Adept HPLC System 8: Ion Chromatography from Cecil Instruments Ltd.

Description:.... The sensitive conductivity detector CE 4710, with twelve ranges from 0.01S to 5000S, houses the measuring cell in a thermostatted environment. The suppressor module CE 4715, is available. Data processing is provided by the CE 4900 interface and software. Solvent delivery is by the high pressure CE 4100 d...
Company:Cecil Instruments Ltd.
Suppressor in Biological Definition

Cancer

.... The process involves both oncogenes and tumor suppressor genes . Oncogenes promote cancer when "switched on" by a mutation, whereas tumor suppressor genes prevent cancer unless "switched off" by a m...ype of mutation and may involve oncogenes or tumor suppressor genes. In general, mutations in both types of gene...

Oncogene

...t kinases (through overexpression ). Adaptor proteins in signal transduction . Transcription factors . Related articles Tumor suppressor gene Apoptosis ...

Phosphorylation

...fic protein kinases , whereas phosphatases de phosphorylate. An example of the important role that phosphorylation plays is the p53 tumor suppressor gene , which—when active—stimulates transcription of gene that suppress the cell cycle , even to the extent that it undergoes apoptosi...
Suppressor in Biological Dictionary

Suppressor

A suppressor , sound suppressor , sound moderator, or silencer, is a device either attached to or part of the barrel of a firearm to reduce the amount of noise and flash generated by firing the weapon. Suppressors are also... SUPPRESSOR FEATURES A REPLACEMENT BLACKOUT THREE PRONG FLASH HIDER...

Tumor suppressor

A tumor suppressor gene, or antioncogene, is a gene that protects a cell from one step on the path to cancer. When this gene is mutated to cause a loss or reduction in its function, the cell can progress to cancer, usually in combination with other genetic changes. will be reviewed...

Untranslated RNA

...nome of tomato bushy ... 3'UTR RNA from Alpha-Tropomyosin Gene Suppresses Tumor Activity. ... Expression of prohibitin 3' untranslated region suppressor RNA alters ... Untranslated Regions of mRNAs Play a Role in Regulating Gene Expression. ... JD: The 3' untranslated region of messenger RNA...

Tissue

...ffers a large selection of antibody reagents to factors that are involved in the cascade of number of key factors including oncogenes and tumor suppressor ... A sarcoma is a type of cancer that develops from certain tissues , such as bone or muscle. ... This document concentrates on soft tissue ...

Revertant

... In microbial genetics, a revertant is a mutant that has reverted to its former genotype or to the original phenotype by means of a suppressor mutation. Definition of revertant from the Merriam-Webster Online Dictionary with audio pronunciations, thesaurus, Word of the Day, and word gam...

Missense Mutation

... number of ways a missense mutation ... If the random mutation model were. correct, then ... Inherited missense mutations in the tumor suppressor gene, BRCA-1, may ... In addition, missense mutations disproportionately perturb conserved amino acids ... Even when expressed as protein, ...
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