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Scientists identify molecule that regulates well-known tumor suppressor

Scientists have discovered that a molecule called DJ-1 is likely to be involved in the generation of human tumors through negative regulation of the well-known tumor suppressor, PTEN. The research, published in the March issue of Cancer Cell, has important implications for determining the prognosis of some human cancers, and may prove to be a suitable target for cancer therapy. The phospha...

New tumor-suppressor gene discovered

A new tumor-suppressor gene has been discovered by a team of researchers at Penn State, which also has discovered how the gene works with another tumor suppressor to control tissue growth. The team's genetic and biochemical studies will be published in the 11 March 2005 issue of the journal Cell. "This discovery extends our understanding of how tissue growth is controlled both during normal devel...

Natural tumor suppressor in body discovered by UCSD medical researchers

A natural tumor suppressor that could potentially be turned on in certain cancer cells to prevent the formation of tumors has been discovered by researchers at the University of California, San Diego (UCSD) School of Medicine. Located on chromosome 18 and called PH domain Leucine-rich repeat Protein Phosphatase (PHLPP, pronounced "flip"), the tumor suppressor is described in the April 1,...

Novel regulatory mechanism identified for key tumor suppressor p53

Collaborating scientists from The Wistar Institute in Philadelphia and The Vienna Biocenter in Austria have identified a novel mechanism involved in normal repression of the p53 protein, perhaps the single most important molecule for the control of cancer in humans. The new molecular pathway described in the study suggests intriguing approaches to diagnosing or intervening in the progress...

Researchers discover how tumor suppressor gene works

A team of University of Minnesota researchers has discovered how a gene that suppresses the development of melanoma and other human cancers works. The study points the way to treatments based on the function of the gene. The researchers, led by Zigang Dong, director of the university's Hormel Institute in Austin, Minn., have applied for a patent on one such treatment. The work will be published o...

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Mouse Anti-LATS, large tumor suppressor, homolog 2 (Drosophila) Monoclonal Antibody, Unconjugated, Clone 3D10 from Novus Biologicals

Description:Mouse monoclonal antibody to Lats2....
Company:Novus Biologicals

Rat Anti-Kinase Suppressor Of Ras Monoclonal Antibody, Unconjugated, Clone MINT/1/4 from GeneTex

Description:Rat Antibody to Kinase Suppressor Of Ras human kinase supressor of Ras...
Company:GeneTex

Tumor Suppressor Sampler Kit from BD Biosciences Pharmingen

Description:Tumor Suppressor Sampler Kit 10 mu g each...
Company:BD Biosciences Pharmingen
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A Screen of shRNAs Targeting Tumor Suppressor Genes to Identify Factors Involved in Paclitaxel Sensitivity

Diana Ji, Stacy L. Deeds, and Edward J. Weinstein RNA interference methodologies have been utilized in small to large scale screening projects. The technology has allowed researchers to perform gene-silencing experiments in timeframes and target cells previously not possible. While siRNA screens have become fairly common, large scale screening wi...
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Little Known DNA Repair Enzyme May Be A Tumor Suppressor Gene

Researchers at the University of Pittsburgh have demonstrated that loss of DNA // repair enzyme’s activity in mouse cells leads to dramatic chromosomal instability. The DNA in our cells is constantly subject to environmental, chemical and cellular impacts. Thanks to nature, our cells contain several enzymes dedicated to detecting and repairing any damage caused by these impacts. Failu...

Tumor Suppressor p53's Contradictory Regulatory System

A new study appearing in the online open-access journal PLoS Biology examines the role played by the tumor suppressor protein called p53. It has been found that any mutations of p53 play a key role in the development of many human cancers. //This particular study was carried out by Min Hu, Yigong Shi and colleagues. To provide a bit of background, when there a cell injury, p53 triggers...

Unusual Tumor-Suppressor Gene Switches Off in Lung Cancer

Researchers at Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute, have found a tumor suppressor gene that could be of vital significance in the development of head and neck cancers as well as lung cancer. //Their study shows that activating this particular gene could slow up the development of the aforementioned cancers.<b...

DNA-bound p53 Tumor Suppressor Protein Structure Determined

More than half of human cancers involve mutations in the p53 tumor-suppressor gene, suggesting the critical role played by the normal p53 protein in defending// against cancer. Similarly, roughly 95 percent of cancer-causing mutations in the p53 protein occur in its DNA-binding core domain, pointing to this region of the p53 protein as being pivotal to its anti-cancer activity. Clearl...

Regulatory Mechanism for Tumor Suppressor Protein Identified

A new mechanism has been identified by scientists from the Wistar Institute in Philadelphia and The Vienna Biocenter in Austria that is involved in normal repression of the p53 protein // which is the most important molecule for the control of cancer in humans. The new molecular pathway described in the study suggests intriguing approaches to diagnosing or intervening in the progressi...

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Study in Cell by Magen BioSciences Co-Founder David E. Fisher Identifies New Roles in Skin Cancer Prevention for Key Tumor Suppressor Protein

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Mar 8, 2007 - Magen BioSciences,Inc., a specialty dermatology company, today announced thepublication of a paper in the March 9, 2007 issue of the journalCell by its co-founder and board member, David E. Fisher, M.D.,Ph.D., that identifies two new functions for an important protein,p53, in the pigmentation of skin. Fisher's study shows that inaddition to i...
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