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Suppressive in Medical News

Acid Suppressive Drugs Found To Increase The Risk for Pneumonia

A recent study shows that people who use stomach-acid suppressive medications for indigestion or gastroesophageal reflux disease (GERD) may be at an increased risk of developing pneumonia .// The use of acid-suppressive drugs for the stomach can increase vulnerability to infections, as stomach...

Heartburn Drugs May Contribute to the Problem

...ng may be causing harm, the study authors said. "It is beyond any doubt that subjects with reflux disease benefit from and need treatment with acid suppressive drugs," said study lead author Dr. Cristina Reimer of Copenhagen University in Denmark. "But it is equally beyond doubt that PPIs are prescribed more ...

Microscopic 'beads' could help create 'designer' immune cells that ignore transplanted organs

...make that call. HLA-G works through inhibitory receptors, ILT2, ILT3 and ILT4, on dendritic cells, triggering a signaling pathway in which several suppressive molecules get activated to help protect the transplanted organ or tissue. Human leukocyte antigen G, or HLA-G, actually is a member of a gene family c...

Herpes medication does not reduce risk of HIV transmission

...ovir arm and 43 in the placebo arm not a significant difference. Acyclovir suppressive treatment reduced the frequency of genital ulcers by 73% and the average am... levels in the blood, consistent with what the preliminary studies of HSV-2 suppressive treatment had shown. However, it appears that these effects were not suffic...

Popular diabetes treatment could trigger pancreatitis, pancreatic cancer

... protective effect may have been either by the actions of metformin to decrease blood glucose values or its recently appreciated properties as a tumor suppressive agent." Butler noted that the present study was undertaken in rats and that it is possible the adverse effects observed would not occur in hum...

Antacid Medication in Pregnancy May Increase Childhood Asthma

...cy foods and peppermint, which all promote acid reflux. However, the researchers aren’t suggesting that all pregnant women stop taking acid suppressive medication. “Some pregnant women have such severe acid reflux they can’t eat because they are in so much pain,” says Hait. &ldq...

Don't 'Worry Yourself Sick' This Winter

...s the following tips to help boost the immune system. 1. Get the flu shot, and time it wisely. According to Dr. Wheeler, stress can have a strong suppressive effect on the immune system's response to vaccinations. Get the shot early in the season, before you get swept up in the holidays and time your flu s...

Towards improved immunotherapy

...litates the induction of a specific type of immune suppressive cells, called 'regulatory T cells' for therapeutic use. These immune suppressive cells show great potential for the treatment of au...important part of the immune system and can play a suppressive role, but naturally occur in low numbers. Micha...

AGA releases evidence-based GERD guidelines

...ommended as initial therapy because of superior safety. IV. When a patient with an esophageal GERD syndrome is responsive to, but intolerant of, acid suppressive therapy, antireflux surgery should be recommended as an alternative. V. Twice-daily PPI therapy as an empirical trial for patients with suspected ref...

Immune Molecule Key to Preventing Organ Rejection

...signaling pathway in which immune molecules IL-6 and STAT3 play a major role. "Biologically, this is an interaction that requires several important suppressive molecules," said Horuzsko, corresponding author of the study, which was published online in the journal Proceedings of the National Academy of Scienc...
Suppressive in Medical Technology

New Study Shows BENICAR(R) (olmesartan medoxomil) Reverses Blood Vessel Damage Independent of Blood Pressure Lowering

... Incidence of End stage renal stage in diabetic Nephropathy Trial," or ORIENT, targeting Japanese and Hong Kong Chinese patients, is investigating the suppressive effects of the drug against the progression of diabetic nephropathy. About BENICAR and BENICAR HCT Angiotensin II is a hormone that interacts with...

Arena Pharmaceuticals Presented Positive Phase 2a Clinical Trial Results of APD125 for the Treatment of Insomnia at 22nd Annual Meeting of the Associated Professional Sleep Societies

...k by activating the GABA-A receptor complex in the brain, causing a general suppressive effect on the central nervous system, or CNS. These GABAergic drugs are gen...one of several CNS activating pathways rather than initiating a general CNS suppressive effect. Because of the different mechanism of action, APD125 may not have t...

Important Progress Toward Control of Hepatitis B and C

...w new, tested molecules that are effective in obtaining viral suppression in hepatitis B virus (HBV). When used in HBV, these new agents have a strong suppressive effect... but none can entirely eradicate the hepatitis B virus. Once the HBV infection is established, it has to be treated for many years... maybe f...

Arena Pharmaceuticals Initiates Phase 2b Clinical Trial of APD125 for the Treatment of Insomnia

...f the 5-HT2A serotonin receptor. The vast majority of approved drugs for insomnia activate the GABA-A receptor complex in the brain, causing a general suppressive effect on the central nervous system, or CNS. These GABAergic drugs are generally associated with CNS side effects, including a sensation of dullness ...

Long-Term Soliris(R) Therapy Improved or Stabilized Kidney Function in Patients With PNH

...lobinuria in the United States and Japan. Medicine 2004;83:193-207. (10) Nath KA, et al. Heme protein-induced chronic renal inflammation: suppressive effect of induced heme oxygenase-1. Kidney Int. 2001;59:106-117. (11) Hill A, Platts PJ, Smith A et al. The incidence and prevalence of p...

St. Jude Finds Molecule That Could Improve Cancer Vaccine and Therapy for Other Diseases

...ytokines stimulate immune system cells; however, IL-35 is one of the few signaling molecules known to inhibit immune system activity. "The maximal suppressive function of regulatory T cells depends on IL-35, so blocking IL-35 activity might reduce the ability of T cells to block anti-tumor immune responses,"...

InterMune Presents Research on ITMN-191 in Hepatitis C at EASL Annual Meeting

...ent of novel therapeutic approaches. The HCV NS3/4 protease is an attractive drug target because of its potential involvement in viral replication and suppressive effects on host response to viral infection. Inhibitors of the HCV protease, such as ITMN-191, represent a promising new class of drugs for HCV. Int...

Telomerase Presentations at the AACR 2007 Annual Meeting

...cer research. Dr. DePinho's own work on manipulating telomerase and growth control genes in mouse models of cancer showed how telomere loss is a tumor suppressive mechanism when growth control genes are generally intact. Telomere shortening in this setting triggers arrest of abnormally dividing cells. However, w...

InterMune Presents Research on ITMN-191 in Hepatitis C at Digestive Disease Week Meeting

...ent of novel therapeutic approaches. The HCV NS3/4 protease is an attractive drug target because of its potential involvement in viral replication and suppressive effects on host response to viral infection. Inhibitors of the HCV protease, such as ITMN-191, represent a promising new class of drugs for HCV. Abo...

Repros' Androxal Shows Highly Statistically Significant Positive Effects in Men with Secondary Hypogonadism

...is a rational approach as pituitary function is normalized and the subjects benefit from a normal testosterone production and are not subjected to the suppressive effects of exogenous testosterone replacement. Androxal has the potential to change the way in which secondary hypogonadism is treated in the future."...
Suppressive in Medical Dictionary

Nematode

...enous only to North America (the United States and ... ... regarding nematode presence, ... · Use of nematode free transplants. ... Nematode suppressive Crops - Auburn University - http://www.aces.edu/pubs /docs/A ... Nematode summary with 11 pages of encyclopedia entries, essays, summaries, rese...

Erythema multiforme

... ... Erythema multiforme is a skin condition considered to be a hypersensitivity ... Patients with recurrent erythema multiforme despite suppressive antiviral ... Overview: Erythema multiforme (EM) was initially described in 1866 by Ferdinand ... Erythema multiforme , Stevens-Johnson sy...

Erythema

...les ... Erythema multiforme is a skin condition considered to be a hypersensitivity ... Patients with recurrent erythema multiforme despite suppressive antiviral ... Erythema nodosum is the most frequent clinicopathologic variant of panniculitis. ... Treatment of erythema nodosum should be dir...
Suppressive in Biological News

Tummy troubles -- gastrin key in bacterial-induced stomach cancer

...or too little gastrin can predispose to carcinogenesis. Therefore, clinicians in the future may need to be more circumspect when prescribing with acid suppressive drugs, such as proton-pump inhibitors, for a long-term use in patients infected with Helicobacter pylori ." In future studies, Dr. Wang and colleagu...

TB -- hiding in plain sight

...fection. This study by Rahman et al "provide[s] evidence that the adaptive immune response in establishment of clinical TB [is] skewed towards a suppressive or regulatory phenotype that may inhibit proper immune activation and down-regulate the host response at the local site of infection. Compartmentaliza...

High blood sugar's impact on immune system holds clues to improving islet cell transplants

... the immune playing field that gives advantage to regulatory T-cells long enough for the body to accept the transplanted cells. One reason may be that suppressive regulatory cells recover differently or are less influenced by hyperglycemia. Researchers at Canada's University of Alberta were the ones to find h...

New insights into the regulation of PTEN tumor suppression function

...fer a novel target for enhancing this gene's tumor suppressive function. "Our laboratory recently discovered t...in the nucleus in order to maintain its full tumor suppressive abilities," explains senior author Pier Paolo Pand...xciting and unique approach to enhancing the tumor suppressive actions of PTEN," he adds. "Because PML is known t...

USC researchers identify mechanism that controls activation of stem cells during hair regeneration

...airs regenerate, they must communicate activation signals among themselves. At different time points the macro-environment can be either permissive or suppressive for stem cell activation. "Our research shows that the formation of new tissues or organs from stem cells -- such as the formation of new hairs --...

Curry-derived molecules might be too spicy for colorectal cancers

...e: two molecular analogues of curcumin that demonstrate even greater tumor suppressive properties. The team presented their findings from the first test of these ...vailable, than natural curcumin. Our new analogues have enhanced growth suppressive abilities against colorectal cancer cell lines, up to 30 times greater than...

JCI table of contents: Aug. 16, 2007

...ournal of Clinical Investigation, David Munn and colleagues found that mouse IDO-expressing pDCs from tumor-draining lymph nodes directly activate the suppressive function of a population of regulatory immune cells characterized as CD4+CD25+Foxp3+ and known as Tregs. Suppression by Tregs activated by IDO-express...

Anti-herpes treatment reduces HIV levels in women infected with both viruses

... vaccine that would either prevent HSV infection or diminish the clinical and sub-clinical manifestations of HSV with a similar efficacy on HIV as HSV suppressive therapy, would represent a long-lasting form of HIV prevention. The development and evaluation of an HSV vaccine should rank high on the international...

Why don't all moles progress to melanoma?

...rmation of these cells," Soengas adds. According to Soengas, the tumor suppressive mechanism induced by the ER in melanocytes with these cancer-causing mutati...t few have melanoma." In the study, U-M scientists found that the tumor suppressive response in melanocytes varied depending on the type of oncogene being expr...

PTEN: the Treg's handbrake

...om mice with T cells that lack phosphatase and tensin homolog (PTEN) proliferate in response to IL-2. Importantly, PTEN-deficient Tregs retained their suppressive function in vitro and in vivo, indicating that loss of PTEN by Tregs only affects their proliferative capabilities in response to IL-2 and not their o...
Suppressive in Biological Technology

Santaris Pharma - Interim Report for the Period 1 January to 30 June 2009

...Pharma and academic partners publiched an article titled: Uncovering growth suppressive microRNAs in lung cancer. Cancer Research In January 2009 San...Pharma and academic partners published an article titled: Uncovering growth suppressive microRNAs in lung cancer Nature Cell Biology In first half of...

DiFUSION Technologies Completes Successful Testing of Antimicrobial Spinal Implant

... improve infection ratios, it will also save the patient from additional surgery, weeks of IV antibiotics and in some cases life long exposure to oral suppressive antibiotics, amputation and even death; benefits that will impact surgeons, patients, hospitals and insurance carriers. "DiFUSION is targeting ...

Laureate Announces Manufacturing Agreement with Tolerx

...clinical development for the treatment of cancer and chronic viral diseases. TRX518 is thought to circumvent immune system tolerance by inhibiting the suppressive activity of T regulatory cells and extending the survival of T effector cells, thereby enhancing responses to tumor and viral antigens. Tolerx also ha...

Monogram Biosciences Launches First Resistance Assay for HIV Integrase Inhibitors

... the HIV tropism assay (Trofile(TM)) are important tools to help clinicians make good choices. They can also help with modifying regimens that are not suppressive by determining whether additional resistance has emerged and which drugs are no longer active." "As the first and only commercially available assay ...

Electrotransformation of E. coli With M13 DNA

...XL1-Blue cells treated with X-Gal and IPTG which does not appear to be due solely to the presence of the X-Gal solvent, DMF. The suppressive effect varies with the amount of X-Gal and IPTG added to the electroporated cells, but is minimized when the reagents are added ...
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