p53, tumor suppression and aging
In the January 1 issue of Genes & Development, Dr. Mary Ellen Perry and colleagues validate the p53 inhibitor, Mdm2, as a promising target for cancer therapies. The p53 tumor suppressor plays a critical role in cancer formation, and many anticancer strategies aim to activate p53 in order to curb tumor formation. Mdm2 is a key inhibitor of p53 and therefore an attractive target to modul...Adrenal Suppression not predicted by inhaled corticosteroids
It is proved beyond doubt that asthma is affected beneficially by long-term treatment with inhaled corticosteroids (ICS) in childhood//. Although there is a lot of side affects that are associated with it. Which include adrenal suppression and growth deceleration; continue to be of concern to physicians that treat asthmatic children. The main researchers were Kostas N. Pri...Transplant Cures Rats’ Type 2 Diabetes without Need for Immune Suppression Drug
An approach proven to cure a rat model of type 1 or juvenile-onset diabetes also works in a rat model of type 2 or adult-onset diabetes//, according to a new report from researchers at Washington University School of Medicine in St. Louis. "Finding that we can cure type 2 diabetes in the same way is very significant because in humans type 2 diabetes is almost 20 times more prevalent th...Long-time Gastric Acid Suppression Does Not Increase The Risk Of Cancer
The use of H2 blocker drugs such as ranitidine (Zantac) and cimetidine (Tagamet)and proton pump inhibitors like omeprazole //(Prilosec) reduce stomach acid. This was believed to increase the risk of cancer of the esophagus or stomach. However, a new finding says that H2 blockers and proton pump inhibitors do not increase the risk of such cancers. The cancer risk is probably due...Suppression of Enzyme Delays a Type of Breast Cancer
Canadian researchers have disclosed that suppression of an enzyme called PTP1B stalls the advancement of a specific type of breast cancer//. This study was conducted on laboratory mice which were genetically modified to develop into a breast cancer condition of humans. This research headed by Michel L.Tremblay along with Sophie Julien of McGill cancer Center, Quebec delayed the advancem...Mayo Clinic Study Finds Heart Transplant Patients Benefit from New Approach to Immunosuppression
A new immunosuppression regimen for heart transplant patients can improve kidney function and prevent transplant coronary artery disease//, according to two new Mayo Clinic studies. Mayo researchers will report their findings on April 26 at The International Society for Heart & Lung Transplantation Annual Meeting and Scientific Session in San Francisco. Heart transplant patients are r...Rosetta Genomics and Weizmann Institute Scientists Identify Role of microRNA in Cancer Suppression
Findings Published in Molecular Cell Show Potential of microRNAs asNovel Cancer Drug Targets REHOVOT, Israel and NORTH BRUNSWICK, New Jersey, July 05, 2007/PRNewswire-FirstCall/ -- Rosetta Genomics Ltd , a leading microRNAcompany, announced today research published in the journalMolecular Cell by scientists from the Weizmann Institute of Scienceand Rosetta Genomics . The findings suggest...